In persons with CIDP, auto-HSCT can be conducted fully on an outpatient basis and induces significant clinical responses: A prospective study in a single center
CONCLUSION: aHSCT conducted fully in an outpatient basis, employing the conditioning regimen of the "Mexican method" appears to be a feasible therapeutic option for persons with CIDP. Additional studies are needed to confirm these observations.PMID:37866669 | DOI:10.1016/j.trim.2023.101944 (Source: Transplant Immunology)
Source: Transplant Immunology - October 22, 2023 Category: Transplant Surgery Authors: Merittzel Abigail Montes-Robles Mois és Manuel Gallardo-Pérez Edgar J Hern ández-Flores Mar ía de Lourdes Pastelín-Martínez Daniela S ánchez-Bonilla Max Robles-Nasta Guillermo Oca ña-Ramm Juan Carlos Olivares-Gazca Guillermo J Ruiz-Delgado Guiller Source Type: research
Nerve transcriptomes in autoimmune and genetic demyelinating neuropathies: Pathogenic pathway assessment of nerve demyelination
The pathogenesis of autoimmune demyelinating neuropathies is poorly understood compared to inherited demyelinating forms. We performed whole transcriptome (RNA-Seq) using nerve biopsy tissues of patients with different autoimmune and inherited demyelinating neuropathies (CIDP n = 10, POEMS n = 18, DADS n = 3, CMT1 n = 3) versus healthy controls (n = 6). A limited number of differentially expressed genes compared to healthy controls were identified (POEMS = 125, DADS = 15, CMT = 14, CIDP = 5). Divergent pathogenic pathways including infl ammatory, demyelinating and neurite regeneration s...
Source: Journal of Neuroimmunology - October 13, 2023 Category: Allergy & Immunology Authors: Hebatallah R. Rashed, Zhiyv Niu, Peter J. Dyck, P. James B. Dyck, Michelle L. Mauermann, Sarah E. Berini, Divyanshu Dubey, John R. Mills, P. Nathan, Yanhong Wu, Robert E. Spinner, Surendra Dasari, Christopher J. Klein Source Type: research
Musculoskeletal adverse events induced by immune checkpoint inhibitors: a large-scale pharmacovigilance study
Conclusion: Immune checkpoint inhibitors administration triggers a range of musculoskeletal adverse events, warranting the optimization of their management during clinical practice. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - October 10, 2023 Category: Drugs & Pharmacology Source Type: research
New-onset chronic inflammatory demyelinating polyradiculoneuropathy after COVID-19 infection: a case report
CONCLUSION: Considering this complication and differentiation between GBS and CIDP, and then initiating maintenance therapy can prevent long-term disability.PMID:37811109 | PMC:PMC10553086 | DOI:10.1097/MS9.0000000000000352 (Source: Annals of Medicine)
Source: Annals of Medicine - October 9, 2023 Category: Internal Medicine Authors: Mohammad Abedi Samakoush Lotfollah Davoodi Mojtaba Khademian Saeed Kargar-Soleimanabad Mohammad-Ali Abedini Source Type: research
Combined central and peripheral demyelination - one-year follow-up of patient with co-incidence of multiple sclerosis and multifocal acquired demyelinating sensory and motor neuropathy - A Case Report
We report on the 37-year-old patient with a coincidence of demyelinating lesions in the brain fulfilling current McDonald's diagnostic criteria for multiple sclerosis, as well as the presence of an atypical variant of chronic inflammatory demyelinating polyneuropathy (CIDP) - multifocal acquired demyelinating sensory-motor neuropathy (MADSAM), as a subtype of combined central and peripheral demyelination (CCPD).PMID:37776551 (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - September 30, 2023 Category: Endocrinology Authors: Peter Mar ček Peter Valkovi č Michal Min ár Darina Slez áková Source Type: research
