Nerve transcriptomes in autoimmune and genetic demyelinating neuropathies: Pathogenic pathway assessment of nerve demyelination

The pathogenesis of autoimmune demyelinating neuropathies is poorly understood compared to inherited demyelinating forms. We performed whole transcriptome (RNA-Seq) using nerve biopsy tissues of patients with different autoimmune and inherited demyelinating neuropathies (CIDP n  = 10, POEMS n = 18, DADS n = 3, CMT1 n = 3) versus healthy controls (n = 6). A limited number of differentially expressed genes compared to healthy controls were identified (POEMS = 125, DADS = 15, CMT = 14, CIDP = 5). Divergent pathogenic pathways including infl ammatory, demyelinating and neurite regeneration such as with the triggering receptor expressed on myeloid cells (TREM1) part of the immunoglobulin superfamily and RhoGD1 are found.

Source: Journal of Neuroimmunology - October 13, 2023 Category: Allergy & Immunology Authors: Hebatallah R. Rashed, Zhiyv Niu, Peter J. Dyck, P. James B. Dyck, Michelle L. Mauermann, Sarah E. Berini, Divyanshu Dubey, John R. Mills, P. Nathan, Yanhong Wu, Robert E. Spinner, Surendra Dasari, Christopher J. Klein Source Type: research