Therapeutic potential of natural killer cells in neuroimmunological diseases
Biomed Pharmacother. 2024 Mar 1;173:116371. doi: 10.1016/j.biopha.2024.116371. Online ahead of print.ABSTRACTNatural killer (NK) cells, a major component of the innate immune system, have prominent immunoregulatory, antitumor proliferation, and antiviral activities. NK cells act as a double-edged sword with therapeutic potential in neurological autoimmunity. Emerging evidence has identified NK cells are involved in the development and progression of neuroimmunological diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, autoimmune encephalitis, Guillain-Barré Syndrome, chronic inflammatory demyeli...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2024 Category: Drugs & Pharmacology Authors: Qing Zhang Jing Lin Mengge Yang Zhijun Li Min Zhang Bitao Bu Source Type: research
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy
CONCLUSIONS: Evidence from RCTs shows that IVIg improves disability for at least two to six weeks compared with placebo, with an NNTB of 4. During this period, IVIg probably has similar efficacy to oral prednisolone and IVMP. Further placebo-controlled trials are unlikely to change these conclusions. In one large trial, the benefit of IVIg compared with placebo in terms of improved disability score persisted for 24 weeks. Further research is needed to assess the long-term benefits and harms of IVIg relative to other treatments.PMID:38353301 | DOI:10.1002/14651858.CD001797.pub4 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - February 14, 2024 Category: General Medicine Authors: Sander Rm Bus Rob J de Haan Marinus Vermeulen Ivo N van Schaik Filip Eftimov Source Type: research
Tacrolimus-Induced Neurotoxicity After Transplant: A Literature Review
AbstractTacrolimus, a calcineurin inhibitor, is an immunosuppressant used globally to prevent rejection after organ transplantation. Although it significantly improves outcomes for solid organ transplant patients, it is associated with various side effects such as nephrotoxicity and neurotoxicity. Tacrolimus-induced neurotoxicity is frequently encountered in clinical practice and can present with a variety of symptoms that may occur even at therapeutic levels. Although tacrolimus-induced neurotoxicity is well documented, there is limited literature available on pharmacologic management. Twenty-eight case reports of tacroli...
Source: Drug Safety - February 14, 2024 Category: Drugs & Pharmacology Source Type: research
Relationship between vitamin D receptor genotypes (FOK1rs2228570) and IL18 gene expression in sample of multiple sclerosis Iraqi patients
CONCLUSION: The VDR(FOK1rs2228570) genotype was significantly correlated with IL18 expression in MS patients from Iraq.PMID:38339924 | DOI:10.3233/HAB-230010 (Source: Human Antibodies)
Source: Human Antibodies - February 10, 2024 Category: Biochemistry Authors: Zahraa Kadhim Lafi And Bushra Jasim Mohammed Source Type: research
