Effectiveness and safety of rituximab in autoimmune nodopathy: a single-center cohort study
AbstractAutoimmune nodopathy is a peripheral neuropathy characterized by acquired motor and sensory deficit with autoantibodies against the node of Ranvier or paranodal region in the peripheral nervous system. The clinical and pathological characteristics of the disease are distinct from that of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and the standard treatment for CIDP is partially effective. Rituximab is a chimeric monoclonal antibody which binds and depletes B cells in peripheral blood. This prospective observational study included 19 patients with autoimmune nodopathy. Participants received in...
Source: Journal of Neurology - August 12, 2023 Category: Neurology Source Type: research
Assessing ‘no evidence of disease activity’ status in patients with relapsing–remitting multiple sclerosis: a long-term follow-up
ConclusionThe results of this study demonstrate the efficacy of targeted and early intervention so as to act in the right time window, ensuring a favorable outcome in both clinical and radiological terms; this could be decisive in reducing clinical relapse, disease progression and related disability. Therefore, prescribing highly effective drug in the early stages of the disease represents a leading strategy with the most favorable cost–benefit ratio. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - August 7, 2023 Category: Neurology Source Type: research
Serum B-cell activating factor is not a potential biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy
B-cell activating factor (BAFF) is a crucial cytokine for differentiation and survival of B-cells and correlates to disease activity in some auto-immune diseases. To evaluate BAFF as a biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy (CIDP), serum BAFF levels were measured at varying disease stages: patients starting treatment, patients starting treatment withdrawal, patients in remission and healthy controls. Serum BAFF levels were elevated in patients compared to healthy controls, but did not differ between patients starting treatment and patients in remission. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 3, 2023 Category: Allergy & Immunology Authors: Milou R. Michael, Luuk Wieske, Marleen J. Koel-Simmelink, Ivo N. van Schaik, Charlotte E. Teunissen, Filip Eftimov Tags: Short Communication Source Type: research
Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency
CONCLUSION: These results point to a critical role for claudin-12 in maintaining the myelin barrier presumably via Pmp22 and highlight restoration of the hedgehog pathway as a potential treatment strategy for painful inflammatory neuropathy.PMID:37527762 | DOI:10.1016/j.nbd.2023.106246 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - August 1, 2023 Category: Neurology Authors: Jeremy Tsung-Chieh Chen Xiawei Hu Isabel U C Otto Christina Sch ürger Bruno Rogalla von Bieberstein Kathrin Doppler Susanne M Krug Mohammed K Hankir Rosel Blasig Claudia Sommer Alexander Brack Ingolf E Blasig Heike L Rittner Source Type: research
Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency
CONCLUSION: These results point to a critical role for claudin-12 in maintaining the myelin barrier presumably via Pmp22 and highlight restoration of the hedgehog pathway as a potential treatment strategy for painful inflammatory neuropathy.PMID:37527762 | DOI:10.1016/j.nbd.2023.106246 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - August 1, 2023 Category: Neurology Authors: Jeremy Tsung-Chieh Chen Xiawei Hu Isabel U C Otto Christina Sch ürger Bruno Rogalla von Bieberstein Kathrin Doppler Susanne M Krug Mohammed K Hankir Rosel Blasig Claudia Sommer Alexander Brack Ingolf E Blasig Heike L Rittner Source Type: research
Demographic and Clinical Characteristics of Familial and Sporadic Multiple Sclerosis Patients
Conclusions : Significant differences were found among different groups of patients in terms of demographical and clinical characteristics. (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - July 30, 2023 Category: International Medicine & Public Health Source Type: research
Case report: MELAS and T3271C mitochondrial mutation in an adult woman
ConclusionsTo our knowledge, it's the first report about MELAS with 3271 mutation that have only shown peripheral nerve motion impairment. Proximal weakness is also common in CIDP. In the context of this patient's experience, mitochondrial genome analysis provides an auxiliary criterion for differential diagnosis between MIDs and CIDP. In the meantime, we discussed the clinical effect of GCs on MIDs. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - July 27, 2023 Category: Neurology Source Type: research
Epidemiology of Chronic Inflammatory Demyelinating Polyneuropathy in South Korea: A Population-Based Study
CONCLUSIONS: The prevalence and incidence rates of CIDP in South Korea were comparable between this nationwide cohort study and previous studies. Common comorbidities such as CVD and diabetes should be appropriately monitored in patients with CIDP to prevent a poor prognosis and socioeconomic burden.PMID:37488959 | DOI:10.3988/jcn.2023.0007 (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 25, 2023 Category: Neurology Authors: Sohee Jung Gucheol Jung Dayoung Kim Jeeyoung Oh Kyomin Choi Source Type: research
