Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) comprises emotional and physical symptoms and functional impairment that lie on the severe end of the continuum of premenstrual symptoms. Women with PMDD have a differential response to normal hormonal fluctuations. This susceptibility may involve the serotonin system, altered sensitivity of the GABAA receptor to the neurosteroid allopregnanalone, and altered brain circuitry involving emotional and cognitive functions. Serotonin reuptake inhibitors are considered the first-line treatment. Second-line treatments include oral contraceptives containing drospirenone, other ovulation suppr...
Source: The Psychiatric Clinics of North America - February 28, 2017 Category: Psychiatry Authors: Teresa Lanza di Scalea, Teri Pearlstein Source Type: research
Estimation of uronic acids using diverse approaches and monosaccharide composition of alkali soluble polysaccharide from Vitex negundo Linn.
Publication date: 1 June 2017 Source:Carbohydrate Polymers, Volume 165 Author(s): Pradeep Kumar, Vineet Kumar Vitex negundo L. is one of the most important species in traditional system of medicine to cure various ailments. Alkali soluble polysaccharide (ASP) from V. negundo stems was isolated and purified in 0.61% yield. Complete hydrolysis of ASP followed by paper chromatography and GLC analysis indicated the presence of l-rhamnose, l-arabinose, d-xylose, d-galactose and d-glucose in mole percent of 1.28, 2.25, 73.49, 8.08, 8.11 along with 2.48 d-galacturonic acid and 4.27 d-glucuronic acid. Uronic acids were also es...
Source: Carbohydrate Polymers - February 23, 2017 Category: Biomedical Science Source Type: research
Identification of the aroma compounds in Vitex doniana sweet: free and bound odorants
Most often, the glycosidically-bound aroma compounds are released during industrial processing or pre-treatment of fruits. This usually introduces modification to the aroma notes of such fruits. Therefore, the... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 23, 2017 Category: Chemistry Authors: Ola Lasekan Source Type: research
The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis
Our objective was to determine the efficacy, tolerability, and acceptability of Vitex agnus castus preparations for treatment of premenstrual syndrome. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 22, 2017 Category: OBGYN Authors: Saskia Verkaik, Astrid M. Kamperman, Roos van Westrhenen, Peter F.J. Schulte Tags: Systematic Review Source Type: research
The treatment of premenstrual syndrome with preparations of Vitex agnus castus: A systematic review and meta-analysis
A high risk of bias and the heterogeneity of the included studies preclude a definite conclusion about the effectiveness of treatment of PMS with Vitex agnus castus (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 22, 2017 Category: OBGYN Authors: Saskia Verkaik, Astrid M. Kamperman, Roos van Westrhenen, Peter F.J. Schulte Tags: Systematic Review Source Type: research
Ethnomedicinal uses of plants for the treatment of malaria in Soon Valley, Khushab, Pakistan
Conclusions To the best of our knowledge seven plant species, viz. Withania coagulans, Fagonia cretica, Carthamus oxyacantha, Ehretia obtusifolia, Helianthus annuus, Olea ferruginea and Vitex trifolia, are reported from this region for the first time for the treatment of malaria. This first ethno-medicinal study highlights potential sources for the development of new antimalarial drugs from indigenous knowledge of medicinal plants found in the Soon Valley, Pakistan. Such investigations could be a subject for in vitro and in vivo anti-plasmodial screening to develop new plant-based antimalarial drugs and can also be evaluat...
Source: Journal of Ethnopharmacology - February 21, 2017 Category: Drugs & Pharmacology Source Type: research
Nanoemulsion for improving solubility and permeability of Vitex agnus-castus extract: formulation and in vitro evaluation using PAMPA and Caco-2 approaches.
Authors: Piazzini V, Monteforte E, Luceri C, Bigagli E, Bilia AR, Bergonzi MC
Abstract
The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion (NE) was selected as lipid-based nanocarrier. The composition of extract-loaded NE resulted in triacetin as oil phase, labrasol as surfactant, cremophor EL as co-surfactant and water. NE contains until 60 mg/mL of extract. It was characterized by DLS and TEM analyses and its ...
Source: Drug Delivery - February 8, 2017 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Report on the Medicinal Use of Eleven Lamiaceae Species in Lebanon and Rationalization of Their Antimicrobial Potential by Examination of the Chemical Composition and Antimicrobial Activity of Their Essential Oils.
Authors: Khoury M, Stien D, Eparvier V, Ouaini N, El Beyrouthy M
Abstract
Many Lamiaceae species are consumed in the Lebanese cuisine as food or condiment and are largely used in the traditional medicine of Lebanon to treat various diseases, including microbial infections. In this article we report the traditional medicinal uses of eleven Lamiaceae species: Coridothymus capitatus L., Lavandula stoechas L., Lavandula angustifolia Mill., Mentha spicata L. subsp. condensata, Origanum syriacum L., Rosmarinus officinalis, Salvia fruticosa Miller., Satureja cuneifolia Ten., Satureja thymbra L., Thymbra spicata L...
Source: Evidence-based Complementary and Alternative Medicine - January 7, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
A Novel Clerodane Diterpene from Vitex cofassus.
Abstract
New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC50 values of 5.4-11.4 µM. Their effec...
Source: Chemical and Pharmaceutical Bulletin - January 5, 2017 Category: Drugs & Pharmacology Authors: Rasyid FA, Fukuyoshi S, Ando H, Miyake K, Atsumi T, Fujie T, Saito Y, Goto M, Shinya T, Mikage M, Sasaki Y, Nakagawa-Goto K Tags: Chem Pharm Bull (Tokyo) Source Type: research
Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells
Casticin, the flavonoid extracted from Vitex rotundifolia L, exerts various biological effects, including anti-inflammatory and anti-cancer activity. The aim of this study is to investigate the effects and mechan... (Source: Cancer Cell International)
Source: Cancer Cell International - January 5, 2017 Category: Cancer & Oncology Authors: Xiao-ling Song, Yun-jiao Zhang, Xue-feng Wang, Wen-jie Zhang, Zheng Wang, Fei Zhang, Yi-jian Zhang, Jian-hua Lu, Jia-wei Mei, Yun-ping Hu, Lei Chen, Huai-feng Li, Yuan-yuan Ye, Ying-bin Liu and Jun Gu Source Type: research
Chemical profiling and chemical standardization of Vitex negundo using 13C NMR
Chemical profiling and standardization of the defatted methanol extract of the leaves of Vitex negundo L. were carried out using 13C nuclear magnetic resonance (NMR) analysis followed by chemometric analysis of the chemical shift data. Chemical profile was obtained using a k-means cluster profile and chemical standardization which was achieved using a multivariate control chart. The V. negun... (Source: Journal of Medicinal Plants Research)
Source: Journal of Medicinal Plants Research - January 2, 2017 Category: Complementary Medicine Source Type: research
SC-CO2 extraction of Vitex agnus-castus L. fruits: The influence of pressure, temperature and water presoaking on the yield and GC –MS profiles of the extracts in comparison to the essential oil composition
The objectives were trifold: 1) to investigate the impact of pressure, temperature and water presoaking on SC-CO2 extraction of Vitex agnus-castus L. fruits with respect to the yield and GC–MS profiles of the extracts; 2) to find optimal extraction conditions by response surface methodology (RSM); 3) to compare GC–MS profiles of the extracts and essential oil. SC-CO2 extraction was performed at different pressures (8.4–36.6MPa) and temperatures (35.8–64.1°C) determined by central composite rotatable design. The essential oil was obtained by hydrodistillation. The extracts and oil were analyzed by GC–MS. Applied ...
Source: The Journal of Supercritical Fluids - December 31, 2016 Category: Chemistry Source Type: research
Nanoemulsions to enhance oral bioavailability of Vitex Agnus-castus extract
Planta Med 2016; 81: S1-S381 DOI: 10.1055/s-0036-1596925 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Planta Medica)
Source: Planta Medica - December 13, 2016 Category: Drugs & Pharmacology Authors: Piazzini, V Monteforte, E Luceri, C Bigagli, E Guccione, C Bilia, AR Bergonzi, MC Tags: Abstracts Source Type: research
Antibacterial activity of Vitex parviflora A. Juss. and Cyanthillium cinereum (L.) H. Rob. against human pathogens
This study investigated the antibacterial activities of methanolic crude extracts of Vitex parviflora (V. parviflora) leaves and stem and Cyanthillium cinereum (C. cinereum) leaves and roots. Crude methanolic extracts of V. parviflora and C. cinereum were tested for their antibacterial activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis. The leaf and stem extracts of V. parviflora and root extracts of C. cinereum exhibited high antibacterial activity against Staphylococcus aureus. Increasing concentration of the V. parviflora leaves and roots crude extracts resulted in a...
Source: Asian Pacific Journal of Tropical Disease - November 22, 2016 Category: Tropical Medicine Source Type: research
Cardioprotective effect of Vitex negundo on isoproterenol-induced myocardial necrosis in wistar rats: A dual approach study.
Abstract
Cardiovascular diseases (CVDs) are becoming the major cause of deaths worldwide, and their treatment demands novel therapeutic strategies. In this connection, we have identified p21 activated kinase 1 (PAK1) as a novel therapeutic target for the treatment of myocardial infarction (MI), where its expression is decreased when MI is induced with isoproterenol (ISO), which was brought back normal with pretreatment of Vitex negundo leaf ethanolic extract (VNE). These results were also supported by histopathological studies, cardiac markers, antioxidants, and inflammatory cytokines (NF-κB and IL-1β). ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2016 Category: Drugs & Pharmacology Authors: Prasad EM, Mopuri R, Islam MS, Kodidhela LD Tags: Biomed Pharmacother Source Type: research
