Repellent activity of Vitex negundo and Curcuma longa herbal extract against simulium species in India
CONCLUSION: At an optimum concentration of 10%, the methanolic extract of vitex negundo cream provided complete protection times (CPTs) 320.4, 358.6, and 346.4 minutes, respectively. This finding offers confirmation of the methanolic extract and chloroform extract potential for use in new blackfly repellents.PMID:38634372 | DOI:10.4103/JVBD.JVBD_181_23 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Chinmoy Bhuyan Dipankar Saha Bipul Rabha Source Type: research
Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential
Conclusion: Vitekwangin B may offer a new direction for cancer therapy by targeting ANO1 protein, potentially improving treatment outcomes in patients with prostate cancer and NSCLC. Further research is needed to explore its full potential and overcome existing drug resistance challenges. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.
Plants, renowned for their rich reservoir of metabolites, play a pivotal role in addressing health-related issues. The Verbenaceae family stands out, showcasing immense potential in preventing and treating chronic diseases. Vitex trifolia L. (V. trifolia), a shrub with a rich history in traditional medicine, particularly in Eastern Asia, has garnered attention for its diverse therapeutic applications. This comprehensive review aims to bridge traditional knowledge and contemporary insights by investigating ethnopharmacology, phytochemistry, and pharmacological effects of V. trifolia. The keyword “V. trifolia” and its sy...
Source: Frontiers in Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Source Type: research
Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from < em > Vitex negundo < /em >
Nat Prod Res. 2024 Feb 9:1-9. doi: 10.1080/14786419.2024.2312542. Online ahead of print.ABSTRACTThe compound 2,3-dehydrosilychristin, a flavonolignan linked to silychristin and silymarin, remains intriguing due to its challenging isolation from silymarin. While silymarin has been the exclusive source of flavonolignans - silybin, silychristin and silydianin - 2,3-dehydrosilychristin is reported in this study from Vitex negundo Linn. leaves. 2,3-Dehydrosilychristin (7) and 14 other compounds were isolated through focused extraction. Its subsequent pharmacological evaluation demonstrated potent antioxidant and in-vitro anti-i...
Source: Natural Product Research - February 9, 2024 Category: Biochemistry Authors: Nancy Tripathi Aliva Naik Dulla Naveen Kumar Nivedita Bhardwaj Bharat Goel Sanjay Kumar Sanheeta Chakrabarty Amit Ranjan Santosh Kumar Guru Sanjeev Kumar Ashish Agrawal Shreyans K Jain Source Type: research
Isolation of New Diterpenoids from the Halophyte, Vitex rotundifolia, and their Antioxidant and Anti-inflammatory Activities
In this study, three diterpenoids (1-3), including one known compound (1), were isolated from the fruits of Vitex rotundifolia and their structures were determined via spectroscopic analysis. In lipopolysaccharide-stimulated RAW264.7 cells, these compounds dose-dependently decreased the intracellular reactive oxygen species levels and nitric oxide production compared to those in the control cells. At 25 μM/mL, these compounds also diminished the protein expression of the pro-inflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-6, with compound 3 exhibiting the most potent inhibitory e...
Source: Chemistry and Biodiversity - February 9, 2024 Category: Biochemistry Authors: Jung Hwan Oh Chang-Suk Kong Jihee Lee Eun-Hee Kim Youngwan Seo Source Type: research
Casticin ameliorates osteoarthritic cartilage damage in rats through PI3K/AKT/HIF-1 α signaling
Chem Biol Interact. 2024 Feb 1;391:110897. doi: 10.1016/j.cbi.2024.110897. Online ahead of print.ABSTRACTKnee osteoarthritis (KOA) is a chronic, disabling knee joint lesion in which degeneration and defects in articular cartilage are the most important features. Casticin (CAS) is a flavonoid extracted from the Chinese herb Vitex species that has anti-inflammatory and antitumor effects. The aim of this study was to investigate the therapeutic and mechanistic effects of CAS on cartilage damage in KOA. A KOA rat model was established by anterior cruciate ligament transection (ACLT), and cartilage morphological changes were as...
Source: Chemico-Biological Interactions - February 3, 2024 Category: Molecular Biology Authors: Deren Liu Wei Mei Junfeng Kang Taiyang Liao Yibao Wei Lishi Jie Lei Shi Peimin Wang Jun Mao Peng Wu Source Type: research
Effects of the PREMEN-CALM ® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
J Diet Suppl. 2024 Jan 11:1-17. doi: 10.1080/19390211.2023.2301398. Online ahead of print.ABSTRACTPremenstrual syndrome is a common disorder in women of reproductive age characterized by a variety of cyclical symptoms with a great impact on their lifestyle. Available pharmacological options include both antidepressants and oral contraceptives, both of which have side effects, are expensive and not always effective. Vitamins, minerals and plant extracts have been proven to alleviate the symptomatology of the premenstrual syndrome. For this reason, the purpose of this study was to test the effectiveness of a commercial phyto...
Source: Journal of Dietary Supplements - January 12, 2024 Category: Nutrition Authors: Andrea Herrera Miriam Al Adib Ana Beatriz Rodr íguez Cristina Carrasco Source Type: research
Evaluation of the therapeutic efficacy of < em > Vitex agnus-castus < /em > extract on cisplatin-induced hematotoxicity in female Wistar rats
CONCLUSION: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses.PMID:38152275 | PMC:PMC10750742 | DOI:10.14202/vetworld.2023.2186-2191 (Source: Cancer Control)
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Aparna Tripathy Archana Parampalli Raghavendra Babi Dutta Sudarshan Surendran Source Type: research
Evaluation of the therapeutic efficacy of < em > Vitex agnus-castus < /em > extract on cisplatin-induced hematotoxicity in female Wistar rats
CONCLUSION: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses.PMID:38152275 | PMC:PMC10750742 | DOI:10.14202/vetworld.2023.2186-2191 (Source: Cancer Control)
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Aparna Tripathy Archana Parampalli Raghavendra Babi Dutta Sudarshan Surendran Source Type: research
Effect of E-PR-01 on non-specific low back pain in the adult population: A randomized, double-blind, placebo-controlled, parallel-group trial
CONCLUSION: E-PR-01 significantly improved low back pain and bending flexibility in adults without adverse effects. Moreover, the effect of E-PR-01 lasted 7 days after stopping the intervention.PMID:38073372 | DOI:10.3233/BMR-230197 (Source: Journal of Back and Musculoskeletal Rehabilitation)
Source: Journal of Back and Musculoskeletal Rehabilitation - December 11, 2023 Category: Orthopaedics Authors: Shalini Srivastava Sagar Karvir Robert N Girandola Source Type: research
