Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immun...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Most Core Longevity Industry Venture Investment Vehicles are Companies, Not Funds
The objective of a venture fund is to exist for a set period of time, invest in startups, and return gains to investors at the end of that time. The objective of a business development company is to go public. This difference in objectives tends to steer groups like Juvenescence and Cambrian towards creating a family of owned companies, via founding startups or purchasing controlling majority stakes in existing ventures, and participating actively in the management of those companies. New Big Pharma entities will likely emerge from this approach, as the industry grows, and the first rejuvenation therapies prove their worth...
Source: Fight Aging! - February 16, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
COVID-19 vaccines: Safety, side effects –– and coincidence
As the pandemic rages on, it’s increasingly clear that widespread vaccination is essential to help contain it. Physical distancing, universal face coverings, and frequent handwashing are effective, but not foolproof. And of course, these measures don’t work if they are not followed.
So, the rapid development of mRNA vaccines and other vaccines to prevent COVID-19 is welcome — some say miraculous — news. But while many people are scrambling to get a vaccine, others are hesitating.
Start here: Are these vaccines safe and effective?
It’s natural to wonder if brand new vaccines against a novel coronavirus, developed ...
Source: Harvard Health Blog - February 8, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Vaccines Source Type: blogs
COVID-19 vaccines: Safety, side effects — and coincidence
As the pandemic rages on, it’s increasingly clear that widespread vaccination is essential to help contain it. Physical distancing, universal face coverings, and frequent handwashing are effective, but not foolproof. And of course, these measures don’t work if they are not followed.
So, the rapid development of mRNA vaccines and other vaccines to prevent COVID-19 is welcome — some say miraculous — news. But while many people are scrambling to get a vaccine, others are hesitating.
Start here: Are these vaccines safe and effective?
It’s natural to wonder if brand new vaccines against a novel coronavirus, developed ...
Source: Harvard Health Blog - February 8, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Vaccines Source Type: blogs
Top 6 Crowdsourcing Examples In Digital Health
During your school years, you might have encountered several instances where your teacher laid out a task or asked a question, and asked you and your classmates to come up with an answer or solution. This “method” somewhat exemplifies crowdsourcing, albeit in analogue form. In essence, the term refers to the act of gathering information or input into a task from a large group of people; or simply, “outsourcing work to the crowd” as the Wired editors who coined the term in 2005 described it.
However, one must not confuse crowdsourcing with crowdfunding. The latter involves raising relatively small amounts of fu...
Source: The Medical Futurist - February 2, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Covid-19 3D Printing Biotechnology Digital Health Research E-Patients Personalized Medicine Telemedicine & Smartphones aids crowdsourcing fda artificial pancreas 3d printed vaccination covid19 immunity passport gaming Foldi Source Type: blogs
Fight Aging! Newsletter, January 25th 2021
In conclusion, our studies highlight the important role of the tyrosine degradation pathway and position TAT as a link between neuromediator production, dysfunctional mitochondria, and aging. (Source: Fight Aging!)
Source: Fight Aging! - January 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Considering the Ethics of Extending the Healthy Human Life Span
To suffer or become incapacitated is to diminish the utility of being alive. The way to minimize this loss is to work towards removing the causes of suffering and incapacitation. The greatest such causes are medical, and of those, aging is by far the largest. Similarly, to die is to suffer the loss of all that one might have been and done after that time. It is a tragedy that any individual ceases to exist. The way to minimize this loss is to work to remove the causes of death. The greatest such causes are medical, and of those, aging is by far the largest. Ethically, the case for working to extend healthy human life spans...
Source: Fight Aging! - January 19, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Responding to Misinformation
By John Halamka and Paul CerratoThe singer/songwriter Paul Simon once penned the lyrics: A man hears what he wants to hear and disregards the rest (The Boxer). If that ’s the case, how do we respond to misinformation that contradicts the data/evidence guiding development of treatment and cures? If the only audience willing to read such articles are already critical thinkers, perhaps we are just preaching to the choir. And if by chance, a person who believes in controversial ideas does read articles based on real world evidence, will they consider them a one-sided discussion by the “medical-industrial es...
Source: Life as a Healthcare CIO - January 14, 2021 Category: Information Technology Source Type: blogs
All you need to know about waterborne diseases
Waterborne diseases are contracted through exposure to contaminated water including drinking water, water used in food preparation, and swimming water.
They can be caused by bacteria, viruses, and parasites. Below is a partial list of waterborne disease pathogens, their microbial classification, and their resulting illnesses.
Classification
Microorganism
Disease
Bacterium
Campylobacter spp.
Campylobacteriosis
Bacterium
Escherichia coli
E. Coli Diarrhea
Bacterium
Legionella pneumophila
Legionnaires’ Disease
Bacterium
Salmonella enterica
Salmonellosis
Bacterium
Salmonella typhi
Typhoid fever
...
Source: GIDEON blog - January 14, 2021 Category: Databases & Libraries Authors: Kristina Symes Tags: Microbiology News Tips Source Type: blogs
Fight Against COVID-19 Aided by Sepsis Researchers
Spike proteins on the surface of a coronavirus. Credit: David Veesler, University of Washington.
Since the start of the COVID-19 pandemic, researchers from many areas of biomedical science have worked together to learn how this new disease affects the human body, how to prevent its spread, and how to treat it. Severe cases of COVID-19 and cases of sepsis share many symptoms. Sepsis is the body’s overactive and extreme response to an infection. It’s unpredictable and can progress rapidly. Without prompt treatment, it can lead to tissue damage, organ failure, and death.
Sepsis has similarities with some cases of COVI...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 13, 2021 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness COVID-19 Infectious Diseases Research Roundup Scientific Process Sepsis Source Type: blogs
Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain.
From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
RNA, in a Nutshell
The mRNA vaccine platform is based on decades of previous studies, highlighting the importance of regularly funding basic research. (Source: virology blog)
Source: virology blog - January 7, 2021 Category: Virology Authors: Trudy Rey Tags: Basic virology Gertrud Rey cancer mRNA vaccines cholesterol encapsulated lipid nanoparticle PEG polyethylene glycol pre-fusion spike protein rsv SARS-CoV-2 Source Type: blogs
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this.
There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
