Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflam...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
We Live in an Age of Biotechnology, In Which We Could Choose to End the Suffering of Aging
Bringing degenerative aging under medical control, ending the tens of millions of deaths each year, ending the suffering of hundreds of millions more. This is a plausible goal for our era of biotechnology. Yet even as the first rejuvenation therapies have become a reality, in the form of first generation senolytic drugs that clear a sizable fraction of senescent cells from the body, there is little public enthusiasm for - and understanding of - the path ahead to a better world. A world in which people have the choice not to decay in body and mind as they gather wisdom and experience in later life. Change is in the air, but...
Source: Fight Aging! - August 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
IBM ’ s Moonshot Ambition In Healthcare
This article is a part of our series Tech Giants In Healthcare. Previous titles included
Amazon’s Dive Into Healthcare: A 2021 UpdateIs Apple Going Into Healthcare?Google’s Masterplan for HealthcareMicrosoft Makes a 16-billion Dollar Bet On Healthcare
Take a deeper dive into what these companies aim for in medicine with our e-book, Tech Giants In Healthcare.
Back in 2015, IBM’s previous CEO, Virginia Rometty famously said that IBM’s “moon shot will be the impact we have on healthcare.” Under the Watson Health banner, the tech company has been leveraging its expertise in cognitive computing to a...
Source: The Medical Futurist - August 9, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Artificial Intelligence in Medicine Digital Health Research Future of Medicine Future of Pharma Health Sensors & Trackers Healthcare Design Personalized Medicine Portable Medical Diagnostics IBM ibm watson xprize A.I. quantum compu Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent T Cells in the Context of Cancer
Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is beneficial in the short term, an important part of the panoply of mechanisms devoted to, separately, cancer suppression and regeneration. When senescent cells begin to linger, however, their secretions become highly disruptive to normal tissue function. Senescent cell accumulatio...
Source: Fight Aging! - August 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Anti ‐Vaxxers Turn to Big Government
Thomas A. FireyCOVID-19hospitalizations anddeaths are rising in the United States as the highly infectious Delta variant of the SARS-CoV-2 virus has becomethe dominant strain in the country. These serious cases arealmost entirely limited to people who are not vaccinated against the virus; for the vaccinated,infection rates are much lower and nearly all infections are no more troublesome than a cold or — at worst – a bout of the flu, and often go unnoticed altogether.COVID-19 causedat least11 percent of all U.S. deaths in 2020, making it thethird leading cause of death, behind only heart disease and cancer. So far in 20...
Source: Cato-at-liberty - August 2, 2021 Category: American Health Authors: Thomas A. Firey Source Type: blogs
Is this blog political?
Of course. Read the paragraph at the top. Public health is fundamentally political -- well, I ' m not sure that ' s exactly the right word, but it ' s very much about public policy, which is a primary determinant of public health. Much of what public health researchers do is to assess the impact of policies on health. Furthermore, all categories of public policy affect public health, not just health care policy or environmental regulations. Transportation, land use management, taxation, education, law enforcement -- you name it. We say " health in all policies, " and it is our job, as scientists, to elucidate those relatio...
Source: Stayin' Alive - July 27, 2021 Category: American Health Source Type: blogs
On the bias of science: a digression
This series has elicited a couple of what I consider idiotic and unpublishable comments to the effect that I have just proved why people don ' t trust science. This is a basic problem in science communication to the general public that is much discussed. Here ' s my two cents.The problem is that scientists are generally reluctant to make highly definitive statements. Science is a continuously progressive endeavor and it ' s not uncommon for what we thought we knew yesterday to turn out to be not quite right today. Many conclusions are probabilistic - we ' re 90% or 95% sure of something. Sometimes an association holds unde...
Source: Stayin' Alive - July 22, 2021 Category: American Health Source Type: blogs
Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens.
Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Biomaterial-Based Vaccine Against Bacterial Infection
Researchers at the Harvard Wyss Institute have developed a biomaterial-based vaccine technology that could provide prophylactic protection against bacterial infection and septic shock. The technology is delivered as a biomaterial scaffold. Once inside the body, it captures bacterial pathogens and then recruits and activates dendritic cells to initiate a broad immune response against the pathogen of choice. So far, the technology has demonstrated protective efficacy against sepsis in animals.
Bacterial infections, once largely controllable with antibiotics, are becoming a growing problem with the rise of bacterial resist...
Source: Medgadget - July 12, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Critical Care Materials Medicine Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Graphene Sensor for Rapid COVID-19 Detection
Researchers at the University of Illinois Chicago have developed a graphene-based sensor that can rapidly detect the SARS-CoV-2 virus. The system includes graphene sheets that are coupled with an antibody against the viral spike protein. When viral particles bind to the antibodies, they change the vibrational properties of the graphene sheets, and the researchers can measure this using Raman spectroscopy. The test takes less than five minutes, and could provide another useful tool in the fight against COVID-19.
While vaccination programs are picking up speed, the global fight against COVID-19 is still a long way from ov...
Source: Medgadget - June 18, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Materials Medicine Public Health Source Type: blogs
A Discussion of Mesenchymal Stem Cell Therapy as a Way to Suppress Age-Related Inflammation
First generation mesenchymal stem cell therapies have been shown over the years to fairly reliably suppress chronic inflammation for some time, whether disease-associated or aging-associated. The transplanted cells die quickly, but the effects of their brief burst of signaling can last for months. Other intended benefits, such as increased regeneration or function, are in comparison unreliable at best. In part the challenge is that there is no standard in this part of the field, every clinic uses different methodologies and cell sources. These differences appear to matter greatly, and the fine details of why they matter gr...
Source: Fight Aging! - June 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Twins For Everyone!
By KIM BELLARD
I have lived my entire life as a twin, and, while it isn’t an unalloyed blessing, on balance I’d recommend it. Most of you, though, probably aren’t twins and have missed the experience. Don’t worry: you may still get a chance – with a digital twin.
It could have profound implications for your health and for healthcare generally.
A digital twin, in case you are not familiar with the concept, is a virtual representation of a physical object. It is created from data about that physical object, and is fed ongoing data (e.g., via IoT) about it to keep the model accurate....
Source: The Health Care Blog - June 16, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech digital twins Kim Bellard Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gr...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
