The Mainstream Media is Slowly Becoming Less Skeptical of Work to Extend the Healthy Human Life Span
One can't maintain dismissive skepticism forever in the face of scientific and medical development communities that are ever more engaged in the development of therapies to address the mechanisms of aging. To pick one example, senolytic treatments that clear senescent cells from aged tissues are producing consistently amazing data in mice: rejuvenation, extension of healthy life, reversal of measures of many specific age-related diseases. We'll soon know how well the more viable senolytics perform in human trials, as the preliminary data from the use of dasatinib and quercetin shows that it does selectively destroy senesce...
Source: Fight Aging! - June 11, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Trojan Horse Virus Makes Tumors Destroy Themselves
Researchers at the University of Zurich have developed a virus-based therapy that causes a tumor to destroy itself. They modified an adenovirus, which is a common virus that typically infects the respiratory tract and which is already widely used in medicine, to deliver genetic material that codes for an anti-cancer protein. In a sneaky move, the researchers designed the therapy so that the virus would infect tumor cells, forcing them to destroy themselves.
Cancer therapies are constantly evolving. Immunotherapies, which include antibodies that stimulate the immune system to destroy cancer cells, are the latest class of...
Source: Medgadget - May 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Oncology Source Type: blogs
Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation.
"Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Let's Talk About Hospitals And Rural Healthcare (Particularly Mother-Baby Care): My Letter To The NC Government Commission/NC State Treasurer In Support Of Randolph County's Application For A Loan To Save Randolph Health
Author ' s Note: The lawyers have a saying, " Res Ipsa Loquitur " " . Translated from Latin, it means, " The thing speaks for itself " . This is the text of the letter I sent to theNC Local Government Commission (embellished with a few links and additional comments in red) . . .in support of the state of North Carolina granting a loan to Randolph County (via the NC Rural Healthcare Stabilization Act) . . . for purposes of assisting in the " rescue " of Asheboro ' s Randolph Health - in a bankruptcy Court-approved buy-out of Randolph ' s assets by American Healthcare Systems, LLC.On May 4th, afte...
Source: Dr.J's HouseCalls - May 7, 2021 Category: American Health Tags: Asheboro Atrium Health Bankruptcy Cone Health Duke Lifepoint LGC Medical Whistle-blower Mother-Baby Care NC Rural Heatlh NCDHHS Non-profit Randolph Health UNC Health Wake Forest Baptist Source Type: blogs
Type 1 diabetes in transgender children and adults
In the face of genetically engineered therapies for many cancers and the incredibly rapid development of effective vaccines for COVID-19, it ’s easy to lose sight of the breadth and depth of unsolved puzzles in medical science. Many of these remaining mysteries may be at least partially resolved as we overcome the mind/body dichotomy. A fascinating […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 30, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/martin-lustick" rel="tag" > Martin Lustick, MD < /a > < /span > Tags: Conditions Diabetes Endocrinology Source Type: blogs
It ’s OK to Break the Rules Now and Then
This study introduces an augmented intelligence platform for the real-time synthesis of institutional knowledge captured in EHRs.” One caveat that the researchers acknowledge in the report was that they had yet to conduct prospective validation of the augmented EHR curation approach.A second nference-based investigation reviewed the records of patients who had received more than 94,000 doses of the Pfizer COVID-19 vaccine, more than 36,000 doses of the Moderna vaccine, and 1,745 doses of the Johnson& Johnson vaccine. The study ’s goal was to determine the incidence of cerebral venous sinus thrombosis (CVST), w...
Source: Life as a Healthcare CIO - April 26, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, April 26th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 25, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Days of Miracles and Wonder
Here ' s a good overview by Derek Thompson in The Atlantic ofthe history of mRNA technology. This heretofore obscure field of biomedical research burst into view with the Covid-19 vaccines, but the apparent suddenness of vaccine development was misleading. As I have noted here before, the technology was decades in development. As the technology became more mature, Pfizer partnered with one of the speculative ventures, BionTech, originally to develop flu vaccines, and then of course pivoted to Covid-19. Unlike Moderna, Pfizer actually didn ' t take federal funding for that final stage of development. But for most of the dec...
Source: Stayin' Alive - April 6, 2021 Category: American Health Source Type: blogs
Fully vaccinated against COVID-19? So, what can you safely do?
Congrats on getting your COVID-19 vaccine! You qualify as fully vaccinated two weeks after your second dose of the Moderna or Pfizer/BioNTech vaccine, or two weeks after your single dose of the Johnson & Johnson vaccine, according to the US Centers for Disease Control and Prevention (CDC).
Maybe you’re wondering what you can safely do now that you’re fully vaccinated. As an infectious disease specialist, I’ve provided answers to some common questions. Please keep in mind that information about COVID-19 and vaccines is evolving, and recommendations may change as we learn more.
Can I gather with people outside my h...
Source: Harvard Health Blog - March 25, 2021 Category: Consumer Health News Authors: Amy C. Sherman, MD Tags: Coronavirus and COVID-19 Health Parenting Relationships Vaccines Source Type: blogs
Nanoparticles On My Mind
By KIM BELLARD
Nanoparticles are everywhere! By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare. But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger.
Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants. They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs
Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Future of Human Longevity will be Very Different from the Past
Human life expectancy has increased through two distinct process; firstly a reduction in child mortality, and second a reduction in the burden of damage accumulated over an adult life span. Control of infectious disease has played a large role in both components of gains in life expectancy. The trend has been slow. In recent decades, something like 0.2 years of life expectancy at birth and 0.1 years of remaining life expectancy at age 60 have been added with each passing calendar year.
Life expectancy is an artificial measure, of course: it is the length of life remaining, on average, assuming that nothing changes i...
Source: Fight Aging! - March 16, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
You got the COVID-19 vaccine? I have vaccine envy
I admit it: I have vaccine envy. It’s that feeling of jealousy, disappointment, or resentment you feel when someone else gets the vaccine for COVID-19 — and you can’t.
I’m not proud of it. We should all be celebrating the astounding speed with which multiple effective and safe COVID-19 vaccines were developed. Millions of people are receiving them daily, bringing the increasingly real possibility of herd immunity closer day by day.
So, I should just be patient, right? It’s not easy.
Vaccine envy is inevitable
Current evidence suggests vaccination could save your life and those around you while helping daily life ...
Source: Harvard Health Blog - March 11, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Coronavirus and COVID-19 Health Health policy Vaccines Source Type: blogs
Fight Aging! Newsletter, March 8th 2021
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-a...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pain model – helping to target change
In my recent post on behavioural approaches to pain management, I had a number of commentators ask why do it, why not focus on pain intensity, and aren’t I invalidating a person’s experience if I target a person’s response to their experience. Today’s post will explore some of these points.
I suppose my first point needs to distinguish between pain as an experience, and pain behaviour – or what we do when we experience pain. I like to use a pretty old “model” or diagram to help untangle these concepts. It’s drawn from Loeser’s “Onion ring” model, and he w...
Source: HealthSkills Weblog - February 28, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Clinical reasoning Coping strategies Pain Pain conditions Therapeutic approaches models pain models Source Type: blogs
