It ’s OK to Break the Rules Now and Then

This study introduces an augmented intelligence platform for the real-time synthesis of institutional knowledge captured in EHRs.” One caveat that the researchers acknowledge in the report was that they had yet to conduct prospective validation of the augmented EHR curation approach.A second nference-based investigation reviewed the records of patients who had received more than 94,000 doses of the Pfizer COVID-19 vaccine, more than 36,000 doses of the Moderna vaccine, and 1,745 doses of the Johnson& Johnson vaccine. The study ’s goal was to determine the incidence of cerebral venous sinus thrombosis (CVST), which has been reported in a small number of patients after receiving one of the vaccines.7The preprint study found no significant association between any of the vaccines as CVST.One of the strengths of RCTs is their prospective nature, a design that is more likely to eliminate confounding variables and bias when compared to retrospective studies. But at the same time, several RCTs have fallen short because they were underpowered, resulting in false-negative results. Also, RCTs are expensive and often require many years to generate results that clinicians can use at the bedside. On the other hand, retrospective analyses can generate results much more quickly, and under the right circumstances, can provide actionable insights and inform the clinical decision-making process.Thomas Frieden, MD, MPH, a former director of the CDC, has pointed out the real-world ad...
Source: Life as a Healthcare CIO - Category: Information Technology Source Type: blogs