Burkholderia Cepacia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of the production and extraction of polyhydroxybutyrate from volatile fatty acids and using mixed cultures of PTAR and B. cepacia
Environ Res. 2024 Feb 13:118448. doi: 10.1016/j.envres.2024.118448. Online ahead of print.ABSTRACTThe global consumption of plastics generates accelerated environmental pollution in landfills and marine ecosystems. Biopolymers are the materials with the greatest potential to replace synthetic polymers in the market due to their good biodegradability, however, there are still several disadvantages, mainly related to their production cost. Considering the above, the generation of biodegradable and biocompatible bioplastics stands out as an alternative solution, some of which are made from renewable raw materials, including p...
Source: Environmental Research - February 15, 2024 Category: Environmental Health Authors: Jeniffer Gracia Armando Espinosa Nubia Moreno Iv án Cabeza Source Type: research

Genomic editing in Burkholderia multivorans by CRISPR/Cas9
Appl Environ Microbiol. 2024 Feb 2:e0225023. doi: 10.1128/aem.02250-23. Online ahead of print.ABSTRACTBurkholderia cepacia complex bacteria have emerged as opportunistic pathogens in patients with cystic fibrosis and immunocompromised individuals, causing life-threatening infections. Because of the relevance of these microorganisms, genetic manipulation is crucial for explaining the genetic mechanisms leading to pathogenesis. Despite the availability of allelic exchange tools to obtain unmarked gene deletions in Burkholderia, these require a step of merodiploid formation and another of merodiploid resolution through two in...
Source: Applied and Environmental Microbiology - February 1, 2024 Category: Microbiology Authors: Mirela R Ferreira Vasco Queiroga Leonilde M Moreira Source Type: research

Molecules, Vol. 29, Pages 628: Experimental and Computational Analysis of Synthesis Conditions of Hybrid Nanoflowers for Lipase Immobilization
ide M. F. Soares This work presents a framework for evaluating hybrid nanoflowers using Burkholderia cepacia lipase. It was expanded on previous findings by testing lipase hybrid nanoflowers (hNF-lipase) formation over a wide range of pH values (5&ndash;9) and buffer concentrations (10&ndash;100 mM). The free enzyme activity was compared with that of hNF-lipase. The analysis, performed by molecular docking, described the effect of lipase interaction with copper ions. The morphological characterization of hNF-lipase was performed using scanning electron microscopy. Fourier Transform Infrared Spectroscopy...
Source: Molecules - January 29, 2024 Category: Chemistry Authors: Danivia Endi S. Souza Lucas M. F. Santos Jo ão P. A. Freitas Lays C. de Almeida Jefferson C. B. Santos Ranyere Lucena de Souza Matheus M. Pereira Álvaro S. Lima Cleide M. F. Soares Tags: Article Source Type: research

Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment
Chronic respiratory infection is the primary cause of morbidity and mortality in people with cystic fibrosis (PWCF) with repeated acute pulmonary exacerbations associated with a decline in lung function and an increased requirement for antimicrobial therapy [1]. Routine aerobic culture-based approaches detect a small number of organisms such as Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia as the principal pathogenic drivers of infection and inflammation in the CF airways [1]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - December 28, 2023 Category: Respiratory Medicine Authors: Gisli G. Einarsson, Laura J. Sherrard, Joseph E. Hatch, Bryan Zorn, Elinor Johnston, Clodagh McGettigan, Katherine O'Neill, Deirdre F. Gilpin, Damian G. Downey, Michelle Murray, Gillian Lavelle, Gerry McElvaney, Matthew C. Wolfgang, Richard Boucher, Maria Source Type: research

Herpesvirus reactivation in respiratory tract is associated with increased mortality of severe pneumonia patients and their respiratory microbiome dysbiosis
Severe pneumonia (SP) is a respiratory tract disease that seriously threatens human health. The herpesvirus detected in patients, especially with severe and immunodeficient diseases, is gradually attracting the attention of clinical doctors. However, little is known about the effect of herpesvirus on the prognosis of SP patients and the pulmonary microbial community. Here, we retrospectively analyzed respiratory samples from 45 SP patients detected by metagenomic next-generation sequencing (mNGS). A total of five types of herpesviruses were detected, with Human alphaherpesvirus 1 (HHV-1) in 19 patients, Human betaherpesvir...
Source: Frontiers in cellular and infection microbiology - December 22, 2023 Category: Microbiology Source Type: research

Distribution, characterization, and evolution of heavy metal resistance genes and Tn7-like associated heavy metal resistance Gene Island of Burkholderia
IntroductionBurkholderia is a rod-shaped aerobic Gram-negative bacteria with considerable genetic and metabolic diversity, which can beused for bioremediation and production applications, and has great biotechnology potential. However, there are few studies on the heavy metal resistance of the Burkholderia genus.MethodsIn this paper, the distribution, characteristics and evolution of heavy metal resistance genes in Burkholderia and the gene island of Tn7-like transposable element associated with heavy metal resistance genes in Burkholderia were studied by comparative genomic method based on the characteristics of heavy met...
Source: Frontiers in Microbiology - November 23, 2023 Category: Microbiology Source Type: research

Genomic analyses of Burkholderia respiratory isolates indicates two evolutionarily distinct B. anthina clades
DiscussionBased on our phylogenetic and comparative genomic analyses, we suggest stratifying B. anthina to recognise a distinct species harbouring increased potential for iron metabolism via siderophore synthesis, for which we propose the name Burkholderia anthinoferum (sp. nov.). (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 21, 2023 Category: Microbiology Source Type: research

In vitro and in vivo activity of cefiderocol against Achromobacter spp. and Burkholderia cepacia complex, including carbapenem-non-susceptible isolates
This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6% from respiratory tract infections (RTIs)], cefiderocol had minimum inhibitory concentration (MIC)50/90 of 0.06/0.5 µg/mL overall and 0.5/4 µg/mL against 52 (15.6%) carbapenem-non-susceptible (Carb-NS) isolates. E...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2023 Category: Microbiology Authors: Miki Takemura Rio Nakamura Merime Ota Ryuichiro Nakai Daniel F Sahm Meredith A Hackel Yoshinori Yamano Source Type: research

 Burkholderia cepacia skin-related ulceration: a case report
Br J Nurs. 2023 Nov 1;32(Sup20):S6-S10. doi: 10.12968/bjon.2023.32.Sup20.S6.ABSTRACTTreatment of infected wounds remains a major challenge for clinicians. Antimicrobial stewardship is an important pillar in wound treatment and, as the role of bacteria in wound repair is not well understood, new treatment options and products are constantly being developed to tackle local infection and biofilm. This case report describes a case of antibiotic-resistant Burkholderia cepacia skin infection and subsequent leg ulceration in an 86-year-old man during the COVID pandemic in Italy, which was successfully treated in a conservative wa...
Source: British Journal of Nursing - November 10, 2023 Category: Nursing Authors: Massimo Rivolo Erind Ruka Salvatore Piazza Source Type: research