Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment

Chronic respiratory infection is the primary cause of morbidity and mortality in people with cystic fibrosis (PWCF) with repeated acute pulmonary exacerbations associated with a decline in lung function and an increased requirement for antimicrobial therapy [1]. Routine aerobic culture-based approaches detect a small number of organisms such as Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia as the principal pathogenic drivers of infection and inflammation in the CF airways [1].

Source: Journal of Cystic Fibrosis - December 28, 2023 Category: Respiratory Medicine Authors: Gisli G. Einarsson, Laura J. Sherrard, Joseph E. Hatch, Bryan Zorn, Elinor Johnston, Clodagh McGettigan, Katherine O'Neill, Deirdre F. Gilpin, Damian G. Downey, Michelle Murray, Gillian Lavelle, Gerry McElvaney, Matthew C. Wolfgang, Richard Boucher, Maria Source Type: research