Bird Flu (H5N1 Avian Influenza) Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection
This study tested the ability of adjuvants based on delta inulin (Advax™) alone or combined with a TLR9 agonist (Advax-CpG™) to enhance the immunogenicity of recombinant H5 hemagglutinin antigen expressed in insect cells (rH5HA) to protect mice against lethal influenza infection. The Advax-adjuvanted rH5HA induced high serum hemagglutination inhibition activity, as well as Th1 and Th2 cytokine secreting CD4 and CD8 T cells. Immunization protected mice against a lethal heterosubtypic H5N1 virus challenge. Mice immunized with an Advax-adjuvanted rHA2 stem antigen prepared by enzymatic cleavage of rH5HA produced serum ant...
Source: Vaccine - August 11, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo E Bart Tarbet Brett L Hurst Nikolai Petrovsky Source Type: research

Viruses, Vol. 15, Pages 1694: Multiple Vaccines and Strategies for Pandemic Preparedness of Avian Influenza Virus
Chenia Avian influenza viruses (AIV) are a continuous cause of concern due to their pandemic potential and devasting effects on poultry, birds, and human health. The low pathogenic avian influenza virus has the potential to evolve into a highly pathogenic avian influenza virus, resulting in its rapid spread and significant outbreaks in poultry. Over the years, a wide array of traditional and novel strategies has been implemented to prevent the transmission of AIV in poultry. Mass vaccination is still an economical and effective approach to establish immune protection against clinical virus infection. At present, some ...
Source: Viruses - August 4, 2023 Category: Virology Authors: Hai Xu Shanyuan Zhu Roshini Govinden Hafizah Y. Chenia Tags: Review Source Type: research

Prediction of highly pathogenic avian influenza vaccine efficacy in chickens by comparison of in vitro and in vivo data: A meta-analysis and systematic review
Vaccine. 2023 Aug 1:S0264-410X(23)00922-2. doi: 10.1016/j.vaccine.2023.07.076. Online ahead of print.ABSTRACTVaccines for avian influenza (AI) can protect poultry against disease, mortality, and virus transmission. Numerous factors, including: vaccine platform, immunogenicity, and relatedness to the field strain, are known to be important to achieving optimal AI vaccine efficacy. To better understand how these factors contribute to vaccine protection, a systematic meta-analysis was conducted to evaluate efficacy data for vaccines in chickens challenged with highly pathogenic (HP) AI. Data from a total of 120 individual tri...
Source: Vaccine - August 3, 2023 Category: Allergy & Immunology Authors: Jongseo Mo Erica Spackman David E Swayne Source Type: research

Prediction of highly pathogenic avian influenza vaccine efficacy in chickens by comparison of in vitro and in vivo data: A meta-analysis and systematic review
Vaccine. 2023 Aug 1:S0264-410X(23)00922-2. doi: 10.1016/j.vaccine.2023.07.076. Online ahead of print.ABSTRACTVaccines for avian influenza (AI) can protect poultry against disease, mortality, and virus transmission. Numerous factors, including: vaccine platform, immunogenicity, and relatedness to the field strain, are known to be important to achieving optimal AI vaccine efficacy. To better understand how these factors contribute to vaccine protection, a systematic meta-analysis was conducted to evaluate efficacy data for vaccines in chickens challenged with highly pathogenic (HP) AI. Data from a total of 120 individual tri...
Source: Herpes - August 3, 2023 Category: Infectious Diseases Authors: Jongseo Mo Erica Spackman David E Swayne Source Type: research

An Advax-CpG55.2 adjuvanted recombinant hemagglutinin vaccine provides immunity against H7N9 influenza in adult and neonatal mice
Vaccine. 2023 Jul 31:S0264-410X(23)00892-7. doi: 10.1016/j.vaccine.2023.07.061. Online ahead of print.ABSTRACTThere is a major unmet need for strategies to improve the immunogenicity and effectiveness of pandemic influenza vaccines, particularly in poor responder populations such as neonates. Recombinant protein approaches to pandemic influenza offer advantages over more traditional inactivated virus approaches, as they are free of problems such as egg adaptation or need for high level biosecurity containment for manufacture. However, a weakness of recombinant proteins is their low immunogenicity. We asked whether the use ...
Source: Vaccine - August 2, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo Isaac G Sakala Greiciely Andr é E Bart Tarbet Brett L Hurst Nikolai Petrovsky Source Type: research

Epidemiology-driven approaches to surveillance in HPAI-vaccinated poultry flocks aiming to demonstrate freedom from circulating HPAIV
Biologicals. 2023 Jul 24;83:101694. doi: 10.1016/j.biologicals.2023.101694. Online ahead of print.ABSTRACTIncursion pressure of high pathogenicity avian influenza viruses (HPAIV) by secondary spread among poultry holdings and/or from infected migratory wild bird populations increases worldwide. Vaccination as an additional layer of protection of poultry holdings using appropriately matched vaccines aims at reducing clinical sequelae of HPAIV infection, disrupting HPAIV transmission, curtailing economic losses and animal welfare problems and cutting exposure risks of zoonotic HPAIV at the avian-human interface. Products der...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 26, 2023 Category: Biotechnology Authors: Timm Harder Sjaak de Wit Jose L Gonzales Jeremy H P Ho Paolo Mulatti Teguh Y Prajitno Arjan Stegeman Source Type: research

"Live IBD vaccine exacerbates disease and pathological effects of Asian lineage H9N2 LPAIV in chickens."
Avian Pathol. 2023 Jul 13:1-25. doi: 10.1080/03079457.2023.2236994. Online ahead of print.ABSTRACTAvian influenza H9N2 is one of the most circulating viruses in numerous Egyptian poultry farms. The Asian lineage H9N2 exhibits an immunosuppressive effect, and its pathogenicity is amplified when it co-infects with other pathogens, especially with the immunosuppressive infectious bursal disease virus (IBDV), resulting in increased mortality rates. Both vaccines and field infection can exacerbate the pathogenicity of H9N2, particularly in the bursa of Fabricius (B.F), causing more significant lymphoid depletion. To comprehend ...
Source: Avian Pathology - July 13, 2023 Category: Pathology Authors: N W Khalil M A Elshorbagy E M Elboraay A M Helal Source Type: research