Bird Flu (H5N1 Avian Influenza) Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vaccination with recombinant Lactococcus lactis expressing HA1-IgY Fc fusion protein provides protective mucosal immunity against H9N2 avian influenza virus in chickens
H9N2 virus is mainly transmitted through the respiratory mucosal pathway, so mucosal immunity is considered to play a good role in controlling avian influenza infection. It is commonly accepted that no adequat... (Source: Virology Journal)
Source: Virology Journal - April 21, 2023 Category: Virology Authors: Ruihua Zhang, Tong Xu, Ziping Li, Longfei Li, Chunhong Li, Xinrui Li, Zhiyue Wang, Shaohua Wang, Xuejing Wang and Hongliang Zhang Tags: Research Source Type: research

The efficacy of an inactivated avian influenza H5N1 vaccine against an African strain of HPAI H5N8 (clade 2.3.4.4 B)
This study confirmed that antigenically-matched inactivated vaccines can induce robust protection and markedly reduce viral shedding.PMID:37079321 | DOI:10.1080/03079457.2023.2181145 (Source: Avian Pathology)
Source: Avian Pathology - April 20, 2023 Category: Pathology Authors: Louis H Maartens Leticia Frizzo da Silva Susan Dawson Nicolette Love Baltus J Erasmus Source Type: research

Antibody responses against heterologous H5N1 strains for an MF59-adjuvanted cell culture –derived H5N1 (aH5n1c) influenza vaccine in adults and older adults
. (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 14, 2023 Category: Allergy & Immunology Authors: Sharon S. Frey Eve Versage Esther Van Twuijver Matthew Hohenboken Source Type: research

Antibody responses against heterologous H5N1 strains for an MF59-adjuvanted cell culture –derived H5N1 (aH5n1c) influenza vaccine in adults and older adults
Volume 19, Issue 1, December 2023 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 14, 2023 Category: Allergy & Immunology Authors: Sharon S. Frey Eve Versage Esther Van Twuijver Matthew Hohenboken Source Type: research

Adjuvanted quaternized chitosan composite aluminum nanoparticles-based vaccine formulation promotes immune responses in chickens
Vaccine. 2023 Apr 7:S0264-410X(23)00374-2. doi: 10.1016/j.vaccine.2023.03.067. Online ahead of print.ABSTRACTAluminum adjuvant is a typical adjuvant that can promote humoral immune response, but it lacks the ability to effectively induce cellular immune response. The water-soluble N-2-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles (N-2-HACC NPs) can enhance humoral and cellular immune responses of vaccines. To enable aluminum adjuvant to induce cellular immunity, the composite nano adjuvant N-2-HACC-Al NPs were synthesized by the N-2-HACC and aluminum sulfate (Al2(SO4)3). The particle size and zeta potent...
Source: Vaccine - April 9, 2023 Category: Allergy & Immunology Authors: Jiali Liu Sihan Guo Zheng Jin Kai Zhao Source Type: research

Protective efficacy of a bivalent H5 influenza vaccine candidate against both clades 2.3.2.1 and 2.3.4.4 high pathogenic avian influenza viruses in SPF chickens
In this study, we developed a bivalent vaccine candidate containing antigens derived from two reassortant KA435/2.3.2.1d and H35/2.3.4.4b strains for Korean national antigen bank. We evaluated its immunogenicity and protective efficacy in specific pathogen free chickens. The two vaccine strains, rgKA435-H9N2 PB2/2.3.2.1d and rgH35/2.3.4.4b, both of which were generated successfully by reverse genetics, were highly immunogenic (titres of haemagglutination inhibition: 8.3 and 8.4 log2, respectively) and showed good protective efficacy (100 and 147 50% protective dose, respectively) against lethal challenge with wild-type vir...
Source: Vaccine - April 6, 2023 Category: Allergy & Immunology Authors: Hyunjun Kim Hyun-Kyu Cho Yong-Myung Kang Mingeun Sagong Sungjun An Sungyeop Kim Youn-Jeong Lee Hyun-Mi Kang Source Type: research

Efficacy of multivalent recombinant herpesvirus of turkey vaccines against high pathogenicity avian influenza, infectious bursal disease, and Newcastle disease viruses
Vaccine. 2023 Apr 1:S0264-410X(23)00349-3. doi: 10.1016/j.vaccine.2023.03.055. Online ahead of print.ABSTRACTVaccines are an essential tool for the control of viral infections in domestic animals. We generated recombinant vector herpesvirus of turkeys (vHVT) vaccines expressing computationally optimized broadly reactive antigen (COBRA) H5 of avian influenza virus (AIV) alone (vHVT-AI) or in combination with virus protein 2 (VP2) of infectious bursal disease virus (IBDV) (vHVT-IBD-AI) or fusion (F) protein of Newcastle disease virus (NDV) (vHVT-ND-AI). In vaccinated chickens, all three vHVT vaccines provided 90-100% clinica...
Source: Vaccine - April 3, 2023 Category: Allergy & Immunology Authors: Miria F Criado Aemro Kassa Kateri Bertran Jung-Hoon Kwon Mariana S á E Silva Lindsay Killmaster Ted M Ross Teshome Mebatsion David E Swayne Source Type: research

A new H9 influenza virus mRNA vaccine elicits robust protective immunity against infection
Vaccine. 2023 Mar 31:S0264-410X(23)00343-2. doi: 10.1016/j.vaccine.2023.03.049. Online ahead of print.ABSTRACTAvian influenza virus (AIV) poses a great threat to the poultry industry and public health. However commercial vaccines only provide limited immunity due to rapid virus mutation and rearrangement. Here, we developed an mRNA-lipid nanoparticle (mRNA-LNP) vaccine expressing AIV immunogenic protein hemagglutinin (HA) and also assessed its safety and immune-protection efficacy in vivo. Specifically, its safety was tested by inoculation of SPF chicken embryos and chicks, and there showed no clinical manifestations and p...
Source: Vaccine - April 2, 2023 Category: Allergy & Immunology Authors: Shengkui Xu Bowen Zhang Jielin Yao Wenke Ruan Source Type: research