Bird Flu (H5N1 Avian Influenza) Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparison of geological clusters between influenza and COVID-19 in Thailand with unsupervised clustering analysis
In this study, unsupervised clustering techniques were used to identify clusters of disease trends in Thailand. The analysis inc orporated three distinct surveillance datasets: the pandemic influenza outbreak, influenza in the endemic stage, and the early stages of COVID-19. The analysis demonstrated a significant difference in the distribution of provinces between Cluster -1, representing those with unique transmission patte rns, and the other clusters, indicating provinces with similar transmission patterns among their members. Specifically, for Pandemic Influenza, the ratio was 61:16, while for Pandemic COVID-19, it was...
Source: PLoS One - January 22, 2024 Category: Biomedical Science Authors: Thanin Methiyothin Source Type: research

Wisconsin bill to restrict pathogen studies worries scientists
A hearing this week in Wisconsin on a proposal to bar research that may make human pathogens more dangerous has scientists worried that such state bans would hamper a broad range of microbiology studies. Bills like Wisconsin’s could also conflict with or exceed new federal restrictions on so-called gain-of-function (GOF) research, due out any moment. The Wisconsin bill is still early in the legislative process, and its prospects are uncertain. But the hearing gave a platform to a small, vocal group of scientists who want to forbid certain GOF studies. Several hold the controversial view that such research is to bla...
Source: Science of Aging Knowledge Environment - January 12, 2024 Category: Geriatrics Source Type: research

Importance of National Influenza Centers in the surveillance of highly pathogenic avian viruses. The time for One-Health is now
Rev Esp Quimioter. 2024 Jan 11:sanz11jan2024. doi: 10.37201/req/137.2023. Online ahead of print.ABSTRACTSince 1996, the highly pathogenic avian influenza subtype A(H5N1) has been causing almost uninterrupted outbreaks in wild and domestic birds, as well as cases in humans with a mortality rate close to 50%. However, the years of greatest circulation have been precisely the years following the COVID-19 pandemic, in which several cases have been recorded in humans in places where they had never appeared before, in addition to multiple cases in wild, domestic and peri-domestic mammals, which raise some concern about the risk ...
Source: Revista Espanola de Quimioterapia - January 11, 2024 Category: Drugs & Pharmacology Authors: I Sanz-Mu ñoz J M Eiros M Hern ández Source Type: research

Immunogenicity and safety of varying dosages of a fifth-wave influenza A/H7N9 inactivated vaccine given with and without AS03 adjuvant in healthy adults
CONCLUSIONS: AS03 adjuvant improved the immune responses to an inactivated fifth-wave H7N9 influenza vaccine, particularly in younger adults, but invoked lower responses to drifted H7N9 strains. These findings may inform future influenza pandemic preparedness strategies.PMID:38105137 | DOI:10.1016/j.vaccine.2023.12.001 (Source: Vaccine)
Source: Vaccine - December 17, 2023 Category: Allergy & Immunology Authors: Lisa A Jackson Jack T Stapleton Emmanuel B Walter Wilbur H Chen Nadine G Rouphael Evan J Anderson Kathleen M Neuzil Patricia L Winokur Michael J Smith Kenneth E Schmader Geeta K Swamy Amelia B Thompson Mark J Mulligan Christina A Rostad Kaitlyn Cross Rach Source Type: research

Efficacy of recombinant H5 vaccines delivered in ovo or day of age in commercial broilers against the 2015 U.S. H5N2 clade 2.3.4.4c highly pathogenic avian Influenza virus
Avian influenza is a highly contagious, agriculturally relevant disease that can severely affect the poultry industry and food supply. Eurasian-origin H5Nx highly pathogenic avian influenza viruses (HPAIV) (cl... (Source: Virology Journal)
Source: Virology Journal - December 15, 2023 Category: Virology Authors: Darrell R. Kapczynski, Klaudia Chrzastek, Revathi Shanmugasundaram, Aniko Zsak, Karen Segovia, Holly Sellers and David L. Suarez Tags: Research Source Type: research

Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector
CONCLUSION: These results demonstrate that the BAdV vectors induce enhanced innate and adaptive immunity-related factors compared to HAdV vectors in mice. Thus, the BAdV vector platform could be an excellent gene delivery system for recombinant vaccines and cancer immunotherapy.PMID:38077380 | PMC:PMC10702558 | DOI:10.3389/fimmu.2023.1305937 (Source: Cancer Control)
Source: Cancer Control - December 11, 2023 Category: Cancer & Oncology Authors: Ekramy E Sayedahmed Nelly O Elshafie GuangJun Zhang Sulma I Mohammed Suryaprakash Sambhara Suresh K Mittal Source Type: research

Mathematical modeling of the infectious spread and outbreak dynamics of avian influenza with seasonality transmission for chicken farms
Comp Immunol Microbiol Infect Dis. 2023 Nov 27;104:102108. doi: 10.1016/j.cimid.2023.102108. Online ahead of print.ABSTRACTA compartmental model with a time-varying contact rate, the seasonality effect, and its corresponding nonautonomous model are investigated. The model is developed based on the six compartments: susceptible, latent, infected, asymptomatic, treated, and recovered individuals. We determine the effective reproduction number for this nonautonomous system, and analytic discussion shows that at least one positive periodic solution exists for R0>1. The model is simulated using the RK-45 numerical method, an...
Source: Comparative immunology, microbiology and infectious diseases. - December 9, 2023 Category: Allergy & Immunology Authors: Abdul Malek Ashabul Hoque Source Type: research

Construction and Immunogenicity Evaluation of Recombinant Bacillus subtilis Expressing HA1 Protein of H9N2 Avian Influenza Virus
This study was the first to use an oral recombinant B. subtilis-HA1 vaccine candidate, and it provides theoretical data and technical reference for the creation of a new live vector vaccine against H9N2 AIV.PMID:38040977 | DOI:10.1007/s00284-023-03548-x (Source: Current Microbiology)
Source: Current Microbiology - December 1, 2023 Category: Microbiology Authors: Zixuan Li Chong Peng Lijun Chen Peng Wang Fangkun Wang Source Type: research

Antiviral options and therapeutics against influenza: history, latest developments and future prospects
Drugs and chemotherapeutics have helped to manage devastating impacts of infectious diseases since the concept of ‘magic bullet’. The World Health Organization estimates about 650,000 deaths due to respiratory diseases linked to seasonal influenza each year. Pandemic influenza, on the other hand, is the most feared health disaster and probably would have greater and immediate impact on humanity than climate change. While countermeasures, biosecurity and vaccination remain the most effective preventive strategies against this highly infectious and communicable disease, antivirals are nonetheless essential to mitigate cl...
Source: Frontiers in cellular and infection microbiology - November 29, 2023 Category: Microbiology Source Type: research

Influenza in Pregnancy: Prevention and Treatment
Obstet Gynecol. 2023 Nov 28. doi: 10.1097/AOG.0000000000005479. Online ahead of print.ABSTRACTPregnant and postpartum individuals are at significantly higher risk of serious complications related to seasonal and pandemic influenza infections compared with nonpregnant people. The Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists (ACOG) recommend that all adults receive an annual influenza vaccine and that individuals who are or will be pregnant during influenza season receive an inactivated or recombinant influenza vaccine as soon as it is available. Although the influenz...
Source: Obstetrics and Gynecology - November 28, 2023 Category: OBGYN Source Type: research