Bird Flu (H5N1 Avian Influenza) Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

How prepared is the world for a pandemic of bird flu in people?
Bird flu is infecting wild birds and poultry around the world. If it were to crossover into humans, some antiviral drugs are available but it would take time to develop a vaccine (Source: New Scientist - Health)
Source: New Scientist - Health - February 14, 2023 Category: Consumer Health News Source Type: research

Regional variation in knowledge and practice regarding common zoonoses among livestock farmers of selective districts in Nepal
ConclusionsLivestock farmers need to be more knowledgeable about many common zoonotic diseases, and their preventive practices still need improvement, with significant regional variation in the study. This has invited various zoonosis threats for them. Therefore, it is recommended that the interventional programs related to common zoonoses be conducted for livestock farmers to solve the problem. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - February 14, 2023 Category: Tropical Medicine Authors: Kosh Bilash Bagale Source Type: research

U.S. scientists brace for tighter scrutiny of potentially risky research
Federally funded scientists who work with potentially harmful bacteria, viruses, and other agents could soon face a major expansion of U.S. government oversight. An expert group last week recommended broadening rules that require universities and funding agencies to determine whether proposed studies count as dual-use research—work that carries the risk of intentionally or accidentally creating a bioweapon. Currently, such reviews are only required for experiments involving 15 dangerous agents. But the panel argues the reviews should now extend to work with all human, plant, and animal pathogens, even those causing only ...
Source: Science of Aging Knowledge Environment - January 30, 2023 Category: Geriatrics Source Type: research

Efficacy of a recombinant turkey herpesvirus (H9) vaccine against H9N2 avian influenza virus in chickens with maternal-derived antibodies
Although vaccines have been widely used for many years, they have failed to control H9N2 avian influenza virus (AIV) in the field in China. The high level of maternal-derived antibodies (MDAs) against H9N2 virus contributes to the H9N2 influenza vaccine failure in poultry. The study aimed to generate a new vaccine to overcome MDAs interference in H9N2 vaccination in chickens. We used turkey herpesvirus (HVT) as a vaccine vector to express H9 hemagglutinin (HA) proteins. The recombinant HVT expressing H9 HA proteins (rHVT-H9) was successfully generated and characterized in primary chicken embryonic fibroblasts (CEFs). Weste...
Source: Frontiers in Microbiology - January 26, 2023 Category: Microbiology Source Type: research

U.S. should expand rules for risky virus research to more pathogens, panel says
U.S. health officials should expand oversight of federally funded research that tweaks deadly viruses to include some less risky types of pathogens, an expert panel has concluded. Its draft report , released today, also recommends funding agencies share more information about decisions to approve such work. The recommendations are welcome news for scientists, lawmakers, and others who have worried the SARS-CoV-2 pandemic has revealed gaps in the rules for so called gain-of-function (GOF) research. The report recommends “significant improvements in policy,” says Stanford University microbiologist David R...
Source: Science of Aging Knowledge Environment - January 20, 2023 Category: Geriatrics Source Type: research

Development of in Ovo-Compatible NS1-truncated live attenuated influenza vaccines by modulation of hemagglutinin cleavage and polymerase Acidic X Frameshifting sites
This study demonstrates that targeted genetic mutations can be applied to further attenuate and enhance the safety of live attenuated influenza vaccines to develop future in ovo vaccines for poultry.PMID:36669965 | DOI:10.1016/j.vaccine.2023.01.018 (Source: Vaccine)
Source: Vaccine - January 20, 2023 Category: Allergy & Immunology Authors: Amir Ghorbani John M Ngunjiri Michael Edward C Abundo Mary Pantin-Jackwood Scott P Kenney Chang-Won Lee Source Type: research

Viruses, Vol. 15, Pages 203: Evaluation of Pre-Pandemic Trivalent COBRA HA Vaccine in Mice Pre-Immune to Historical H1N1 and H3N2 Influenza Viruses
In this study, we explored the effect influenza seasonal virus-induced immunity has on pre-pandemic influenza virus vaccination. The mice that were pre-immune to historical H1N1 and H3N2 seasonal influenza viruses were vaccinated with adjuvanted pre-pandemic (H2, H5, and H7) HA-based computationally optimized broadly reactive antigen (COBRA) vaccines, and were fully protected from lethal challenge, whereas the mock-vaccinated mice, with or without pre-immunity, were not protected from morbidity or mortality. Detectable antibody titers were present in the pre-immune mice vaccinated with a single dose of vaccine, but not in ...
Source: Viruses - January 11, 2023 Category: Virology Authors: Pan Ge Ted M. Ross Tags: Article Source Type: research

Viruses, Vol. 15, Pages 184: Multi-Influenza HA Subtype Protection of Ferrets Vaccinated with an N1 COBRA-Based Neuraminidase
d M. Ross The influenza neuraminidase (NA) is a promising target for next-generation vaccines. Protection induced by vaccination with the computationally optimized broadly reactive NA antigen (N1-I COBRA NA) was characterized in both influenza serologically naive and pre-immune ferret models following H1N1 (A/California/07/2009, CA/09) or H5N1 (A/Vietnam/1203/2004, Viet/04) influenza challenges. The N1-I COBRA NA vaccine elicited antibodies with neutralizing ELLA activity against both seasonal and pandemic H1N1 influenza, as well as the H5N1 influenza virus. In both models, N1-I COBRA NA-vaccinated ferrets that were ch...
Source: Viruses - January 9, 2023 Category: Virology Authors: Amanda L. Skarlupka Xiaojian Zhang Uriel Blas-Machado Spencer F. Sumner Ted M. Ross Tags: Article Source Type: research

Isolation and Identification of Novel Highly Pathogenic Avian Influenza Virus (H5N8) Subclade 2.3.4.4b from Geese in Northeastern China
Appl Environ Microbiol. 2023 Jan 5:e0157222. doi: 10.1128/aem.01572-22. Online ahead of print.ABSTRACTH5N8, a highly pathogenic avian influenza, has become a new zoonotic threat in recent years. As of December 28, 2021, at least 3,206 H5N8 cases had been reported in wild birds and poultry worldwide. In January 2021, a novel virus strain named A/goose/China/1/2021 was isolated during an H5N8 goose influenza outbreak in northeastern China. The PB2, PB1, HA, and M genes of A/goose/China/1/2021 were highly identical to those of H5N8 strains emerging in Kazakhstan and Russia in Central Asia from August to September 2020, while ...
Source: Applied and Environmental Microbiology - January 5, 2023 Category: Microbiology Authors: Yanting Zhu Yulin Cong Yixue Sun Jinhong Han Lili Gai Tiantian Yang Chang Liu Lifeng Zhao Yanlong Cong Source Type: research