Bird Flu (H5N1 Avian Influenza) Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Viruses, Vol. 14, Pages 1431: Isolation of Genetically Diverse H5N8 Avian Influenza Viruses in Poultry in Egypt, 2019 & ndash;2021
Viruses, Vol. 14, Pages 1431: Isolation of Genetically Diverse H5N8 Avian Influenza Viruses in Poultry in Egypt, 2019–2021 Viruses doi: 10.3390/v14071431 Authors: Ahmed H. Salaheldin Ahmed R. Elbestawy Abdelkader M. Abdelkader Hesham A. Sultan Awad A. Ibrahim Hatem S. Abd El-Hamid Elsayed M. Abdelwhab The global spread of avian influenza virus (AIV) of clade 2.3.4.4b since 2016 has caused severe losses in wild birds and poultry and has posed a risk for the infection of mammals including humans. The vaccination of poultry has been used to limit the spread of the virus and mitigate its socioecon...
Source: Viruses - June 29, 2022 Category: Virology Authors: Ahmed H. Salaheldin Ahmed R. Elbestawy Abdelkader M. Abdelkader Hesham A. Sultan Awad A. Ibrahim Hatem S. Abd El-Hamid Elsayed M. Abdelwhab Tags: Communication Source Type: research

Genetic variation in chicken interferon signalling pathway genes in research lines showing differential viral resistance
This study focuses on the interferon genes and their receptors in different chicken lines that are known to be more resistant or susceptible to particular avian viruses. Comparing genotypic differences in these core immune genes between the chicken lines may explain the phenotypic differences observed and aid the identification of causative variations. The relative resistance/susceptibility of each line to viruses of interest (Marek's disease virus, infectious bursal disease, infectious bronchitis virus and avian influenza virus) has previously been determined. Here we identify single nucleotide polymorphisms in interferon...
Source: Animal Genetics - June 23, 2022 Category: Genetics & Stem Cells Authors: Joshua Mountford Almas Gheyas Lonneke Vervelde Jacqueline Smith Source Type: research

GSE112293 Characterization of innate immune responses to AS03 adjuvanted H5N1 vaccine compared to non-adjuvanted H5N1 vaccine.
Contributor : Foo CheungSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe primary objective is to compare multiplex immune response signatures following two (primary and a boost) vaccinations with the GSK AS03 adjuvanted H5N1 influenza vaccine or the non-adjuvanted form of the H5N1 influenza vaccineat the 3.75 mcg dose and given 21 days apart and identify differences in very early innate immune responses. These immune signatures will also be correlated with the clinical observations especially safety related local and systemic events. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 21, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Using social contact data to improve the overall effect estimate of a cluster-randomized influenza vaccination program in Senegal
This study estimates the overall effect of two influenza vaccination programs consecutively administered in a cluster-randomized trial in western Senegal over the course of two influenza seasons from 2009-2011. We apply cutting-edge methodology combining social contact data with infection data to reduce bias in estimation arising from contamination between clusters. Our time-varying estimates reveal a reduction in seasonal influenza from the intervention and a nonsignificant increase in H1N1 pandemic influenza. We estimate an additive change in overall cumulative incidence (which was 6.13% in the control arm) of -0.68 perc...
Source: Cancer Control - June 20, 2022 Category: Cancer & Oncology Authors: Gail E Potter Nicole Bohme Carnegie Jonathan D Sugimoto Aldiouma Diallo John C Victor Kathleen M Neuzil M Elizabeth Halloran Source Type: research

A Brief History of Human Challenge Studies (1900-2021) Emphasising the Virology, Regulatory and Ethical Requirements, Raison D'etre, Ethnography, Selection of Volunteers and Unit Design
Curr Top Microbiol Immunol. 2022 Jun 16. doi: 10.1007/82_2022_253. Online ahead of print.ABSTRACTVenetian quarantine 400 years ago was an important public health measure. Since 1900 this has been refined to include "challenge" or deliberate infection with pathogens be they viruses, bacteria, or parasites. Our focus is virology and ranges from the early experiments in Cuba with Yellow Fever Virus to the most widespread pathogen of our current times, COVID-19. The latter has so far caused over four million deaths worldwide and 190 million cases of the disease. Quarantine and challenge were also used to investigate the Spanis...
Source: Current Topics in Microbiology and Immunology - June 15, 2022 Category: Microbiology Authors: J S Oxford A Catchpole A Mann A Bell N Noulin D Gill J R Oxford A Gilbert Shobana Balasingam Source Type: research