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Transcutaneous immunization via dissolving microneedles protects mice from lethal influenza H7N9 virus challenge
Vaccine. 2022 Oct 12:S0264-410X(22)01102-1. doi: 10.1016/j.vaccine.2022.09.008. Online ahead of print.ABSTRACTAvian influenza H7N9 virus has first emerged in 2013 and since then has spread in China in five seasonal waves. In humans, influenza H7N9 virus infection is associated with a high fatality rate; thus, an effective vaccine for this virus is needed. In the present study, we evaluated the usefulness of dissolving microneedles (MNs) loaded with influenza H7N9 vaccine in terms of the dissolution time, insertion capacity, insertion depth, and structural integrity of H7N9 virus in vitro. Our in vitro results showed MNs di...
Source: Vaccine - October 15, 2022 Category: Allergy & Immunology Authors: Siqi Liu Guozhong Yang Minghui Li Fang Sun Yufeng Li Xiliang Wang Yunhua Gao Penghui Yang Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research

Epidemiology and molecular characterization of avian influenza virus in backyard poultry of Chattogram, Bangladesh
Infect Genet Evol. 2022 Oct 8:105377. doi: 10.1016/j.meegid.2022.105377. Online ahead of print.ABSTRACTDucks, the natural reservoir of avian influenza virus (AIV), act as reassortment vessels for HPAI and low pathogenic avian influenza (LPAI) virus for domestic and wild bird species. In Bangladesh, earlier research was mainly focused on AIV in commercial poultry and live bird markets, where there is scanty literature reported on AIV in apparently healthy backyard poultry at the household level. The present cross-sectional study was carried out to reveal the genomic epidemiology of AIV of backyard poultry in coastal (Anowar...
Source: Infection, Genetics and Evolution - October 11, 2022 Category: Genetics & Stem Cells Authors: Pronesh Dutta Ariful Islam Md Abu Sayeed Md Ashiqur Rahman Md Sadeque Abdullah Otun Saha Mohammed Ziaur Rahman Marcel Klaassen Md Ahasanul Hoque Mohammad Mahmudul Hassan Source Type: research