Development and applications of genome-scale metabolic network models
Adv Appl Microbiol. 2024;126:1-26. doi: 10.1016/bs.aambs.2024.02.002. Epub 2024 Mar 1.ABSTRACTThe genome-scale metabolic network model is an effective tool for characterizing the gene-protein-response relationship in the entire metabolic pathway of an organism. By combining various algorithms, the genome-scale metabolic network model can effectively simulate the influence of a specific environment on the physiological state of cells, optimize the culture conditions of strains, and predict the targets of genetic modification to achieve targeted modification of strains. In this review, we summarize the whole process of model...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Jinyi Qian Chao Ye Source Type: research
Stress response and adaptation mechanisms in Kluyveromyces marxianus
Adv Appl Microbiol. 2024;126:27-62. doi: 10.1016/bs.aambs.2024.02.003. Epub 2024 Mar 12.ABSTRACTKluyveromyces marxianus is a non-Saccharomyces yeast that has gained importance due to its great potential to be used in the food and biotechnology industries. In general, K. marxianus is a known yeast for its ability to assimilate hexoses and pentoses; even this yeast can grow in disaccharides such as sucrose and lactose and polysaccharides such as agave fructans. Otherwise, K. marxianus is an excellent microorganism to produce metabolites of biotechnological interest, such as enzymes, ethanol, aroma compounds, organic acids, a...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: G Flores-Cos ío J A Garc ía-Béjar D Sandoval-Nu ñez L Amaya-Delgado Source Type: research
Selenium bioactive compounds produced by beneficial microbes
Adv Appl Microbiol. 2024;126:63-92. doi: 10.1016/bs.aambs.2024.02.004. Epub 2024 Mar 29.ABSTRACTSelenium (Se) is an essential trace element present as selenocysteine (SeCys) in selenoproteins, which have an important role in thyroid metabolism and the redox system in humans. Se deficiency affects between 500 and 1000 million people worldwide. Increasing Se intake can prevent from bacterial and viral infections. Se deficiency has been associated with cancer, Alzheimer, Parkinson, decreased thyroid function, and male infertility. Se intake depends on the food consumed which is directly related to the amount of Se in the soil...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: L Crespo B Sede Lucena F G Mart ínez F Mozzi M Pescuma Source Type: research
The infant gut microbiota as the cornerstone for future gastrointestinal health
Adv Appl Microbiol. 2024;126:93-119. doi: 10.1016/bs.aambs.2024.02.001. Epub 2024 Feb 19.ABSTRACTThe early postnatal period represents a critical window of time for the establishment and maturation of the human gut microbiota. The gut microbiota undergoes dramatic developmental changes during the first year of life, being influenced by a variety of external factors, with diet being a major player. Indeed, the introduction of complementary feeding provides novel nutritive substrates and triggers a shift from milk-adapted gut microbiota toward an adult-like bacterial composition, which is characterized by an enhancement in d...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Chiara Tarracchini Christian Milani Gabriele Andrea Lugli Leonardo Mancabelli Francesca Turroni Douwe van Sinderen Marco Ventura Source Type: research
Development and applications of genome-scale metabolic network models
Adv Appl Microbiol. 2024;126:1-26. doi: 10.1016/bs.aambs.2024.02.002. Epub 2024 Mar 1.ABSTRACTThe genome-scale metabolic network model is an effective tool for characterizing the gene-protein-response relationship in the entire metabolic pathway of an organism. By combining various algorithms, the genome-scale metabolic network model can effectively simulate the influence of a specific environment on the physiological state of cells, optimize the culture conditions of strains, and predict the targets of genetic modification to achieve targeted modification of strains. In this review, we summarize the whole process of model...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Jinyi Qian Chao Ye Source Type: research
Stress response and adaptation mechanisms in Kluyveromyces marxianus
Adv Appl Microbiol. 2024;126:27-62. doi: 10.1016/bs.aambs.2024.02.003. Epub 2024 Mar 12.ABSTRACTKluyveromyces marxianus is a non-Saccharomyces yeast that has gained importance due to its great potential to be used in the food and biotechnology industries. In general, K. marxianus is a known yeast for its ability to assimilate hexoses and pentoses; even this yeast can grow in disaccharides such as sucrose and lactose and polysaccharides such as agave fructans. Otherwise, K. marxianus is an excellent microorganism to produce metabolites of biotechnological interest, such as enzymes, ethanol, aroma compounds, organic acids, a...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: G Flores-Cos ío J A Garc ía-Béjar D Sandoval-Nu ñez L Amaya-Delgado Source Type: research
Selenium bioactive compounds produced by beneficial microbes
Adv Appl Microbiol. 2024;126:63-92. doi: 10.1016/bs.aambs.2024.02.004. Epub 2024 Mar 29.ABSTRACTSelenium (Se) is an essential trace element present as selenocysteine (SeCys) in selenoproteins, which have an important role in thyroid metabolism and the redox system in humans. Se deficiency affects between 500 and 1000 million people worldwide. Increasing Se intake can prevent from bacterial and viral infections. Se deficiency has been associated with cancer, Alzheimer, Parkinson, decreased thyroid function, and male infertility. Se intake depends on the food consumed which is directly related to the amount of Se in the soil...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: L Crespo B Sede Lucena F G Mart ínez F Mozzi M Pescuma Source Type: research
The infant gut microbiota as the cornerstone for future gastrointestinal health
Adv Appl Microbiol. 2024;126:93-119. doi: 10.1016/bs.aambs.2024.02.001. Epub 2024 Feb 19.ABSTRACTThe early postnatal period represents a critical window of time for the establishment and maturation of the human gut microbiota. The gut microbiota undergoes dramatic developmental changes during the first year of life, being influenced by a variety of external factors, with diet being a major player. Indeed, the introduction of complementary feeding provides novel nutritive substrates and triggers a shift from milk-adapted gut microbiota toward an adult-like bacterial composition, which is characterized by an enhancement in d...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Chiara Tarracchini Christian Milani Gabriele Andrea Lugli Leonardo Mancabelli Francesca Turroni Douwe van Sinderen Marco Ventura Source Type: research
Development and applications of genome-scale metabolic network models
Adv Appl Microbiol. 2024;126:1-26. doi: 10.1016/bs.aambs.2024.02.002. Epub 2024 Mar 1.ABSTRACTThe genome-scale metabolic network model is an effective tool for characterizing the gene-protein-response relationship in the entire metabolic pathway of an organism. By combining various algorithms, the genome-scale metabolic network model can effectively simulate the influence of a specific environment on the physiological state of cells, optimize the culture conditions of strains, and predict the targets of genetic modification to achieve targeted modification of strains. In this review, we summarize the whole process of model...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Jinyi Qian Chao Ye Source Type: research
Stress response and adaptation mechanisms in Kluyveromyces marxianus
Adv Appl Microbiol. 2024;126:27-62. doi: 10.1016/bs.aambs.2024.02.003. Epub 2024 Mar 12.ABSTRACTKluyveromyces marxianus is a non-Saccharomyces yeast that has gained importance due to its great potential to be used in the food and biotechnology industries. In general, K. marxianus is a known yeast for its ability to assimilate hexoses and pentoses; even this yeast can grow in disaccharides such as sucrose and lactose and polysaccharides such as agave fructans. Otherwise, K. marxianus is an excellent microorganism to produce metabolites of biotechnological interest, such as enzymes, ethanol, aroma compounds, organic acids, a...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: G Flores-Cos ío J A Garc ía-Béjar D Sandoval-Nu ñez L Amaya-Delgado Source Type: research
Selenium bioactive compounds produced by beneficial microbes
Adv Appl Microbiol. 2024;126:63-92. doi: 10.1016/bs.aambs.2024.02.004. Epub 2024 Mar 29.ABSTRACTSelenium (Se) is an essential trace element present as selenocysteine (SeCys) in selenoproteins, which have an important role in thyroid metabolism and the redox system in humans. Se deficiency affects between 500 and 1000 million people worldwide. Increasing Se intake can prevent from bacterial and viral infections. Se deficiency has been associated with cancer, Alzheimer, Parkinson, decreased thyroid function, and male infertility. Se intake depends on the food consumed which is directly related to the amount of Se in the soil...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: L Crespo B Sede Lucena F G Mart ínez F Mozzi M Pescuma Source Type: research
The infant gut microbiota as the cornerstone for future gastrointestinal health
Adv Appl Microbiol. 2024;126:93-119. doi: 10.1016/bs.aambs.2024.02.001. Epub 2024 Feb 19.ABSTRACTThe early postnatal period represents a critical window of time for the establishment and maturation of the human gut microbiota. The gut microbiota undergoes dramatic developmental changes during the first year of life, being influenced by a variety of external factors, with diet being a major player. Indeed, the introduction of complementary feeding provides novel nutritive substrates and triggers a shift from milk-adapted gut microbiota toward an adult-like bacterial composition, which is characterized by an enhancement in d...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Chiara Tarracchini Christian Milani Gabriele Andrea Lugli Leonardo Mancabelli Francesca Turroni Douwe van Sinderen Marco Ventura Source Type: research
Promoters and introns as key drivers for enhanced gene expression in Saccharomyces cerevisiae
Adv Appl Microbiol. 2023;124:1-29. doi: 10.1016/bs.aambs.2023.07.002. Epub 2023 Jul 27.ABSTRACTThe transcription of genes in the yeast Saccharomyces cerevisiae is governed by multiple layers of regulatory elements and proteins, cooperating to ensure optimum expression of the final protein product based on the cellular requirements. Promoters have always been regarded as the most important determinant of gene transcription, but introns also play a key role in the expression of intron-encoding genes. Some introns can enhance transcription when introduced either promoter-proximal or embedded in the open reading frame of genes...
Source: Advances in Applied Microbiology - August 19, 2023 Category: Microbiology Authors: Marthinus Wessel Myburgh Kirstie Susan Schwerdtfeger Rosemary Anne Cripwell Willem Heber van Zyl Marinda Viljoen-Bloom Source Type: research
From methane to value-added bioproducts: microbial metabolism, enzymes, and metabolic engineering
Adv Appl Microbiol. 2023;124:119-146. doi: 10.1016/bs.aambs.2023.07.004. Epub 2023 Jul 21.ABSTRACTMethane is abundant in nature, and excessive emissions will cause the greenhouse effect. Methane is also an ideal carbon and energy feedstock for biosynthesis. In the review, the microorganisms, metabolism, and enzymes for methane utilization, and the advances of conversion to value-added bioproducts were summarized. First, the physiological characteristics, classification, and methane oxidation process of methanotrophs were introduced. The metabolic pathways for methane utilization and key intermediate metabolites of native a...
Source: Advances in Applied Microbiology - August 19, 2023 Category: Microbiology Authors: Caihong Weng Xiaowei Peng Yejun Han Source Type: research
Significance of the plasma membrane H < sup > + < /sup > -ATPase and V-ATPase for growth and pathogenicity in pathogenic fungi
Adv Appl Microbiol. 2023;124:31-53. doi: 10.1016/bs.aambs.2023.07.001. Epub 2023 Jul 28.ABSTRACTPathogenic fungi are widespread and cause a variety of diseases in human beings and other organisms. At present, limited classes of antifungal agents are available to treat invasive fungal diseases. With the wide use of the commercial antifungal agents, drug resistance of pathogenic fungi are continuously increasing. Therefore, exploring effective antifungal agents with novel drug targets is urgently needed to cope with the challenges that the antifungal area faces. pH homeostasis is vital for multiple cellular processes, reveal...
Source: Advances in Applied Microbiology - August 19, 2023 Category: Microbiology Authors: S Z Yang L T Peng Source Type: research
