Bird Flu (H5N1 Avian Influenza) Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Viruses, Vol. 14, Pages 2097: Indirect Protection from Vaccinating Children against Influenza A Virus Infection in Households
Benjamin J. Cowling Influenza vaccination is an important intervention to prevent influenza virus infection. Our previous analysis suggested that indirect protection is limited in an influenza B epidemic in Hong Kong. We further analyzed six influenza A epidemics to determine such potential. We applied a statistical model to estimate household transmission dynamics in the 3 influenza A(H3N2) and 3 pandemic influenza A(H1N1) epidemics. Then, we estimated the reduction in infection risk among unvaccinated household members when all children in households are vaccinated, with different assumptions on vaccine efficacy (VE)...
Source: Viruses - September 21, 2022 Category: Virology Authors: Tim K. Tsang Can Wang Vicky J. Fang Ranawaka A. P. M. Perera Hau Chi So Dennis K. M. Ip J. S. Malik Peiris Gabriel M. Leung Simon Cauchemez Benjamin J. Cowling Tags: Article Source Type: research

Viruses, Vol. 14, Pages 1890: Epidemiological Features of the Highly Pathogenic Avian Influenza Virus H5N1 in a Densely Populated Area of Lombardy (Italy) During the Epidemic Season 2021 & ndash;2022
Viruses, Vol. 14, Pages 1890: Epidemiological Features of the Highly Pathogenic Avian Influenza Virus H5N1 in a Densely Populated Area of Lombardy (Italy) During the Epidemic Season 2021–2022 Viruses doi: 10.3390/v14091890 Authors: Silvia Bellini Alessandra Scaburri Erika Molica Colella Monica Pierangela Cerioli Veronica Cappa Stefania Calò Marco Tironi Mario Chiari Claudia Nassuato Ana Moreno Marco Farioli Giuseppe Merialdi In the last two years, there have been three major epidemic seasons in the territory of the European Union and the HPAI epizootic in 2021&ndash;2022 is ...
Source: Viruses - August 26, 2022 Category: Virology Authors: Silvia Bellini Alessandra Scaburri Erika Molica Colella Monica Pierangela Cerioli Veronica Cappa Stefania Cal ò Marco Tironi Mario Chiari Claudia Nassuato Ana Moreno Marco Farioli Giuseppe Merialdi Tags: Article Source Type: research

Insight into the first multi-epitope-based peptide subunit vaccine against avian influenza A virus (H5N6): An immunoinformatics approach
In conclusion, predicting the overall in silico assessment, we anticipated that our designed vaccine would be a plausible prevention against avian influenza A (H5N6) virus.PMID:36007760 | DOI:10.1016/j.meegid.2022.105355 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - August 25, 2022 Category: Genetics & Stem Cells Authors: Md Mukthar Mia Mahamudul Hasan Shakil Ahmed Mohammad Nahian Rahman Source Type: research

Insight into the first multi-epitope-based peptide subunit vaccine against avian influenza A virus (H5N6): An immunoinformatics approach
In conclusion, predicting the overall in silico assessment, we anticipated that our designed vaccine would be a plausible prevention against avian influenza A (H5N6) virus.PMID:36007760 | PMC:PMC9394107 | DOI:10.1016/j.meegid.2022.105355 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - August 25, 2022 Category: Genetics & Stem Cells Authors: Md Mukthar Mia Mahamudul Hasan Shakil Ahmed Mohammad Nahian Rahman Source Type: research

Editorial: Pandemic influenza vaccine approaches: Current status and future directions
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - August 18, 2022 Category: Allergy & Immunology Source Type: research

New rapid detection by using a constant temperature method for avian leukosis viruses
The avian leukemia virus causes avian leukemia (AL), a severe immunosuppressive disease in chickens (ALV). Since the 1990s, the diversity of ALV subpopulations caused by ALV genome variation and recombination, and the complexity of the infection and transmission, with currently no effective commercial vaccine and therapeutic for ALV, has resulted in severe economic losses to the chicken business in various parts of the world. Therefore, as a key means of prevention and control, an effective, rapid, and accurate detection method is imperative. A new real-time reverse transcription recombinase-aided amplification (RT-RAA) as...
Source: Frontiers in Microbiology - August 18, 2022 Category: Microbiology Source Type: research

Duck CD8 < sup > + < /sup > T Cell Response to H5N1 Highly Pathogenic Avian Influenza Virus Infection In Vivo and In Vitro
J Immunol. 2022 Aug 8:ji2101147. doi: 10.4049/jimmunol.2101147. Online ahead of print.ABSTRACTDomestic ducks are the important host for H5N1 highly pathogenic avian influenza virus (HPAIV) infection and epidemiology, but little is known about the duck T cell response to H5N1 AIV infection. In infection experiments of mallard ducks, we detected significantly increased CD8+ cells and augmented expression of cytotoxicity-associated genes, including granzyme A and IFN-γ, in PBMCs from 5 to 9 d postinfection when the virus shedding was clearly decreased, which suggested the importance of the duck cytotoxic T cell response in e...
Source: Journal of Immunology - August 8, 2022 Category: Allergy & Immunology Authors: Manman Dai Hui Sun Li Zhao Qingxin Wu Bowen You Fengxiang Xu Jiayu Liao Sufang Zhu Ziwei Li Yongxiu Yao Venugopal Nair Ming Liao Source Type: research

Thermal stabilization of diverse biologics using reversible hydrogels
Sci Adv. 2022 Aug 5;8(31):eabo0502. doi: 10.1126/sciadv.abo0502. Epub 2022 Aug 5.ABSTRACTImproving the thermal stability of biologics, including vaccines, is critical to reduce the economic costs and health risks associated with the cold chain. Here, we designed a versatile, safe, and easy-to-use reversible PEG-based hydrogel platform formed via dynamic covalent boronic ester cross-linking for the encapsulation, stabilization, and on-demand release of biologics. Using these reversible hydrogels, we thermally stabilized a wide range of biologics up to 65°C, including model enzymes, heat-sensitive clinical diagnostic enzyme...
Source: Adv Data - August 5, 2022 Category: Epidemiology Authors: Bruno Marco-Dufort John R Janczy Tianjing Hu Marco L ütolf Francesco Gatti Morris Wolf Alex Woods Stephan Tetter Balaji V Sridhar Mark W Tibbitt Source Type: research

Molecular characterization of SARS-CoV-2 detected in Tokyo, Japan during five waves: Identification of the amino acid substitutions associated with transmissibility and severity
In this study, we analyzed 112 whole genome sequences of SARS-CoV-2 collected from patients at Juntendo University Hospital in Tokyo and the genome data from entire Japan deposited in Global Initiative on Sharing Avian Influenza Data (GISAID) to examine the relationship of amino acid changes with the transmissibility and the severity of each strain/lineage. We identified 12 lineages, including B.1.1.284, B.1.1.214, R.1, AY.29, and AY.29.1, which were prevalent specifically in Japan. B.1.1.284 was most frequently detected in the second wave, but B.1.1.214 became the predominant lineage in the third wave, indicating that B.1...
Source: Frontiers in Microbiology - July 27, 2022 Category: Microbiology Source Type: research

Viruses, Vol. 14, Pages 1629: Influenza Viruses Suitable for Studies in Syrian Hamsters
iro Kawaoka Several small animal models, including mice, Syrian hamsters, guinea pigs, and ferrets are used to study the pathogenicity, transmissibility, and antigenicity of seasonal and pandemic influenza viruses. Moreover, animal models are essential for vaccination and challenge studies to evaluate the immunogenicity and protective efficacy of new vaccines. However, authentic human influenza viruses do not always replicate efficiently in these animal models. Previously, we developed a high-yield A/Puerto Rico/8/34 (PR8-HY) vaccine virus backbone that conferred an increased virus yield to several seasonal influenza v...
Source: Viruses - July 26, 2022 Category: Virology Authors: Shufang Fan Chunyang Gu Huihui Kong Lizheng Guan Gabriele Neumann Yoshihiro Kawaoka Tags: Article Source Type: research

Inhibitory effects of cedar pine needle extract on H9N2 avian influenza virus in vitro and in vivo
Virology. 2022 Jul 19;574:25-36. doi: 10.1016/j.virol.2022.07.011. Online ahead of print.ABSTRACTH9N2 avian influenza virus causes significant economic losses to the poultry industry, due to its wide-spread prevalence and propensity to induce secondary and mixed infections. Antigenic drift limits vaccine efficacy. New anti-viral therapies are needed to complement existing control measures. At the maximum non-cytotoxic concentration (25 mg/mL), cedar pine needle extract inhibited H9N2 avian influenza virus proliferation in vitro and in vivo. Cedar pine needle extract reduced the haemagglutinin titre, inhibited H9N2 avian in...
Source: Virology - July 25, 2022 Category: Virology Authors: Mingzheng Han Shuang Gao Wenfeng Hu Qingfeng Zhou Hongxin Li Wencheng Lin Feng Chen Source Type: research