Efficacy, tolerability and impact on quality of life of clindamycin phosphate and benzoyl peroxide for the treatment of cetuximab-associated acneiform eruption in patients with metastatic colorectal cancer.
CONCLUSION: A clindamycin phosphate-benzoyl peroxide gel may be an effective and safe option in the treatment of cetuximab-associated acneiform eruptions.
PMID: 26313697 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Antibiotic resistance to Propionobacterium acnes: worldwide scenario, diagnosis and management.
Authors: Sardana K, Gupta T, Garg VK, Ghunawat S
Abstract
Antibiotic resistance in cutaneous Propionobacterium is a global problem. As a general rule, resistance levels are high to macrolides, trimethoprim/sulfamethoxazole and clindamycin, while tetracyclines and levofloxacin have low resistance potential. Newer preparations like doxycycline MR and doxycycline 20 mg are subantimicrobial and may not lead to resistance. Sampling techniques are crucial to determine resistance. Genomic evaluation using 16S ribosomal RNA gene sequencing can be useful in diagnosing mutations and mapping phylotypes of Propionobac...
Source: Expert Review of Anti-Infective Therapy - February 14, 2016 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
A cross-sectional pilot study of antibiotic resistance in Propionibacterium acnes strains in Indian acne patients using 16s-RNA polymerase chain reaction: A comparison among treatment modalities including antibiotics, benzoyl peroxide, and isotretinoin
Conclusions: High resistance was seen among the P. acnes strains to macrolides-lincosamides (AZI and CL) while MINO and LEVO resistance was low. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - January 15, 2016 Category: Dermatology Authors: Kabir SardanaTanvi GuptaBipul KumarHemant K GautamVijay K Garg Source Type: research
[Bacterial resistance in acne? A meta-analysis of the controversy].
CONCLUSIONS: An increase in bacterial resistance to topical erythromycin and clindamycin can be confirmed, thus the use of these antibiotics is recommended in selective cases for short periods, and in combination with benzoyl peroxide for the best clinical outcome in patients with acne vulgaris.
PMID: 26738649 [PubMed - as supplied by publisher] (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - December 28, 2015 Category: Surgery Authors: Alvarez-Sánchez M, Rodríguez-Ayala E, Ponce-Olivera RM, Tirado-Sánchez A, Arellano-Mendoza MI Tags: Cir Cir Source Type: research
Profile of clindamycin phosphate 1.2%/benzoyl peroxide 3.75% aqueous gel for the treatment of acne vulgaris.
Authors: Nguyen TA, Eichenfield LF
Abstract
Acne vulgaris is a common and chronic skin disease, and is a frequent source of morbidity for affected patients. Treatment of acne vulgaris is often difficult due to the multifactorial nature of this disease. Combination therapy, such as that containing clindamycin and benzoyl peroxide, has become the standard of care. Several fixed formulations of clindamycin 1% and benzoyl peroxide of varying concentrations are available and have been used with considerable success. The major limitation is irritation and dryness from higher concentrations of benzoyl peroxide, a...
Source: Clinical, Cosmetic and Investigational Dermatology - November 30, 2015 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Reduction of Inflammatory and Noninflammatory Lesions with Topical Tyrothricin 0.1% in the Treatment of Mild to Severe Acne Papulopustulosa: A Randomized Controlled Clinical Trial
Conclusion: The results indicate that tyrothricin might be a candidate for treating acne and it seems to be more tolerable than both comparator treatments.Skin Pharmacol Physiol 2016;29:1-8 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 12, 2015 Category: Dermatology Source Type: research
Efficacy and Tolerability of a Fixed Combination of Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (3.75%) Aqueous Gel in Moderate and Severe Acne Vulgaris Subpopulations.
CONCLUSIONS: Clindamycin-BP 3.75% aqueous gel is an effective and well-tolerated once-daily topical treatment for both moderate and severe acne <br /><br /> <em>J Drugs Dermatol.</em> 2015;14(9):969-974.
PMID: 26355615 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - September 12, 2015 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC®) in the treatment of EGFR inhibitors‐associated acneiform eruption
(Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - August 20, 2015 Category: Dermatology Authors: M. Vaccaro, F. Guarneri, F. Borgia, A. Pollicino, G. Altavilla, S. P. Cannavò Tags: Letter to the Editor Source Type: research
Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC ®) in the treatment of EGFR inhibitors‐associated acneiform eruption
(Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - August 19, 2015 Category: Dermatology Authors: M. Vaccaro, F. Guarneri, F. Borgia, A. Pollicino, G. Altavilla, S. P. Cannav ò Tags: Letter to the Editor Source Type: research
Topical Treatments in Acne Vulgaris: Guidance for the Busy Dermatologist.
Authors: Stein Gold L
Abstract
Acne is a very common skin disease; frequently seen in adolescents and often persisting or occurring into adulthood. Topical therapy is very effective in mild to moderate disease, and is used as maintenance therapy. Fixed combination products have been studied in moderately severe disease. Combinations of benzoyl peroxide and either clindamycin or adapalene appear very effective. When utilizing a topical retinoid alone or in combination, it is essential to incorporate an appropriate skin care regimen to minimize local irritation. In the absence of direct comparative clinical ...
Source: Journal of Drugs in Dermatology - June 21, 2015 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Allergic contact dermatitis caused by topical antiacne drugs.
Abstract
Acne is a chronic inflammatory disease for which a long-lasting therapy, very often with topical drugs, is necessary. Despite the fact that several topical antiacne drugs (in particular, tretinoin, benzoyl peroxide, clindamycin and erythromycin) are used for many years, often on broad skin surfaces and for long periods of time, their potential for contact sensitization is low. Their potential for phototoxic and photoallergic reactions is also low. Much more frequent is irritant contact dermatitis caused by some of these drugs, in particular, retinoids and benzoyl peroxide, for which the short cont...
Source: Pharmacological Reviews - May 17, 2015 Category: Drugs & Pharmacology Authors: Veraldi S, Brena M, Barbareschi M Tags: Expert Rev Clin Pharmacol Source Type: research
Efficacy and safety of clindamycin gel plus either benzoyl peroxide gel or adapalene gel in the treatment of acne: a randomized open-label study
Conclusion
Clindamycin + benzoyl peroxide gel and clindamycin + adapalene gel are both effective in the treatment of mild to moderate acne, with clindamycin + adapalene showing a significantly greater reduction in the overall acne grading in this small study. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 22, 2015 Category: Drugs & Pharmacology Source Type: research
The Efficacy and Tolerability of a Fixed Combination Clindamycin (1.2%) and Benzoyl Peroxide (3.75%) Aqueous Gel in Patients With Facial Acne Vulgaris: Gender as a Clinically Relevant Outcome Variable.
CONCLUSIONS: Clindamycin phosphate 1.2%/BP 3.75% gel provides statistically significant greater efficacy than vehicle with a favorable safety and tolerability profile. It appears to be more effective in female patients.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(4):381-384.
PMID: 25844612 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 7, 2015 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Topical acne treatments in Europe and the issue of antimicrobial resistance
Abstract
Acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by Propionibacterium acnes (P. acnes) as well as immune reactions and inflammation. Despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in Europe to treat acne. This intensive use led to antimicrobial‐resistant P. acnes and staphylococci strains becoming one of the main health issues worldwide. This is an upda...
Source: Journal of the European Academy of Dermatology and Venereology - February 10, 2015 Category: Dermatology Authors: M.T. Leccia, N. Auffret, F. Poli, J.‐P. Claudel, S. Corvec, B. Dreno Tags: Review Article Source Type: research
Clindamycin phosphate 1·2%–benzoyl peroxide 3·0% fixed‐dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase 3, multicentre, randomized, single‐blinded, active‐controlled, parallel group study
ConclusionsCompared with CLNP twice daily, CLNP/BPO 3·0% once daily was more effective and CLNP/BPO 3·0% twice daily at least as effective, with an early onset of action and an acceptable safety and tolerability profile in Japanese patients. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 7, 2015 Category: Dermatology Authors: M. Kawashima, H. Hashimoto, A.B. Alió Sáenz, M. Ono, M. Yamada Tags: Therapeutics Source Type: research
