27615 Impact of body mass index (BMI) on efficacy of three topical acne treatments in patients with moderate-to-severe acne
Acne prevalence may be higher in overweight/obese individuals, potentially due to hormonal, inflammatory, and/or dietary factors. However, BMI effect on topical acne treatments is largely unknown. This post hoc analysis investigated BMI impact on efficacy of clindamycin/benzoyl peroxide 1.2%/3.75% gel (C/BPO), tretinoin 0.05% lotion (polymeric emulsion), and tazarotene 0.045% lotion (polymeric emulsion) using data from 5 phase 3, double-blind studies. Participants with moderate-to-severe acne (Evaluator ’s Global Severity Score 3 or 4) were randomized 1:1 to once-daily drug or vehicle for 12 weeks. (Source: Journal of th...
Source: Journal of the American Academy of Dermatology - August 8, 2021 Category: Dermatology Authors: Fran Cook-Bolden, Fran E. Cook-Bolden, Lawrence Green, Jonette Keri, Leon Kircik, Hilary Baldwin, William P. Wershchler, Eric Guenin, Varsha Bhatt, Radhakrishnan Pillai Source Type: research
Pediatric Hidradenitis Suppurativa: Epidemiology, Disease Presentation, and Treatments
CONCLUSIONS: Pediatric HS patients have varied presentations and response to treatment. Further studies are needed to characterize the disease and the most effective treatments.PMID:34057384 | DOI:10.1080/09546634.2021.1937484 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 31, 2021 Category: Dermatology Authors: Justine Seivright Erin Collier Tristan Grogan Terri Shih Marcia Hogeling Vivian Y Shi Jennifer L Hsiao Source Type: research
Topical preparations for the treatment of mild to moderate acne vulgaris: systematic review and network meta-analysis
CONCLUSIONS: Adapalene+BPO may be the most effective but with a slightly higher incidence of withdrawal than monotherapy. Inconsistent reporting of trial results precluded firmer conclusions.PMID:33825196 | DOI:10.1111/bjd.20080 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 7, 2021 Category: Dermatology Authors: B Stuart E Maund C Wilcox K Sridharan G Sivaramakrishnan C Regas D Newell I Soulsby K F Tang A Y Finlay H C Bucher P Little A M Layton M Santer Source Type: research
Topical preparations for the treatment of mild to moderate acne vulgaris: systematic review and network meta-analysis
CONCLUSIONS: Adapalene+BPO may be the most effective but with a slightly higher incidence of withdrawal than monotherapy. Inconsistent reporting of trial results precluded firmer conclusions.PMID:33825196 | DOI:10.1111/bjd.20080 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 7, 2021 Category: Dermatology Authors: B Stuart E Maund C Wilcox K Sridharan G Sivaramakrishnan C Regas D Newell I Soulsby K F Tang A Y Finlay H C Bucher P Little A M Layton M Santer Source Type: research
Tolerability and Efficacy of Clindamycin/Tretinoin versus Adapalene/Benzoyl Peroxide in the Treatment of Acne Vulgaris
J Drugs Dermatol. 2021 Mar 1;20(3):295-301. doi: 10.36849/JDD.2021.5641.ABSTRACTAcne vulgaris is the most common dermatological disorder worldwide, causing significant physical and psychological morbidity. Topical combination therapy has shown superior efficacy compared to monotherapy, especially when combined with retinoids. Few studies have directly compared combined formulations. This evaluator-blinded pilot study compared the efficacy and tolerability of two marketed topical combination acne gels, clindamycin 1%-tretinoin 0.025% (CT) and benzoyl peroxide 2.5%-adapalene 0.1% (BA) in 20 patients with mild to moderate acn...
Source: Journal of Drugs in Dermatology - March 8, 2021 Category: Dermatology Authors: Roland Aschoff Sebastian M öller Rocco Haase Marvin Kuske Source Type: research
