Tolerability of topical antimicrobials in treatment of acne vulgaris.
CONCLUSIONS: Topical antimicrobial acne therapy is generally well tolerated. Discontinuation rates are low under study conditions. Tolerability of topical antimicrobial therapy for acne may not have great clinical significance.
PMID: 24918554 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 2, 2014 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% for the once-daily treatment of moderate to severe acne vulgaris.
CONCLUSIONS: Clindamycin-BP 3.75% provides statistically significant greater efficacy than vehicle with a favorable safety and tolerability profile.
PMID: 25226009 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 2, 2014 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single-blinded, active-controlled, parallel-group study.
CONCLUSION: Compared with CLNP-BID, CLNP/BPO 3%-QD was more effective and CLNP/BPO 3%-BID at least as effective, with an early onset of action and an acceptable safety and tolerability profile in Japanese patients. This article is protected by copyright. All rights reserved.
PMID: 25040180 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 12, 2014 Category: Dermatology Authors: Kawashima M, Hashimoto H, Alió Sáenz AB, Ono M, Yamada M Tags: Br J Dermatol Source Type: research
Clindamycin phosphate 1.2%–benzoyl peroxide 3% fixed‐dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single‐blinded, active‐controlled, parallel‐group study
ConclusionCompared with CLNP‐BID, CLNP/BPO 3%‐QD was more effective and CLNP/BPO 3%–BID at least as effective, with an early onset of action and an acceptable safety and tolerability profile in Japanese patients.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - July 12, 2014 Category: Dermatology Authors: M. Kawashima, H. Hashimoto, A.B. Alió Sáenz, M. Ono, M. Yamada Tags: Therapeutics Source Type: research
Clinical pearls in dermatology 2014
A 34-year-old female presents with papulopustular acne. She has tried topical tretinoin, benzoyl peroxide wash, topical clindamycin, and oral doxycycline. She has adhered to her treatment regimen for 3 months without improvement. She has deep, painful, persistent nodules on the jawline, chin, and neck (). (Source: Disease a Month)
Source: Disease a Month - June 19, 2014 Category: Infectious Diseases Authors: Catherine C. Newman, John B. Bundrick Source Type: research
Systemic exposure to benzoic acid and hippuric acid following topical application of clindamycin 1%/benzoyl peroxide 3% fixed‐dose combination gel in Japanese patients with acne vulgaris
In this study, plasma and urine concentrations of benzoic acid (BA) and hippuric acid (HA) were analyzed to estimate the pharmacokinetics (PK) of BPO after application of CLDM/BPO3% twice‐daily for 7 days in Japanese patients with acne vulgaris. Seven‐day repeated application of CLDM/BPO3% appears to be safe in this patient population. Concentrations of plasma and urine BA were below the limit of quantification before and after repeated application in most of the 12 adult male patients. Mean difference in Cmax and AUC0–last for plasma HA indicated increased exposures after repeated application, but with wide 90% conf...
Source: Clinical Pharmacology in Drug Development - June 9, 2014 Category: Drugs & Pharmacology Authors: Hiroko Ino, Naoki Takahashi, Alessandra Alio Saenz, Akira Wakamatsu, Hirofumi Hashimoto, Norie Nakahara, Setsuo Hasegawa Tags: Original Article Source Type: research
Treatment of acne vulgaris in pregnant patients
Abstract
The management of acne vulgaris in the setting of pregnancy raises important clinical considerations regarding the efficacy and safety of acne treatments in this special patient population. Particular challenges include the absence of safety data, discrepancy in safety data between different safety rating systems, and lack of evidence‐based recommendations for the treatment of acne during pregnancy. Nonetheless, many therapeutic options exist, and the treatment of acne in pregnant women can be safely and often effectively accomplished. For mild or moderate disease, patients can be treated with topical antimicrob...
Source: Dermatologic Therapy - August 5, 2013 Category: Dermatology Authors: Rupa Pugashetti, Kanade Shinkai Tags: Invited Article Source Type: research
