Management of Severe Acne Vulgaris With Topical Therapy.
Authors: Stein Gold L, Baldwin HE, Lin T
Abstract
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potent...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Fixed Combination of Clindamycin Phosphate 1.2% and Benzoyl Peroxide 3.75% Aqueous Gel: Long-Term Use in Adult Females With Moderate Acne Vulgaris.
CONCLUSIONS: Clindamycin-BP 3.75% gel demonstrates continued improvement in symptoms of moderate acne over 24 weeks, with good tolerability, demonstrating a clinical benefit of continued clindamycin-BP 3.75% gel as a maintenance therapy for acne in adult female patients.</p> <p><em>J Drugs Dermatol. 2017;16(6):543-546.</em></p>.
PMID: 28686771 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 9, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Benzoyl peroxide and clindamycin topical skin preparation decreases Propionibacterium acnes colonization in shoulder arthroscopy
The objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative skin preparation reduces the incidence of P. acnes colonization during shoulder arthroscopy. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - May 4, 2017 Category: Orthopaedics Authors: Hailey H. Dizay, Diana G. Lau, Wesley M. Nottage Tags: Original Article Source Type: research
Benzoyl peroxide and clindamycin topical skin preparation decreases Propionibacterium acnes deep colonization in shoulder arthroscopy
The objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative surgical skin preparation reduces the incidence of P. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - April 11, 2017 Category: Orthopaedics Authors: Hailey Dizay, Diana Lau, Wesley M. Nottage Source Type: research
Light therapies for acne: abridged Cochrane systematic review including GRADE assessments.
This article is protected by copyright. All rights reserved.
PMID: 28338214 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 24, 2017 Category: Dermatology Authors: Barbaric J, Abbott R, Posadzki P, Car M, Gunn LH, Layton AM, Majeed A, Car J Tags: Br J Dermatol Source Type: research
Light therapies for acne: abridged Cochrane systematic review including GRADE assessments
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - March 24, 2017 Category: Dermatology Authors: J. Barbaric, R. Abbott, P. Posadzki, M. Car, L.H. Gunn, A.M. Layton, A. Majeed, J. Car Tags: Systematic Review Source Type: research
Measuring acne using Coproporphyrin III, Protoporphyrin IX, and lesion-specific inflammation: an exploratory study
AbstractPropionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized byP. acnes. In this exploratory study, for the first time, the possible relationships of Coproporphyrin III (CpIII) and Protoporphyrin IX (PpIX) fluorescence as well as acne lesion-specific inflammation measurements with clinical signs of acne are investigated. Furthermore, the sensitivity of these...
Source: Archives of Dermatological Research - February 7, 2017 Category: Dermatology Source Type: research
Lincosamides: Chemical Structure, Biosynthesis, Mechanism of Action, Resistance, and Applications.
Abstract
Lincomycin and its derivatives are antibiotics exhibiting biological activity against bacteria, especially Gram-positive ones, and also protozoans. Lincomycin and its semi-synthetic chlorinated derivative clindamycin are widely used in clinical practice. Both antibiotics are bacteriostatic, inhibiting protein synthesis in sensitive bacteria; however, at higher concentrations, they may be bactericidal. Clindamycin is usually much more active than lincomycin in the treatment of bacterial infections, in particular those caused by anaerobic species; it can also be used for the treatment of important p...
Source: Biochemical Pharmacology - December 6, 2016 Category: Drugs & Pharmacology Authors: Spížek J, Řezanka T Tags: Biochem Pharmacol Source Type: research
Light therapies for acne.
CONCLUSIONS: High-quality evidence on the use of light therapies for people with acne is lacking. There is low certainty of the usefulness of MAL-PDT (red light) or ALA-PDT (blue light) as standard therapies for people with moderate to severe acne.Carefully planned studies, using standardised outcome measures, comparing the effectiveness of common acne treatments with light therapies would be welcomed, together with adherence to the Consolidated Standards of Reporting Trials (CONSORT) guidelines.
PMID: 27670126 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 26, 2016 Category: Journals (General) Authors: Barbaric J, Abbott R, Posadzki P, Car M, Gunn LH, Layton AM, Majeed A, Car J Tags: Cochrane Database Syst Rev Source Type: research
The Management of Acne Vulgaris in Primary Care: A cohort study of consulting and prescribing patterns using CPRD
ConclusionThese data suggest that patients with acne are receiving sub‐optimal initial choice of ARMs, longitudinal care and prescribing.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - September 21, 2016 Category: Dermatology Authors: N.A. Francis, K. Entwistle, M. Santer, A.M. Layton, E.A. Eady, C.C. Butler Tags: Original Article Source Type: research
The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin.
CONCLUSIONS: Our findings suggest topical erythromycin use for acne has essentially ceased. By contrast, clindamycin use is increasing. Current recommendations discourage topical antibiotic monotherapy in favour of combination therapy with benzoyl peroxide and topical retinoids. Our group's previous work demonstrated that this trend is indeed occurring.
PMID: 27425633 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 20, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research
A multicentre, randomized, single ‐blind comparison of topical clindamycin 1%/benzoyl peroxide 5% once‐daily gel versus clindamycin 1% twice‐daily gel in the treatment of mild to moderate acne vulgaris in Chinese patients
ConclusionCDP/BPO gel demonstrated superior efficacy over CDP gel along with acceptable safety and tolerability in Chinese patients with mild to moderate acne.
Clinical Trials.gov number: NCT01915732 (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - April 12, 2016 Category: Dermatology Authors: J.H. Xu, Q.J. Lu, J.H. Huang, F. Hao, Q.N. Sun, H. Fang, J. Gu, X.Q. Dong, J. Zheng, D. Luo, F.Q. Li, G. Wang, H. Gu, H.Q. Tian, H.L. Yang, L.Y. Xi, M. Li, M. Zheng, Y. Wu, Y.T. Tu, Y.L. He, G. Zhao, W.X. Sheng, J. Li, A.G. Hamedani Tags: Original Article Source Type: research
A multicentre, randomized, single‐blind comparison of topical clindamycin 1%/benzoyl peroxide 5% once‐daily gel versus clindamycin 1% twice‐daily gel in the treatment of mild to moderate acne vulgaris in Chinese patients
ConclusionCDP/BPO gel demonstrated superior efficacy over CDP gel along with acceptable safety and tolerability in Chinese patients with mild to moderate acne.
Clinical Trials.gov number: NCT01915732 (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - April 12, 2016 Category: Dermatology Authors: J.H. Xu, Q.J. Lu, J.H. Huang, F. Hao, Q.N. Sun, H. Fang, J. Gu, X.Q. Dong, J. Zheng, D. Luo, F.Q. Li, G. Wang, H. Gu, H.Q. Tian, H.L. Yang, L.Y. Xi, M. Li, M. Zheng, Y. Wu, Y.T. Tu, Y.L. He, G. Zhao, W.X. Sheng, J. Li, A.G. Hamedani Tags: Original Article Source Type: research
Treatment of Acne in Pregnancy
We describe the safety profile of common therapies and outline approaches based on available evidence. Topical azelaic acid or benzoyl peroxide can be recommended as baseline therapy. A combination of topical erythromycin or clindamycin with benzoyl peroxide is recommended for inflammatory acne. Oral erythromycin or cephalexin is generally considered safe for moderate to severe inflammatory acne when used for a few weeks. A short course of oral prednisolone may be useful for treating fulminant nodular cystic acne after the first trimester. In general, topical and oral antibiotics should not be used as monotherapy, but comb...
Source: Journal of the American Board of Family Medicine - March 8, 2016 Category: Primary Care Authors: Chien, A. L., Qi, J., Rainer, B., Sachs, D. L., Helfrich, Y. R. Tags: Clinical Reviews Source Type: research
A multicentre, randomized, single‐blind, parallel‐group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild‐to‐moderate acne vulgaris
ConclusionBPO + CLN demonstrated greater efficacy than AzA in the treatment of mild‐to‐moderate acne vulgaris and has a positive tolerability and safety profile. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - February 24, 2016 Category: Dermatology Authors: M. Schaller, M. Sebastian, C. Ress, D. Seidel, M. Hennig Tags: Original Article Source Type: research
