Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
CONCLUSIONS: Compared to benzoyl peroxide, azelaic acid probably leads to a worse treatment response, measured using PGA. When compared to tretinoin, azelaic acid probably makes little or no difference to treatment response. For other comparisons and outcomes the quality of evidence was low or very low. Risk of bias and imprecision limit our confidence in the evidence. We encourage the comparison of more methodologically robust head-to-head trials against commonly used active drugs.
PMID: 32356369 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 30, 2020 Category: General Medicine Authors: Liu H, Yu H, Xia J, Liu L, Liu GJ, Sang H, Peinemann F Tags: Cochrane Database Syst Rev Source Type: research
Topical benzoyl peroxide for acne.
CONCLUSIONS: Current evidence suggests that BPO as monotherapy or add-on treatment may be more effective than placebo or no treatment for improving acne, and there may be little to no difference between BPO and either adapalene or clindamycin. Our key efficacy evidence is based on participant self-assessment; trials of BPO versus erythromycin or salicylic acid did not report this outcome. For adverse effects, the evidence is very uncertain regarding BPO compared with adapalene, erythromycin, or salicylic acid. However, risk of treatment discontinuation may be higher with BPO compared with placebo or no treatment. Withdrawa...
Source: Cochrane Database of Systematic Reviews - March 15, 2020 Category: General Medicine Authors: Yang Z, Zhang Y, Lazic Mosler E, Hu J, Li H, Zhang Y, Liu J, Zhang Q Tags: Cochrane Database Syst Rev Source Type: research
Minocycline Foam (Amzeeq) for Acne
Date: May 4, 2020
Issue #:
1597Summary:
The FDA has approved a 4% aerosol foam formulation
of minocycline (Amzeeq– Foamix) for topical
treatment of inflammatory lesions of non-nodular
moderate to severe acne in patients≥9 years old. It is
the first topical tetracycline formulation to be approved
for use in patients with acne. Oral minocycline
(Minocin,Solodyn, and generics) is (Source: The Medical Letter)
Source: The Medical Letter - March 4, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Acanya Acne Amzeeq Antibacterials Apprilon Benzaclin Benzamycin Benzoyl peroxide Clindamycin Clindoxy Doryx Doxycycline Erythromycin Minocin Minocycline Onexton periostat Retinoids sarecycline Seysara solodyn Source Type: research
Trifarotene (Aklief) - A New Topical Retinoid for Acne
Date: December 16, 2019
Issue #:
1587Summary:
The FDA has approved trifarotene 0.005% cream
(Aklief– Galderma) for topical treatment of acne
vulgaris in patients ≥9 years old. Trifarotene is the
fourth topical retinoid to be approved in the US for
treatment of acne; tretinoin (Retin-A, and others),
adapalene (Differin, and generics), and tazarotene
(Tazorac, and others) have been available by
prescription for decades. Adapalene 0.1% gel has been
available over the counter since 2016 for treatment of
acne in patients ≥12 years old. (Source: The Medical Letter)
Source: The Medical Letter - November 12, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Acne Adapalene Aklief Atralin Avita Benzoyl peroxide Biacna Clindamycin Differin Epiduo Retin-A Retinoids Stieva Tactupump Tazarotene Tazorac Tretinoin trifarotene Veltin Ziana Source Type: research
Knowledge, belief, and perception among youths with acne vulgaris
Conclusion: There are several misconceptions and a gross lack of knowledge about acne amongst our younger population, that needs to be addressed. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - September 4, 2019 Category: Dermatology Authors: Afzaa Nizar Machiwala Ganesh Kamath Tanvi Pradeep Vaidya Source Type: research
Cutibacterium acnes persists despite topical clindamycin and benzoyl peroxide
Cutibacterium (formerly Propionibacterium) acnes persists in the dermis despite standard skin antiseptic agents, prompting some surgeons to use topical antimicrobials such as benzoyl peroxide and clindamycin prior to shoulder arthroplasty surgery. However, the efficacy of these topical agents has not been established. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - August 26, 2019 Category: Orthopaedics Authors: Nathanael Heckmann, K. Soraya Heidari, Omid Jalali, Alexander E. Weber, Rosemary She, Reza Omid, C. Thomas Vangsness, George F. “Rick” Hatch Source Type: research
Treatment of Moderate Acne Vulgaris in Fitzpatrick Skin Type V or VI: Efficacy and Tolerability of Fixed Combination Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% Gel.
CONCLUSIONS: Patients with Fitzpatrick Skin Type V and VI treated with clindamycin phosphate 1.2%/ benzoyl peroxide 3.75% gel experienced significant reductions in facial acne severity, lesion counts and PIH severity/distribution. Tolerability was excellent. J Drugs Dermatol. 2018;17(10):1107-1112.
PMID: 30365592 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - October 28, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Comparative Trial of Silver Nanoparticle Gel and 1% Clindamycin Gel when Use in Combination with 2.5% Benzoyl Peroxide in Patients with Moderate Acne Vulgaris.
Conclusion: Silver nanoparticle gel is effective with good safety profile for the treatment of acne vulgaris. The present study demonstrated that there were no clinical significant differences between silver nanoparticle gel and clindamycin gel for the treatment of moderate severity of acne vulgaris when use in combination with 2.5% benzoyl peroxide. The clinical application as alternative treatment for acne is advised.
PMID: 29911775 [PubMed - in process] (Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet)
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - June 21, 2018 Category: General Medicine Tags: J Med Assoc Thai Source Type: research
Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed ‐dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator‐blind, parallel‐group study
The Journal of Dermatology, EarlyView. (Source: The Journal of Dermatology)
Source: The Journal of Dermatology - June 15, 2018 Category: Dermatology Authors: Nobukazu Hayashi
,
Ichiro Kurokawa
,
Obukohwo Siakpere
,
Akira Endo
,
Toshiki Hatanaka
,
Masahiro Yamada
,
Makoto Kawashima Source Type: research
Topical Vehicle Formulations in the Treatment of Acne.
This article will review the goals of topical therapy for the treatment of acne, in addition to common therapies and their challenges. Advanced formulations and combination formulations of benzoyl peroxide, clindamycin, and tretinoin will also be discussed. J Drugs Dermatol. 2018;17(6 Suppl):s6-10.
PMID: 29879262 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Hidradenitis suppurativa: Inside and out
Sharmila Patil, Astuty Apurwa, Nitin Nadkarni, Shweta Agarwal, Parag Chaudhari, Manjyot GautamIndian Journal of Dermatology 2018 63(2):91-98
Hidradenitis suppurativa is a chronic, disabling, suppurative disease characterized by deep tender subcutaneous nodules; complicated by fibrosis and extensive sinuses affecting primarily the apocrine gland bearing areas. It affects all races in early 20s with greater prevalence seen in women (3 to 5:1). The estimated disease prevalence is 1 - 4 %. The disease is speculated to be caused by follicular structural abnormalities with associated risk factors as smoking, obesity,...
Source: Indian Journal of Dermatology - April 6, 2018 Category: Dermatology Authors: Sharmila Patil Astuty Apurwa Nitin Nadkarni Shweta Agarwal Parag Chaudhari Manjyot Gautam Source Type: research
Erythema ‐directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris
ConclusionThis study has demonstrated for the first time that erythema‐directed digital photography can enhance the evaluation of the efficacy and tolerability of topical acne treatments. These cases show that Clin‐RA was associated with improved efficacy and tolerability vs previous treatments with topical monotherapy (benzoyl peroxide 5%) or a topical fixed‐dose combination (clindamycin 1%/benzoyl peroxide 5%). (Source: Skin Research and Technology)
Source: Skin Research and Technology - January 31, 2018 Category: Dermatology Authors: G. Micali, F. Dall'Oglio, A. Tedeschi, F. Lacarrubba Tags: ORIGINAL ARTICLE Source Type: research
Management of comedonal acne vulgaris with fixed ‐combination topical therapy
ConclusionsClindamycin 1.2%‐benzoyl peroxide 3.75% gel may afford similar benefits to adapalene 0.3%‐benzoyl peroxide 2.5% gel in this sometimes difficult to treat patient population. (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - December 1, 2017 Category: Dermatology Authors: Michael H Gold, Hilary Baldwin, Tina Lin Tags: ORIGINAL CONTRIBUTION Source Type: research
