Active surveillance of antimicrobial resistance in companion animals: A pilot study in a Spanish Veterinary Teaching Hospital
Comp Immunol Microbiol Infect Dis. 2024 Apr 2;108:102169. doi: 10.1016/j.cimid.2024.102169. Online ahead of print.ABSTRACTThe role of small animal veterinary hospitals in the onset and dissemination of antimicrobial-resistant organisms (AMROs) is still not clear, and the implementation of an internal surveillance systems is a cost-effective tool to better understand their impact. The aim of this study was to describe a pilot program of active surveillance in a Spanish Veterinary Teaching Hospital, developed to estimate the detection frequency of AMROs in the commensal flora of patients and in the environment. Surveillance ...
Source: Comparative immunology, microbiology and infectious diseases. - April 5, 2024 Category: Allergy & Immunology Authors: Raffaele Scarpellini Laura Leal V élez De Mendizábal Sergio Quevedo-Caraballo Jos é L Blanco Marta E Garc ía Marta P érez-Sancho Miriam Portero Fuentes Silvia Penelo Erika Esposito Elisabetta Mondo Silvia Piva Source Type: research
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: Indian J Med Res - April 5, 2024 Category: Research Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research
Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea
CONCLUSION: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline, oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would...
Source: Biomed Res - April 5, 2024 Category: Research Authors: Khalid Hussein Berhe Tesfai Okbu Frezgi Hagos Hayelom Yosan Gebremeskel Azania Werede Hailemichael Gebremariam Fitsum Kibreab Mohammed Elfatih Hamida Source Type: research
Antibacterial activity of a short de novo designed peptide against fish bacterial pathogens
Amino Acids. 2024 Apr 5;56(1):28. doi: 10.1007/s00726-024-03388-4.ABSTRACTIn the face of increasing antimicrobial resistance in aquaculture, researchers are exploring novel substitutes to customary antibiotics. One potential solution is the use of antimicrobial peptides (AMPs). We aimed to design and evaluate a novel, short, and compositionally simple AMP with potent activity against various bacterial pathogens in aquaculture. The resulting peptide, KK12YW, has an amphipathic nature and net charge of + 7. Molecular docking experiments disclosed that KK12YW has a strong affinity for aerolysin, a virulence protein produced b...
Source: Amino Acids - April 5, 2024 Category: Biochemistry Authors: Raja Aadil Hussain Bhat Victoria C Khangembam Vinita Pant Ritesh Shantilal Tandel Pramod Kumar Pandey Dimpal Thakuria Source Type: research
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research
Resistome analysis of Escherichia coli isolates from layers in Hungary
This study employed shotgun sequencing-based genetic and bioinformatic analysis along with determining phenotypic minimum inhibitory concentrations. A total of 59 ARGs were identified in the eight E. coli isolates, carrying ARGs against 15 groups of antibiotics. Among these, 28 ARGs were identified as transferable. Specifically, four ARGs were plasmid-derived, 18 ARGs were phage-derived and an additional six ARGs were predicted to be mobile, contributing to their mobility and potential spread between bacteria.PMID:38578711 | DOI:10.1556/004.2024.00988 (Source: Acta Veterinaria Hungarica)
Source: Acta Veterinaria Hungarica - April 5, 2024 Category: Veterinary Research Authors: Ádám Kerek Ábel Szabó Kriszti án Bányai Eszter Kaszab Krisztina Bali M árton Papp L ászló Kovács Ákos Jerzsele Source Type: research
Distribution of antimicrobial resistance and virulence markers in chicken originated Proteus mirabilis isolates
Acta Vet Hung. 2024 Apr 4. doi: 10.1556/004.2023.00990. Online ahead of print.ABSTRACTProteus mirabilis is a common enteric bacterium in livestock and humans. The increase and spread of the antimicrobial resistant P. mirabilis is considered alarming worldwide. Transmission mainly occurs through consumption of contaminated poultry products. We investigated antimicrobial resistance (AMR) and virulence markers in broiler chicken-originated P. mirabilis isolates from 380 fecal samples. Phenotypic AMR test was performed against seventeen different antimicrobials. Genotypic AMR test was performed to detect sixteen different AMR ...
Source: Acta Veterinaria Hungarica - April 5, 2024 Category: Veterinary Research Authors: Seyyide Sar ıçam İnce Mehmet Akan Source Type: research
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: Indian J Med Res - April 5, 2024 Category: Research Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research
Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea
CONCLUSION: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline, oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would...
Source: Biomed Res - April 5, 2024 Category: Research Authors: Khalid Hussein Berhe Tesfai Okbu Frezgi Hagos Hayelom Yosan Gebremeskel Azania Werede Hailemichael Gebremariam Fitsum Kibreab Mohammed Elfatih Hamida Source Type: research
Resistome analysis of Escherichia coli isolates from layers in Hungary
This study employed shotgun sequencing-based genetic and bioinformatic analysis along with determining phenotypic minimum inhibitory concentrations. A total of 59 ARGs were identified in the eight E. coli isolates, carrying ARGs against 15 groups of antibiotics. Among these, 28 ARGs were identified as transferable. Specifically, four ARGs were plasmid-derived, 18 ARGs were phage-derived and an additional six ARGs were predicted to be mobile, contributing to their mobility and potential spread between bacteria.PMID:38578711 | DOI:10.1556/004.2024.00988 (Source: Acta Veterinaria Hungarica)
Source: Acta Veterinaria Hungarica - April 5, 2024 Category: Veterinary Research Authors: Ádám Kerek Ábel Szabó Kriszti án Bányai Eszter Kaszab Krisztina Bali M árton Papp L ászló Kovács Ákos Jerzsele Source Type: research
Distribution of antimicrobial resistance and virulence markers in chicken originated Proteus mirabilis isolates
Acta Vet Hung. 2024 Apr 4. doi: 10.1556/004.2023.00990. Online ahead of print.ABSTRACTProteus mirabilis is a common enteric bacterium in livestock and humans. The increase and spread of the antimicrobial resistant P. mirabilis is considered alarming worldwide. Transmission mainly occurs through consumption of contaminated poultry products. We investigated antimicrobial resistance (AMR) and virulence markers in broiler chicken-originated P. mirabilis isolates from 380 fecal samples. Phenotypic AMR test was performed against seventeen different antimicrobials. Genotypic AMR test was performed to detect sixteen different AMR ...
Source: Acta Veterinaria Hungarica - April 5, 2024 Category: Veterinary Research Authors: Seyyide Sar ıçam İnce Mehmet Akan Source Type: research
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: Indian J Med Res - April 5, 2024 Category: Research Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research
Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research
Resistome analysis of Escherichia coli isolates from layers in Hungary
This study employed shotgun sequencing-based genetic and bioinformatic analysis along with determining phenotypic minimum inhibitory concentrations. A total of 59 ARGs were identified in the eight E. coli isolates, carrying ARGs against 15 groups of antibiotics. Among these, 28 ARGs were identified as transferable. Specifically, four ARGs were plasmid-derived, 18 ARGs were phage-derived and an additional six ARGs were predicted to be mobile, contributing to their mobility and potential spread between bacteria.PMID:38578711 | DOI:10.1556/004.2024.00988 (Source: Acta Veterinaria Hungarica)
Source: Acta Veterinaria Hungarica - April 5, 2024 Category: Veterinary Research Authors: Ádám Kerek Ábel Szabó Kriszti án Bányai Eszter Kaszab Krisztina Bali M árton Papp L ászló Kovács Ákos Jerzsele Source Type: research
