Isolation and Identification of < em > Pasteurella multocida < /em > and < em > Mannheimia haemolytica < /em > from Pneumonic Small Ruminants and Their Antibiotic Susceptibility in Haramaya District, Eastern Ethiopia
CONCLUSION: This study showed that M. haemolytica and P. multocida are the common causes of mannheimiosis and pasteurellosis in small ruminants, respectively, and isolates were resistant to commonly used antibiotics in the study area. Thus, an integrated vaccination strategy, antimicrobial resistance monitoring, and avoidance of stress-inducing factors are recommended.PMID:38655561 | PMC:PMC11039012 | DOI:10.1155/2024/5605552 (Source: The Scientific World Journal)
Source: The Scientific World Journal - April 24, 2024 Category: Science Authors: Mohammed Abdulkadir Taju Nigussie Isayas Asefa Kebede Source Type: research
Genes, Vol. 15, Pages 532: Resistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populations: A Cross-Sectional Study
Patricia Poeta
This cross-sectional study investigates the methicillin-resistant Staphylococcus aureus (MRSA): its prevalence, antimicrobial resistance, and molecular characteristics in healthy swine populations in central Portugal. A total of 213 samples were collected from pigs on twelve farms, and MRSA prevalence was assessed using selective agar plates and confirmed via molecular methods. Antimicrobial susceptibility testing and whole genome sequencing (WGS) were performed to characterize resistance profiles and genetic determinants. Among the 107 MRSA-positive samples (83.1% prevalence), fattening pigs and breed...
Source: Genes - April 24, 2024 Category: Genetics & Stem Cells Authors: Vanessa Silva Adriana Silva Raquel Barbero Mario Romero Rosa del Campo Manuela Cani ça Rui Cordeiro Gilberto Igrejas Patricia Poeta Tags: Article Source Type: research
Development of a risk prediction model for subsequent infection after colonization with carbapenem-resistant Enterobacterales: a retrospective cohort study
ConclusionsOur nomogram has a good predictive performance and could contribute to early identification of CRE carriers with a high-risk of subsequent infection, although external validation would be required. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 24, 2024 Category: Infectious Diseases Source Type: research
Changing Epidemiology and Antimicrobial Resistance of Bacterial Childhood Diarrhea: Insights from a 7-Year Study in an Iranian Referral Hospital
Foodborne Pathogens and Disease, Ahead of Print. (Source: Foodborne Pathogens and Disease)
Source: Foodborne Pathogens and Disease - April 24, 2024 Category: Food Science Authors: Forough Mohamadi Babak Pourakbari Reihaneh Hosseinpour Sadeghi Maryam Sotoudeh Shima Mahmoudi Setareh Mamishi Source Type: research
Genetic diversity of KPC-2-producing Klebsiella pneumoniae complex from aquatic ecosystems
In this study,blaKPC-2-positiveKlebsiella pneumoniae complex strains were isolated from different anthropogenically affected aquatic ecosystems and characterized using phenotypic, molecular, and genomic methods.K. pneumoniae complex strains exhibited multidrug-resistant and extensively drug-resistant profiles, spotlighting the resistance to carbapenems, ceftazidime-avibactam, colistin, and tigecycline, which are recognized as last-line antimicrobial treatment options. Molecular analysis showed the presence of several antimicrobial resistance, virulence, and metal tolerance genes. In-depth analysis showed that theblaKPC-2 g...
Source: World Journal of Microbiology and Biotechnology - April 24, 2024 Category: Microbiology Source Type: research
Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis
The rise in antimicrobial resistance is a global health crisis and necessitates the development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) was the second leading infectious killer after COVID-19, with multi-drug-resistant strains of TB having an ∼ 40% fatality rate. Targeting essential biosynthetic pathways in pathogens has proven to be successful for the development of novel antimicrobial treatments. Fatty-acid synthesis (FAS) in bacteria proceeds via the type II pathway, which is substantially different from the type I pathway utilized in animals. This makes bacterial fatty-ac...
Source: Acta Crystallographica Section F - April 24, 2024 Category: Biochemistry Authors: Ran, X. Parikh, P. Abendroth, J. Arakaki, T.L. Clifton, M.C. Edwards, T.E. Lorimer, D.D. Mayclin, S. Staker, B.L. Myler, P. McLaughlin, K.J. Tags: Mycobacterium FabG structural genomics Seattle Structural Genomics Center for Infectious Disease NIAID oxidoreductases HMwFabG Mycolicibacterium smegmatis Mycobacterium smegmatis Mycobacterium tuberculosis research communications Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia
Current guidelines recommend broad-spectrum antibiotics for high-severity community-acquired pneumonia (CAP), potentially contributing to antimicrobial resistance (AMR). We aim to compare outcomes in CAP patients treated with amoxicillin (narrow-spectrum) versus co-amoxiclav (broad-spectrum), to understand if narrow-spectrum antibiotics could be used more widely. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Jia Wei, Aashna Uppal, Christy Nganjimi, Hermione Warr, Yasin Ibrahim, Qingze Gu, Hang Yuan, Najib M Rahman, Nicola Jones, A Sarah Walker, David W Eyre Source Type: research
Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea: A systematic review of WGS use on human pathogens in individual patient care
The utility of whole genome sequencing (WGS) to inform sexually transmitted infection (STI) patient management is unclear. Timely WGS data might support clinical management of STIs by characterising epidemiological links and antimicrobial resistance profiles. We conducted a systematic review of clinical application of WGS to any human pathogen that may be transposable to gonorrhoea. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Roeann Osman, Emily Dema, Alexandra David, Gwenda Hughes, Nigel Field, Michelle Cole, Xavier Didelot, John Saunders Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
Mitigating antimicrobial resistance, an approach to stewardship in canine urinary tract infection
AbstractUrinary tract infection (UTI) caused by antimicrobial resistant bacteria is common in dogs leading to serious health impact in pet animal as well as on human health. Understanding the prevalent uropathogens and their drug susceptibility is essential for limiting the antimicrobial resistance through implementation of stewardship policies. In view of this, present study was envisaged to determine the prevalent bacterial uropathogens and their antibiogram from clinical cases of canine UTI. Urine samples were collected from 35 dogs presented with clinical signs of UTI and a total of 27 bacterial isolates were recovered...
Source: Veterinary Research Communications - April 22, 2024 Category: Veterinary Research Source Type: research
Antimicrobial resistance and carbapenemase dissemination in < em > Pseudomonas aeruginosa < /em > isolates from Libyan hospitals: a call for surveillance and intervention
This study aimed to assess resistance of clinical isolates from Libyan hospitals to antipseudomonal antibiotics, the prevalence of selected extended-spectrum β-lactamases and carbapenemase genes among these isolates, and the microorganisms' capacity for alginate and biofilm production. Forty-five isolates were collected from four hospitals in Benghazi and Derna, Libya. Antimicrobial susceptibility was determined using agar disc diffusion. The presence of resistance genes (blaCTXM, blaTEM, blaSHV-1, blaGES-1, blaKPC, and blaNDM) was screened using PCR. Biofilm formation was quantified via the crystal violet assay, while al...
Source: Libyan Journal of Medicine - April 21, 2024 Category: General Medicine Authors: Nasrin K Gadaime Randa N Haddadin Asem A Shehabi Intisar N Omran Source Type: research
Heavy Metals as Catalysts in the Evolution of Antimicrobial Resistance and the Mechanisms Underpinning Co-selection
Curr Microbiol. 2024 Apr 20;81(6):148. doi: 10.1007/s00284-024-03648-2.ABSTRACTThe menace caused by antibiotic resistance in bacteria is acknowledged on a global scale. Concerns over the same are increasing because of the selection pressure exerted by a huge number of different antimicrobial agents, including heavy metals. Heavy metals are non-metabolizable and recalcitrant to degradation, therefore the bacteria can expel the pollutants out of the system and make it less harmful via different mechanisms. The selection of antibiotic-resistant bacteria may be influenced by heavy metals present in environmental reservoirs. Th...
Source: Current Microbiology - April 20, 2024 Category: Microbiology Authors: Chandra Kant Singh Kushneet Kaur Sodhi Pallee Shree V Nitin Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Emergence of OXA-48-producing < em > Klebsiella pneumoniae < /em > in Lithuania, 2023: a multi-cluster, multi-hospital outbreak
Euro Surveill. 2024 Apr;29(16):2400188. doi: 10.2807/1560-7917.ES.2024.29.16.2400188.ABSTRACTIn 2023, an increase of OXA-48-producing Klebsiella pneumoniae was noticed by the Lithuanian National Public Health Surveillance Laboratory. Whole genome sequencing (WGS) of 106 OXA-48-producing K. pneumoniae isolates revealed three distinct clusters of carbapenemase-producing K. pneumoniae high-risk clones, including sequence type (ST) 45 (n = 35 isolates), ST392 (n = 32) and ST395 (n = 28), involving six, six and nine hospitals in different regions, respectively. These results enabled targeted investigation and control, and under...
Source: Euro Surveill - April 19, 2024 Category: Infectious Diseases Authors: Paulius Grei čius Marius Linkevicius Jelena Razmuk Jekaterina Sinotova Erik Alm Olov Svartstr öm Valeria Bortolaia Egl ė Kudirkienė Louise Roer Rene S Hendriksen Gabija Tamoli ūnaitė Daniel Palm Dominique L Monnet Anke Kohlenberg Algirdas Gri škevi Source Type: research
