Development of a risk prediction model for subsequent infection after colonization with carbapenem-resistant Enterobacterales: a retrospective cohort study
ConclusionsOur nomogram has a good predictive performance and could contribute to early identification of CRE carriers with a high-risk of subsequent infection, although external validation would be required. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 24, 2024 Category: Infectious Diseases Source Type: research
Changing Epidemiology and Antimicrobial Resistance of Bacterial Childhood Diarrhea: Insights from a 7-Year Study in an Iranian Referral Hospital
Foodborne Pathogens and Disease, Ahead of Print. (Source: Foodborne Pathogens and Disease)
Source: Foodborne Pathogens and Disease - April 24, 2024 Category: Food Science Authors: Forough Mohamadi Babak Pourakbari Reihaneh Hosseinpour Sadeghi Maryam Sotoudeh Shima Mahmoudi Setareh Mamishi Source Type: research
Genetic diversity of KPC-2-producing Klebsiella pneumoniae complex from aquatic ecosystems
In this study,blaKPC-2-positiveKlebsiella pneumoniae complex strains were isolated from different anthropogenically affected aquatic ecosystems and characterized using phenotypic, molecular, and genomic methods.K. pneumoniae complex strains exhibited multidrug-resistant and extensively drug-resistant profiles, spotlighting the resistance to carbapenems, ceftazidime-avibactam, colistin, and tigecycline, which are recognized as last-line antimicrobial treatment options. Molecular analysis showed the presence of several antimicrobial resistance, virulence, and metal tolerance genes. In-depth analysis showed that theblaKPC-2 g...
Source: World Journal of Microbiology and Biotechnology - April 24, 2024 Category: Microbiology Source Type: research
Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis
The rise in antimicrobial resistance is a global health crisis and necessitates the development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) was the second leading infectious killer after COVID-19, with multi-drug-resistant strains of TB having an ∼ 40% fatality rate. Targeting essential biosynthetic pathways in pathogens has proven to be successful for the development of novel antimicrobial treatments. Fatty-acid synthesis (FAS) in bacteria proceeds via the type II pathway, which is substantially different from the type I pathway utilized in animals. This makes bacterial fatty-ac...
Source: Acta Crystallographica Section F - April 24, 2024 Category: Biochemistry Authors: Ran, X. Parikh, P. Abendroth, J. Arakaki, T.L. Clifton, M.C. Edwards, T.E. Lorimer, D.D. Mayclin, S. Staker, B.L. Myler, P. McLaughlin, K.J. Tags: Mycobacterium FabG structural genomics Seattle Structural Genomics Center for Infectious Disease NIAID oxidoreductases HMwFabG Mycolicibacterium smegmatis Mycobacterium smegmatis Mycobacterium tuberculosis research communications Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia
Current guidelines recommend broad-spectrum antibiotics for high-severity community-acquired pneumonia (CAP), potentially contributing to antimicrobial resistance (AMR). We aim to compare outcomes in CAP patients treated with amoxicillin (narrow-spectrum) versus co-amoxiclav (broad-spectrum), to understand if narrow-spectrum antibiotics could be used more widely. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Jia Wei, Aashna Uppal, Christy Nganjimi, Hermione Warr, Yasin Ibrahim, Qingze Gu, Hang Yuan, Najib M Rahman, Nicola Jones, A Sarah Walker, David W Eyre Source Type: research
Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea: A systematic review of WGS use on human pathogens in individual patient care
The utility of whole genome sequencing (WGS) to inform sexually transmitted infection (STI) patient management is unclear. Timely WGS data might support clinical management of STIs by characterising epidemiological links and antimicrobial resistance profiles. We conducted a systematic review of clinical application of WGS to any human pathogen that may be transposable to gonorrhoea. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Roeann Osman, Emily Dema, Alexandra David, Gwenda Hughes, Nigel Field, Michelle Cole, Xavier Didelot, John Saunders Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
Climate change and its impact on infectious diseases in Asia
Singapore Med J. 2024 Apr 1;65(4):211-219. doi: 10.4103/singaporemedj.SMJ-2023-180. Epub 2024 Apr 23.ABSTRACTClimate change, particularly increasing temperature, changes in rainfall, extreme weather events and changes in vector ecology, impacts the transmission of many climate-sensitive infectious diseases. Asia is the world's most populous, rapidly evolving and diverse continent, and it is already experiencing the effects of climate change. Climate change intersects with population, sociodemographic and geographical factors, amplifying the public health impact of infectious diseases and potentially widening existing dispa...
Source: Singapore Medical Journal - April 22, 2024 Category: General Medicine Authors: Amanda Zain Sapna P Sadarangani Lynette Pei-Chi Shek Shawn Vasoo Source Type: research
