Response to Emerging Antimicrobial Resistance With Containment Microbiota Therapy (REACT)
Conditions: Multi-Drug Resistant Organism Colonization Interventions: Drug: Allogeneic Microbiota in Glycerol (9%) (AMG) Sponsors: Emory University; Centers for Disease Control and Prevention Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials

Resistance Profile of Escherichia Coli in Infections of Community Origin: The Importance of Antimicrobial Stewardship
Conditions: Antimicrobial Resistance Interventions: Biological: Escherichia coli ESBL Sponsors: Jos é Raimundo Araujo de Azevedo Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials

Antimicrobial Resistance in Acute Cholangitis
Conditions: Cholangitis Acute; Biliary Tract Diseases; Jaundice; Malignant; Jaundice, Obstructive; Choledocholithiasis Interventions: Procedure: ERCP Sponsors: Bogdan Miutescu, MD Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2024 Category: Research Source Type: clinical trials

Statistical analysis plan for the LAKANA trial: a cluster-randomized, placebo-controlled, double-blinded, parallel group, three-arm clinical trial testing the effects of mass drug administration of azithromycin on mortality and other outcomes among 1 –11-month-old infants in Mali
ConclusionThe SAP written prior to data collection completion will help avoid reporting bias and data-driven analysis for the primary and secondary aims of the trial. If there are deviations from the analysis methods described here, they will be described and justified in the publications of the trial results.Trial registrationClinicalTrials.gov IDNCT04424511. Registered on 11 June 2020. (Source: Trials)
Source: Trials - November 15, 2023 Category: Research Source Type: clinical trials

Antimicrobial Resistance in Hospitals From Meta, Colombia
Condition:   Increased Drug Resistance Intervention:   Other: Factors associated Sponsors:   Hospital Departamental de Villavicencio;   Cooperative University of Colombia Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Reducing antimicrobial overuse through targeted therapy for patients with community-acquired pneumonia: a study protocol for a cluster-randomized factorial controlled trial (CARE-CAP)
DiscussionOur study aims to determine whether identifying an etiological agent early and pharmacist-led de-escalation (calling attention to negative cultures) can safely reduce the use of ESA in patients with CAP. If successful, our findings should lead to better antimicrobial stewardship, as well as improved patient outcomes and reduced healthcare costs. Our findings may also inform clinical guidelines on the optimal management of CAP.Trial registrationClinicalTrials.govNCT05568654. Registered on October 4, 2022. (Source: Trials)
Source: Trials - September 16, 2023 Category: Research Source Type: clinical trials

Pivmecillinam with Amoxicillin/Clavulanic acid as step down oral therapy in febrile Urinary Tract  Infections caused by ESBL-producing Enterobacterales (PACUTI)
DiscussionIf the combination of pivmecillinam and amoxicillin/clavulanic acid is found to be non-inferior to the control drugs there are potential benefits in terms of tolerability, frequency of interactions, outpatient treatment, side effects, nosocomial infections and drive for further antimicrobial resistance compared to existing drugs.Trial registrationNCT05224401. Registered on February 4, 2022 (Source: Trials)
Source: Trials - September 2, 2023 Category: Research Source Type: clinical trials

A Novel Approach to Antimicrobial Resistance: Machine Learning Predictions for Carbapenem-Resistant Klebsiella in ICUs
Conditions:   Carbapenem Resistant Enterobacteriaceae Infection;   Artificial Intelligence;   Intensive Care Unit Intervention:   Other: Artificial intelligence Sponsor:   Kocaeli University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 14, 2023 Category: Research Source Type: clinical trials