The effect of amantadine on acute cognitive disability after severe traumatic brain injury: An institutional pilot study
Amantadine is used in the post-acute care setting to improve cognitive function after a traumatic brain injury. Its utility in the acute postinjury period is unknown. In this pilot study, we sought to examine the effect of amantadine on short-term cognitive disability among patients with a severe traumatic brain injury and hypothesized that patients receiving amantadine would have a greater improvement in disability throughout their acute hospitalization. (Source: Surgery)
Source: Surgery - November 17, 2023 Category: Surgery Authors: Brett M. Tracy, Shruthi Srinivas, Kelly D. Nahum, Wendy L. Wahl, Rondi B. Gelbard Source Type: research
Improvement of Tardive Dyskinesias with Olanzapine
Case Rep Psychiatry. 2023 Oct 23;2023:6688623. doi: 10.1155/2023/6688623. eCollection 2023.ABSTRACTTardive dyskinesia (TD) is characterized by abnormal and involuntary movements that generally occur after prolonged exposure to neuroleptic medications. In this article, we present the case of a 29-year-old man with schizophrenia who developed TD following treatment with haloperidol. Despite various attempts with benzodiazepines, amantadine, and anticholinergics, the dyskinesias persisted. However, after 2 years of treatment with olanzapine alone, a progressive improvement occurred, leading to the complete disappearance of th...
Source: Case Reports in Psychiatry - November 1, 2023 Category: Psychiatry Authors: S Echater B Oneib Source Type: research
Improved Treatment Outcome with Haloperidol Decanoate and Amantadine in an Adolescent with Schizoaffective Disorder
Journal of Child and Adolescent Psychopharmacology,Volume 33, Issue 8, Page 337-341, October 2023. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - October 16, 2023 Category: Pediatrics Authors: Michelle Zaydlin Julia A. Bernal Yasin Bez Barbara J. Coffey Source Type: research
A current overview of the pharmacological composition of “La Chimique” consumed in Mayotte: Preliminary results of the CHASSE‐MAREE protocol
Mayotte Island, a French department, has for several years been faced with the consumption of a drug called “La Chimique.” The CHASSE-MAREE protocol aims to assess the composition of “La Chimique” products through successive sample collection campaigns. The first analytical results (80 samples collected in 2022) revealed that, as suspected, the main psychoactive constituents of this drug are SCRAs . This overview of SCRAs often includes associations and seems to vary from month to month and according to geographical location. AbstractMayotte Island, a French department located in the Mozambique Channel, has for sev...
Source: Drug Testing and Analysis - October 8, 2023 Category: Drugs & Pharmacology Authors: Camille Richeval,
Alexandr Gish,
Victoire Cottereau,
Alexandre Peyre,
Eric Pleignet,
Sabrina Cherki,
Delphine Allorge,
Jean ‐Michel Gaulier,
Damien A. Devault Tags: RESEARCH ARTICLE Source Type: research
Bioinspired Adhesive Antibacterial Hydrogel with Self-Healing and On-Demand Removability for Enhanced Full-Thickness Skin Wound Repair
Biomacromolecules. 2023 Oct 6. doi: 10.1021/acs.biomac.3c00576. Online ahead of print.ABSTRACTAdhesive-caused injury is a great threat for extensive full-thickness skin trauma because extra-strong adhesion can incur unbearable pain and exacerbate trauma upon removal. Herein, inspired by the mussel, we designed and fabricated an adhesive antibacterial hydrogel dressing based on dynamic host-guest interaction that enabled on-demand stimuli-triggered removal to effectively care for wounds. In contrast with most hard-to-removable dressing, this adhesive antibacterial hydrogel exhibited strong adhesion property (85 kPa), which ...
Source: Biomacromolecules - October 6, 2023 Category: Biochemistry Authors: Minwei Yang Jing Tian Kaiwen Zhang Xu Fei Fawen Yin Longquan Xu Yi Wang Yao Li Source Type: research
Bioinspired Adhesive Antibacterial Hydrogel with Self-Healing and On-Demand Removability for Enhanced Full-Thickness Skin Wound Repair
Biomacromolecules. 2023 Oct 6. doi: 10.1021/acs.biomac.3c00576. Online ahead of print.ABSTRACTAdhesive-caused injury is a great threat for extensive full-thickness skin trauma because extra-strong adhesion can incur unbearable pain and exacerbate trauma upon removal. Herein, inspired by the mussel, we designed and fabricated an adhesive antibacterial hydrogel dressing based on dynamic host-guest interaction that enabled on-demand stimuli-triggered removal to effectively care for wounds. In contrast with most hard-to-removable dressing, this adhesive antibacterial hydrogel exhibited strong adhesion property (85 kPa), which ...
Source: Biomacromolecules - October 6, 2023 Category: Biochemistry Authors: Minwei Yang Jing Tian Kaiwen Zhang Xu Fei Fawen Yin Longquan Xu Yi Wang Yao Li Source Type: research
Bioinspired Adhesive Antibacterial Hydrogel with Self-Healing and On-Demand Removability for Enhanced Full-Thickness Skin Wound Repair
Biomacromolecules. 2023 Oct 6. doi: 10.1021/acs.biomac.3c00576. Online ahead of print.ABSTRACTAdhesive-caused injury is a great threat for extensive full-thickness skin trauma because extra-strong adhesion can incur unbearable pain and exacerbate trauma upon removal. Herein, inspired by the mussel, we designed and fabricated an adhesive antibacterial hydrogel dressing based on dynamic host-guest interaction that enabled on-demand stimuli-triggered removal to effectively care for wounds. In contrast with most hard-to-removable dressing, this adhesive antibacterial hydrogel exhibited strong adhesion property (85 kPa), which ...
Source: Biomacromolecules - October 6, 2023 Category: Biochemistry Authors: Minwei Yang Jing Tian Kaiwen Zhang Xu Fei Fawen Yin Longquan Xu Yi Wang Yao Li Source Type: research
A current overview of the pharmacological composition of “La Chimique” consumed in Mayotte: Preliminary results of the CHASSE‐MAREE protocol
Mayotte Island, a French department, has for several years been faced with the consumption of a drug called “La Chimique.” The CHASSE-MAREE protocol aims to assess the composition of “La Chimique” products through successive sample collection campaigns. The first analytical results (80 samples collected in 2022) revealed that, as suspected, the main psychoactive constituents of this drug are SCRAs . This overview of SCRAs often includes associations and seems to vary from month to month and according to geographical location. AbstractMayotte Island, a French department located in the Mozambique Channel, has for sev...
Source: Drug Testing and Analysis - October 6, 2023 Category: Drugs & Pharmacology Authors: Camille Richeval,
Alexandr Gish,
Victoire Cottereau,
Alexandre Peyre,
Eric Pleignet,
Sabrina Cherki,
Delphine Allorge,
Jean ‐Michel Gaulier,
Damien A. Devault Tags: RESEARCH ARTICLE Source Type: research
6.32 N-Methyl-D-Aspartate (NMDA) Receptor Antagonist and ASD: A Systematic Review
The objective was to review the efficacy and safety of N-methyl-D-aspartate (NMDA) antagonists (amantadine and memantine) in youths with ASD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Nihit Gupta, Mayank Gupta, Kelechi N. Emereonye, Raghu Gandhi Source Type: research
Prognostication in Prolonged and Chronic Disorders of Consciousness
Semin Neurol DOI: 10.1055/s-0043-1775792Patients with prolonged disorders of consciousness (DOCs) longer than 28 days may continue to make significant gains and achieve functional recovery. Occasionally, this recovery trajectory may extend past 3 (for nontraumatic etiologies) and 12 months (for traumatic etiologies) into the chronic period. Prognosis is influenced by several factors including state of DOC, etiology, and demographics. There are several testing modalities that may aid prognostication under active investigation including electroencephalography, functional and anatomic magnetic resonance imaging, and event-rel...
Source: Seminars in Neurology - September 27, 2023 Category: Neurology Authors: Carlson, Julia M. Lin, David J. Tags: Review Article Source Type: research
Revisiting the pK < sub > a < /sub > -Flux method for determining intrinsic membrane permeability
Eur J Pharm Sci. 2023 Sep 24:106592. doi: 10.1016/j.ejps.2023.106592. Online ahead of print.ABSTRACTIntrinsic membrane permeability is one of several factors that critically determine the intestinal absorption of a chemical. The intrinsic membrane permeability of a chemical is usually extracted from transwell experiments with Caco-2 or MDCK cells, preferably by the pKa-Flux method, which is considered the method of choice when aqueous boundary layer effects need to be excluded. The pKa-Flux method has two variants, the iso-pH method, where apical and basolateral pH are equal, and the gradient-pH method, where apical and ba...
Source: European Journal of Pharmaceutical Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: Carolin Dahley Kai-Uwe Goss Andrea Ebert Source Type: research
Revisiting the pK < sub > a < /sub > -Flux method for determining intrinsic membrane permeability
Eur J Pharm Sci. 2023 Sep 24:106592. doi: 10.1016/j.ejps.2023.106592. Online ahead of print.ABSTRACTIntrinsic membrane permeability is one of several factors that critically determine the intestinal absorption of a chemical. The intrinsic membrane permeability of a chemical is usually extracted from transwell experiments with Caco-2 or MDCK cells, preferably by the pKa-Flux method, which is considered the method of choice when aqueous boundary layer effects need to be excluded. The pKa-Flux method has two variants, the iso-pH method, where apical and basolateral pH are equal, and the gradient-pH method, where apical and ba...
Source: European Journal of Pharmaceutical Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: Carolin Dahley Kai-Uwe Goss Andrea Ebert Source Type: research
Revisiting the pK < sub > a < /sub > -Flux method for determining intrinsic membrane permeability
Eur J Pharm Sci. 2023 Sep 24:106592. doi: 10.1016/j.ejps.2023.106592. Online ahead of print.ABSTRACTIntrinsic membrane permeability is one of several factors that critically determine the intestinal absorption of a chemical. The intrinsic membrane permeability of a chemical is usually extracted from transwell experiments with Caco-2 or MDCK cells, preferably by the pKa-Flux method, which is considered the method of choice when aqueous boundary layer effects need to be excluded. The pKa-Flux method has two variants, the iso-pH method, where apical and basolateral pH are equal, and the gradient-pH method, where apical and ba...
Source: European Journal of Pharmaceutical Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: Carolin Dahley Kai-Uwe Goss Andrea Ebert Source Type: research
