Ethical challenges of clinical trials with a repurposed drug in outbreaks
AbstractDrug repurposing is a strategy of identifying new potential uses for already existing drugs. Many researchers adopted this method to identify treatment or prevention during the COVID-19 pandemic. However, despite the considerable number of repurposed drugs that were evaluated, only some of them were labeled for new indications. In this article, we present the case of amantadine, a drug commonly used in neurology that attracted new attention during the COVID-19 outbreak. This example illustrates some of the ethical challenges associated with the launch of clinical trials to evaluate already approved drugs. In our di...
Source: Medicine, Healthcare and Philosophy - March 7, 2023 Category: Medical Ethics Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
Celiac disease and catatonia: more than a coincidence?
CONCLUSIONS: Even without gastrointestinal manifestations, CD may present with neuropsychiatric symptoms. According to this case report, CD should be investigated in patients with unexplained catatonia, and that CD may only present with neuropsychiatric symptoms.PMID:36866995 | DOI:10.24953/turkjped.2022.411 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: P ınar Özbudak Alev El çi Karaduman Deniz Karg ın Menderes Hakan Öztürk K ıvılcım Gücüyener Source Type: research
