Stability-indicating HPTLC method for the simultaneous detection and quantification of alfuzosin hydrochloride, solifenacin succinate along with four of their official impurities
Publication date: Available online 7 May 2020Source: Microchemical JournalAuthor(s): Mahmoud A. Tantawy, Soheir A. Weshahy, Mina Wadie, Mamdouh R. Rezk (Source: Microchemical Journal)
Source: Microchemical Journal - May 8, 2020 Category: Chemistry Source Type: research
Sensitive analysis of five alpha blockers in dosage forms and human plasma by field amplified sample injection combined with micellar electrokinetic chromatography
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Fathalla Belal, Mohamed Walash, Mona Fathy, Sahar Zayed, Hadeer BorgAbstractA new, sensitive and simple field amplified sample injection (FASI) combined with micellar electrokinetic chromatography (MEKC) was developed for the analysis of terazosin (TER), alfuzosin (ALF), tamsulosin (TAM), doxazosin (DOX) and silodosin (SIL). The separation was achieved with Tris buffer (30 mM, pH 9.2) containing 30 mM SDS and 8% butanol, applying a voltage of 28 kV at 25 °C. Under the optimal conditions, the sensitivity of FASI-MEKC was improved 25.3â€...
Source: Microchemical Journal - February 27, 2019 Category: Chemistry Source Type: research
Management of Urinary Retention in Patients with Benign Prostatic Obstruction: A Systematic Review and Meta-analysis
ConclusionsThere is some evidence that usage of α1-blockers (alfuzosin and tamsulosin) may improve resolution of UR/BPO. As most nonpharmacological treatments have not been evaluated in patients with UR/BPO, the evidence is inconclusive about their benefits and harms.Patient summaryThere is some evidence that alfuzosin and tamsulosin may increase the rates of successful trial without catheter, but little or no evidence on various nonpharmacological treatment options for managing patients with urinary retention secondary to benign prostatic obstruction. (Source: European Urology)
Source: European Urology - February 15, 2019 Category: Urology & Nephrology Source Type: research
The Evidence Paradox of the Effectiveness between the Paediatric and Adult Stone-Forming Population: A Narrative Review
Conclusion: The effectiveness of α-blockers and other medication as MET needs to be studied in multi-institutional, double-blind, placebo-controlled studies that would aim to prove superiority to placebo in contemporary clinical situations, with realistic end points and standardized outcome measure determination.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - January 22, 2019 Category: Urology & Nephrology Source Type: research
Cost-Effectiveness of Combination Therapy Versus Monotherapy in Benign Prostatic Hyperplasia: A Colombian Experience
ConclusionsThe combination of finasteride and doxazosin is cost-effective compared with dutasteride, tamsulosin, terazosin, and alfuzosin in patients with benign prostatic hyperplasia with moderate or severe symptoms who are older than 40 years. (Source: Value in Health Regional Issues)
Source: Value in Health Regional Issues - December 19, 2018 Category: International Medicine & Public Health Source Type: research
Drug adherence and drug-related problems in pharmacotherapy for lower urinary tract symptoms related to benign prostatic hyperplasia.
Authors: Zabkowski T, Saracyn M
Abstract
Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is one of the most common urinary disorders in elderly men. In recent years, pharmacotherapy of BPH has increased the efficacy, including combination treatment mostly with two drug classes, namely, 5-α-reductase inhibitors and α-1-adrenolytics (alpha blockers) with a different pharmacological activity. Although pharmacological treatment of BPH is a success story in urology, daily practice suggests that several medical needs remain unmet. We aimed to evaluate drug adherence in pa...
Source: Journal of Physiology and Pharmacology - December 16, 2018 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
How to Read a Research Paper: An Exercise in Critical Thinking in the Context of an Epidemiologic Study on Tamsulosin and the Risk of Dementia.
This article discusses the study from the perspective of whether the hypothesis relating tamsulosin to dementia was set a priori or emerged after an exploratory exercise; whether tamsulosin crosses the blood-brain barrier for dementia as the event of interest to be attributable to treatment; whether the action of tamsulosin is plausibly related to dementia as a possible outcome; whether confounding was adequately addressed in the analyses; whether the duration of follow-up was sufficient for the event of interest to be attributable to tamsulosin; whether the absolute increase in the rate of incident dementia was clinically...
Source: Journal of Clinical Psychiatry - December 16, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Cost Effectiveness of Combination Therapy Versus Monotherapy in Benign Prostatic Hyperplasia: A Colombian Experience
ConclusionsThe combination of finasteride and doxazosin is cost-effective compared with dutasteride, tamsulosin, terazosin, and alfuzosin in patients with benign prostatic hyperplasia with moderate or severe symptoms who are older than 40 years. (Source: Value in Health Regional Issues)
Source: Value in Health Regional Issues - November 9, 2018 Category: International Medicine & Public Health Source Type: research
Development and Evaluation of Compression Coating Gastro-Floating Tablet of Alfuzosin Hydrochloride for Zero-Order Controlled Release.
Abstract
Alfuzosin hydrochloride is an appropriate candidate drug to prepare a gastro-retention controlled release dosage form since it demonstrates a narrow absorption window in the proximal section of the gastrointestinal tract with a short half-life. The purpose of the present study was to develop and optimize a gastro-floating tablet of alfuzosin hydrochloride by using the compression coating method for controlling drug release in a controlled manner. The floating tablets were developed utilizing hydroxypropyl methylcellulose and carbomer as matrix materials. The impact of formulation factors on buoyan...
Source: AAPS PharmSciTech - September 13, 2018 Category: Drugs & Pharmacology Authors: Gong L, Sun Y, Yu M, Gao Y, Zou M, Cheng G Tags: AAPS PharmSciTech Source Type: research
Effects of Alfuzosin, an α1-Adrenergic Antagonist, on Anal Pressures and Bowel Habits in Women With and Without Defecatory Disorders
Some patients with defecatory disorders (DD) have high anal pressures that may impede rectal evacuation. Alpha-1 adrenoreceptors mediate as much as 50% of anal resting pressure in humans. We performed a randomized, placebo-controlled study of the effects of alfuzosin, an alpha1-adrenergic receptor antagonist, on anal pressures alone in healthy women and also on bowel symptoms in women with DD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2018 Category: Gastroenterology Authors: Subhankar Chakraborty, Kelly Feuerhak, Anjani Muthyala, William S. Harmsen, Kent R. Bailey, Adil E. Bharucha Source Type: research
Effects of Alfuzosin, an Alpha-1 Αdrenergic Antagonist on Anal Pressures and Bowel Habits, in Women With and Without Defecatory Disorders
Some patients with defecatory disorders (DD) have high anal pressures that may impede rectal evacuation. Αlpha-1 adrenoreceptors mediate as much as 50% of anal resting pressure in humans. We performed a randomized, placebo-controlled study of the effects of alfuzosin, an alpha1-adrenergic receptor antagonist, on anal pressures alone in healthy women and also on bowel symptoms in women with DD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2018 Category: Gastroenterology Authors: Subhankar Chakraborty, Kelly Feuerhak, Anjani Muthyala, William S. Harmsen, Kent R. Bailey, Adil E. Bharucha Source Type: research
Design and Optimization of Gastric Floating Sustained-Release Mini-tablets of Alfuzosin Hydrochloride Based on a Factorial Design: In vitro/In vivo Evaluation.
Authors: Gong L, Yu M, Sun Y, Gao Y, An T, Zou M, Cheng G
Abstract
The purpose of this research was to develop multiple-unit gastric floating mini-tablets and to evaluate the possibility of using these mini-tablets as a delivery system to improve the drug absorption for drugs with a narrow absorption window. Mini-tablets were prepared using Hydroxypropyl methylcellulose (HPMC K100M) and carbopol 971P as release retarding agents and sodium bicarbonate (NaHCO3) as gas-forming agent. The properties of the prepared mini-tablets in terms of floating characteristic parameters and in vitro release were evaluated....
Source: Drug Development and Industrial Pharmacy - August 1, 2018 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Combination of solifenacin and tamsulosin may provide additional beneficial effects for ureteral stent-related symptoms —outcomes from a network meta-analysis
ConclusionsTam plus Soli might be the most effective intervention for SRSs. As for monotherapy, Soli showed advantages in most respects except for pain relief compared to Tam or Alfu. Tam and Alfu showed similar efficacy on urinary symptoms and body pain relief. (Source: World Journal of Urology)
Source: World Journal of Urology - July 20, 2018 Category: Urology & Nephrology Source Type: research
Is Tamsulosin Linked to Dementia in the Elderly?
AbstractPurpose of ReviewLower urinary tract symptoms (LUTS) result from age-related changes in detrusor function and prostatic growth that are driven by alterations in the ratio of circulating androgens and estrogens. Alpha-adrenergic receptor blockers are commonly used to treat LUTS because they influence urethral tone and intra-urethral pressure. Molecular cloning studies have identified three α1-adrenergic receptor subtypes ( α1A, α1B, and α1D). The α1A subtype is predominant in the human prostate but is also present in many parts of the brain that direct cognitive function. Tamsulosin is the most widely used α1-...
Source: Current Urology Reports - July 3, 2018 Category: Urology & Nephrology Source Type: research
Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
Conclusions: Silodosin has higher apoptosis effect than other alpha-blockers in prostate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis. (Source: International Braz J Urol)
Source: International Braz J Urol - June 25, 2018 Category: Urology & Nephrology Source Type: research
