Effects of Alfuzosin, an α1-Adrenergic Antagonist, on Anal Pressures and Bowel Habits in Women With and Without Defecatory Disorders

Some patients with defecatory disorders (DD) have high anal pressures that may impede rectal evacuation. Alpha-1 adrenoreceptors mediate as much as 50% of anal resting pressure in humans. We performed a randomized, placebo-controlled study of the effects of alfuzosin, an alpha1-adrenergic receptor antagonist, on anal pressures alone in healthy women and also on bowel symptoms in women with DD.

Source: Clinical Gastroenterology and Hepatology - August 18, 2018 Category: Gastroenterology Authors: Subhankar Chakraborty, Kelly Feuerhak, Anjani Muthyala, William S. Harmsen, Kent R. Bailey, Adil E. Bharucha Source Type: research