Re: Mark Douglas Tyson II, Tatsuki Koyama, Dan Lee, et al. Effect of Prostate Cancer Severity on Functional Outcomes After Localized Treatment: Comparative Effectiveness Analysis of Surgery and Radiation Study Results. Eur Urol 2018;74:26–33
Publication date: Available online 14 December 2018Source: European UrologyAuthor(s): Ahmet Gokce, Deniz Gul (Source: European Urology)
Source: European Urology - December 15, 2018 Category: Urology & Nephrology Source Type: research

The Cancer Immunogram: A Pledge for a Comprehensive Biomarker Approach for Personalized Immunotherapy in Urothelial Cancer
Publication date: Available online 15 December 2018Source: European UrologyAuthor(s): Haris Zahoor, Petros Grivas (Source: European Urology)
Source: European Urology - December 15, 2018 Category: Urology & Nephrology Source Type: research

In-bore Multiparametric Magnetic Resonance Imaging Targeted Biopsy: As Good as it Gets?
Publication date: Available online 15 December 2018Source: European UrologyAuthor(s): Derek J. Rosario, Thomas J. Walton, Steven J. Kennish (Source: European Urology)
Source: European Urology - December 15, 2018 Category: Urology & Nephrology Source Type: research

Prospective Validation of an mRNA-based Urine Test for Surveillance of Patients with Bladder Cancer
ConclusionsXpert has an improved NPV compared with UroVysion and cytology in patients under follow-up for BC. It represents a promising tool for excluding BC in these patients, reducing the need for cystoscopy.Patient summaryXpert is an easy-to-perform urine test with good performance compared with standard urine tests. It should help optimize the follow-up of recurrent bladder cancer patients. (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Compound Genomic Alterations of TP53, PTEN, and RB1 Tumor Suppressors in Localized and Metastatic Prostate Cancer
ConclusionsDeleterious TSG variants are associated with an increased risk of relapse (L) and death (M1) in CSPC. Poorer outcomes are seen with compound gene hits in both early and advanced disease, and this may in part reflect increasing global genomic instability.Patient summaryMen with prostate tumors with compound tumor suppressor gene mutations have poorer outcomes. These findings help identify patients with aggressive features who may benefit from intensified treatment. (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Urethra and Ejaculation Preserving Robot-assisted Simple Prostatectomy: Near-infrared Fluorescence Imaging-guided Madigan Technique
ConclusionsWe described a novel NIFI-guided technique to perform US-RASP. This technique showed promising early functional results, suggesting a significant role of intraprostatic urethral integrity for the preservation of ejaculatory function.Patient summaryWe developed a novel robotic technique to perform simple prostatectomy with integral preservation of the prostatic urethra. This technique provided a high rate of ejaculatory function preservation. (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Micropapillary Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-analysis of Disease Characteristics and Treatment Outcomes
ConclusionsWhile MP UBC is associated with clinicopathological features of advanced disease, it is not associated with worse survival outcomes in patients undergoing RC. NAC results in pathological downstaging in a significant number of patients. Nevertheless, this does not translate into better survival outcomes. The optimal treatment of patients with cT1 remains controversial.Patient summaryOur results suggest that micropapillary urothelial bladder cancer does not necessarily mandate different treatment algorithms. Nevertheless, each case should be discussed individually considering other clinicopathological factors. (So...
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Local Treatment in Metastatic Prostate Cancer: A Cultural Shift Confronts Power and Selection
Publication date: Available online 13 December 2018Source: European UrologyAuthor(s): Alan Dal Pra, Matthew Abramowitz, Alan Pollack (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: January 2019Source: European Urology, Volume 75, Issue 1Author(s): (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

The Platinum Hall of Fame
Publication date: January 2019Source: European Urology, Volume 75, Issue 1Author(s): (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Contents
Publication date: January 2019Source: European Urology, Volume 75, Issue 1Author(s): (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology
ConclusionsThe emergence of new drugs for mCRPC has improved treatment options dramatically. Currently, systemic treatment options for mCRPC include hormonal therapy, chemotherapy, immunotherapy, and radionuclide therapy as well as bone-modifying agents and palliative or supportive measures. Further, new genetically targeted agents (PARP inhibitors and PD-1 inhibitors) are on the horizon for certain subsets of biomarker-selected patients. The best strategies for patient selection and optimal sequential use to achieve the longest cumulative survival improvement and to prevent early resistance remain unclear.Patient summaryT...
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Congress Calendar
Publication date: January 2019Source: European Urology, Volume 75, Issue 1Author(s): (Source: European Urology)
Source: European Urology - December 13, 2018 Category: Urology & Nephrology Source Type: research

The Long Noncoding RNA TTTY15, Which Is Located on the Y Chromosome, Promotes Prostate Cancer Progression by Sponging let-7
ConclusionsThe Y-chromosomal lncRNA TTTY15 was upregulated in most PCa tissues and could promote PCa progression by sponging let-7.Patient summaryWe found that TTTY15 levels were frequently elevated in prostate cancer (PCa) tissues compared with those in paracancerous normal tissues in a large group of PCa patients, and we observed a tumour suppressive effect after TTTY15 knockout using CRISPR/Cas9. These results may have therapeutic implications for PCa patients. (Source: European Urology)
Source: European Urology - December 8, 2018 Category: Urology & Nephrology Source Type: research

Homeobox B13 G84E Mutation and Prostate Cancer Risk
Publication date: Available online 8 December 2018Source: European UrologyAuthor(s): Tommy Nyberg, Koveela Govindasami, Goska Leslie, Tokhir Dadaev, Elizabeth Bancroft, Holly Ni Raghallaigh, Mark N. Brook, Nafisa Hussain, Diana Keating, Andrew Lee, Romayne McMahon, Angela Morgan, Andrea Mullen, Andrea Osborne, Reshma Rageevakumar, The UK Genetic Prostate Cancer Study Collaborators, Zsofia Kote-Jarai, Rosalind Eeles, Antonis C. AntoniouAbstractBackgroundThe homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutati...
Source: European Urology - December 8, 2018 Category: Urology & Nephrology Source Type: research

Reply to Pontus Eriksson and Gottfrid Sjödahl's Letter to the Editor re: Tuan Zea Tan, Mathieu Rouanne, Kien Thiam Tan, Ruby Yun-Ju Huang, Jean-Paul Thiery. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.08.027
Publication date: Available online 5 December 2018Source: European UrologyAuthor(s): Tuan Zea Tan, Mathieu Rouanne, Ruby Yun-Ju Huang, Jean-Paul Thiery (Source: European Urology)
Source: European Urology - December 6, 2018 Category: Urology & Nephrology Source Type: research

Evolution of Robot-assisted Partial Nephrectomy: Techniques and Outcomes from the Transatlantic Robotic Nephron-sparing Surgery Study Group
ConclusionsRAPN represents an effective minimally invasive alternative to OPN in the treatment of clinically localized renal tumors.Patient summaryWe reported contemporary experience with RAPN for the treatment of kidney cancer. RAPN appears to be a safe and effective procedure, resulting in optimal outcomes in the majority of individuals despite tumor complexity. (Source: European Urology)
Source: European Urology - December 6, 2018 Category: Urology & Nephrology Source Type: research

The SmartTarget Biopsy Trial: A Prospective, Within-person Randomised, Blinded Trial Comparing the Accuracy of Visual-registration and Magnetic Resonance Imaging/Ultrasound Image-fusion Targeted Biopsies for Prostate Cancer Risk Stratification
ConclusionsVisual-registration and image-fusion targeting strategies combined had the highest detection rate for clinically significant cancers. Targeted prostate biopsy should be performed using both strategies together.Patient summaryWe compared two prostate cancer biopsy strategies: visual registration and image fusion. A combination of the two strategies found the most clinically important cancers and should be used together whenever targeted biopsy is being performed. (Source: European Urology)
Source: European Urology - December 6, 2018 Category: Urology & Nephrology Source Type: research

Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint
ConclusionsCabozantinib treatment did not demonstrate better pain palliation than mitoxantrone-prednisone in heavily pretreated patients with mCRPC and symptomatic bone metastases. Future pain-palliation trials should incorporate briefer timelines from enrollment to treatment initiation.Patient summaryCabozantinib was not better than mitoxantrone-prednisone for pain relief in patients with castration-resistant prostate cancer and debilitating pain from bone metastases. (Source: European Urology)
Source: European Urology - December 5, 2018 Category: Urology & Nephrology Source Type: research

Re: Henrik Grönberg, Martin Eklund, Wolfgang Picker, et al. Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.06.022
Publication date: Available online 4 December 2018Source: European UrologyAuthor(s): Erik Rud, Peter Lauritzen, Eduard Baco (Source: European Urology)
Source: European Urology - December 5, 2018 Category: Urology & Nephrology Source Type: research

Inflammatory Bowel Disease and the Risk of Prostate Cancer
Publication date: Available online 4 December 2018Source: European UrologyAuthor(s): Jacob A. Burns, Adam B. Weiner, William J. Catalona, Eric V. Li, Edward M. Schaeffer, Stephen B. Hanauer, Scott Strong, James Burns, Maha H.A. Hussain, Shilajit D. KunduAbstractBackgroundThere are limited data examining the risk of prostate cancer (PCa) in patients with inflammatory bowel disease (IBD).ObjectiveTo compare the incidence of PCa between men with and those without IBD.Design, setting, and participantsThis was a retrospective, matched-cohort study involving a single academic medical center and conducted from 1996 to 2...
Source: European Urology - December 5, 2018 Category: Urology & Nephrology Source Type: research

Robotic Urologic Surgical Interventions Performed with the Single Port Dedicated Platform: First Clinical Investigation
We report the first clinical investigation for surgical procedures performed using the da Vinci SP robotic surgical platform (Intuitive Surgical, Sunnyvale, CA, USA) during the first 10 days (September 28–October 12, 2018) after the system was installed at our institution. The aim of the study was to determine the feasibility and safety of major urologic procedures, measured as the rate of conversions and the incidence of perioperative complications. Secondary aims of the study consisted of key perioperative surgical outcomes, including operative time, blood loss, and length of stay. Pathology data were reported. Dat...
Source: European Urology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Re: Tuan Zea Tan, Mathieu Rouanne, Kien Thiam Tan, Ruby Yun-Ju Huang, Jean-Paul Thiery. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.08.027
Publication date: Available online 3 December 2018Source: European UrologyAuthor(s): Pontus Eriksson, Gottfrid Sjödahl (Source: European Urology)
Source: European Urology - December 4, 2018 Category: Urology & Nephrology Source Type: research

The FUTURE Trial: A Multicenter Randomised Controlled Trial on Target Biopsy Techniques Based on Magnetic Resonance Imaging in the Diagnosis of Prostate Cancer in Patients with Prior Negative Biopsies
ConclusionsWe found no significant differences in the detection rates of (cs)PCa among the three MRI-based TB techniques.Patient summaryIn this study, we compared the detection rates of (aggressive) prostate cancer among men with prior negative biopsies and a persistent suspicion of cancer using three different techniques of targeted biopsy based on magnetic resonance imaging. We found no significant differences in the detection rates of (aggressive) prostate cancer among the three techniques. (Source: European Urology)
Source: European Urology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Reply from Authors re: Jens. J. Rassweiler, Marcel Fiedler-Hruza. The Learning Curve for Robot-assisted Partial Nephrectomy: There is Much Beyond a Trifecta. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.10.022: The Clinical Implications of Surgical Learning Curve Analysis: Can We Optimize Patient Outcomes Using Structured Training Programs?
Publication date: Available online 4 December 2018Source: European UrologyAuthor(s): Alessandro Larcher, Fabio Muttin, Gianfranco Baiamonte, Benoit Peyronnet, Geert De Naeyer, Zine-Eddine Khene, Paolo Dell’Oglio, Cristina Ferreiro, Peter Schatteman, Umberto Capitanio, Frederiek D’Hondt, Francesco Montorsi, Karim Bensalah, Alexandre Mottrie (Source: European Urology)
Source: European Urology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Synergistic Interactions: Targeted Radiopharmaceuticals and Homologous Recombination Repair Alterations in Prostate Cancer
Publication date: Available online 1 December 2018Source: European UrologyAuthor(s): Oliver Sartor (Source: European Urology)
Source: European Urology - December 2, 2018 Category: Urology & Nephrology Source Type: research

Reply to Erik Rud, Peter Lauritzen, and Eduard Baco's Letter to the Editor re: Henrik Grönberg, Martin Eklund, Wolfgang Picker, et al. Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.06.022
Publication date: Available online 1 December 2018Source: European UrologyAuthor(s): Martin Eklund, Peter Ström, Henrik Grönberg, Tobias Nordström (Source: European Urology)
Source: European Urology - December 2, 2018 Category: Urology & Nephrology Source Type: research

Posterior, Anterior, and Periurethral Surgical Reconstruction of Urinary Continence Mechanisms in Robot-assisted Radical Prostatectomy: A Description and Video Compilation of Commonly Performed Surgical Techniques
ConclusionsAlthough many of the procedures report a benefit with respect to early continence, benefits seem to diminish with longer follow-up. Whether any of the reconstructive techniques is superior to another is a matter of study.Patient summaryEarly continence rates might be improved by surgical reconstruction of the pelvic floor. (Source: European Urology)
Source: European Urology - December 2, 2018 Category: Urology & Nephrology Source Type: research

Reply to Alba Fiorentino, Angelo Errico, and Marcello Scarcia's Letter to the Editor re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.034.: Radiation Therapy Versus Radical Prostatectomy: No Way Out Without a Randomized Trial
Publication date: Available online 30 November 2018Source: European UrologyAuthor(s): Marco Moschini, Emanuele Zaffuto, Agostino Mattei, Pierre I. Karakiewicz, Shahrokh F. Shariat (Source: European Urology)
Source: European Urology - December 1, 2018 Category: Urology & Nephrology Source Type: research

Robot-assisted Vescica Ileale Padovana: A New Technique for Intracorporeal Bladder Replacement Reproducing Open Surgical Principles
ConclusionsOur preliminary results showed that ra-VIP appears to be a feasible technique for robot-assisted totally intracorporeal bladder replacement following robotic radical cystectomy.Patient summaryVescica Ileale Padovana (VIP) was first described almost 30 yr ago for bladder replacement after radical cystectomy. We report a step-by-step technique of robot-assisted VIP that follows the open surgical principles of detubularization and double folding, mixing the advantages of VIP with the benefits of the robotic approach. (Source: European Urology)
Source: European Urology - December 1, 2018 Category: Urology & Nephrology Source Type: research

Detection of Individual Prostate Cancer Foci via Multiparametric Magnetic Resonance Imaging
ConclusionsmpMRI detects less than half of all and less than two-thirds of clinically significant CaP foci. The moderate per-lesion sensitivity and significant proportion of men with undetected tumor foci demonstrate the current limitations of mpMRI.Patient summaryMagnetic resonance imaging of the prostate before surgical removal for prostate cancer finds less than half of all individual prostate cancer tumors. Large, solitary, aggressive tumors are more likely to be visualized on imaging. (Source: European Urology)
Source: European Urology - December 1, 2018 Category: Urology & Nephrology Source Type: research

Reply to Herney Andrés García-Perdomo's Letter to the Editor re: Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.008. High-volume Disease Has a Different Standard of Care: Is Local Treatment Really Beneficial in Low-volume Metastatic Prostate Cancer?
Publication date: Available online 30 November 2018Source: European UrologyAuthor(s): Liselotte M.S. Boevé, André N. Vis (Source: European Urology)
Source: European Urology - November 30, 2018 Category: Urology & Nephrology Source Type: research

Reply to Nicholas G. Zaorsky, Daniel E. Spratt, and Pierre Blanchard's Letter to the Editor re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.034
Publication date: Available online 30 November 2018Source: European UrologyAuthor(s): Marco Moschini, Emanuele Zaffuto, Agostino Mattei, Pierre I. Karakiewicz, Shahrokh F. Shariat (Source: European Urology)
Source: European Urology - November 30, 2018 Category: Urology & Nephrology Source Type: research

Nodal Oligorecurrent Prostate Cancer: Anatomic Pattern of Possible Treatment Failure in Relation to Elective Surgical and Radiotherapy Treatment Templates
Publication date: Available online 29 November 2018Source: European UrologyAuthor(s): Aurélie De Bruycker, Elise De Bleser, Karel Decaestecker, Valérie Fonteyne, Nicolaas Lumen, Pieter De Visschere, Kathia De Man, Louke Delrue, Bieke Lambert, Piet OstAbstractBackgroundPatients with biochemical recurrence following primary prostate cancer (PCa) treatment often experience relapse in the lymph nodes (LNs). Both salvage LN dissection (sLND) and elective nodal radiotherapy (ENRT) are potential treatment options.ObjectiveTo describe anatomic patterns of nodal oligorecurrent PCa in relation to different surgical and...
Source: European Urology - November 29, 2018 Category: Urology & Nephrology Source Type: research

Re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.034: Radiation Therapy Versus Radical Prostatectomy: No Way Out Without a Randomized Trial
Publication date: Available online 27 November 2018Source: European UrologyAuthor(s): Alba Fiorentino, Angelo Errico, Marcello Scarcia (Source: European Urology)
Source: European Urology - November 28, 2018 Category: Urology & Nephrology Source Type: research

PD-L1 Antibody Comparison in Urothelial Carcinoma
Publication date: Available online 27 November 2018Source: European UrologyAuthor(s): Maud Rijnders, Astrid A.M. van der Veldt, Tahlita C.M. Zuiverloon, Katrien Grünberg, Erik Thunnissen, Ronald de Wit, Geert J.L.H. van Leenders (Source: European Urology)
Source: European Urology - November 28, 2018 Category: Urology & Nephrology Source Type: research

Re: Stephanie Guillaumier, Max Peters, Manit Arya, et al. A Multicentre Study of 5-year Outcomes Following Focal Therapy in Treating Clinically Significant Nonmetastatic Prostate Cancer. Eur Urol 2018;74:422–9
Publication date: Available online 28 November 2018Source: European UrologyAuthor(s): Zhien Zhou, Yi Zhou, Weigang Yan (Source: European Urology)
Source: European Urology - November 28, 2018 Category: Urology & Nephrology Source Type: research

Dissemination of Misinformative and Biased Information about Prostate Cancer on YouTube
Publication date: Available online 28 November 2018Source: European UrologyAuthor(s): Stacy Loeb, Shomik Sengupta, Mohit Butaney, Joseph N. Macaluso, Stefan W. Czarniecki, Rebecca Robbins, R. Scott Braithwaite, Lingshan Gao, Nataliya Byrne, Dawn Walter, Aisha LangfordAbstractYouTube is a social media platform with more than 1 billion users and>600 000 videos about prostate cancer. Two small studies examined the quality of prostate cancer videos on YouTube, but did not use validated instruments, examine user interactions, or characterize the spread of misinformation. We performed the largest, most comprehensive exam...
Source: European Urology - November 28, 2018 Category: Urology & Nephrology Source Type: research

Corrigendum re: “Atezolizumab in Platinum-treated Locally Advanced or Metastatic Urothelial Carcinoma: Outcomes by Prior Number of Regimens” [Eur Urol 2018;73:462–8]
Publication date: Available online 28 November 2018Source: European UrologyAuthor(s): Jose Luis Perez-Gracia, Yohann Loriot, Jonathan E. Rosenberg, Thomas Powles, Andrea Necchi, Syed A. Hussain, Rafael Morales-Barrera, Margitta M. Retz, Günter Niegisch, Ignacio Durán, Christine Théodore, Enrique Grande, Xiaodong Shen, Jingjing Wang, Betty Nelson, Christina L. Derleth, Michiel S. van der Heijden (Source: European Urology)
Source: European Urology - November 28, 2018 Category: Urology & Nephrology Source Type: research

Androgen Deprivation Therapies and Changes in Comorbidity: A Comparison of Gonadotropin-releasing Hormone Agonists and Antiandrogen Monotherapy as Primary Therapy in Men with High-risk Prostate Cancer
Publication date: Available online 26 November 2018Source: European UrologyAuthor(s): Kerri Beckmann, Hans Garmo, Jan Adolfsson, Cecilia Bosco, Eva Johansson, David Robinson, Lars Holmberg, Par Stattin, Mieke Van HemelrijckAbstractBackgroundSome studies suggest that gonadotropin-releasing hormone (GnRH) agonists are associated with higher risk of adverse events than antiandrogens (AAs) monotherapy. However, it has been unclear whether this is due to indication bias.ObjectiveTo investigate rates of change in comorbidity for men on GnRH agonists versus AA monotherapy in a population-based register study.Design, setting, and ...
Source: European Urology - November 27, 2018 Category: Urology & Nephrology Source Type: research

Predicting Renal Function Outcomes After Partial and Radical Nephrectomy
Publication date: Available online 23 November 2018Source: European UrologyAuthor(s): Bimal Bhindi, Christine M. Lohse, Phillip J. Schulte, Ross J. Mason, John C. Cheville, Stephen A. Boorjian, Bradley C. Leibovich, R. Houston ThompsonAbstractBackgroundPartial nephrectomy (PN) is generally favored for cT1 tumors over radical nephrectomy (RN) when technically feasible. However, it can be unclear whether the additional risks of PN are worth the magnitude of renal function benefit.ObjectiveTo develop preoperative tools to predict long-term estimated glomerular filtration rate (eGFR) beyond 30 d following PN and RN, separ...
Source: European Urology - November 24, 2018 Category: Urology & Nephrology Source Type: research

Head-to-head Comparison of Transrectal Ultrasound-guided Prostate Biopsy Versus Multiparametric Prostate Resonance Imaging with Subsequent Magnetic Resonance-guided Biopsy in Biopsy-naïve Men with Elevated Prostate-specific Antigen: A Large Prospective Multicenter Clinical Study
Publication date: Available online 23 November 2018Source: European UrologyAuthor(s): Marloes van der Leest, Erik Cornel, Bas Israël, Rianne Hendriks, Anwar R. Padhani, Martijn Hoogenboom, Patrik Zamecnik, Dirk Bakker, Anglita Yanti Setiasti, Jeroen Veltman, Huib van den Hout, Hans van der Lelij, Inge van Oort, Sjoerd Klaver, Frans Debruyne, Michiel Sedelaar, Gerjon Hannink, Maroeska Rovers, Christina Hulsbergen-van de Kaa, Jelle O. BarentszAbstractBackgroundThere is growing interest to implement multiparametric magnetic resonance imaging (mpMRI) and MR-guided biopsy (MRGB) for biopsy-naïve men with suspected pro...
Source: European Urology - November 24, 2018 Category: Urology & Nephrology Source Type: research

Re: Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.008: High-volume Disease Has a Different Standard of Care
Publication date: Available online 23 November 2018Source: European UrologyAuthor(s): Herney Andrés García-Perdomo (Source: European Urology)
Source: European Urology - November 24, 2018 Category: Urology & Nephrology Source Type: research

Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Thomas B.L. Lam, Steven MacLennan, Karin Plass, Peter-Paul M. Willemse, Malcolm D. Mason, Philip Cornford, James Donaldson, Niall F. Davis, Paolo Dell’Oglio, Christian Fankhauser, Nikos Grivas, Alexandre Ingels, Michael Lardas, Matthew Liew, Karl H. Pang, Catherine Paterson, Muhammad I. Omar, Fabio Zattoni, Karel T. Buddingh, Thomas Van den Broeck (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research

Re: Friederike Haidl, David Pfister, Axel Heidenreich. Re: Prostatic Artery Embolization in the Treatment of Localized Prostate Cancer: A Bicentric Prospective Proof-of-Concept Study of 12 Patients. Mordasini L, Hechelhammer L, Diener PA, et al. J Vasc Interv Radiol 2018;29:589–97. Eur Urol 2018;74:525–6: Could Morphologic Changes in Periprostatic Arteries Have an Influence on Prostatic Artery Embolization?
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Alessia Cimadamore, Marina Scarpelli, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Francesco Montorsi, Rodolfo Montironi (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research

In the Line of Fire: Should Urologists Stop Prescribing Fluoroquinolones as Default?
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Gernot Bonkat, Florian Wagenlehner (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research

Does the Evidence Support Adolescent Varicocelectomy?
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Jack Elder (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research

Re: Guido Giusti, Silvia Proietti, Moises E. Rodríguez-Socarrás, et al. Simultaneous Bilateral Endoscopic Surgery (SBES) for Patients with Bilateral Upper Tract Urolithiasis: Technique and Outcomes. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.06.034
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Jie Gu, Dongjie Li, Xiaobo Zhang (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research

Reply to Ashwin Shinde, Richard Li, Arya Amini, and Scott Glaser's Letter to the Editor re: Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.008: Future Steps for Definitive Therapy in Metastatic Prostate Cancer: Lessons from the HORRAD TrialUntil Randomised Controlled Trials Prove Different, Treat the Patient, Not His Imaging Results
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Liselotte M.S. Boevé, Paul C.M.S. Verhagen, André N. Vis (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research

Re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.09.034
Publication date: Available online 22 November 2018Source: European UrologyAuthor(s): Nicholas G. Zaorsky, Daniel E. Spratt, Pierre Blanchard (Source: European Urology)
Source: European Urology - November 23, 2018 Category: Urology & Nephrology Source Type: research