Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma
ConclusionsIn patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival.Patient summaryThe relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. (Source: European Urology)
Source: European Urology - August 10, 2018 Category: Urology & Nephrology Source Type: research

Re: Nivolumab plus Ipilimumab Versus Sunitinib in Advanced Renal-cell Carcinoma
Publication date: Available online 10 August 2018Source: European UrologyAuthor(s): Tom Powles (Source: European Urology)
Source: European Urology - August 10, 2018 Category: Urology & Nephrology Source Type: research

Re: Isabel Rauscher, Charlotte Düwel, Bernhard Haller, et al. Efficacy, Predictive Factors, and Prediction Nomograms for 68Ga-labeled Prostate-specific Membrane Antigen–ligand Positron-emission Tomography/Computed Tomography in Early Biochemical Recurrent Prostate Cancer After Radical Prostatectomy. Eur Urol 2018;73:656–61: Clinical Significance of Prostate-specific Membrane Antigen Immunohistochemistry and Role of the Uropathologists
Publication date: Available online 6 August 2018Source: European UrologyAuthor(s): Alessia Cimadamore, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Francesco Montorsi, Rodolfo Montironi (Source: European Urology)
Source: European Urology - August 6, 2018 Category: Urology & Nephrology Source Type: research

Prostate Cancer Grading: Are We Heading Towards Grade Grouping Version 2?
Publication date: Available online 6 August 2018Source: European UrologyAuthor(s): Rodolfo Montironi, Liang Cheng, Alessia Cimadamore, Antonio Lopez-Beltran (Source: European Urology)
Source: European Urology - August 6, 2018 Category: Urology & Nephrology Source Type: research

Re: Comparison of Prostatic Artery Embolization (PAE) Versus Transurethral Resection of the Prostate (TURP) for Benign Prostatic Hyperplasia: Randomised, Open Label, Non-inferiority Trial
Publication date: Available online 3 August 2018Source: European UrologyAuthor(s): Stephan Madersbacher (Source: European Urology)
Source: European Urology - August 4, 2018 Category: Urology & Nephrology Source Type: research

Prediction of High-grade Prostate Cancer Following Multiparametric Magnetic Resonance Imaging: Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculators
Publication date: Available online 3 August 2018Source: European UrologyAuthor(s): Arnout R. Alberts, Monique J. Roobol, Jan F.M. Verbeek, Ivo G. Schoots, Peter K. Chiu, Daniël F. Osses, Jasper D. Tijsterman, Harrie P. Beerlage, Christophe K. Mannaerts, Lars Schimmöller, Peter Albers, Christian ArsovAbstractBackgroundThe Rotterdam European Randomized Study of Screening for Prostate Cancer risk calculators (ERSPC-RCs) help to avoid unnecessary transrectal ultrasound-guided systematic biopsies (TRUS-Bx). Multivariable risk stratification could also avoid unnecessary biopsies following multiparametric magnetic reson...
Source: European Urology - August 4, 2018 Category: Urology & Nephrology Source Type: research

Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies
Publication date: Available online 1 August 2018Source: European UrologyAuthor(s): Eleanor L. Watts, Paul N. Appleby, Aurora Perez-Cornago, H. Bas Bueno-de-Mesquita, June M. Chan, Chu Chen, Barbara A. Cohn, Michael B. Cook, Leon Flicker, Neal D. Freedman, Graham G. Giles, Edward Giovannucci, Randi E. Gislefoss, Graeme J. Hankey, Rudolf Kaaks, Paul Knekt, Laurence N. Kolonel, Tatsuhiko Kubo, Loïc Le Marchand, Robert N. LubenAbstractBackgroundExperimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations ma...
Source: European Urology - August 2, 2018 Category: Urology & Nephrology Source Type: research

Robot-assisted Partial Adrenalectomy for the Treatment of Conn's Syndrome: Surgical Technique, and Perioperative and Functional Outcomes
ConclusionsWe demonstrated feasibility and safety of RAPA for UAPA; this technique had very low risk of complications and excellent functional results. Increased availability of robotic platform and increasing robotic skills among urologists make RAPA a treatment option with potential for widespread use in urologic community.Patient summaryRobot-assisted partial adrenalectomy is a safe, feasible, and minimally invasive surgical approach. Promising perioperative and functional outcomes suggest an increasing adoption of this technique in the near future. (Source: European Urology)
Source: European Urology - August 2, 2018 Category: Urology & Nephrology Source Type: research

The Promise and Perils of Sequencing Individual Prostate Cancer Nuclei
Publication date: Available online 31 July 2018Source: European UrologyAuthor(s): Paul C. Boutros (Source: European Urology)
Source: European Urology - August 1, 2018 Category: Urology & Nephrology Source Type: research

Re: Docetaxel Versus Surveillance After Radical Prostatectomy for High-risk Prostate Cancer: Results from the Prospective Randomised, Open-label Phase 3 Scandinavian Prostate Cancer Group 12 Trial
Publication date: Available online 30 July 2018Source: European UrologyAuthor(s): David D’Andrea, Shahrokh F. Shariat, Francesco Soria (Source: European Urology)
Source: European Urology - July 31, 2018 Category: Urology & Nephrology Source Type: research

Adjuvant Therapy for Resected Renal Cell Carcinoma—Still Searching
Publication date: Available online 30 July 2018Source: European UrologyAuthor(s): Lori Wood (Source: European Urology)
Source: European Urology - July 31, 2018 Category: Urology & Nephrology Source Type: research

A Randomized, Double-blind, Placebo-controlled Trial of Certolizumab Pegol in Women with Refractory Interstitial Cystitis/Bladder Pain Syndrome
ConclusionsWomen with moderate to severe refractory IC/BPS were more likely to experience significant improvement in symptoms with certolizumab pegol compared with placebo therapy. Further investigation of certolizumab pegol for the treatment of IC/BPS is warranted with a larger, longer, multicenter, randomized, placebo-controlled trial.Patient summaryWomen with moderate to severe interstitial cystitis/bladder pain syndrome were helped with a medication used to treat autoimmune diseases. (Source: European Urology)
Source: European Urology - July 31, 2018 Category: Urology & Nephrology Source Type: research

Reply to Vincenzo Di Nunno, Matteo Santoni, Alessia Cimadamore, Nicola Battelli, and Francesco Massari's Letter to the Editor re: Gladell P. Paner, Walter M. Stadler, Donna E. Hansel, et al. Updates in the Eight Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers. Eur Urol 2018;73:560–9
Publication date: Available online 26 July 2018Source: European UrologyAuthor(s): Gladell P. Paner, Mahul B. Amin (Source: European Urology)
Source: European Urology - July 27, 2018 Category: Urology & Nephrology Source Type: research

How Are Gleason Scores Categorized in the Current Literature: An Analysis and Comparison of Articles Published in 2016–2017
Publication date: Available online 26 July 2018Source: European UrologyAuthor(s): Amy G. Zhou, Daniela C. Salles, Iryna V. Samarska, Jonathan I. EpsteinAbstractBackgroundA new prostate cancer grading system was proposed in 2013 and endorsed by major journals and societies in 2014, in part because of anecdotal evidence that Gleason scores (GSs) were incorrectly combined in the literature.ObjectiveTo examine how published studies categorized GSs in current practice.Design, setting, and participantsA PubMed search was conducted on articles published in 2016–2017 using the search terms “Gleason” and “pr...
Source: European Urology - July 27, 2018 Category: Urology & Nephrology Source Type: research

Re: Molecular Subtypes of Clear-cell Renal Cell Carcinoma Are Prognostic for Outcome After Complete Metastasectomy
Publication date: Available online 26 July 2018Source: European UrologyAuthor(s): Baijun Dong, Wei Xue (Source: European Urology)
Source: European Urology - July 27, 2018 Category: Urology & Nephrology Source Type: research

Re: Tamsulosin and the Risk of Dementia in Older Men with Benign Prostatic Hyperplasia
Publication date: Available online 26 July 2018Source: European UrologyAuthor(s): Stephan Madersbacher, Martin C. Michel (Source: European Urology)
Source: European Urology - July 27, 2018 Category: Urology & Nephrology Source Type: research

Re: Safety of Vaginal Mesh Surgery Versus Laparoscopic Mesh Sacropexy for Cystocele Repair: Results of the Prosthetic Pelvic Floor Repair Randomized Controlled Trial
Publication date: Available online 26 July 2018Source: European UrologyAuthor(s): Dmitry Pushkar, George Kasyan (Source: European Urology)
Source: European Urology - July 27, 2018 Category: Urology & Nephrology Source Type: research

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy
ConclusionsThis study demonstrates that ribosome-targeting drugs may be effective against diverse CRPC subtypes including AR-null disease, and highlights the potential of contemporary patient-derived models to prioritise treatment strategies for clinical translation.Patient summaryDiverse types of therapy-resistant prostate cancers are sensitive to a new combination of drugs that inhibit protein synthesis pathways in cancer cells. (Source: European Urology)
Source: European Urology - July 23, 2018 Category: Urology & Nephrology Source Type: research

Retrograde Release of the Neurovascular Bundle with Preservation of Dorsal Venous Complex During Robot-assisted Radical Prostatectomy: Optimizing Functional Outcomes
ConclusionsRetrograde release of the neurovascular bundle with preservation of dorsal venous complex during RARP is safe and associated with excellent oncological and functional outcomes. Future comparative studies are needed.Patient summaryRobot-assisted radical prostatectomy (RARP) presents consistent oncological outcomes for prostate cancer; yet continence and potency results are not uniform. We present a technical modification for RARP aiming to preserve the nerves and vascular structures anterior to the prostate. We evaluated 128 consecutive patients with clinically localized or locally advanced prostate cancer underg...
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Simultaneous Bilateral Endoscopic Surgery (SBES) for Patients with Bilateral Upper Tract Urolithiasis: Technique and Outcomes
ConclusionsSBES is safe and effective, with minimal morbidity. SBES has the potential advantages of shorter operative time, reduced anesthesia, and reduced hospital time, which can benefit patients, surgeons, and health care systems.Patient summarySimultaneous bilateral endoscopic surgery is an effective treatment with low complication rates for bilateral urolithiasis. This innovative and complicated procedure should be performed in high-volume centers by experienced surgeons. (Source: European Urology)
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Re: Differences in Survival Associated with Lymph Node Dissection in Patients with Invasive Penile Cancer: Results from the National Cancer Database
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Atiqullah Aziz, Matthias May, Oliver W. Hakenberg, Sabine D. Brookman-May (Source: European Urology)
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Re: Detrusor Acontractility After Acute Spinal Cord Injury—Myth or Reality?
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Jürgen Pannek (Source: European Urology)
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Re: Acute Pyelonephritis in Adults
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Florian M.E. Wagenlehner, Thorsten Diemer (Source: European Urology)
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Analysis of the Enteric Microbiome: First Tentative Steps Towards a Comprehensive Work-up of Prostate Cancer?
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Ilaria Cavarretta, Nicasio Mancini, Andrea Salonia (Source: European Urology)
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Comparison of Perioperative Outcomes Between Cytoreductive Radical Prostatectomy and Radical Prostatectomy for Nonmetastatic Prostate Cancer
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Felix Preisser, Elio Mazzone, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Michele Marchioni, Thomas Steuber, Fred Saad, Francesco Montorsi, Shahrokh F. Shariat, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. KarakiewiczAbstractCytoreductive radical prostatectomy (CRP) may offer a survival advantage, according to several retrospective analyses. However, few data are available regarding the morbidity of radical prostatectomy in the metastatic setting. We addressed intra- and postoperative complications of CRP relative to radical prosta...
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Re: The Impact of Implementation of the European Association of Urology Guidelines Panel Recommendations on Reporting and Grading Complications on Perioperative outcomes after Robot-assisted Radical Prostatectomy
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Dmitry Pushkar, Alexander Govorov (Source: European Urology)
Source: European Urology - July 21, 2018 Category: Urology & Nephrology Source Type: research

Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications
ConclusionsOur results support the feasibility of clinically relevant integrative bladder cancer profiling and challenge the intrinsic nature of expression subtypes in histologically diverse bladder cancers.Patient summaryA targeted RNA sequencing assay is capable of assessing gene expression-based subtypes in individual components of clinical bladder cancer tissue specimens. Different histological components of the same tumor may yield divergent expression profiles, suggesting that expression-based subtypes should be interpreted with caution in heterogeneous cancers. (Source: European Urology)
Source: European Urology - July 20, 2018 Category: Urology & Nephrology Source Type: research

Tradeoffs in Refining the Diagnosis of Prostate Cancer
Publication date: Available online 19 July 2018Source: European UrologyAuthor(s): Parth K. Modi, Todd M. Morgan (Source: European Urology)
Source: European Urology - July 19, 2018 Category: Urology & Nephrology Source Type: research

Conventional and PD-L1-expressing Regulatory T Cells are Enriched During BCG Therapy and may Limit its Efficacy
Publication date: Available online 19 July 2018Source: European UrologyAuthor(s): Mathieu F. Chevalier, Anna K. Schneider, Valerie Cesson, Florence Dartiguenave, Ilaria Lucca, Patrice Jichlinski, Denise Nardelli-Haefliger, Laurent DerréAbstractThe regulation of immune responses occurring during Bacillus Calmette-Guerin (BCG) therapy need to be better scrutinized in order to identify new targetable pathways for non-muscle invasive bladder cancer treatment. Immunoregulatory mechanisms have emerged as key players in various cancers. While T lymphocytes are crucial for the control of tumor growth, they often include reg...
Source: European Urology - July 19, 2018 Category: Urology & Nephrology Source Type: research

Re: Fabio Conforti, Laura Pala, Vincenzo Bagnardi, et al. Cancer Immunotherapy Efficacy and Patients’ Sex: A Systematic Review and Meta-analysis. Lancet Oncol 2018;19:737–46: Outcomes of Metastatic Renal Cell Carcinoma by Gender: Contrasting Results from the International mRCC Database Consortium
Publication date: Available online 18 July 2018Source: European UrologyAuthor(s): Jeffrey Graham, Omar Abdel-Rahman, Toni K. Choueiri, Daniel Y.C. Heng, on behalf of the International mRCC Database Consortium (Source: European Urology)
Source: European Urology - July 19, 2018 Category: Urology & Nephrology Source Type: research

Atorvastatin Versus Placebo for Prostate Cancer Before Radical Prostatectomy—A Randomized, Double-blind, Placebo-controlled Clinical Trial
Publication date: Available online 18 July 2018Source: European UrologyAuthor(s): Teemu J. Murtola, Heimo Syvälä, Teemu Tolonen, Mika Helminen, Jarno Riikonen, Juha Koskimäki, Tomi Pakarainen, Antti Kaipia, Taina Isotalo, Paula Kujala, Teuvo L.J. TammelaAbstractWe tested whether intervention with atorvastatin affects the prostate beneficially compared with placebo in men with prostate cancer in a randomized clinical trial. A total of 160 statin-naïve prostate cancer patients scheduled for radical prostatectomy were randomized to use 80 mg atorvastatin or placebo daily from recruitment to surgery fo...
Source: European Urology - July 19, 2018 Category: Urology & Nephrology Source Type: research

Reply to John T. Leppert and James D. Brooks’ Letter to the Editor re: Brandon A. Mahal, David D. Yang, Natalie Q. Wang, et al. Clinical and Genomic Characterization of Low-Prostate-specific Antigen, High-grade Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.01.043
Publication date: Available online 18 July 2018Source: European UrologyAuthor(s): Brandon A. Mahal, David D. Yang, Paul L. Nguyen (Source: European Urology)
Source: European Urology - July 19, 2018 Category: Urology & Nephrology Source Type: research

Reply to Andrea Necchi, Antonella Messina, and Alberto Briganti's Letter to the Editor re: Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, et al. Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting and Data System). Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.04.029
Publication date: Available online 17 July 2018Source: European UrologyAuthor(s): Valeria Panebianco, Jelle Barentsz, Yoshifumi Narumi, James Catto, on behalf of the VI-RADS authors (Source: European Urology)
Source: European Urology - July 18, 2018 Category: Urology & Nephrology Source Type: research

A Molecular Marker for Eosinophilic Solid and Cystic Renal Cell Carcinoma
Publication date: Available online 17 July 2018Source: European UrologyAuthor(s): Pedram Argani (Source: European Urology)
Source: European Urology - July 18, 2018 Category: Urology & Nephrology Source Type: research

Neoadjuvant Chemotherapy Reinforces Antitumour T cell Response in Urothelial Urinary Bladder Cancer
In this report, we analysed the effect of chemotherapy on immune cell subsets of 40 patients with advanced bladder cancer. We found that chemotherapy has a positive effect on immune effector T cells, whereas an opposite, diminishing effect was observed for immune-suppressive regulatory T cells. We conclude that chemotherapy reinforces the antitumour immune response in bladder cancer patients. (Source: European Urology)
Source: European Urology - July 18, 2018 Category: Urology & Nephrology Source Type: research

Corrigendum re: “A Larger Prospective Study is Needed when Judging Robotic Radical Nephrectomy” [Eur Urol 2018;74:123–9]
Publication date: Available online 17 July 2018Source: European UrologyAuthor(s): Giovanni E. Cacciamani, Mihir M. Desai, Inderbir S. Gill (Source: European Urology)
Source: European Urology - July 18, 2018 Category: Urology & Nephrology Source Type: research

“To Cut or Not to Cut”, a Biomolecular Approach to Metastasectomy in Metastatic Clear Cell Renal Cell Carcinoma
Publication date: Available online 17 July 2018Source: European UrologyAuthor(s): Sergio Bracarda, Annalisa Guida, Claudia Caserta (Source: European Urology)
Source: European Urology - July 18, 2018 Category: Urology & Nephrology Source Type: research

Finding a Needle in the Haystack: The Search for Germline Variants Associated with Prostate Cancer Clinical Outcomes
Publication date: Available online 17 July 2018Source: European UrologyAuthor(s): Kathleen A. Cooney, Jennifer L. Beebe-Dimmer (Source: European Urology)
Source: European Urology - July 18, 2018 Category: Urology & Nephrology Source Type: research

Re: Exercise and Cancer Treatment: Balancing Patient Needs. Lancet Oncol 2018;19:715: Cancer Prevention and Treatment: More than Exercising
Publication date: Available online 14 July 2018Source: European UrologyAuthor(s): Giovanni Lavorgna, Francesco Montorsi, Andrea Salonia (Source: European Urology)
Source: European Urology - July 15, 2018 Category: Urology & Nephrology Source Type: research

Simultaneous Bilateral Endoscopic Surgery for Patients with Bilateral Upper Tract Urolithiasis: Technique and Outcomes
ConclusionsSBES is safe and effective, with minimal morbidity. SBES has the potential advantages of shorter operative time, reduced anesthesia, and reduced hospital time, which can benefit patients, surgeons, and health care systems.Patient summarySimultaneous bilateral endoscopic surgery is an effective treatment with low complication rates for bilateral urolithiasis. This innovative and complicated procedure should be performed in high-volume centers by experienced surgeons. (Source: European Urology)
Source: European Urology - July 15, 2018 Category: Urology & Nephrology Source Type: research

Prediction of Aggressive Histology: The Ongoing Dilemma of Renal Masses in the “Omics” Era
Publication date: Available online 13 July 2018Source: European UrologyAuthor(s): Uzoma A. Anele, Lance J. Hampton, Mayer B. Grob, Riccardo Autorino (Source: European Urology)
Source: European Urology - July 14, 2018 Category: Urology & Nephrology Source Type: research

Therapeutic Discovery for Castration Resistant Prostate Cancer: Patient-derived Xenograft Modelling Brings New Options to the Table
Publication date: Available online 13 July 2018Source: European UrologyAuthor(s): Simon J. Crabb (Source: European Urology)
Source: European Urology - July 14, 2018 Category: Urology & Nephrology Source Type: research

Re: Giorgio Gandaglia, Carlo Andrea Bravi, Paolo Dell’Oglio, et al. The Impact of Implementation of the European Association of Urology Guidelines Panel Recommendations on Reporting and Grading Complications on Perioperative Outcomes after Robot-assisted Radical Prostatectomy. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.02.025
Publication date: Available online 12 July 2018Source: European UrologyAuthor(s): Riccardo Bertolo (Source: European Urology)
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

Re: Gladell P. Paner, Walter M. Stadler, Donna E. Hansel, Rodolfo Montironi, Daniel W. Lin, Mahul B. Amin. Updates in the Eighth Edition of the Tumor-node-metastasis Staging Classification for Urologic Cancers. Eur Urol 2018;73:560–9: Tumour, Node, and Metastasis Staging System for Urological Malignancies: Are We Ready for the Next Step?
Publication date: Available online 12 July 2018Source: European UrologyAuthor(s): Vincenzo Di Nunno, Matteo Santoni, Alessia Cimadamore, Nicola Battelli, Francesco Massari (Source: European Urology)
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

Active Surveillance Magnetic Resonance Imaging Study (ASIST): Results of a Randomized Multicenter Prospective Trial
ConclusionsThe addition of MRI with targeted biopsies to systematic biopsies did not significantly increase the upgrading rate compared with systematic biopsy alone. Furthermore, 2-core targeted biopsies alone resulted in a nonsignificant trend to less upgrading than 12-core systematic biopsy (p = 0.09). In men on active surveillance, targeted biopsies identify most, but not all, clinically significant cancers. (Source: European Urology)
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

Treatment Strategy for Newly Diagnosed T1 High-grade Bladder Urothelial Carcinoma: New Insights and Updated Recommendations
ConclusionsT1HG tumours are heterogeneous in nature and challenging to treat. Bladder preservation with BCG induction and maintenance, or radical cystectomy is the current standard treatment modality of choice for these tumours. Promising therapies for BCG-unresponsive disease are currently under investigation.Patient summaryPatients with high-grade T1 bladder cancer are at a high risk of tumour recurrence and progression, requiring more aggressive treatment such as bladder removal. Bladder preservation therapies are available (and new therapies are being tested in clinical trials); however, patients should be aware that c...
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

The Probability of Aggressive Versus Indolent Histology Based on Renal Tumor Size: Implications for Surveillance and Treatment
ConclusionsWe present tumor size-based estimates of the probability of aggressive histology for renal masses. This information should be useful for initial patient counseling and management.Patient summaryActive surveillance is an option for kidney masses, even if they are malignant. Beyond knowing whether the mass is benign or cancer, it is important to know whether or not it is an aggressive tumor. This study presents tumor size-specific and sex-specific estimates of the probability of cancer overall and aggressive cancer among patients with a kidney mass in order to aid with initial decision-making. (Source: European Urology)
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

Re: Brandon A. Mahal, David D. Yang, Natalie Q. Wang, et al. Clinical and Genomic Characterization of Low–Prostate-specific Antigen, High-grade Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.01.043
Publication date: Available online 13 July 2018Source: European UrologyAuthor(s): John T. Leppert, James D. Brooks (Source: European Urology)
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

Getting the Balance Right—The Benefits and Uncertainties of Focal Therapy for Significant Prostate Cancer
Publication date: Available online 12 July 2018Source: European UrologyAuthor(s): Declan G. Murphy, Derya Tilki (Source: European Urology)
Source: European Urology - July 13, 2018 Category: Urology & Nephrology Source Type: research

Reply to Riccardo Bertolo's Letter to the Editor re: Giorgio Gandaglia, Carlo Andrea Bravi, Paolo Dell’Oglio, et al. The Impact of Implementation of the European Association of Urology Guidelines Panel Recommendations on Reporting and Grading Complications on Perioperative Outcomes after Robot-assisted Radical Prostatectomy. Eur Urol 2018;74:4–7
Publication date: Available online 12 July 2018Source: European UrologyAuthor(s): Giorgio Gandaglia, Nicola Fossati, Francesco Montorsi, Alberto Briganti (Source: European Urology)
Source: European Urology - July 12, 2018 Category: Urology & Nephrology Source Type: research