Separating the Dreadful from the Merely Bad: Towards Prognostic and Predictive Biomarkers in Metastatic Castration-resistant Prostate Cancer
Publication date: Available online 19 April 2019Source: European UrologyAuthor(s): Michael Fraser (Source: European Urology)
Source: European Urology - April 20, 2019 Category: Urology & Nephrology Source Type: research

Initial Experience with da Vinci Single-port Robot-assisted Radical Prostatectomies
Publication date: Available online 19 April 2019Source: European UrologyAuthor(s): Deepak K. Agarwal, Vidit Sharma, Amir Toussi, Boyd R. Viers, Matthew K. Tollefson, Matthew T. Gettman, Igor FrankAbstractBackgroundSingle-port robotic surgery is being adopted for various surgical procedures. There have been interest in and clinical use of single-port robot-assisted radical prostatectomy (spRARP), but little reported data on feasibility and early outcomes.ObjectiveTo describe our institution's initial experience with spRARP utilizing the da Vinci single-port (SP) robotic system.Design, setting, and participantsA retrospectiv...
Source: European Urology - April 20, 2019 Category: Urology & Nephrology Source Type: research

Atezolizumab in “Real World” Patients: Do Phase 3b Trials Help Bridge the Gap Between Efficacy and Effectiveness?
Publication date: Available online 19 April 2019Source: European UrologyAuthor(s): Vaibhav G. Patel, Matthew D. Galsky (Source: European Urology)
Source: European Urology - April 19, 2019 Category: Urology & Nephrology Source Type: research

Should We Perform Multiparametric Magnetic Resonance Imaging of the Bladder Before Transurethral Resection of Bladder? Time to Reconsider the Rules
Publication date: Available online 15 April 2019Source: European UrologyAuthor(s): Valeria Panebianco, Yoshi Narumi, Giovanni Barchetti, Rodolfo Montironi, James W.F. Catto (Source: European Urology)
Source: European Urology - April 16, 2019 Category: Urology & Nephrology Source Type: research

Prostate-only Versus Whole-pelvis Radiation with or Without a Brachytherapy Boost for Gleason Grade Group 5 Prostate Cancer: A Retrospective Analysis
ConclusionsWPRT was not associated with improved PCSS or DMFS in patients with GG 5 PCa who received either EBRT or EBRT + BT. However, WPRT was associated with a significant improvement in bRFS among patients receiving EBRT + BT. Strategies to optimize WPRT, potentially with the use of advanced imaging techniques to identify occult nodal disease, are warranted.Patient summaryWhen men with a high Gleason grade prostate cancer receive radiation with external radiation and brachytherapy, the addition of radiation to the pelvis results in a longer duration of prostate-specific antigen control. However, we ...
Source: European Urology - April 14, 2019 Category: Urology & Nephrology Source Type: research

Re: Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial
Publication date: Available online 12 April 2019Source: European UrologyAuthor(s): Francesco Soria, Paolo Gontero (Source: European Urology)
Source: European Urology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Re: Health Economic Analysis of Open and Robot-assisted Laparoscopic Surgery for Prostate Cancer Within the Prospective Multicentre LAPPRO Trial
Publication date: Available online 12 April 2019Source: European UrologyAuthor(s): Andrea Minervini, Andrea Mari, Riccardo Campi, Marco Carini (Source: European Urology)
Source: European Urology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Re: Impact of Adjuvant Chemotherapy in Patients with Adverse Features and Variant Histology at Radical Cystectomy for Muscle-invasive Carcinoma of the Bladder: Does Histologic Subtype Matter?
Publication date: Available online 12 April 2019Source: European UrologyAuthor(s): Marco Moschini, Idir Ouzaid, Evanguelos Xylinas, on behalf of the Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology (Source: European Urology)
Source: European Urology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Re: Effect of Adding Docetaxel to Androgen-Deprivation Therapy in Patients with High-risk Prostate Cancer with Rising Prostate-specific Antigen Levels After Primary Local Therapy A Randomized Clinical Trial
Publication date: Available online 12 April 2019Source: European UrologyAuthor(s): Alexander Kretschmer, Derya Tilki (Source: European Urology)
Source: European Urology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Single Lesion on Prostate-specific Membrane Antigen-ligand Positron Emission Tomography and Low Prostate-specific Antigen Are Prognostic Factors for a Favorable Biochemical Response to Prostate-specific Membrane Antigen-targeted Radioguided Surgery in Recurrent Prostate Cancer
Publication date: Available online 12 April 2019Source: European UrologyAuthor(s): Thomas Horn, Markus Krönke, Isabel Rauscher, Bernhard Haller, Stephanie Robu, Hans-Jürgen Wester, Margret Schottelius, Fijs W.B. van Leeuwen, Henk G. van der Poel, Matthias Heck, Jürgen E. Gschwend, Wolfgang Weber, Matthias Eiber, Tobias MaurerAbstractBackgroundProstate-specific membrane antigen (PSMA)-ligand positron emission tomography (PET) allows detection of metastatic prostate cancer (PC) lesions at low prostate-specific antigen (PSA) values. To facilitate their intraoperative detection during salvage surgery, we recentl...
Source: European Urology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Assessing the Feasibility and Accuracy of High-resolution Microultrasound Imaging for Bladder Cancer Detection and Staging
ConclusionsOur findings showed that mUS is able to differentiate the bladder wall layers and identify the bladder cancer stage. Further studies with a larger population and imaging correlation with MRI are warranted before its introduction in clinical practice.Patient summaryIn this report, a new imaging technique was tested for the characterization of bladder cancer. Microultrasound appears to be feasible and capable of discriminating between superficial and invasive tumors. (Source: European Urology)
Source: European Urology - April 11, 2019 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: May 2019Source: European Urology, Volume 75, Issue 5Author(s): (Source: European Urology)
Source: European Urology - April 11, 2019 Category: Urology & Nephrology Source Type: research

The Platinum Hall of Fame
Publication date: May 2019Source: European Urology, Volume 75, Issue 5Author(s): (Source: European Urology)
Source: European Urology - April 11, 2019 Category: Urology & Nephrology Source Type: research

Contents
Publication date: May 2019Source: European Urology, Volume 75, Issue 5Author(s): (Source: European Urology)
Source: European Urology - April 11, 2019 Category: Urology & Nephrology Source Type: research

Congress Calendar
Publication date: May 2019Source: European Urology, Volume 75, Issue 5Author(s): (Source: European Urology)
Source: European Urology - April 11, 2019 Category: Urology & Nephrology Source Type: research

Three-dimensional Elastic Augmented-reality Robot-assisted Radical Prostatectomy Using Hyperaccuracy Three-dimensional Reconstruction Technology: A Step Further in the Identification of Capsular Involvement
Publication date: Available online 9 April 2019Source: European UrologyAuthor(s): Francesco Porpiglia, Enrico Checcucci, Daniele Amparore, Matteo Manfredi, Federica Massa, Pietro Piazzolla, Diego Manfrin, Alberto Piana, Daniele Tota, Enrico Bollito, Cristian FioriAbstractBackgroundIn prostate cancer (PCa) surgical procedures, in order to maximize potency recovery, a nerve-sparing (NS) procedure is preferred. However, cancer abutting or focally extending beyond the prostate capsule increases the risk of a positive surgical margin.ObjectiveTo evaluate the accuracy of our new three-dimensional (3D) elastic augmented-reality (...
Source: European Urology - April 10, 2019 Category: Urology & Nephrology Source Type: research

The ERUS Curriculum for Robot-assisted Partial Nephrectomy: Structure Definition and Pilot Clinical Validation
Publication date: Available online 9 April 2019Source: European UrologyAuthor(s): Alessandro Larcher, Geert De Naeyer, Filippo Turri, Paolo Dell’Oglio, Umberto Capitanio, Justin W. Collins, Peter Wiklund, Henk Van Der Poel, Francesco Montorsi, Alexandre Mottrie, on behalf of the ERUS Educational Working Group and the Young Academic Urologist Working Group on Robot-assisted SurgeryAbstractBackgroundNo validated training program for robot-assisted partial nephrectomy (RAPN) exists.ObjectiveTo define the structure and provide a pilot clinical validation of a curriculum for robot-assisted partial nephrectomy (RAPN).Desig...
Source: European Urology - April 10, 2019 Category: Urology & Nephrology Source Type: research

Will Favourable Functional Results with Salvage Robot-assisted Laparoscopic Radical Prostatectomy Increase the Uptake of Primary Focal Therapy for Localised Prostate Cancer?
Publication date: Available online 10 April 2019Source: European UrologyAuthor(s): John W. Yaxley (Source: European Urology)
Source: European Urology - April 10, 2019 Category: Urology & Nephrology Source Type: research

APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer
Publication date: Available online 8 April 2019Source: European UrologyAuthor(s): Ming-Jun Shi, Xiang-Yu Meng, Philippe Lamy, A. Rouf Banday, Jie Yang, Aura Moreno-Vega, Chun-Long Chen, Lars Dyrskjøt, Isabelle Bernard-Pierrot, Ludmila Prokunina-Olsson, François RadvanyiAbstractFGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC → TGC), represents an APOBEC-type motif and is probably caused by the APOBEC-mediated mutagenic process, accounting for its over-represe...
Source: European Urology - April 9, 2019 Category: Urology & Nephrology Source Type: research

Solid Science for the Upside but Lack of Solid Science for the Downside—Towards Cutting-edge Prostate-cancer Screening
Publication date: Available online 8 April 2019Source: European UrologyAuthor(s): Gunnar Steineck, Olof Akre, Anna Bill-Axelson (Source: European Urology)
Source: European Urology - April 9, 2019 Category: Urology & Nephrology Source Type: research

Reply to Xueliang Zhou and Xinwei Han's Letter to the Editor re: Thomas Van den Broeck, Roderick C.N. van den Bergh, Nicolas Arfi, et al. Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.10.011
Publication date: Available online 6 April 2019Source: European UrologyAuthor(s): Thomas Van den Broeck, Nicolas Mottet, Thomas Lam (Source: European Urology)
Source: European Urology - April 8, 2019 Category: Urology & Nephrology Source Type: research

End-to-side Somatic-to-autonomic Nerve Grafting to Restore Erectile Function and Improve Quality of Life After Radical Prostatectomy
ConclusionsEnd-to-side nerve grafting restored erectile function in 71% of men with ED following RP, supporting previous findings. Of the men, 94% had clinically relevant improvements in sexual QoL. We recommend multicentre implementation of post-RP nerve grafting into clinical practice with appropriate data collection to confirm its efficacy and feasibility.Patient summaryWe provide confirmatory evidence that end-to-side nerve grafting surgery restored erectile function and improved sexual quality of life in, respectively, 71% and 94% of men with erectile dysfunction following radical prostatectomy. (Source: European Urology)
Source: European Urology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Re: Use of Active Surveillance or Watchful Waiting for Low-risk Prostate Cancer and Management Trends Across Risk Groups in the United States 2010–2015
Publication date: Available online 5 April 2019Source: European UrologyAuthor(s): Ryan P. Werntz, Scott E. Eggener (Source: European Urology)
Source: European Urology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Re: 68Ga-Labeled Prostate-specific Membrane Antigen Ligand Positron Emission Tomography/Computed Tomography for Prostate Cancer: A Systematic Review and Meta-analysis
Publication date: Available online 5 April 2019Source: European UrologyAuthor(s): Mark Frydenberg (Source: European Urology)
Source: European Urology - April 6, 2019 Category: Urology & Nephrology Source Type: research

PARP Inhibitors for Advanced Prostate Cancer: Validating Predictive Biomarkers
Publication date: Available online 4 April 2019Source: European UrologyAuthor(s): Joaquin Mateo, Suzanne Carreira, Johann S. de Bono (Source: European Urology)
Source: European Urology - April 5, 2019 Category: Urology & Nephrology Source Type: research

External Validation of the European Association of Urology Biochemical Recurrence Risk Groups to Predict Metastasis and Mortality After Radical Prostatectomy in a European Cohort
Publication date: Available online 5 April 2019Source: European UrologyAuthor(s): Derya Tilki, Felix Preisser, Markus Graefen, Hartwig Huland, Raisa S. PompeAbstractThe impact of biochemical recurrence (BCR) after radical treatment of prostate cancer on oncological outcomes remains unclear. A new European Association of Urology BCR risk stratification (low and high risk) has been proposed. To validate these risk groups, we retrospectively analyzed data for 1125 post-radical prostatectomy (RP) BCR patients (surgery between 1992 and 2006). Univariable Kaplan-Meier plots and multivariable Cox regression models with time-depen...
Source: European Urology - April 5, 2019 Category: Urology & Nephrology Source Type: research

Re: Radical Prostatectomy or Watchful Waiting in Prostate Cancer—29-Year Follow-up
Publication date: Available online 5 April 2019Source: European UrologyAuthor(s): Xavier Cathelineau, Petr Macek, Rafael Sanchez-Salas (Source: European Urology)
Source: European Urology - April 5, 2019 Category: Urology & Nephrology Source Type: research

Re: Predictors of Long-term Bladder Management in Spinal Cord Injury Patients—Upper Extremity Function May Matter Most
Publication date: Available online 3 April 2019Source: European UrologyAuthor(s): Sean P. Elliott (Source: European Urology)
Source: European Urology - April 3, 2019 Category: Urology & Nephrology Source Type: research

Re: Radical Prostatectomy or Watchful Waiting in Prostate Cancer—29-Year Follow-up
Publication date: Available online 1 April 2019Source: European UrologyAuthor(s): Michael Stöckle (Source: European Urology)
Source: European Urology - April 2, 2019 Category: Urology & Nephrology Source Type: research

Re: Thomas Van den Broeck, Roderick C.N. van den Bergh, Nicolas Arfi, et al. Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.10.011
Publication date: Available online 1 April 2019Source: European UrologyAuthor(s): Xueliang Zhou, Xinwei Han (Source: European Urology)
Source: European Urology - April 2, 2019 Category: Urology & Nephrology Source Type: research

Lifelong Congenital Urology: The Challenges for Patients and Surgeons
ConclusionsLifelong care of congenital problems is challenging and essential for many but not all. Expertise is needed to provide the best care for patients and make the best use of resources. Specialist centres appear to be the most effective and safe model. In the long term it would be ideal to establish an evidence base focused on the common long-term problems with these conditions to ensure excellent care with appropriate expertise.Patient summaryPatients born with complex congenital anomalies of the genitourinary system require specialist care in childhood. Many will need lifelong care to manage their condition and th...
Source: European Urology - March 30, 2019 Category: Urology & Nephrology Source Type: research

Anticholinergic Burden in the Elderly Population: An Emerging Concern
Publication date: Available online 28 March 2019Source: European UrologyAuthor(s): Hudson Pierce, Dominique Thomas, Tirsit Asfaw, Bilal Chughtai (Source: European Urology)
Source: European Urology - March 30, 2019 Category: Urology & Nephrology Source Type: research

Multiparametric Magnetic Resonance Imaging Before Prostate Biopsy: A Chain is Only as Strong as its Weakest Link
Publication date: Available online 29 March 2019Source: European UrologyAuthor(s): Olivier Rouvière, Ivo G. Schoots, Nicolas Mottet, on behalf of the EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guidelines Panel (Source: European Urology)
Source: European Urology - March 30, 2019 Category: Urology & Nephrology Source Type: research

Could Differences in Treatment Between Trial Arms Explain the Reduction in Prostate Cancer Mortality in the European Randomized Study of Screening for Prostate Cancer?
ConclusionsUse of prostate-specific antigen remains the predominant explanation for the reduction in PC mortality seen in the ERSPC trial and is not attributable to differential treatment between trial arms.Patient summaryThis study shows that prostate cancer deaths in the European screening trial (European Randomized Study of Screening for Prostate Cancer) were prevented because men were diagnosed and treated earlier through prostate-specific antigen screening, and not because of different, or better, treatment in the screening arm compared with the control arm. (Source: European Urology)
Source: European Urology - March 28, 2019 Category: Urology & Nephrology Source Type: research

Personalised Medicine for Advanced Urothelial Cancer: What is the Right Way to Identify the Right Patient for the Right Treatment?
Publication date: Available online 28 March 2019Source: European UrologyAuthor(s): Simon J. Crabb (Source: European Urology)
Source: European Urology - March 28, 2019 Category: Urology & Nephrology Source Type: research

Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer
ConclusionsThe presence of two RB1 DNA alterations identified in our WGS analysis was independently associated with poor OS among men with mCRPC. The Wnt/β-catenin pathway plays an important role in enzalutamide resistance, with differential pathway expression and enrichment of β-catenin mutations in enzalutamide-resistant patients. Moreover, β-catenin mutations were predictive of poor OS in our cohort.Patient summaryWe observed a correlation between genomic findings for biopsy samples from metastases from men with metastatic castration-resistant prostate cancer (mCRPC) and clinical outcomes. This work sheds...
Source: European Urology - March 28, 2019 Category: Urology & Nephrology Source Type: research

Reply to Joe O'Sullivan, Daniel Heinrich, Nicholas D. James, et al's Letter to the Editor re: The Case Against the European Medicines Agency's Change to the Label for Radium-223 for the Treatment of Metastatic Castration-resistant Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.11.053
Publication date: Available online 28 March 2019Source: European UrologyAuthor(s): Raya Leibowitz-Amit (Source: European Urology)
Source: European Urology - March 28, 2019 Category: Urology & Nephrology Source Type: research

Re: Paul C.M.S. Verhagen, Egbert R. Boevé. The European Association of Urology Guideline on Renal Cell Carcinoma (RCC) is Not Concise in its Recommendation to Perform Partial Nephrectomy in T1b RCC. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.01.020
Publication date: Available online 25 March 2019Source: European UrologyAuthor(s): Lorenzo Marconi, Karim Bensalah, Axel Bex, on behalf of the European Association of Urology Renal Cell Carcinoma Guideline Panel (Source: European Urology)
Source: European Urology - March 27, 2019 Category: Urology & Nephrology Source Type: research

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment
ConclusionsThere is a temptation to label OAB as “idiopathic” without obvious causation, given the poorly understood nature of its pathophysiology. OAB should be seen as a complex, multifactorial symptom syndrome, resulting from multiple potential pathophysiological mechanisms. Identification of the underlying causes on an individual basis may lead to the definition of OAB phenotypes, paving the way for personalised medical care.Patient summaryOveractive bladder (OAB) is a storage symptom syndrome with multiple possible causes. Identification of the mechanisms causing a patient to experience OAB symptoms may he...
Source: European Urology - March 27, 2019 Category: Urology & Nephrology Source Type: research

Diagnostic Accuracy and Interobserver Agreement for the Vesical Imaging-Reporting and Data System for Muscle-invasive Bladder Cancer: A Multireader Validation Study
In this study we evaluated the interobserver agreement and diagnostic performance of VI-RADS. We retrospectively evaluated data for 74 consecutive patients with bladder cancer who had undergone mp-MRI before transurethral resection in a single institution from January 2010 to August 2018. Five readers assessed the probability of the presence of MIBC using VI-RADS scores. The interobserver agreement was assessed by measuring intraclass correlation coefficients (ICCs). Receiver operating characteristic (ROC) analysis was used to evaluate the MIBC diagnostic performance. The area under the ROC curve (AUC) was estimated for or...
Source: European Urology - March 27, 2019 Category: Urology & Nephrology Source Type: research

RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression
ConclusionsGain of function of BHC80-2 through alternative RNA splicing activates immune responses of cancer cells to promote t-NEPC development.Patient summaryThe main obstacle to develop effective therapies for patients with t-NEPC is the lack of understanding on how t-NEPC is developed. Our study not only identifies a previously unknown BHC80-2-MyD88 signaling pathway that plays an important role during t-NEPC development, but also provides a proof of principle that targeting this signal pathway may offer an avenue to treat t-NEPC. (Source: European Urology)
Source: European Urology - March 24, 2019 Category: Urology & Nephrology Source Type: research

Primary Results from SAUL, a Multinational Single-arm Safety Study of Atezolizumab Therapy for Locally Advanced or Metastatic Urothelial or Nonurothelial Carcinoma of the Urinary Tract
ConclusionsSAUL confirms the tolerability of atezolizumab in a real-world pretreated population with urinary tract carcinoma. Efficacy overall and in the IMvigor211-like subgroup is consistent with previous pivotal anti-PD-L1/PD-1 urothelial carcinoma trials. These results support the use of atezolizumab in urinary tract carcinoma, including patients with limited treatment options.Patient summaryIn this international study we investigated the efficacy and safety of atezolizumab treatment for advanced urinary tract cancer in a large population of pretreated patients, including those who would not normally be candidates for ...
Source: European Urology - March 24, 2019 Category: Urology & Nephrology Source Type: research

Reply to Lorenzo Marconi, Karim Bensalah, and Axel Bex's Letter to the Editor re: Paul C.M.S. Verhagen, Egbert R. Boevé. The European Association of Urology Guideline on Renal Cell Carcinoma (RCC) is Not Concise in its Recommendation to Perform Partial Nephrectomy in T1b RCC. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.01.020
Publication date: Available online 23 March 2019Source: European UrologyAuthor(s): Paul C.M.S. Verhagen, Egbert R. Boevé (Source: European Urology)
Source: European Urology - March 24, 2019 Category: Urology & Nephrology Source Type: research

Reply from Authors re: Ananya Choudhury, Peter J. Hoskin. Predictive Biomarkers for Muscle-invasive Bladder Cancer: The Search for the Holy Grail Continues. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.01.040: Towards Biomarker-Informed Management of Muscle-Invasive Bladder Cancer
Publication date: Available online 23 March 2019Source: European UrologyAuthor(s): Kent W. Mouw, David T. Miyamoto, Jason A. Efstathiou (Source: European Urology)
Source: European Urology - March 24, 2019 Category: Urology & Nephrology Source Type: research

Setting Research Priorities in Partnership with Patients to Provide Patient-centred Urological Cancer Care
Publication date: Available online 23 March 2019Source: European UrologyAuthor(s): Sabrina H. Rossi, Alison Fielding, Christopher Blick, Catherine Handforth, Janet E. Brown, Grant D. Stewart (Source: European Urology)
Source: European Urology - March 24, 2019 Category: Urology & Nephrology Source Type: research

Re: A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy
Publication date: Available online 22 March 2019Source: European UrologyAuthor(s): Fumihiko Urabe, Takahiro Ochiya, Shin Egawa (Source: European Urology)
Source: European Urology - March 22, 2019 Category: Urology & Nephrology Source Type: research

Robot-assisted Radical Prostatectomy After Focal Therapy: Oncological, Functional Outcomes and Predictors of Recurrence
This study represents the largest series of salvage surgery after FT and shows that this approach is safe with no increase in toxicity when compared to primary RALP. Men identified as having infield recurrence after FT appear to have phenotypically aggressive disease and should be counselled regarding the potential need for a multimodal therapeutic approach.Patient summaryRobotic surgery after focal therapy for prostate cancer is safe and achieves postoperative continence results similar to those for robotic radical prostatectomy in treatment-naïve patients. However, if the cancer recurrence is within the previously t...
Source: European Urology - March 22, 2019 Category: Urology & Nephrology Source Type: research

Corrigendum to “Comparison of different techniques for prostate biopsy: Systematic versus cognitive versus software fusion” [Eur Urol Suppl 2018;17(12);e2637]
Publication date: Available online 19 March 2019Source: European UrologyAuthor(s): M. Mokrzyś, A. Lewicki, M. Zagrodzka, M. Pyzlak, J. Ostrowska, K. Sklinda, J. Dobruch (Source: European Urology)
Source: European Urology - March 21, 2019 Category: Urology & Nephrology Source Type: research

Robot-assisted Partial Nephrectomy for Complex (PADUA Score ≥10) Tumors: Techniques and Results from a Multicenter Experience at Four High-volume Centers
ConclusionsIn experienced hands, RAPN can be considered as an effective treatment option even in cases of complex renal lesions. However, increasing tumor complexity may affect the surgical outcomes in this highly selected patient population.Patient summaryWe reported our multicentric experience with robot-assisted partial nephrectomy (RAPN) in patients with complex renal tumors. We demonstrated that, in experienced hands, RAPN is a feasible and safe treatment option even in such patients. Novel technologies applied to RAPN may further extend the indications without compromising the outcomes. (Source: European Urology)
Source: European Urology - March 21, 2019 Category: Urology & Nephrology Source Type: research

Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2
Publication date: Available online 18 March 2019Source: European UrologyAuthor(s): Baris Turkbey, Andrew B. Rosenkrantz, Masoom A. Haider, Anwar R. Padhani, Geert Villeirs, Katarzyna J. Macura, Clare M. Tempany, Peter L. Choyke, Francois Cornud, Daniel J. Margolis, Harriet C. Thoeny, Sadhna Verma, Jelle Barentsz, Jeffrey C. WeinrebAbstractThe Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) was developed with a consensus-based process using a combination of published data, and expert observations and opinions. In the short time since its release, numerous studies have validated the value of PI-RADS v2 but,...
Source: European Urology - March 19, 2019 Category: Urology & Nephrology Source Type: research