Prophylactic effects of alpha-blockers, Tamsulosin and Alfuzosin, on postoperative urinary retention in male patients undergoing urologic surgery under spinal anaesthesia
Conclusion This study suggests that the use of prophylactic tamsulosin or alfuzosin can reduce the incidence of urinary retention and the need for catheterization after urologic surgical procedures under spinal anaesthesia. (Source: International Braz J Urol)
Source: International Braz J Urol - June 30, 2016 Category: Urology & Nephrology Source Type: research
Therapy of calcium oxalate urolithiasis in a rhesus macaque (Macaca mulatta)
Abstract
A rhesus macaque (Macaca mulatta) was presented for anuria. Examination revealed calcium oxalate concrements in the bladder. A cystotomy was performed, and a therapy with alfuzosin was conducted. Over 1 year after the treatment, the rhesus macaque had not shown any more signs of stranguria. This is the first case reporting the successful treatment of urolithiasis in a rhesus macaque. (Source: Journal of Medical Primatology)
Source: Journal of Medical Primatology - May 31, 2016 Category: Research Authors: Theresa Conze, Axel Wehrend, Cornelia Exner, André Kaminiarz Tags: Case Report Source Type: research
A randomized, comparative, open-label study of efficacy and tolerability of alfuzosin, tamsulosin and silodosin in benign prostatic hyperplasia
Conclusion: Alfuzosin, tamsulosin, and silodosin showed similar efficacy in improvement of LUTS secondary to BPH, with good tolerability, acceptability, and minimum hemodynamic adverse effects. Alfuzosin, tamsulosin, and silodosin are comparable in efficacy in symptomatic management of BPH. The occurrence of QTc prolongation in three subjects with tamsulosin in the present study is an unexpected adverse event as there are no reports of QTc prolongation with tamsulosin in any of the previous studies. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 17, 2016 Category: Drugs & Pharmacology Authors: R ManjunathaHP PundarikakshaHR MadhusudhanaJ AmarkumarBK Hanumantharaju Source Type: research
Outcome of α-blockers, with or without methylprednisolone combination, in medical expulsive therapy for lower ureteric stones: A prospective randomised study
Conclusions The combination of alfuzosin or tamsulosin with methylprednisolone seems to be effective and safe for managing lower ureteric stones of <1cm. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - February 7, 2016 Category: Urology & Nephrology Source Type: research
α1-Blockers Improve Benign Prostatic Obstruction in Men with Lower Urinary Tract Symptoms: A Systematic Review and Meta-analysis of Urodynamic Studies
Conclusion ABs improve BOOI in patients with LUTS/BPE mainly by reducing P det Q max, and this effect is higher in patients presenting with urodynamic obstruction at baseline. The free Q max variation underestimates the real effect of ABs on benign prostatic obstruction. Patient summary Results of this meta-analysis suggest that α1-blockers objectively improve urinary voiding function in patients with benign prostatic obstruction. α-Blockers improve the bladder outlet obstruction index in patients with lower urinary tract symptoms suggestive of benign prostate enlargement mainly by reducing detrusor pressure. This eff...
Source: European Urology - January 30, 2016 Category: Urology & Nephrology Source Type: research
Temperature influencing permeation pattern of alfuzosin: An investigation using DoE
Conclusion The method reported here is a simple and useful tool for studying the effect of heat on percutaneous absorption. Such temperature dependent enhancement of flux can be more pronounced at skin surface temperatures >45°C. (Source: Medicina)
Source: Medicina - December 12, 2015 Category: Journals (General) Source Type: research
Effects of alpha1-blockers on urodynamic parameters of bladder outlet obstruction in patients with lower urinary tract symptoms suggestive of benign prostatic enlargement: a review.
Authors: Creta M, Bottone F, Sannino S, Maisto E, Franco M, Mangiapia F, La Rocca R, Imperatore V, Longo N, Vivaldi O, Fusco F
Abstract
α1-adrenergic receptors blockers (ABs) are recommended as first-line medical therapy in men with Lower Urinary Tract Symptoms suggestive of Benign Prostatic Enlargement (LUTS/BPE). Available ABs include: terazosin, doxazosin, tamsulosin, naftopidil, alfuzosin and silodosin. These agents have different profiles of selectivity for α1-adrenergic receptors subtypes. All these agents are efficacious in improving both storage and voiding LUTS. In recent years the efficacy of A...
Source: Minerva Urologica e Nefrologica - November 19, 2015 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Temperature influencing permeation pattern of alfuzosin: An investigation using DoE.
CONCLUSION: The method reported here is a simple and useful tool for studying the effect of heat on percutaneous absorption. Such temperature dependent enhancement of flux can be more pronounced at skin surface temperatures >45°C.
PMID: 26424191 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 2, 2015 Category: Universities & Medical Training Authors: Pattnaik S, Swain K, Rao JV, Varun T, Mallick S Tags: Medicina (Kaunas) Source Type: research
Appropriateness of oral drugs for long-term treatment of lower urinary tract symptoms in older persons: results of a systematic literature review and international consensus validation process (LUTS-FORTA 2014)
Conclusions: dutasteride, fesoterodine and finasteride were classified as beneficial in older persons or frail elderly people (FORTA B). For most drugs, in particular those from the group of α-blockers and antimuscarinics, use in this group seems questionable (FORTA C) or should be avoided (FORTA D). (Source: Age and Ageing)
Source: Age and Ageing - August 24, 2015 Category: Geriatrics Authors: Oelke, M., Becher, K., Castro-Diaz, D., Chartier-Kastler, E., Kirby, M., Wagg, A., Wehling, M. Tags: Systematic Reviews Source Type: research
Decreased urinary glycosaminoglycan excretion following alfuzosin treatment on ureteral stent-related symptoms: a prospective, randomized, placebo-controlled study
The objectives of the study were to evaluate changes in ureteral stent-related symptoms and urinary glycosaminoglycan (GAG) excretion after alfuzosin treatment, and to further investigate the relationship between stent-related symptoms and loss of urinary GAGs. Seventy consecutive patients scheduled for unilateral retrograde ureteroscopy with stent placement were recruited. Patients were randomly assigned to treatment with alfuzosin 10 mg/day or placebo for 3 weeks starting on the third postoperative day. The ureteral stent was removed when treatment stopped. International Prostate Symptom Score (IPSS), visual analog sca...
Source: Urolithiasis - August 4, 2015 Category: Urology & Nephrology Source Type: research
Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study.
CONCLUSIONS: The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group.
PMID: 26126440 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 5, 2015 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
Swellable floating tablet based on spray-dried casein nanoparticles: Near-infrared spectral characterization and floating matrix evaluation
In this study, spray-dried alfuzosin hydrochloride (ALF)-loaded casein (CAS) nanoparticles were successfully used for the preparation of a swellable floating matrix via direct compression. The developed NIR calibration model was able to assess ALF and CAS levels in five different batches of drug-loaded nanoparticles. The calibration and prediction plots exhibited good linearity with correlation coefficients of more than 0.9. The standard error of calibration and cross-validation was less than 5% of the measured values, confirming the accuracy of the model. A linear relationship was obtained correlating the actual drug entr...
Source: International Journal of Pharmaceutics - July 2, 2015 Category: Drugs & Pharmacology Source Type: research
Comparative Effectiveness and Safety of Monodrug Therapies for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: A Network Meta-analysis
In conclusion, α-blockers, 5ARIs, and PDE5-Is are effective for BPH, with doxazosin and terazosin appearing to be the most effective agents. Drug therapies for BPH are generally safe and well-tolerated, with no major difference regarding the overall safety profile. (Source: Medicine)
Source: Medicine - July 1, 2015 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
The beneficial effect of alpha-blockers for ureteral stent-related discomfort: systematic review and network meta-analysis for alfuzosin versus tamsulosin versus placebo
Conclusion:
The alpha-blockers significantly decreased USS and BPS in comparison with placebo. Tamsulosin might be more effective than alfuzosin. (Source: BMC Urology)
Source: BMC Urology - June 24, 2015 Category: Urology & Nephrology Authors: Jong KwonKang ChoCheol OhDong KangHyungmin LeeWon HamYoung ChoiJoo Lee Source Type: research
Alfuzosin Treatment Improves The Rate and Time for Stone Expulsion in Patients with Distal Uretral Stones: A Prospective Randomized Controlled Study
ConclusionAlfuzosin is safe and effective in increasing stone expulsion rates and shortening stone passage times for uncomplicated distal ureteral stones. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 26, 2015 Category: Drugs & Pharmacology Authors: Nouran O. El Said, Lamia El Wakeel, Khaled M. Kamal, Abd El Reheem Morad Tags: Original Research Article Source Type: research
