Enzalutamide in patients with castration-resistant prostate cancer: retrospective, multicenter, real life study.
Authors: Gacci M, Marchioni M, De Francesco P, Natoli C, Calabrò F, Losanno T, Giammartin C, Serni S, Doni L, De Nunzio C, De Tursi M, Valeriani M, Giacinti S, Alvarez-Maestro M, Scarcia M, Ludovico GM, Del Bene G, Simone G, Ferriero M, Tuderti G, Bove P, Laudisi A, Carrieri G, Cormio L, Verze P, La Rocca R, Falsaperla M, Frantellizzi V, Greco F, Di Nicola M, Schips L, Cindolo L Abstract BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) is the final stage of pCa history and represents a clinically relevant phenotype with an elevated burden of mortality. The aim of the present study is to ev...
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Impact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database.
Authors: Ryan ST, Patel DN, Ghali F, Patel SH, Sarkar R, Yim K, Eldefrawy A, Cotta BH, Bradshawh AW, Meagher MF, Hamilton ZA, Murphy JD, Derweesh IH Abstract BACKGROUND: The impact of positive surgical margins (PSM) on outcomes in partial nephrectomy (PN) is controversial. We investigated impact of PSM for patients undergoing PN on overall survival (OS) in different stages of renal cell carcinoma (RCC). METHODS: Retrospective analysis of patients from the US National Cancer Database who underwent PN for cT1a-cT2b N0M0 RCC between 2004-13. Patients were stratified by pathological stage [pT1a, pT1b, pT2a, pT2b, a...
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The performance improvement-score algorithm applied to endoscopic stone. Treatment step 1 protocol.
CONCLUSIONS: Our exploratory study demonstrates that Pi-score can be effectively adapted to EST s1. Our algorithm successfully provided an objective score that equals the average performance improvement scores assigned by of a cohort of experts, in relation to a small amount of training attempts. PMID: 32748615 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Management of erectile disfunction following robot-assisted radical prostatectomy: a systematic review.
CONCLUSIONS: Penile rehabilitation with PDE5i is effective after nerve sparing RARP. The association of PDE5i with vacuum devices could led to a faster recovery. A multimodal approach with pre-operative specific care seems to be effective to fasten erectile function recovery. PMID: 32748616 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Minimally invasive strategies for the treatment of prostate cancer recurrence after radiation therapy: a systematic review.
CONCLUSIONS: Minimally invasive therapeutic options offer promising results in terms of biochemical control in the local recurrence setting. Unfortunately, the absence of high quality and comparative studies makes it difficult to establish which method is the best in terms of oncological and safety outcomes. PMID: 32748617 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The role of metabolic syndrome in high grade prostate cancer: development of a clinical nomogram.
CONCLUSIONS: Metabolic syndrome is highly prevalent in patients at risk of prostate cancer and is particularly associated with high-grade prostate cancer. Our nomogram offers the possibility to include metabolic status in the assessment of patients at risk of prostate cancer to identify men who may have a high-grade form of the disease. External validation is warranted before its clinical implementation. PMID: 32748618 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Radium-223 in mCPRC patients: a large real-life Italian multicenter study.
CONCLUSIONS: This study offers a cross-section of the clinical performance of Radium-223 treatment in a real-world context, confirming on a large scale the effectiveness of Radium-223 in improving the OS and quality of life, along with the preservation of an excellent safety profile. PMID: 32748619 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Retzius-sparing robot-assisted radical prostatectomy versus open retropubic radical prostatectomy: a prospective comparative study with 19-month follow-up.
Authors: Raheem AA, Hagras A, Ghaith A, Alenzi MJ, Elghiaty A, Gameel T, Alowidah I, Ham WS, Choi YD, El-Bahnasy AH, Omar A, El-Bendary M, Rha KH Abstract BACKGROUND: The aim of the present study was to compare the surgical outcomes of retzius-sparing robot-assisted radical prostatectomy (RS-RARP) and open retropubic radical prostatectomy (ORP). METHODS: We included patients with clinically localized prostate cancer who underwent RSRARP or ORP and met our inclusion criteria. We compared the perioperative, oncological, and continence outcomes between both surgical approaches. Continence function was assessed usi...
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot-assisted laparoscopic pyeloplasty in children: a systematic review.
CONCLUSIONS: RALP offers excellent outcomes in the pediatric population. However, there is still a strong need for higher quality evidence in the form of prospective observational studies and clinical trials. The rising of new robotic systems, such as single-port platform, might further enhance the applications of RALP in children. PMID: 32748621 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Functional and oncological outcomes of 3D clampless sutureless laparoscopic partial nephrectomy for renal tumors with low nephrometry score.
CONCLUSIONS: Different techniques has been proposed to reduce WIT. In our experience we found many benefits in an off-clamp procedure: it gives an ischemiarelated advantage, reduces the overall operating time, eliminates the risks associated with the isolation of hilar vassels. In conclusion CSLPN is a safe and effective procedure for selected renal masses; it doesn't increase complication rate and offers excellent functional and oncological outcomes. PMID: 32748622 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 13, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Triggers for delayed intervention in patients with small renal masses undergoing active surveillance: a systematic review.
CONCLUSIONS: The available evidence shows that both tumor-related and patient-related factors are ultimate triggers for DI in patients with SRMs undergoing AS. However, the level of evidence is still low and further research is needed to individualize AS strategies according to both tumor biology and patient-related characteristics and values. PMID: 32734748 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Complications and quality of life of ileal conduit, orthotopic neobladder and ureterocutaneostomy: systematic review of reports using the Clavien-Dindo Classification.
CONCLUSIONS: The use of a standardized system such as CCS improves analyses of literature. However, rigorous patient selection for UD type makes unable a randomized comparison between UDs in terms of complications and QoL impact. PMID: 32734749 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - August 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Four dilation techniques in percutaneous nephrolithotomy: a single-institute comparative analysis.
Authors: Chiancone F, Meccariello C, Fedelini M, Giannella R, Fedelini P Abstract BACKGROUND: The aim of this study was to compare four renal access techniques in percutaneous nephrolithotomy (PCNL). METHODS: A total of 437 patients who underwent PCNL at our Center from January 2015 to December 2019 were included in the analysis. Telescopic metallic coaxial dilation (TMD) was usedin 146 patients, single step balloon dilation (BD) in 98 patients, one-shot dilation with 30 F Amplatz (OS 30F) in 106 patients, and one-shot dilation with 16 F Amplatz (OS 6F) in 87 patients. Primary endpoints were perioperative outco...
Source: Minerva Urologica e Nefrologica - July 10, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Artifacts and abnormal findings may limit the use of asymptomatic volunteers as controls for studies of multi-channel urodynamics.
Authors: Swavely NR, Speich JE, Klausner AP Abstract BACKGROUND: Multi-channel urodynamics is the gold-standard for the evaluation of LUTS. When performing studies to validate new adjuncts to urodynamic testing with control patients undergoing urodynamic investigation there is difficulty in interpretation of urodynamic results in the asymptomatic patient due to artifacts and the invasive nature of the procedure. The purpose of this investigation was to examine urodynamics in asymptomatic volunteers in order to better understand the role of control participants in urodynamic research studies. METHODS: Asymptomat...
Source: Minerva Urologica e Nefrologica - July 10, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Focal irreversible electroporation for localized prostate cancer management: prospective assessment of efficacy and safety.
Authors: Enikeev D, Taratkin M, Morozov A, Shpikina A, Singla N, Rivas JG, Barret E, Glybochko P PMID: 32638576 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 10, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

What is the role of residents during a pandemic?
Authors: Esperto F, Papalia R, Pang KH, Cataldo R, Scarpa RM PMID: 32580536 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 27, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

On-clamp versus purely off-clamp robot-assisted partial nephrectomy in solitary kidneys: comparison of perioperative outcomes and chronic kidney disease progression at two high- volume centers.
Authors: Anceschi U, Brassetti A, Bertolo R, Tuderti G, Ferriero MC, Mastroianni R, Flammia RS, Costantini M, Kaouk J, Leonardo C, Gallucci M, Simone G Abstract BACKGROUND: Minimal literature describes the impact of hilar control on the progression to chronic kidney disease (pCKD) after robotic partial nephrectomy (RPN) in solitary kidneys (SK). The aim of this study was to compare purely off-clamp (ocRPN) vs on-clamp robotic partial nephrectomy (onRPN) in SK and to identify predictors of pCKD at two high-volume centers. METHODS: Between December 2013 and October 2019, 54 patients with SK underwent ocRPN and on...
Source: Minerva Urologica e Nefrologica - June 24, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Is urodynamic evaluation able to change and improve the management of women with idiopathic overactive bladder?
CONCLUSIONS: we showed that OAB management tailored according to the UDS diagnosis results in higher subjective satisfaction if compared with a pharmacological treatment symptoms-based. Our study confirmed a lack of correlation between OAB symptoms and the urodynamically proven diagnosis of detrusor overactivity (DO). It also suggested that UDS can determine the underlying pathophysiology of every woman with OAB syndrome, whether complicated or uncomplicated, allowing treatment to be appropriately tailored with better results. PMID: 32573171 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 24, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Bipolar plasmakinetic transurethral enucleation and resection versus bipolar plasmakinetic transurethral resection for surgically treating large ( ≥ 60 g) prostates: a propensity score-matched analysis with a 3-year follow-up.
CONCLUSIONS: For patients with large (≥ 60 g) prostates, BP-TUERP and BP-TURP are safe options, but the former is a more effective choice in long-term follow-up outcomes. BP-TUERP is related to reduced CT and hemoglobin decrease with more removal of prostatic tissue at the expense of longer OT than BP-TURP. PMID: 32573172 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 24, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The efficacy and safety of the tranexamic acid in reducing blood loss and transfusion requirements during percutaneous nephrolithotomy: a systematic review and meta-analysis of randomized controlled trials.
Authors: Feng D, Zhang F, Liu S, Han P, Wei W Abstract INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is a minimally invasive approach used for large kidney stones. Although tranexamic acid (TA) has the property of reducing perioperative bleeding, the effect of this drug on PCNL is equivocal. This meta-analysis was conducted to determine the efficacy and safety of TA in preventing hemorrhagic complications, transfusion requirements and other perioperative outcomes during PCNL with available randomized-controlled trials (RCTs). EVIDENCE ACQUISITION: We performed a systematic review of the literature according...
Source: Minerva Urologica e Nefrologica - June 24, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Urologic surgery in a safe hospital during the COVID-19 pandemic scenario.
Authors: Papalia R, Cataldo R, Alloni R, Pang KH, Alcini A, Flammia G, Salerno A, Notarangelo MG, Angeletti S, Venditti A, Sommella L, Scarpa RM, Esperto F Abstract The COVID-19 pandemic induced a global emergency that overwhelmed most hospitals around the world. Access to Hospitals has been restricted to selective oncological and urgent patients to minimize surgeries requiring Intensive Care Unit care. All other kind of non- urgent and benign surgeries have been rescheduled. The burden of oncological and urgent cases on the healthcare system has increased. We have been asked to become the referral center for major...
Source: Minerva Urologica e Nefrologica - June 24, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

PSMA PET/CT and staging high risk prostate cancer: a non-systematic review of high clinical impact literature.
CONCLUSIONS: PSMA PET/CT has the potential to become a gold standard in staging high risk prostate cancer, providing clinicians with accurate information on the extent of disease within the prostate and the presence of loco-regional and distant metastatic disease within a single scan. PMID: 32550630 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 20, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The Urothelium, the urinary microbioma and men LUTS: a systematic review.
CONCLUSIONS: The urothelium and the urinary microbiota are still poorly studied in men with LUTS. Most of the evidence and the hypothesis on the relationship between urothelium/urinary microbiota and LUTS comes from animal/in vitro evidence while clinical trials are lacking. These pathways seem interesting even in LUTS pathogenesis in men but their possible role as a new therapeutic target is still an open debate. PMID: 32550631 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 20, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Metastasis-directed therapy and prostate-targeted therapy in oligometastatic prostate cancer: a systematic review.
CONCLUSIONS: We performed a comprehensive overview of the current literature on MDT and PTT. The feasibility of MDT and PTT is supported by several retrospective studies. Nevertheless, there remains a lack of high-quality trials to prove its survival benefits. Results from ongoing prospective trials data are awaited. PMID: 32550632 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 20, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Intracorporeal versus extracorporeal urinary diversion after robotic-assisted radical cystectomy: evidence from a systematic review and pooled analysis of observational studies.
Authors: Feng D, Tang Y, Yang Y, Han P, Wei W Abstract INTRODUCTION: To compare the perioperative, pathological and oncological outcomes of patients undergoing extracorporeal urinary diversion (EUD) and intracorporeal urinary diversion (IUD) following robot-assisted radical cystectomy (RARC). EVIDENCE ACQUISITION: Multiple scientific databases were searched up to January 2020 for comparative studies comparing IUD and EUD. The data was analyzed by Review Manager 5.3. EVIDENCE SYNTHESIS: A total of 9 observational studies comprising 3582 patients were included in the final analysis. We observed that IUD appro...
Source: Minerva Urologica e Nefrologica - June 20, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Laparoscopic radical cystectomy with extracorporeal urinary diversion: an Italian single center experience with 10-year outcomes.
Authors: Bada M, De Concilio B, Crocetto F, Creta M, Silvestri T, Di Mauro M, Celia A PMID: 32550634 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 20, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The role of additional standard biopsy in the MRI-targeted biopsy era.
Authors: Checcucci E, De Cillis S, Piramide F, Amparore D, Kasivisvanathan V, Giganti F, Fiori C, Moore CM, Porpiglia F PMID: 32495611 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - June 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The role of MRI-guided biopsy for diagnosis of prostate cancer; comparison between FUSION and "IN-BORE" approaches.
The role of MRI-guided biopsy for diagnosis of prostate cancer; comparison between FUSION and "IN-BORE" approaches. Minerva Urol Nefrol. 2020 May 26;: Authors: D'agostino D, Casablanca C, Mineo Bianchi F, Corsi P, Romagnoli D, Giampaoli M, Fiori C, Schiavina R, Brunocilla E, Artibani W, Porreca A Abstract BACKGROUND: The aim of the present study is to evaluate the difference in terms of feasibility and detection rate of two magnetic resonance imaging (MRI) guided biopsy approaches (MRI fusion versus "in-bore" MRI) in a single tertiary centre. METHODS: We retrospectively identifi...
Source: Minerva Urologica e Nefrologica - May 29, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

A systematic review and meta-analysis of prognostic impact of different Gleason patterns in ISUP grade group 4.
CONCLUSIONS: GS 4 + 4 in patients with PC was associated with better OS and positive surgical margin rates. It seems likely that there is heterogeneity within ISUP GG 4. However, caution should be exercised in interpreting the conclusions drawn from this study, given the limitations of the study, which include the heterogeneity of the population of interest and the retrospective nature of the primary data evaluated. PMID: 32432435 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - May 22, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Conservative management of urinary incontinence following robot-assisted radical prostatectomy.
CONCLUSIONS: The use of pads is associated with a detrimental effect on quality of life thus active treatment for UI post-RARP are warranted. PFMT has the main advantage to shorten the time for recovery. The use of solifenacin seems to not offer striking advantages in UI following RARP. Future studies should focus on testing the efficacy of these treatments when used after robotic vs. open radical prostatectomy. PMID: 32432436 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - May 22, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Smart learning for urology residents during the COVID-19 pandemic and beyond: insights from a nationwide survey in Italy.
Authors: Claps F, Amparore D, Esperto F, Cacciamani G, Fiori C, Minervini A, Liguori G, Trombetta C, Porpiglia F, Serni S, Checcucci E, Campi R, European Society of Residents in Urology (ESRU) PMID: 32432437 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - May 22, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Do we need an "ad Hoc" informed consent for patients treated in the COVID-19 era? The risk of falling from heroes to zeros.
Do we need an "ad Hoc" informed consent for patients treated in the COVID-19 era? The risk of falling from heroes to zeros. Minerva Urol Nefrol. 2020 May 20;: Authors: Gennari R, Naspro R PMID: 32432438 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - May 22, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

What do patients say about telephone-based urological consultations at the time of the COVID-19 pandemic?
Authors: Cai T, Verze P, Luciani L, Malossini G, Bjerklund Johansen TE, Benettollo PP, Guarrera GM PMID: 32432439 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - May 22, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Triage of functional, female and neuro-urology patients during and immediately after the Covid-19 outbreak.
Authors: Finazzi Agrò E, Farullo G, Balzarro M, Del Popolo G, Giannantoni A, Herms A, Li Marzi V, Musco S, Giammò A, Costantini E PMID: 32400146 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - May 15, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Efficacy of modified radical prostatectomy technique for recovery of urinary incontinence in high-grade prostate cancer.
This study was conducted to evaluate predictive factors of urinary continence recovery after radical prostatectomy (RP) for high-grade prostate cancer (PCa). METHODS: A total of 241 patients with high-grade (Gleason score 8 or 9) PCa who underwent RP in a single Korean center between January 2011 and May 2018 were retrospectively reviewed. Urinary continence was defined as no pads use. Urinary continence was evaluated at 1, 3, 6, and 12 months after RP. Univariate and multivariate analyses were performed to determine the predictive factors of urinary continence recovery after RP. RESULTS: The mean age was 67.6&plus...
Source: Minerva Urologica e Nefrologica - April 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Androgen deprivation therapy prescription, blood and bone-density testing in a French population-based study exploring adherence to the French prostate cancer guidelines.
Authors: Scailteux LM, Balusson F, Oger E, Vincendeau S, Mathieu R Abstract The safety profile of androgen deprivation therapy (ADT) is well known, and cardiovascular and osteoporosis risk factors should be assessed before ADT initiation. In order to examine whether the French Committee of Urologic Oncology prostate cancer (PCa) guidelines were properly followed by clinicians, including urologists, oncologists and radiotherapists, we used a nationwide comprehensive cohort of prostate cancer patients, who were new ADT users in 2011 and were followed up to 2013. Reimbursements for biological examinations and prescrib...
Source: Minerva Urologica e Nefrologica - April 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Biomarkers predicting oncological outcomes of high-risk non-muscle-invasive bladder cancer.
CONCLUSIONS: Despite a long history of attempts to discover accurate biomarkers predicting oncological outcomes for HR NMIBC, contradictory or uncertain findings render the adoption of this ancillary techniques in clinical practice still unlikely. Future attempts should be directed to the development of prospective trials and the definition of standardized cut-off levels to render findings worthy of comparison. PMID: 32298067 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - April 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Active treatment of renal stones in Pelvic Ectopic Kidney: systematic review of literature.
CONCLUSIONS: The choice of approach depends on different factors such as stone size, density and location in accordance with upper urinary tract alterations, kidney anatomy and operator experience. The choice of a retrograde, percutaneous or lap/robot approach should be carefully selected evaluating upper urinary tract anatomy and stone features. PMID: 32298068 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - April 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comprehensive long-term assessment of outcomes following robot-assisted partial nephrectomy for renal cell carcinoma: the ROMe's achievement and its predicting nomogram.
Authors: Brassetti A, Anceschi U, Bertolo R, Ferriero M, Tuderti G, Costantini M, Capitanio U, Larcher A, Antonelli A, Mottrie A, Minervini A, Dell'oglio P, Veccia A, Amparore D, Flammia RS, Lombardo R, De Nunzio C, Benecchi L, Mari A, Porpiglia F, Montorsi F, Kaouk J, Autorino R, Gallucci M, Simone G Abstract BACKGROUND: We proposed a new tool (named ROMe's) to summarize long-term outcomes after partial nephrectomy (PN), identified its predictors and generated a predicting nomogram. METHODS: A retrospective analysis of a multicenter dataset of patients with non-metastatic pT1-3a renal cell carcinoma was perfor...
Source: Minerva Urologica e Nefrologica - April 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Less invasivity for more complex diseases: the new paradigm of the robotic era.
Authors: Campobasso D, Riviere J PMID: 32298070 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - April 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Operative profile, safety and functional outcomes after GreenLight laser prostate surgery: results from a 12 months follow-up multicenter Italian cohort analyses.
Authors: Reale G, Marchioni M, Altieri V, Greco F, De Nunzio C, Destefanis P, Ricciardulli S, Bergamaschi F, Fasolis G, Varvello F, Voce S, Palmieri F, Divan C, Malossini G, Oriti R, Tuccio A, Ruggera L, Tubaro A, Delicato G, Laganá A, Dadone C, De Rienzo G, Ditonno A, Frattini A, Pucci L, Carrino M, Montefiore F, Germani S, Miano R, Schips L, Rabito S, Ferrari G, Cindolo L Abstract BACKGROUND: Over the two past decades, Greenlight laser therapy has been considered a valid alternative for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia/benign prostatic obstru...
Source: Minerva Urologica e Nefrologica - April 15, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Prognostic role of early PSA drop in castration resistant prostate cancer patients treated with abiraterone acetate or enzalutamide.
Authors: Buttigliero C, Tucci M, Sonetto C, Vignani F, Di Stefano RF, Pisano C, Turco F, Lacidogna G, Guglielmini P, Numico G, Scagliotti GV, Di Maio M Abstract BACKGROUND: Previous studies demonstrated a predictive value of prostate-specific antigen (PSA) kinetics for treatment outcome. Our retrospective study evaluates the prognostic role of early PSA drop in metastatic castration resistant prostate cancer (mCRPC) patients receiving abiraterone acetate (AA) or enzalutamide (E). METHODS: All mCRPC patients treated with AA or E at the San Luigi Hospital in Orbassano between 2010 and 2018 and at the Ordine Mauri...
Source: Minerva Urologica e Nefrologica - April 15, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Pure Retroperitoneoscopic Extravesical Standardized Seeable (PRESS) excision of distal ureter and bladder cuff in radical nephroureterectomy: step-by-step technique.
CONCLUSIONS: Herein, we demonstrate a standardized retroperitoneoscopic RNU technique that is safe and reproducible, enabling the visual confirmation of complete BCE and facilitating LND. BCE trifecta should be a routine goal in minimally invasive RNU. Prospective comparison with the standard open surgical technique is warranted. PMID: 32284528 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - April 15, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Is there additional value of 68Ga-PSMA PET/CT in patients with suspicion of prostate cancer despite negative MRI and systematic biopsy?
Authors: Heetman JG, Lavalaye J, Selm SV, van der Hoeven EJ, van Melick HH, van den Bergh RC PMID: 32284529 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - April 15, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Night shift workers refer higher urinary symptoms with an impairment quality of life: a single cohort study.
CONCLUSIONS: Night shift workers presented worst OAB score and poor QL when compared to similar traditional workers. Long-term data on NSWs patients are also needed to further clarify this relationship. PMID: 32284530 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - April 15, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Impact of the COVID-19 pandemic on urology residency training in Italy.
Authors: Amparore D, Claps F, Cacciamani GE, Esperto F, Fiori C, Liguori G, Serni S, Trombetta C, Carini M, Porpiglia F, Checcucci E, Campi R Abstract In the global emergency scenario caused by COVID-19 pandemic, the Urology residents' training might be critically affected. To provide insights on this issue, a 25-items online Survey was sent to all Italian residents one month after the first case of COVID-19 in Italy, to evaluate their routine involvement in "clinical" (on-call duty, outpatient visits, diagnostic procedures) and "surgical" (endoscopic, open and minimally invasive surgery) traini...
Source: Minerva Urologica e Nefrologica - April 9, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Pathways for urology patients during the COVID-19 pandemic.
Authors: Simonato A, Giannarini G, Abrate A, Bartoletti R, Crestani A, De Nunzio C, Gregori A, Liguori G, Novara G, Pavan N, Trombetta C, Tubaro A, Porpiglia F, Ficarra V, Members of the Research Urology Network (RUN) Abstract The public health emergency caused by the Coronavirus Disease 2019 (COVID-19) pandemic has resulted in a significant reallocation of health resources with a consequent reorganization of the clinical activities also in several urological centers. A panel of Italian urologists has agreed on a set of recommendations on pathways of pre-, intra- and post-operative care for urological patients unde...
Source: Minerva Urologica e Nefrologica - April 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Urology practice during COVID-19 pandemic.
Authors: Ficarra V, Novara G, Abrate A, Bartoletti R, Crestani A, De Nunzio C, Giannarini G, Gregori A, Liguori G, Mirone V, Pavan N, Scarpa RM, Simonato A, Trombetta C, Tubaro A, Porpiglia F, Members of the Research Urology Network (RUN) Abstract The severe acute respiratory syndrome coronavirus 2 and the disease it causes, coronavirus disease 2019 (COVID-19) is generating a rapid and tragic health emergency in Italy due to the need to provide assistance to an overwhelming number of infected patients and, at the same time, treat all the non-deferrable oncological and benign conditions. A panel of Italian urologist...
Source: Minerva Urologica e Nefrologica - March 25, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The role of renal biopsy to improve diagnosis and management of small renal masses: are there predictive factors for detective higher diagnostic rate? The first Italian study of 100 cases.
CONCLUSIONS: RTB for SRMs helps establish pre-treatment diagnosis, reduce overtreatment, with a low risk of complications and high diagnostic rate. In our experience, we did not find predictive factors more likely associated with a diagnostic biopsy. PMID: 32182227 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 19, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

64CuCl2 PET/CT as a potential new imaging method in prostate cancer: illusion or reality?
Authors: Cantiello F, Crocerossa F, Cascini GL, Russo GI, Ferro M, Cimino S, Lucarelli G, Damiano R Abstract Copper (Cu) is an essential element for many cellular functions, including proliferation and angiogenesis. High serum Cu levels have been demonstrated in patients with neoplasia as well as high intra-tumoral Cu levels have been reported. Preclinical and clinical evidences suggest its use, in the form of 64Copper chloride (64CuCl2), as metabolic PET tracer in cancer diagnosis and therapy. Specifically, the use of 64CuCl2 in human Prostate Cancer (PCa) evidenced a high uptake of 64CuCl2 in tumoral prostate and...
Source: Minerva Urologica e Nefrologica - March 19, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research