The role of RENAL score in predicting complications after robotic partial nephrectomy.
Authors: Daza J, Okhawere KE, Ige O, Elbakry A, Sfakianos JP, Abaza R, Bhandari A, Eun DD, Hemal AK, Porter J, Badani KK Abstract BACKGROUND: The aim of this study is to evaluate the association between tumor complexity based on RENAL nephrometry score and complications. METHODS: We retrospectively identified 2555 patients who underwent RPN for renal cell carcinoma. Major complication was defined as clavien grade≥3. The relationship between baseline demographic, clinical characteristics, perioperative and postoperative outcomes, and tumor complexity were assessed using Chi-square test of independence, Fisher...
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The timing of initial imaging in testicular cancer: impact on radiological findings and clinical decision making.
CONCLUSIONS: Timing of imaging affects the detection rate of unspecific lymph node enlargements but does not show a significant effect on the rate of adjuvant therapies. PMID: 33439568 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

External validation of SPARE nephrometery score in predicting overall complications, trifecta and pentafecta outcomes following robot-assisted partial nephrectomy.
CONCLUSIONS: Our study validates the SPARE nephrometry scoring system in predicting postoperative complications, trifecta, and pentafecta outcomes in a RAPN cohort. The predictive accuracy of SPARE is similar to RNS. PMID: 33439569 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Health-related quality of life 24-month after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study.
This study analyzes patient health-related quality of life (QoL) 24-month after prostate cancer (PCa) diagnosis within the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study. METHODS: Pros-IT CNR is an ongoing, longitudinal and observational study, considering a convenience sample of patients enrolled at PCa diagnosis and followed at 6, 12, 24, 36, 48 and 60 months from the diagnosis. Patients were grouped according to the treatment received: nerve sparing radical prostatectomy (NSRP), non-nerve sparing radical prostatectomy (NNSRP), radiotherapy (RT), radiotherapy plus androgen ...
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Association of statin use and oncological outcomes in patients with first diagnosis of T1 high grade non-muscle invasive urothelial bladder cancer: results from a multicentre study.
CONCLUSIONS: Statin daily intake do not compromise oncological outcomes in high risk NMIBC patients treated with BCG. Moreover, statin may have a beneficial effect on recurrence rates in this cohort of patients. PMID: 33439571 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Impact of chronic exposure to 5-alpha reductase inhibitors on the risk of hospitalization for COVID-19: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy).
Authors: Lazzeri M, Duga S, Azzolini E, Fasulo V, Buffi N, Saita A, Lughezzani G, Paraboschi EM, Hurle R, Nobili A, Cecconi M, Guazzoni G, Casale P, Asselta R, Humanitas COVID-19 Task Force; The Humanitas Gavazzeni COVID-19 Task Force Abstract BACKGROUND: There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chro...
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Classification and Standardized Reporting of Percutaneous Nephrolithotomy (PCNL): International Alliance of Urolithiasis (IAU) consensus statements.
CONCLUSIONS: The consensus statements will be useful to clarify operative technique, in the design of clinical trials and standardized reporting, and presentation of results to compare outcomes of different types of PCNLs. PMID: 33439573 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Spontaneous ureteral stone passage: a novel and comprehensive nomogram.
CONCLUSIONS: Our novel nomogram can be used as a predictor for SSP and can be used clinically in decision making. PMID: 33439574 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis.
Authors: Afferi L, Abufaraj M, Soria F, D'Andrea D, Xylinas E, Seisen T, Roupret M, Lonati C, De la Taille A, Peyronnet B, Laukhtina E, Pradere B, Mari A, Krajewski W, Alvarez-Maestro M, Kikuchi E, Shigeta K, Chlosta P, Montorsi F, Briganti A, Simone G, Ornaghi PI, Cerruto MA, Antonelli A, Matsumoto K, Karakiewicz PI, Mordasini L, Mattei A, Shariat SF, Moschini M Abstract BACKGROUND: Radical nephroureterectomy (RNU) with the concomitant excision of the distal ureter and bladder cuff is the current standard of care for the treatment of muscle invasive and/or high-risk upper tract urothelial carcinoma (UTUC). In smal...
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comparison of outcomes between laparoscopic and robot-assisted partial nephrectomy for complex renal tumors (RENAL score ≥ 7 or maximum tumor size > 4cm): a systematic review and meta-analysis.
Comparison of outcomes between laparoscopic and robot-assisted partial nephrectomy for complex renal tumors (RENAL score ≥ 7 or maximum tumor size> 4cm): a systematic review and meta-analysis. Minerva Urol Nefrol. 2021 Jan 13;: Authors: Lin P, Wu M, Gu H, Tu L, Liu S, Yu Z, Chen Q, Liu C Abstract INTRODUCTION: We reviewed current studies and performed a meta-analysis to compare outcomes between laparoscopic partial nephrectomy (LPN) and robot-assisted partial nephrectomy (RAPN) treating complex renal tumors (RENAL score ≥ 7 or maximum clinical tumor size> 4cm). EVIDENCE ACQUISITION: Usi...
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Molecular biomarkers in the context of focal therapy for prostate cancer: recommendations of a Delphi Consensus from the Focal Therapy Society.
CONCLUSIONS: The present study detailed an initial consensus on the use of MB in FT for PCa. This is until evidence becomes available on the subject. PMID: 33439577 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

A systematic review of nerve-sparing surgery for high-risk prostate cancer.
CONCLUSIONS: NSS may provide benefits for patients with urinary continence and significantly improves EF in high-risk patients. Moreover, it is not associated with an increased risk of relapse in short- and middle-term follow-up. However, the advantages of using such a surgical technique are unclear. PMID: 33439578 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Totally intracorporeal robotic ileal ureter replacement: focus on surgical technique and outcomes.
CONCLUSIONS: Robotic ileal ureter replacement can be performed completely intracorporeal with optimal results and limited complication rate, in selected cases. According to our considerations, specific surgical steps are needed to reduce the risks related to this procedure, including avoiding partial ileal substitution. PMID: 33439579 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 14, 2021 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Trimodal therapy in muscle invasive bladder cancer management.
CONCLUSIONS: Published data and clinical experience strongly support trimodal therapy as an acceptable bladder sparing strategy in terms of oncological outcomes and quality of life in selected patients with MIBC. A strong need exists for specialized centers, to increase awareness among urologists, to discuss these options with patients and to stress the increased participation of patients and their families in treatment path decision-making. PMID: 33263367 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 4, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Percutaneous tumor ablation versus partial nephrectomy for small renal mass: the impact of histologic variant and tumor size.
Authors: Bianchi L, Mineo Bianchi F, Chessa F, Barbaresi U, Casablanca C, Piazza P, Mottaran A, Droghetti M, Roveroni C, Balestrazzi E, Gentile G, Gaudiano C, Bertaccini A, Marcelli E, Porreca A, De Concilio B, Serra C, Celia A, Brunocilla E, Schiavina R Abstract BACKGROUND: To investigate recurrence rates in patients with T1 renal cell carcinoma (RCC) undergone partial nephrectomy (PN), radiofrequency ablation (RFA) or cryoablation (Cryo). METHODS: We retrospectively evaluated data from 665 (81.4%), 68 (8.3%) and 83 (10.3%) patients who underwent PN, RFA and Cryo, respectively. Kaplan-Meier curves depict recur...
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Predictive factors for opioid-free management after robotic radical prostatectomy: the value of the SP ® Robotic Platform.
The objective was to evaluate perioperative factors associated with opioid-free management after robotic radical prostatectomy in a single institution. METHODS: From January 2019 to January 2020, data from patients who underwent robotic radical prostatectomy was retrospectively entered in a pre-approved IRB database. Data were analyzed according to the postoperative opioid administration in hospital and/or after discharge. Robotic radical prostatectomy was performed using either the standard multi-port Da Vinci Si robotic platform with a transperitoneal approach(MP-RALP) or the novel DaVinci SP® robotic platform wi...
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Development and validation of a simple stone score (SSS) to estimate the probability of residual stones prior to percutaneous nephrolithotomy.
Authors: M Harraz A, El-Nahas AR, Nabeeh MA, Laymon M, Sheir KZ, El-Kappany HA, Osman Y Abstract BACKGROUND: The purpose is to develop and internally validate a simple stone score (SSS) to estimate the probability of clinically significant residual fragments (CSRF) prior to percutaneous nephrolithotomy (PNL). METHODS: The files of 1170 PNL procedures between January and December 2015 were evaluated. CT-derived stone characteristics were examined. Caliceal stone distribution (CSD) was assigned three grades based on the number of calices involved regardless of the renal pelvis (I: no or single calix; II: more tha...
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The surgical learning curve for salvage robot-assisted radical prostatectomy: a prospective single-surgeon study.
CONCLUSIONS: Our data may suggest a decreasing trend in terms of OT and EBL through the sRARP learning curve. While morbidity remained stable through the time, radiographic anastomotic leaks trended towards a decline. A higher degree of NS was observed through the groups and there was a slight correlation trend between surgical expertise and potency recovery. PSM and GS 8-10 were predictors of BCF and non-radiation primary treatment predicted a better continence after sRARP. PMID: 33256361 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The invisible impact of COVID-19: indirect mortality in urology.
Authors: Sánchez-González JV, Colet O, Gómez-Palomo F, Pérez-Ardavin J, Bernal A, Boronat F PMID: 33256362 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Non-papillary percutaneous nephrolithotomy for treatment of staghorn stones.
CONCLUSIONS: The use of non-papillary access for PCNL in the treatment of staghorn stones resulted in promising results in terms of stone-free rate, operating time, complication rate, hemoglobin drop and reduced the number of percutaneous tracts. These parameters of the current investigation were directly comparable to current literature. The safety and efficacy of a non-papillary approach for the treatment of staghorn stones could be advocated. PMID: 33256363 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robotic repair of iatrogenic ureteral stricture after pelvic surgery: a changing treatment paradigm.
Authors: Sforza S, Tellini R, Grosso AA, Di Maida F, Mari A, Cocci A, Cito G, Carini M, Minervini A, Masieri L PMID: 33256364 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The impact of anticoagulant and antiplatelet drugs therapy on perioperative outcomes of purely off-clamp robot-assisted partial nephrectomy: a single-center experience.
Authors: Anceschi U, Brassetti A, Torregiani G, Tuderti G, Costantini M, Mastroianni R, Bove AM, Ferriero MC, Gallucci M, Simone G PMID: 33256365 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Intravesical ureteral stent position is highly variable over time and with patient position: an analysis of 1'466 radiographic images.
Authors: Tekin AC, Pratsinis M, Zumstein V, Güsewell S, Schmid HP, Abt D, Betschart P PMID: 33256366 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comparing the risk of cardiovascular disease following GnRH agonist and GnRH antagonist therapy for patient with prostate cancer: a systematic review and meta-analysis.
CONCLUSIONS: This meta-analysis indicates that compared treatment with GnRH antagonist, risks of CVD in PCa patients was the same as GnRH agonist. Further RCTs are strongly required to provide more definitive evidence. PMID: 33242948 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 28, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Perioperative and oncologic outcomes of open radical nephrectomy and inferior vena cava thrombectomy with liver mobilization and Pringle maneuver for Mayo III level tumor thrombus: single institution experience.
CONCLUSIONS: We reported surgical techniques, intra and perioperative complications and follow-up in the largest cohort of RCC patients requiring LM and PM. PMID: 33242949 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 28, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Postoperative outcomes of Fast Track enhanced recovery protocol in open radical cystectomy: comparison with standard management in a high-volume center and Trifecta proposal.
Authors: Ercolino A, Droghetti M, Schiavina R, Bianchi L, Chessa F, Mineo Bianchi F, Barbaresi U, Angiolini A, Casablanca C, Mottaran A, Molinaroli E, Pultrone C, Dababneh H, Bertaccini A, Brunocilla E Abstract BACKGROUND: We aimed at comparing perioperative outcomes in patients submitted to radical cystectomy followed by Fast Track (FT) protocol or standard management, and propose a definition of Trifecta, to improve standardized quality assessment for RC. METHODS: We considered 191 patients submitted to RC between January 2017 and January 2019. Patients followed FT or standard management according to surgeon'...
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The waiting time for prostate cancer treatment in Italy: analysis from the Pros-IT CNR study.
CONCLUSIONS: In our study age, clinical T stage and provenance from Southern regions of Italy are associated with a WT> 90 days. WT might have no impact on functional and oncological outcome. PMID: 33200896 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Impairment of autophagy may represent the molecular mechanism behind the relationship between obesity and inflammation in patients with BPH and LUTS.
Authors: De Nunzio C, Giglio S, Baldassarri V, Cirombella R, Mallel G, Nacchia A, Tubaro A, Vecchione A Abstract BACKGROUND: Aim of this study was to evaluate the roles of inflammation and autophagy in obese patients with Benign prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS). METHODS: We analyzed 150 surgical specimens from patients underwent Transurethral Resection of the Prostate (TURP) for LUTS/BPH (Median age 70.3±8.1 years, Median BMI 25.7±4.0 kg/m2 and median PSA 6.0±5.4 ng/ml). All surgical specimens were investigated for the presence inflammatory infiltrates, ac...
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The impact of anterior calyceal stones on the outcomes of percutaneous nephrolithotomy for complex kidney stones: a comparative study.
CONCLUSIONS: The presence of complex kidney stones with anterior calyceal extension are associated with higher residual stones rates in the anterior calyx. Also, it increases multiple access, the operation time, and level of hemoglobin drop. PMID: 33200898 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Holmium laser enucleation of prostate versus minimally invasive simple prostatectomy for large volume ( ≥ 120 ml) prostate glands: a prospective multicenter randomized study.
CONCLUSIONS: This prospective randomized study is the first to compare extraperitoneal LSP, RASP and HoLEP in the treatment of LUTS secondary to benign prostatic hyperplasia for prostate volumes ≥ 120 ml. Our findings confirm the safety and efficacy of MISP, demonstrating its equivalence in functional outcomes and perioperative morbidity in comparison to HoLEP. PMID: 33200899 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot-assisted versus open surgery for radical nephrectomy with level 1-2 vena cava tumor thrombectomy : a French monocenter experience (UroCCR study #73).
Authors: Vuong NS, Ferriere JM, Michiels C, Calen L, Tesi L, Capon G, Bensadoun H, Alezra E, Estrade V, Robert G, Bladou F, Bernhard JC Abstract BACKGROUND: To assess the feasibility of Robot-assisted Radical nephrectomy with Inferior Vena Cava Thrombectomy (RRVCT) and compare peri operative and oncological outcomes of this approach to open surgery for renal tumors with Level 1-2 Inferior Vena Cava (IVC) Thrombus. METHODS: We performed a retrospective analysis of patients surgically treated for renal cancer with IVC level 1-2 thrombus in the Urology department of Bordeaux University Hospital between December 20...
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Single overnight stay after robot-assisted partial nephrectomy: a bi-center experience.
Authors: Carbonara U, Lee J, Crocerossa F, Veccia A, Hampton LJ, Eun D, Autorino R Abstract BACKGROUND: Despite hospital length of stay (LOS) being shorter for robot-assisted partial nephrectomy (RAPN) compared to its open counterpart, several series in the literature report on average a LOS of 2-3 days or more. We aimed to assess factors predicting a prolonged length of stay (beyond a single overnight stay) in patients undergoing RAPN. METHODS: Patients who underwent RAPN between 2010 and 2019 at two U.S. Centers were included and divided into two groups according to LOS: the study group included all patients ...
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Evaluating the utility of antibiotic prophylaxis prior to ESWL in patients with sterile urine: a systematic review and meta-analysis.
CONCLUSIONS: AP is not necessary for patients with sterile urine prior to ESWL for the prevention of UTI. Also, patients that undergo instrumentation of the urinary tract prior to or during ESWL do not benefit from antibiotic prophylaxis but further research is required. PMID: 33200902 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Computed tomography features predicting aggressiveness of malignant parenchymal renal tumors suitable for partial nephrectomy: a review.
CONCLUSIONS: Tumor size, enhancement characteristics, tumor margins and distance to the renal sinus are highly relevant CT features predicting biological aggressiveness of malignant parenchymal renal tumors. Combination of these parameters might be useful to generate tools to predict the unfavorable behavior of renal tumors suitable for PN. PMID: 33200903 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Ultrasound prostate parameters as predictors of successful trial without catheter after acute urinary retention in patients ongoing medical treatment for benign prostatic hyperplasia: a prospective multicenter study.
Authors: De Nunzio C, Voglino O, Cicione A, Tema G, Cindolo L, Bada M, Lombardo R, Nacchia A, Trucchi A, Schips L, Gacci M, Milanesi M, Cito G, Serni S, Tubaro A Abstract BACKGROUND: Alpha-blockers (ABs) are considered the standard treatment after initial management of acute urinary retention (AUR). However, no data are available on the predictors of a successful trial without catheter (TWOC) in patients previously on treatment with ABs and 5alpha reductase inhibitors (5ARI). Aim of our study was to investigate prostate ultrasound parameters as predictors of TWOC outcome. METHODS: A consecutive series of patien...
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Outcomes of combination therapy with daily Tadalafil 5mg plus Tamsulosin 0.4mg to treat lower urinary tract symptoms and erectile dysfunction in men with or without metabolic syndrome.
CONCLUSIONS: Patients with MetS have worse LUTS and ED profiles. However, tadalafil plus tamsulosin combination treatment provided them a similar ED profile and a greater relief of OAB symptoms at the end of the trial. Combination therapy had the same safety profile in men besides MetS. Further randomized controlled trials are needed. PMID: 33200905 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The importance of anatomical reconstruction for continence recovery after robot assisted radical prostatectomy: a systematic review and pooled analysis from referral centres.
Authors: Checcucci E, Pecoraro A, De Cillis S, Manfredi M, Amparore D, Aimar R, Piramide F, Granato S, Volpi G, Autorino R, Fiori C, Porpiglia F Abstract INTRODUCTION: Urinary incontinence is one of the most scared sequelae of robot assisted radical prostatectomy (RARP). Therefore, different surgical modifications, aimed to restore the original anatomy, were proposed to overcome this issue. The purpose of this study is to assess which is the best reconstruction technique (posterior only: PR; anterior only: AR; total: TR) compared to the standard approach for continence recovery after RARP in a tertiary care centre....
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot-assisted partial nephrectomy: 7-year outcomes.
CONCLUSIONS: Our findings show excellent 7-year oncologic and functional outcomes of the procedure, which duplicate those achieved in historical series of open and laparoscopic surgery. PMID: 33200907 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 18, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Penile prosthesis implant in the management of Peyronies' disease: a systematic review of the literature.
CONCLUSIONS: Overall, patients with PD and ED can expect excellent outcomes with PPI against a minimal risk of side effects. No definite conclusions can be made regarding which technique is superior. PMID: 33179867 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 14, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Fusion US/MRI prostate biopsy using a Computer Aided Diagnostic (CAD) system.
Authors: Ferriero M, Anceschi U, Bove AM, Bertini L, Flammia RS, Zeccolini G, De Concilio B, Tuderti G, Mastroianni R, Misuraca L, Brassetti A, Guaglianone S, Gallucci M, Celia A, Simone G Abstract BACKGROUND: To investigate the impact of Computer Aided Diagnostic (CAD) system on the detection rate of prostate cancer (PCa) in a series of fusion prostate biopsy (FPB). METHODS: Two prospective transperineal FPB series (with or without CAD assistance) were analyzed and PCa detection rates compared with per patient and per target analyses. Chi-Square and Mann-Whitney test were used to compare categorical and contin...
Source: Minerva Urologica e Nefrologica - November 14, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The revolution of congress meetings and scientific events: how to navigate among their heterogeneous modalities?
Authors: Porpiglia F, Amparore D, Checcucci E, Fiori C, Artibani W, Scarpa RM PMID: 33034431 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 10, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot-assisted radical cystectomy with intracorporeal neobladder: impact of learning curve and long-term assessment of functional outcomes.
Authors: Tuderti G, Mastroianni R, Brassetti A, Bove AM, Misuraca L, Anceschi U, Ferriero M, Gallucci M, Simone G Abstract BACKGROUND: There is paucity of data about functional outcomes of Robot-assisted Radical Cystectomy (RARC) with intracorporeal orhotopic neobladder (ICON), and the impact of learning curve (LC) on those outcomes remains to be addressed. We aimed to report long-term functional outcomes of our single center series of RARC with ICON, assessing the role of LC in their achievement. METHODS: Patients treated with Robot assisted radical cystectomy with intracorporeal orthotopic neobladder in our c...
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Semi-closed-circuit vacuum-assisted mini percutaneous nephrolithotomy in the pediatric population: the initial experience of two tertiary referral centers.
CONCLUSIONS: The vmPCNL seems to be sustainable, safe and feasible for kidney stones treatment in the pediatric population. PMID: 33016029 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comparison of multiple abbreviated multiparametric MRI-derived protocols for the detection of clinically significant prostate cancer.
CONCLUSIONS: Among multiple abbreviated mpMRI-derived protocols, cesMRI was the one equaling mpMRI in terms of csPCa detection and minimizing PI-RADSv2 category 3 assignments. PMID: 33016030 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Prone versus supine PNL: a systematic review and metaanalysis of current literature.
CONCLUSIONS: Efficacy of PNL seems balanced between prone and supine position, with comparable overall SFR and shorter operative time in favor of supine PNL. Safety of PNL appears in favor of supine PNL, with lower fever rate. Because of study heterogeneity and possible risks of outcome bias, results from this study should be interpreted with caution. Altogether, both prone and supine PNL account for appropriate therapy options. PMID: 33016031 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Is androgen deprivation therapy protective against SARS-CoV-2 infection and related complications in prostate cancer patients?
Authors: Dalla Volta A, Valcamonico F, Zamboni S, Ferrari VD, Grisanti S, Simeone C, Berruti A PMID: 33016032 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Fluoroless versus conventional ureteroscopy for urinary stones: a systematic review and meta-analysis.
CONCLUSIONS: Fluoroless URS is equally safe and effective to conventional URS procedure with zero radiation exposure. However, it needs to be cautiously conducted in selected patients and fluoroscopy equipment should always be available intraoperatively. PMID: 33016033 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The train has already left the station: analyzing the rise of PSMA PET/CT as new standard for staging high risk prostate cancer.
Authors: Albisinni S, Diamand R, De Nunzio C PMID: 33016034 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 6, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Active surveillance for small renal masses in elderly patients does not increase overall mortality rates compared to primary intervention: a propensity score weighted analysis.
Authors: Marchioni M, Cheaib JG, Takagi T, Pavan N, Antonelli A, Everaerts W, Heck M, Rha KH, Mottrie A, Kaouk J, Capitanio U, Lima E, Veccia A, Crivellaro S, Linares E, Celia A, Porpiglia F, Autorino R, Di Nicola M, Schips L, Pierorazio PM, Mir MC Abstract BACKGROUND: To test the effect of active surveillance (AS) versus primary intervention (PI) on overall mortality (OM) in elderly patients diagnosed with SRM. METHODS: Elderly patients (75 years or older) diagnosed with SRMs (
Source: Minerva Urologica e Nefrologica - October 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Systematic review of neoadjuvant therapy by Immune checkpoint inhibitors before radical cystectomy: where do we stand?
CONCLUSIONS: Pembrolizumab and Atezolizumab single-agent demonstrated favorable results for ICI in the neoadjuant setting. Patients with a higher tumor expression of PD-1 and PD-L1 appear to experience a higher response to ICI, although the adequate biomarker remains to be identified. Radical cystectomy appears to be safe after ICI treatment. The results of the currently ongoing prospective trial are awaited with impatience by the urooncologic community. PMID: 32993274 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research