Incidence, predictive factors and survival outcomes of incidental prostate cancer in patients who underwent radical cystectomy for bladder cancer.
Authors: Claps F, Pavan N, Umari P, Rizzo M, Barbone F, Giangreco M, Liguori G, Mir CM, Bussani R, Trombetta C Abstract BACKGROUND: To analyze the incidence, preoperative findings, pathological features and prognosis in patients with incidental prostate cancer (iPCa) detected at radical cystectomy (RC) for bladder cancer (BCa). METHODS: We retrospectively reviewed data of patients who underwent RC for BCa at our Institution between January 2005 and March 2018. Data regarding patient's history, preoperative digital rectal examination (DRE), total serum PSA level were collected from the chart review. Univariable ...
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Neoadjuvant vs adjuvant chemotherapy for muscle-invasive bladder cancer: a propensity matched analysis.
Authors: Jue JS, Koru-Sengul T, Miao F, Velásquez MC, Sávio LF, Alameddine M, Kroeger ZA, Punnen S, Parekh DJ, Ritch CR, Gonzalgo ML Abstract BACKGROUND: We compared survival outcomes among patients who received either NAC or AC and RC. METHODS: We identified patients in the National Cancer Data Base (NCDB) diagnosed with clinical T2-T4, N0, M0 urothelial carcinoma who underwent RC. Patients who received NAC were propensity matched by age, race, ethnicity, sex, insurance type, academic/research program, comorbidity, and clinical stage to patients receiving AC within 90 days of RC. Median survival ...
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Detrusor overactivity and underactivity: implication for lower urinary tract symptoms related to benign prostate hyperplasia diagnosis and treatment.
CONCLUSIONS: In patients with DUA or DO, surgery for LUTS/BPH provides overall good results. However, a number of factors can affect these outcomes. PMID: 32026666 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Impact of urodynamic evaluation on the treatment of women with idiopathic overactive bladder: a systematic review.
CONCLUSIONS: UDS can have a useful role in the diagnosis of idiopathic OAB in women given the possibility to gain a precise diagnosis and, therefore, a tailored treatment based on the underlying cause. The integration of clinics with UDS and all the other diagnostic available tools is desirable. PMID: 32026667 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Thulium-laser Retrograde Intra Renal Ablation (T-RIRA) of upper urinary tract transitional cell carcinoma: an ESUT study.
CONCLUSIONS: On the short term, thulium Laser ablation of UTUC is safe and feasible especially in lowgrade UTUC. PMID: 32026668 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Clinical predictors and significance of adherent perinephric fat assessed with Mayo Adhesive Probability (MAP) score and Perinephric Fat Surface Density (PnFSD) at the time of partial nephrectomy for localized renal mass. A single high-volume referral centre experience.
Authors: Di Maida F, Vittori G, Campi R, Mari A, Tellini R, Sforza S, Sessa F, Lucarini S, Miele V, Vignozzi L, Masieri L, Carini M, Minervini A Abstract INTRODUCTION: Adherent perinephric fat (APF) could negatively influence surgical outcomes of partial nephrectomy (PN). Novel radiological scores have been introduced to preoperatively detect APF, i.e. Mayo Adhesive Probability (MAP) score and Perinephric Fat Surface Density (PnFSD). We aimed to evaluate clinical predictors of APF and the association of MAP and PnFSD with perioperative outcomes after PN. METHODS: Clinical and radiological data of patients under...
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

En-bloc endoscopic enucleation of the prostate: a systematic review of the literature.
CONCLUSIONS: En bloc endoscopic enucleation of the prostate has been shown to be technically feasible and safe, with potential technical advantages over the classic three-lobe technique. Larger comparative studies are needed to evaluate the ultimate impact of the en-bloc approach on postoperative outcomes, in light of the surgeon's learning curve. PMID: 32026670 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 8, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

En-bloc resection of bladder tumors (ERBT) for pathological staging: the value of lateral margins analysis.
CONCLUSIONS: ERBT may improve the pathological report of bladder tumor. There was a trend toward increased rate of recurrence in patients with dysplasia or malignancy in their lateral margins; however, this was not statistically significant on multivariate analysis. Further studies with larger sample sizes are required to assess the value of lateral margin analysis. PMID: 32003203 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Incidental prostate cancer after transurethral resection of the prostate: analysis of incidence and risk factors in 458 patients.
CONCLUSIONS: In a contemporary cohort of patients undergoing TURP for the treatment of LUTS, the risk of IPCA was not negligible with a rate of being 6,6%. BMI and serum leukocyte count were found to be independent factors that were positively associated with the risk of IPCA. PMID: 32003204 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

What urologists need to know about male to female genital confirmation surgery (vaginoplasty): techniques, complications and how to deal with them.
Authors: Drinane JJ, Santucci R Abstract Vaginoplasty is the most commonly performed genital surgery for gender affirmation. Male-to- female (MTF) patients are roughly four times more likely to undergo genital surgery than female-to-male (FTM) patients. Penile inversion vaginoplasty is the most common technique used today, although there are also lesser used alternative methods including visceral interposition and pelvic peritoneal vaginoplasty. In general, outcomes are excellent, and many of the complications are self-limited. Most surgeons performing genital surgery for gender dysphoria adhere to the World Profes...
Source: Minerva Urologica e Nefrologica - February 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

How to manage a partial detachment of the ureter - too close to the anastomosis line- during robotic radical prostatectomy?
We present a technique to ensure the successful outcome in cases of a partial detachment of the ureter during RARP. When the orifice is identified after the incision of the bladder neck and it appears very close to the anastomosis line setting up a partial detachment of the ureter, before implanting a DJ stent, one tip could be to perform a small incision of the anterior wall of the orifice to spatulate it and then proceeding to a short slip of the ureter: the eversion of the mucosa - creating a sort of "folded shirt cuff"- allows the fixation of the ureter to the bladder wall. We successfully performed this tech...
Source: Minerva Urologica e Nefrologica - February 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The optimal core number and site for MRI-targeted biopsy of prostate? A systematic review and pooled analysis.
CONCLUSIONS: Increasing the number of samples per target from one to two, or two to three resulted in a nonnegligible incremental detection rate of clinically significant lesions, while obtaining more than 3 cores per target provided a diminished incremental value. And performing targeted cores accurately through center of the lesions may help improve diagnostic accuracy. PMID: 32003207 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 2, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Role of prostate specific antigen and prostate specific antigen density as biomarkers for medical and surgical treatment response in men with lower urinary tract symptoms: a systematic review and meta-analysis.
Authors: Corona G, Salvi M, Sebastianelli A, Bossa R, Vignozzi L, Maggi M, De Nunzio C, Serni S, Gratzke C, Gravas S, Gacci M Abstract INTRODUCTION: Prostate specific antigen and Prostate specific antigen-density are used for the initial evaluation of patient with LUTS due to benign prostatic enlargement in order to discriminate between benign conditions and prostate cancer. Conversely, the role of these markers during the follow up of benign prostatic enlargement patients is still unclear. The aim of our study is to evaluate the role of PSA and PSAD as outcome parameter for both medical and surgical treatment in p...
Source: Minerva Urologica e Nefrologica - January 12, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study).
Authors: Antonelli A, Palumbo C, Noale M, Artibani W, Bassi P, Bertoni F, Bracarda S, Bruni A, Corvò R, Gacci M, Magrini SM, Montironi R, Porreca A, Tubaro A, Zagonel V, Maggi S, and the Pros-IT CNR study group Abstract BACKGROUND: We assessed patients and tumor characteristics, as well as health-related quality of life (HRQoL) items, associated with curative intent treatment decision-making in clinically localized prostate cancer (PCa) patients. METHODS: Clinically localized PCa treated with either radical prostatectomy (RP) or radiation therapy (RT) within 12 months from diagnosis were abstracted from ...
Source: Minerva Urologica e Nefrologica - January 12, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Efficacy and safety of renal drainage options for percutaneous nephrolithotomy.
CONCLUSIONS: Tubeless PCNL encompasses lower morbidity and should be considered as an option for select patients, particularly with less stone burden and uncomplicated procedures. Regarding ureteral stents, SL is a safe option and does not require further procedures for removal. PMID: 31920064 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 12, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The utilization status of neoadjuvant chemotherapy in muscle-invasive bladder cancer: a systematic review and meta-analysis.
Authors: Liu W, Tian J, Zhang S, Yang E, Shen H, Li F, Li K, Zhang T, Wang H, Svatek RS, Rodriguez R, Wang Z Abstract INTRODUCTION: To give a comprehensive depiction of the utilization status of neoadjuvant chemotherapy (NAC) in muscle invasive bladder cancer (MIBC) worldwide. EVIDENCE ACQUISITION: Potential relevant research papers of Pubmed, Embase, Web of Science, and the Cochrane Library were reviewed to identify eligible studies. Primary outcomes of this meta-analysis were utilization rate of NAC and its utility distribution in different genders, races, ages, countries and temporal trends. The utilization ...
Source: Minerva Urologica e Nefrologica - January 12, 2020 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Is there a clinical role for Frozen Section Analysis during partial nephrectomy? A multicenter experience over 10 years.
Authors: Bozzini G, Seveso M, Romero Otero J, Osmolorskij B, Garcia Cruz E, Margreiter M, Verze P, Besana U, Buizza C Abstract BACKGROUND: Frozen section analysis (FSA) is frequently performed during partial nephrectomy (PN). We investigate the utility of intraoperative FSA by evaluating its impact on final surgical margin (SM) status. METHODS: Between January 1995 and December 2005 we prospectively analysed a series of patients who were treated with open PN for Renal Cell Carcinoma. During PN each patient underwent a FSA on renal parenchyma distal margin . If FSA was positive for infiltration a deeper excision...
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Prospective evaluation of urinary steroids and prostate carcinoma-induced deviation: preliminary results.
CONCLUSIONS: Three USP steroids resulted significantly altered in our PCa population. These preliminary results, combined with the simplicity and low-cost of the analysis, open to further investigation of the potential role of this restricted USP in PCa diagnosis. PMID: 31833333 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Role of cultural analysis in patients with indwelling ureteral stent submitted to ureteroscopy for stones.
CONCLUSIONS: About one to five patients treated with URS developed an infectious complication and E. Faecalis and E. Coli were the most frequent pathogen isolated. A positive SC is the only independent risk factor for postoperative infection: consequently, an early SC analysis could allow a prompt antibiotic therapy in all patients with positive SC even if mildly symptomatic. PMID: 31833334 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Analysis of clinical utility of abdominopelvic computer tomography in the follow up of Stage I Seminoma. A single center evaluation.
CONCLUSIONSː Follow-up schedules for stage I seminoma exposes patients to potential risks of radiation- induced tumors, emotional distress and represent a significant burden for the healthcare system. The current series suggests that a better risk adapted patient-tailored follow-up program is needed in order to avoid unnecessary investigations. PMID: 31833335 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Possible role of 5-alpha reductase inhibitors in non-invasive bladder urothelial neoplasm: multicentre study.
CONCLUSIONS: Long-term treatment with 5- ARIs might reduce the risk of bladder tumour recurrence, extension of lesions and increase the recurrence-free survival rate. A long-term, randomized prospective study could definitively assess the possible role of these drugs. PMID: 31833718 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Laparoscopic simple prostatectomy: a large single center prospective cohort study.
Authors: Zarraonandia Andraca A, Lombardo R, Carrion Valencia A, González-Dacal JA, Núñez HR, Samper Mateo P, Sica A, Tema G, De Nunzio C, Tubaro A, Moldes MR Abstract BACKROUND: Aim of our study was to analyse outcomes and safety of laparoscopic simple prostatectomy (LSP) in a high volume center. METHODS: A consecutive series of men with lower urinary tract symptoms and large prostates (>80cc) prospectively enrolled between November 2015 and December 2017 in one center. All patients underwent laparoscopic simple prostatectomy. Outcomes were evaluated considering the trifecta favourable ...
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Surgical quality, cancer control and functional preservation: introducing a novel Trifecta for robot-assisted partial nephrectomy.
Authors: Brassetti A, Anceschi U, Bertolo R, Ferriero M, Tuderti G, Capitanio U, Larcher A, Garisto J, Antonelli A, Mottire A, Minervini A, Dell'oglio P, Veccia A, Amparore D, Flammia RS, Mari A, Porpiglia F, Montorsi F, Kaouk J, Autorino R, Carini M, Gallucci M, Simone G Abstract BACKGROUND: To improve standard reporting of outcomes after partial nephrectomy, different "Trifecta" systems have been conceived. The subjective assessment of the included parameters and the unreliability for off-clamp procedures limited their reproducibility; their role in predicting functional and oncologic outcomes has never...
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Thermal ablation of the small renal mass: a critical analysis of current literature.
Authors: Mershon JP, Tuong MN, Schenkman NS Abstract INTRODUCTION: Thermal ablation is increasingly utilized as a management strategy for small renal masses (
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Open approach, extended pelvic lymph node dissection and seminal vesicle invasion are independent predictors of hospital readmission after prostate cancer surgery: a large retrospective study.
CONCLUSIONS: ORP, ePLND and seminal vesicle invasion are independent predictors of the risk of hospital readmission over the long term at a large single tertiary referral center. When surgery is chosen as a primary treatment of PCA, patients should be informed of the risk of hospital readmission and related risk factors. Assessing seminal vesicle invasion by preoperative clinical staging identifies locally advanced disease, which is associated with an increased risk of hospital readmission. PMID: 31833722 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Persistence and adherence to androgen deprivation therapy in men with prostate cancer: an administrative database study.
CONCLUSIONS: Our data show high adherence and persistence rates in men on ADT. The overall survival in the super-elderly is not influenced by persistence and/or adherence but rather by co-prescriptions. PMID: 31833723 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Absolok ® versus Hem-o-Lok® clips for renorrhaphy during partial nephrectomy for parenchymal renal tumors.
CONCLUSIONS: Absolok® clips are a valid alternative to Hem-o-Lok® clips to secure blood vessels at the level of tumor bed and to perform a sliding-clip renorrhaphy in patients who underwent open or robot-assisted partial nephrectomy. PMID: 31833724 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Artificial intelligence and neural networks in urology: current clinical applications.
CONCLUSIONS: AI technologies are growing their role in health care; but, up to now, their "real-life" implementation remains limited. However, in the near future, the potential of AI-driven era could change the clinical practice in Urology, improving overall patient outcomes. PMID: 31833725 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Ex vivo confocal fluorescence microscopy for rapid evaluation of renal core biopsy.
We report the feasibility of using confocal technology for determining the quality of the renal core at renal mass biopsy on 4 consecutive cases at our institution. PMID: 31833726 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Predictors of early postoperative and mid-term functional outcomes in patients treated with Endoscopic Robot Assisted Simple Enucleation (ERASE): results from a tertiary referral centre.
CONCLUSIONS: Age at surgery and higher PADUA score are significant predictors of early post- operative RF loss after ERASE for T1 renal tumors, while age at surgery, female gender, higher BMI,CCI and baseline RF significantly affect mid-term RF. Larger studies and a longer follow-up are needed to confirm these results. PMID: 31833727 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 14, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
CONCLUSIONS: Anesthetic preconditioning is a promising strategy to prevent I-R injury associated with transplantation. Our results suggest that sirtuin 2 is involved in the protective mechanisms of some commonly used anesthetics against I-R damage. PMID: 31726818 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 19, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The current use of human cadaveric models in urology: a systematic review.
CONCLUSIONS: The quality of the materials and methods described in most studies is often characterized by poor detail with regards to the preservation and preparation of the bodies and the satisfaction of use, which might affect training and testing. PMID: 31726819 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 19, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Implant of ATOMS ® system for the treatment of postoperative male stress urinary incontinence: an Italian multicentric study.
Implant of ATOMS® system for the treatment of postoperative male stress urinary incontinence: an Italian multicentric study. Minerva Urol Nefrol. 2019 Nov 04;: Authors: Giammò A, Ammirati E, Tullio A, Morgia G, Sandri S, Introini C, Canepa G, Timossi L, Rossi C, Mozzi C, Carone R Abstract BACKGROUND: The aim of this study is to evaluate efficacy and safety of the ATOMS system for the treatment of postoperative stress urinary incontinence (SUI). METHODS: We included all consevutive male patients referring for postoperative SUI and treated with ATOMS system from June 2013 to July 2017. Pat...
Source: Minerva Urologica e Nefrologica - November 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Epidemiology and unmet needs of bladder cancer in Italy: a critical review.
CONCLUSIONS: Bladder cancer represents a health burden in Italy, with high incidence and prevalence rates, and important unmet needs for patients, including the limited therapeutic options for advanced/metastatic cancers, the low quality of life after radical cystectomy, the lack of widespread clinical pathway schemes, and the low patients empowerment. PMID: 31692303 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The concealed penis: the "two corners" surgical technique.
CONCLUSIONS: The "two-corners" technique allows easy and effective correction of the concealed penis in both congenital and acquired conditions. It can be performed as outpatient procedure and results are stable at long-term follow-up. PMID: 31692304 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Laparoscopic ureterolithotomy versus ureteroscopic laser lithotripsy for large proximal ureteral stones: a systematic review and meta-analysis.
Authors: Li J, Chang X, Wang Y, Han Z Abstract INTRODUCTION: To review current studies and conduct a meta-analysis on the topic of laparoscopic ureterolithotomy (LU) versus ureteroscopic lithotripsy (URSL) with holmium laser for large proximal ureteral stones. EVIDENCE ACQUISITION: A systematic research of PubMed, Ovid, Scopus (up to March 2019), and citation lists was performed to identify eligible comparative studies. All studies comparing LU versus URSL with holmium laser in proximal ureteral stones were included. Statistical analyses were performed using the Cochrane Collaboration's Review Manager (RevMan) ...
Source: Minerva Urologica e Nefrologica - November 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Lower urinary tract and gastrointestinal dysfunction in sportswomen: systematic review and meta-analysis of observational studies.
CONCLUSIONS: All the analysed studies showed bias. This meta-analysis indicated that competitive sport activities represent a risk factor for urinary incontinence and gastrointestinal disorders. To prevent urinary leakage athletes should be instructed to strengthen the pelvic floor muscles. PMID: 31692306 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

What urologists need to know about female to male genital confirmation surgery (phalloplasty and metoidioplasty): techniques, complications, and how to deal with them.
Authors: Jun MS, Crane CN, Santucci RA Abstract Transmasculine gender-affirming surgery (GAS) is technically challenging, and in the past associated with a high but improving complication rate. Few surgical centers are performing this surgery, which can include metoidioplasty and phalloplasty, and patients often travel great distances for their surgery. While many will continue care with their original surgeons, others cannot due to social/geographic factors, or because emergencies arise. Thus, patients may seek care with their local urologist for relief of delayed complications, the most common of which include ur...
Source: Minerva Urologica e Nefrologica - November 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Ejaculation disorders in prostate surgery.
Authors: De Nunzio C, Tabatabaei S, Tubaro A Abstract PMID: 31646849 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 26, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Risk of Gleason Score 3 + 4 = 7 prostate cancer upgrading at radical prostatectomy is significantly reduced by target biopsy compared to standard biopsy technique.
Authors: De Luca S, Fiori C, Bollito E, Garrou D, Aimar R, Cattaneo G, De Cillis S, Manfredi M, Tota D, Massa F, Passera R, Porpiglia F Abstract BACKGROUND: To evaluate if multiparametric magnetic resonance (mpMRI)- transrectal ultrasound (TRUS) fusion targeted biopsy (TBx) versus untargeted standard biopsy (SBx) may decrease the rate of pathological upgrading of Gleason score (GS) 3+4 prostate cancer (PCa) at radical prostatectomy (RP). We also evaluated the impact of percent pattern 4 and cribriform glands at biopsy in the risk of GS 3 + 4 = 7 upgrading. METHODS: 301 patients with GS 3+4 PCa on biopsy (159 SB...
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Which patients with clinical localized renal mass would achieve the trifecta after partial nephrectomy? The impact of surgical technique.
Authors: Bianchi L, Schiavina R, Borghesi M, Chessa F, Casablanca C, Angiolini A, Ercolino A, Pultrone CV, Mineo Bianchi F, Barbaresi U, Piazza P, Manferrari F, Bertaccini A, Fiorentino M, Ferro M, Porreca A, Marcelli E, Brunocilla E Abstract BACKGROUND: To develop a clinical nomogram aimed to predict the achievement of trifecta in patients treated with open, laparoscopic and robotic partial nephrectomy (PN) for localized renal masses (
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

How many surgically-treated angiomyolipomas are related to tuberous sclerosis complex? Insights from a retrospective multicenter study.
CONCLUSIONS: A non-negligible proportion of surgically-treated, putative sporadic AMLs were reclassified as potentially hereditary (TSC-related). As TSC patients may be treated with targeted therapies, our findings may increase urologists' awareness of TSC-related AML and prompt the design of future studies evaluating targeted diagnostic pathways for these patients. PMID: 31619031 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Laparoscopic simple prostatectomy: complications and functional results after 5 years of follow-up.
CONCLUSIONS: The present findings confirm that LSP carries a low rate of early and late complications, and it offers good functional outcomes at 5 years. PMID: 31619032 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

A systematic review and meta-analysis comparing the outcomes of open and robotic assisted radical cystectomy.
Authors: Albisinni S, Veccia A, Aoun F, Diamand R, Esperto F, Porpiglia F, Roumeguère T, De Nunzio C Abstract INTRODUCTION: Robotic assisted radical cystectomy (RARC) is gaining popularity worldwide, although its enthusiastic implementation is supported mainly by retrospective studies. Aim of this review is to compare the outcomes of RARC and open radical cystectomy (ORC) in the setting of randomized controlled trials (RCTs). EVIDENCE ACQUISITION: Three search engines (PubMed, Embase®, and Web of Science) were queried up to January 1, 2019. Studies selections followed The Preferred Reporting Items fo...
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Combined reporting of surgical quality, cancer control and functional outcomes of Robot-assisted radical cystectomy with intracorporeal orthotopic neobladder into a novel Trifecta.
CONCLUSIONS: Learning curve in RARC-iON has a significant impact on achievement of Trifecta. This tool combines accurate measurement of surgical proficiency with an independent predictive value in assessing 3-yr OS probabilities. PMID: 31619034 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

What is the standard surgical approach to large volume BPE? Systematic review of existing randomized clinical trials.
CONCLUSIONS: According to our review no technique may be considered better than the other when treating large adenomas. Studies are still lacking to prove long term efficacy and future studies should clarify the role of prostatic artery embolization and minimally invasive simple prostatectomy in the management of prostates larger than 80 ml. PMID: 31619035 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 18, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome.
Authors: Di Vico T, Durante J, Polito C, Tognarelli A, Canale D, Caglieresi C, Morelli G, Bartoletti R Abstract BACKGROUND: Proxelan® and antibiotics combined therapy was successfully previously used in the treatment of symptoms of patients with chronic prostatitis. Aim of the present study was to investigate the effects of Proxelan® monotherapy on pain symptoms of patients with chronic prostatitis (CP) or chronic pelvic pain syndrome (CPPS) in a prospective pilot study. METHODS: Thirty consecutive patients with CP/CPPS symptoms younger than 50, without urinary obstruction, total prostate-specific antigen (PSA)
Source: Minerva Urologica e Nefrologica - September 28, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robotic partial nephrectomy versus radical nephrectomy in elderly patients with large renal masses.
Authors: Veccia A, Dell'oglio P, Antonelli A, Minervini A, Simone G, Challacombe B, Perdoná S, Porter J, Zhang C, Capitanio U, Sundaram CP, Cacciamani G, Aron M, Anele U, Hampton LJ, Simeone C, de Naeyer G, Bradshawh A, Mari A, Campi R, Carini M, Fiori C, Gallucci M, Jacobsohn K, Eun D, Lau C, Kaouk J, Derweesh IH, Porpiglia F, Mottrie A, Autorino R Abstract BACKGROUND: Recent evidence suggests that the "oldest old" patients might benefit of partial nephrectomy (PN), but decisionmaking for this subset of patients is still controversial. Aim of this study is to compare outcomes of robotic partial (R...
Source: Minerva Urologica e Nefrologica - September 20, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Clinical implications of prostatic capsular abutment or bulging on multiparametric magnetic resonance imaging.
In this study we aimed to test the clinical implications of capsular abutment or bulging on preoperative multiparametric magnetic resonance imaging (mpMRI). METHODS: We analyzed the data of 291 patients who underwent radical prostatectomy (RP) for a cT1-2N0 prostate cancer in a single surgeon series. All patients underwent preoperative staging with mpMRI. PIRADS v2 was used for characterizing lesions. The role of capsular abutment or bulging was tested in a multivariable logistic regression adjusting for PSA and highest ipsilateral biopsy Gleason grade. The presence of focal vs. extensive ECE was investigated. RESU...
Source: Minerva Urologica e Nefrologica - September 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Multimodal treatment in Focal Therapy for localized prostate cancer using concomitant short-term androgen deprivation therapy: the ENHANCE prospective pilot study.
Authors: Marra G, Dell'oglio P, Baghdadi M, Cathelineau X, Sanchez-Salas R, EvaluatioN of HIFU Hemiablation and short term AndrogeN deprivation therapy Combination to Enhance prostate cancer control (ENHANCE) study investigators Abstract FT for localized PCa is emerging to reduce adverse effects of radical treatments, while maintaining comparable oncological outcomes. However, an area for improvement still exists and a gap in cancer control needs to be filled by complementing the with additional forms of treatment to minimize failures. Part of the recurrences/persistences after FT may be related to PCa microenviron...
Source: Minerva Urologica e Nefrologica - September 13, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research