Bladder-sparing treatment in MIBC: where do we stand?
CONCLUSIONS: Bladder-sparing treatment is an option for patients with bladder cancer. Those who may benefit most are those with solitary invasive cancers, those with good bladder capacity and compliance, those who choose to preserve their bladder and sexual function and who are not fit for RC. Multimodal bladder- sparing approaches may have comparable oncological outcomes to RC and so appear an attractive alternative in suitable patients. PMID: 30895765 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 23, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot assisted laparoscopic prostatectomy in liver transplant recipient.
We present two cases of RALP in LTRs with localized prostate cancer (PCa). In both cases, a transperitoneal approach was used, and they were successfully completed without perioperative complications. Thus, RALP seems to be a feasible, safe and effective treatment for PCa in LTRs. Significant modifications to the surgical technique do not seem to be required, and patient optimization in preparation for surgery remains the key factor. History of liver transplant should not discourage embarking in a RALP in Centers with adequate robotic expertise. PMID: 30895766 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 23, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comparison between Near-infrared fluorescence imaging with indocyanine green and InfraRed imaging: on-bench trial for kidney perfusion analysis. A project by ESUT-YAUWP group.
CONCLUSIONS: Although NIRF technology with ICG is providing more image detail, we demonstrated that IRT is capable of detecting kidney parenchyma perfusion with warm fluids. Further studies will show its feasibility in graft re-perfusion assessment during kidney transplant or similar applications. PMID: 30895767 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 23, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot-assisted versus open partial nephrectomy: comparison of outcomes. A systematic review.
CONCLUSIONS: Current evidence demonstrate that RAPN is a reasonable alternative to OPN with regard to oncological and early functional outcomes with a straightforward advantage of improved perioperative morbidity, as expected by minimally invasive techniques. Nevertheless, there is still a great need for well-designed randomized studies with an extended follow-up. PMID: 30895768 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - March 23, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Outcome of posterior urethral valve in 64 children. Single center experience of 22 years.
CONCLUSIONS: Our results confirm that PUV has a considerable risk for CKD development. Antenatal diagnosis, management of proteinuria and hypertension may modify this progression. But already injured kidneys still have a potential risk. The need for further research to evaluate the impact of any intervention on long term renal outcome is obvious. PMID: 30767491 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robot-assisted pyeloplasty for ureteropelvic junction obstruction: experience from a tertiary referral centre.
CONCLUSIONS: In our experience, RAP with Anderson-Hynes technique performed in a tertiary referral center by expert surgeons represent a safe and feasible procedure with an overall low rate of postoperative complications. PMID: 30767492 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Actual evidences and future perspectives about the role of iXip ® in the diagnosis of prostate cancer: a narrative review.
Actual evidences and future perspectives about the role of iXip® in the diagnosis of prostate cancer: a narrative review. Minerva Urol Nefrol. 2019 Feb 14;: Authors: Antonelli A, Francavilla S, Gallotta A, Da Pozzo LF, Ferretti S, Sigala S, Simeone C, Mirone V, Artibani W, Porreca A Abstract The iXip (Immune CompleX Predictive Index, Xeptagen SpA) is a diagnostic tool which biological bases ground on PSA-IgM complexes. An algorithm merges the data of PSA-IgM and serum total PSA dosage, prostate volume and patient's age, providing as output a numerical value that correlates with the risk of finding ...
Source: Minerva Urologica e Nefrologica - February 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The efficacy and safety of bilateral same-session ureteroscopy with holmium laser lithotripsy in the treatment of bilateral ureteral stones.
CONCLUSIONS: BS-URS is as safe and efficient procedure as unilateral ureteroscopy with high stone-free and minimal morbidity rates in the treatment of bilateral ureteral stones in appropriate patients. PMID: 30767494 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Extended pelvic lymphadenectomy for prostate cancer: should the cloquet's nodes dissection be considered only an option?
Authors: Cacciamani GE, Porcaro AB, Sebben M, Tafuri A, Rizzetto R, De Luyk N, Ciochetta E, Processali T, Pirozzi M, Amigoni N, Corsi P, Brunelli M, De Marco V, Artibani W Abstract BACKGROUND: To assess the anatomical prevalence and secondary involvement of Cloquet's nodes in patients undergoing robotic radical prostatectomy (RRP) and extended pelvic lymph node dissection (ePLND) for prostate cancer (PCa). METHODS: RRP and ePLND were performed by two expert surgeons (WA and VDM). Data were prospectively collected and retrospectively analysed. Dissected pelvic lymph nodes were sampled according to an anatomical ...
Source: Minerva Urologica e Nefrologica - February 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

[-2]proPSA for predicting biochemical recurrence of prostate cancer earlier than total PSA after radical prostatectomy: an observational prospective cohort study.
Authors: Casale P, Saita A, Lazzeri M, Lughezzani G, Hurle R, Fasulo V, Mondellini GM, Paciotti M, Domanico L, Lista G, Maffei D, Monari M, Motta L, Bini V, Ceriotti F, Guazzoni G, Buffi N Abstract BACKGROUND: There is an unmet clinical need for more biochemical specific tests that may detect clinically significant recurrent PCa at an early stage after radical prostatectomy (RP). Our purpose is to test the hypothesis that p2PSA (index test) detects prostate cancer relapse (BCR) earlier than the current reference standard test (total PSA, tPSA) in patients who underwent RP for localized PCa. METHODS: This is an ...
Source: Minerva Urologica e Nefrologica - February 1, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comparison of safety and efficacy of bipolar plasmakinetic transurethral enucleation and bipolar plasmakinetic transurethral resection of prostate gland greater than 60gm in patients receiving anticoagulants and/or platelet aggregation inhibitors: a tertiary care center experience.
Authors: Rai P, Srivastva A, Singh S, Dhayal IR Abstract BACKGROUND: To evaluate the safety and efficacy of Bipolar plasmakinetic enucleation of the prostate (BPEP) and Bipolar plasmakinetic transurethral resection of prostate (B-TURP) for patients on oral anticoagulants (OA) and/or platelet aggregation inhibitors (PAI) with benign prostatic obstruction (BPO) and having a gland size of>60 grams. METHODS: Patient database of our hospital for the period of May 2012 to September 2017 was retrospectively reviewed for BPH patients with a gland size of>60 g who either underwent BPEP or B-TURP and were on OA and...
Source: Minerva Urologica e Nefrologica - February 1, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Benefits and risks of testosterone therapy in older men.
Authors: Cardona Attard C, Fava S Abstract Adult-onset hypogonadism is used to define androgen deficiency and its associated symptoms commonly occurring in middle-aged and elderly men, who are unable to mount an adequate compensatory gonadotropin response but may also have an element of testicular failure. It often occurs in relation with chronic metabolic conditions such as diabetes and the metabolic syndrome. There is a growing demand from elderly men for testosterone therapy. The physician should therefore be well-informed so as the patient can make an informed decision. Indeed, testosterone therapy in older men...
Source: Minerva Urologica e Nefrologica - February 1, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Precision prostate cancer surgery: an overview of new technologies and techniques.
Authors: Checcucci E, Amparore D, De Luca S, Autorino R, Fiori C, Porpiglia F Abstract Over the past few years several new technologies have become available for the management of PCa. The implementation of robotic surgery allowed an unprecedented refinement of surgical techniques, and the RARP procedure is constantly evolving. Nowadays research is mainly focused towards a "tailored" case-specific surgical approach that might allow to achieve PCa control while preserving urinary continence and erectile function. Therefore, in contemporary urology era, several new tools have been introduced to optimize sur...
Source: Minerva Urologica e Nefrologica - February 1, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Single-site robotic platform in clinical practice: first cases in the USA.
Authors: Kaouk J, Bertolo R Abstract The initial experience with urological robotic interventions performed by using the Da Vinci SP® robotic surgical platform (Intuitive Surgical, Sunnyvale, CA, USA) during the first month (September 28th - October 30th, 2018) after the system was installed at our institution is reported herein. The aim of the study was to determine the feasibility and the safety of major urologic procedures as measured by the rate of conversions and the incidence of perioperative complications. Secondary aims of the study consisted of key perioperative surgical outcomes including operative ti...
Source: Minerva Urologica e Nefrologica - February 1, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Radiological Wheeler staging system: a retrospective cohort analysis to improve the local staging of prostate cancer with multiparametric Magnetic Resonance Imaging.
Authors: Russo F, Manfredi M, Panebianco V, Armando E, De Luca S, Mazzetti S, Giannini V, Mele F, Bollito E, Appendino E, Regge D, Porpiglia F Abstract BACKGROUND: The knowledge of tumour location and extension can allow a modulated radical prostatectomy in order to minimize positive surgical margins and reduce functional morbidity after surgery in patients with prostate cancer (PCa). Multiparametric (mp) magnetic resonance imaging (MRI) could allow the assessment of tumour extension and of its relationship with external structures. Aim of this study is to propose a new radiological Wheeler (rW) staging system appl...
Source: Minerva Urologica e Nefrologica - January 19, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Impact of hospital admissions subsequent to renal transplantation on Italian regional resources: a retrospective study in the region Emilia-Romagna.
CONCLUSIONS: Costs due to admissions of RTRs appeared to gradually increase in the long term probably due to the increasing number of admissions and increasing mean age of admitted RTRs. PMID: 30654602 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 19, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Bladder recurrence of primary upper tract urinary carcinoma following nephro-ureterectomy, and risk of upper urinary tract recurrence after ureteral stent positioning in patients with primary bladder cancer: a contemporary non-systematic review of the literature.
Authors: Mistretta FA, Carrion DM, Nazzani S, Vásquez JL, Fiori C, De Cobelli O, Porpiglia F, Esperto F Abstract Upper tract urinary carcinoma (UTUC) and bladder cancer (BCa) share similar biological, histological and pathological characteristics. These resemblances could explain the high rate of synchronous and metachronous tumours affecting both upper urinary tract and bladder. In patients affected by primary UTUC bladder recurrence is quite common and it represents one of the major concerns during the follow-up of patients who underwent radical nephro-ureterectomy. Conversely, UTUC recurrence after primar...
Source: Minerva Urologica e Nefrologica - January 19, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Retroperitoneoscopy in urology: a systematic review.
CONCLUSIONS: Retroperitoneoscopic approach in urological diseases is a valid alternative to the anterior approach. Evidence suggest lower morbidity for the retroperitoneoscopic approach however technical complexity may limit its widespread. PMID: 30607927 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - January 5, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The role of vascular clamping during robot-assisted partial nephrectomy for localised renal cancer: rationale and design of the CLOCK randomised phase III study.
Authors: Cindolo L, Antonelli A, Sandri M, Annino F, Celia A, De Concilio B, Giommoni V, Nucciotti R, Sessa F, Porreca A, Veccia A, Schips L, Minervini A, AGILE Group (Italian Group for advanced laparo-endoscopic surgery) Abstract Outline the design and rationale of CLOCK, a large, phase III randomised controlled trial which examines the role vascular clamping during robot-assisted partial nephrectomy (RAPN) for localised renal cancer. To be eligible for study entry, patients must have normal coagulative function, preoperative estimated glomerular filtration rate (eGFR)>60 ml/min, normal contralateral kidney and...
Source: Minerva Urologica e Nefrologica - January 5, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Flexible ureteroscopy for kidney stones in the third millennium: lights and shadows.
Authors: Fiori C, Autorino R Abstract PMID: 30567423 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 22, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

External validation of Imamura nomogram as a tool to predict preoperatively laser semi-rigid ureterolithotripsy outcomes.
CONCLUSIONS: We firstly validated Imamura nomogram in an European cohort study. It proved a reasonable accuracy (AUC 0.67) and a good PPV (83%). Further studies should confirm our results to support the routine clinical use of Imamura nomogram as a tool to predict ULT outcomes. PMID: 30547902 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 16, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Smoking and susceptibility to prostate cancer: what is the truth?
Authors: Mormile R Abstract PMID: 30547903 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 16, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Effect of puboprostatic ligament reconstruction on continence recovery after robot-assisted laparoscopic prostatectomy: our initial experience.
CONCLUSIONS: Despite anterior reconstruction of the puboprostatic ligament showed no significant effect on the overall continence, it showed earlier return to continence up to 6 months, which supports the theory that anterior puboprostatic reconstruction may provide better immediate continence and shorten the time to continence for RALP patients. However, most of the published literature showed better continence rates with the total anatomical reconstruction (combined anterior and posterior). Therefore, we started to offer patients in our center total anatomical reconstruction during RALP. PMID: 30547904 [PubMed - as s...
Source: Minerva Urologica e Nefrologica - December 16, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Low dose CT scan in stone detection for stone treatment follow up: is there a relation between stone composition and radiation delivery? Study on a porcine-kidney model.
CONCLUSIONS: Ultra-low-dose CT has a good detection rate for all kinds of stone, even when the fragment size is small. Only small uric acid fragments need higher energy settings in order to be detected. When the stone composition is known after surgery for urolithiasis, the most appropriate CT scan setting could be suggested by the urologist during their follow-up. PMID: 30547905 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 16, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up.
CONCLUSIONS: In experienced centres, RARP allows optimal oncologic outcomes at long term follow up. Adverse pathologic characteristics are independent predictors of BCR and CR. PMID: 30547906 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - December 16, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Cytoreductive prostatectomy: what is the evidence? A systematic review.
Authors: Albisinni S, Aoun F, Diamand R, Al-Hajj Obeid W, Porpiglia F, Roumeguere T, De Nunzio C Abstract INTRODUCTION: Cytreductive prostatectomy is an experimental surgical approach to metastatic prostate cancer (mPCa), with the scope of improving local symptoms and potentially ameliorate oncologic outcomes. Aim of the current systematic review is to analyze available evidence to support this approach and explore published data a future trial on cytoreductive prostatectomy. EVIDENCE ACQUISITION: A systematic review was conducted searching all relevant studies published in PubMed, EMBASE, Cochrane Library, CIN...
Source: Minerva Urologica e Nefrologica - December 16, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Role of apparent diffusion coefficient values in prostate diseases characterization on diffusion-weighted magnetic resonance imaging.
Authors: Salvaggio G, Calamia M, Purpura P, Bartolotta TV, Picone D, Dispensa N, Lunetta C, Bruno A, Raso L, Salvaggio L, Lo Re G, Galia M, Simonato A, Midiri M, Lagalla R Abstract BACKGROUND: To evaluate if normal and pathological prostate tissue can be distinguished by using apparent diffusion coefficient (ADC) values on magnetic resonance imaging (MRI) and to understand if it is possible to differentiate among pathological prostate tissues using ADC values. METHODS: Our population consisted in 81 patients (mean age 65.4) in which 84 suspicious areas were identified. Regions of interest were placed over suspi...
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Small cell carcinoma of the upper urinary tract and factors associated with progress survival: a systematic review and pooled analysis.
CONCLUSIONS: In multivariable analyses, no variables were associated with OS and CSS. UUT-SCC is a rare tumor characterized by an aggressive clinical course. Pathological stage and platinum-based chemotherapy regimen are the most important factors related to OS and CSS. PMID: 30421591 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Surgical management of a rare case of giant penile cancer.
We present a case of a patient with a giant primary penile cancer managed with radical penectomy, bilateral inguinal lymphadenectomy and perineal urethrostomy, who experienced disease recurrence 6 months after surgery and died with metastatic disease after denial of further treatment. The management of our case was challenging due to the extremely late diagnosis, the huge dimensions and the infiltrative nature of the tumour; however, from a histopathological perspective, the cancer itself did not display any microscopic peculiarity. Our case highlights that such bulky penile tumors can still occur in current urologic pract...
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Phase I study of a new tablet based image guided surgical system in robotic assisted radical prostatectomy.
Authors: Kratiras Z, Gavazzi A, Belba A, Willis B, Chew S, Allen C, Amoroso P, Dasgupta P Abstract Robotic assisted radical prostatectomy is, currently, the most commonly utilized procedure for the treatment of localized prostate cancer. Image-guided surgical systems have been proposed in the literature as a valuable tool for the better utilization of the preoperative data in theatre. In this Phase 1 trial, we tested the feasibility and safety of a new, cutting - edge tablet based surgical imaging system designed for Robotic assisted radical prostatectomy (RARP). It utilizes the preoperative MRI images of the prost...
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

R.U.G. technique: replacement of the ureter with gonadal vein. A cadaveric study.
CONCLUSIONS: The RUG technique resulted in an adequate, safe and easy-to-perform surgical alternative. PMID: 30421594 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Cold ischemia technique during robotic partial nephrectomy: a propensity score-matched comparison with open approach.
Authors: Garisto J, Bertolo R, Agudelo J, Armanyous S, Gao T, Lioudis M, Kaouk J Abstract BACKGROUND: Open ice slush for renal cooling during partial nephrectomy (PN) has been reproduced during robotic PN (RPN). The aim of this study is to compare the perioperative and functional outcomes between RPN and open PN (OPN) using a cold ischemia technique. METHODS: Consecutive patients undergoing PN using cold ischemia technique were extracted from our prospectively-maintained database (2007-2016). RPN and OPN patients were 1:2 propensity-score (PS) matched via a greedy algorithm. The balance of the baseline variable...
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography: a pilot study and systematic review of the literature.
CONCLUSIONS: IFV during RAKT is feasible and safe and provides a reliable assessment of graft reperfusion. Larger studies are needed to standardize the technique and to evaluate the association between fluorescence signal, ultrasound parameters and postoperative kidney function. PMID: 30421596 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The role of side-specific biopsy and dominant tumor location at radical prostatectomy in predicting the side of nodal metastases in organ confined prostate cancer: is lymphatic spread really unpredictable?
CONCLUSIONS: Our results suggest confirmed that a unilateral LN dissection limited to the tumor-bearing side of the gland evaluated by biopsy specimens should not be recommended due to the substantial risk of missing contralateral LNMs. PMID: 30421597 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

BCG unresponsive in patients with NMIBC: what the urologists must know. A review of the current literature.
Authors: Moschini M, Zamboni S, Mattei A, Amparore D, Fiori C, De Dominicis C, Esperto F Abstract Transurethral resection of bladder (TURB) with adjuvant intravesical bacillus Calmette-Guerin (BCG) remains the gold standard therapy for intermediate and high risk non-muscle invasive bladder cancer (NMIBC). However, this disease is burdened with a high risk of recurrence or progression. For this reason, we sought to review and summarize the current evidence with a non-systematic Medline/Pubmed literature search, regarding optimal treatment in BCG-failure patients. Radical cystectomy (RC) should be considered as the p...
Source: Minerva Urologica e Nefrologica - November 15, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Prostate specific antigen levels and proportion of biopsy positive cores are independent predictors of upgrading patterns in low risk prostate cancer.
Authors: Porcaro AB, Inverardi D, Corsi P, Sebben M, Cacciamani G, Tafuri A, Processali T, Pirozzi M, Mattevi D, De Marchi D, Amigoni N, Rizzetto R, Cerruto MA, Brunelli M, Siracusano S, Artibani W Abstract BACKGROUND: To evaluate clinical factors associated with the risk of tumour upgrading patterns in low risk prostate cancer (PCA) patients undergoing radical prostatectomy. METHODS: In a period running from January 2013 to December 2016, 245 low risk patients underwent RP. Patients were classified into three groups, which included case with pathology grade group one (no upgrading pattern), two-three (intermed...
Source: Minerva Urologica e Nefrologica - October 10, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Intraprostatic Injections for LUTS/BPH treatment.
CONCLUSIONS: Intraprostatic injections are still to be considered investigational for the minimally invasive management of LUTS/BPE patients. Emerging data suggest a possible role of new agents in the near future when definitive data of ongoing RCTs will be available. PMID: 30298711 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 10, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Biological bases of radical prostatectomy in the management of prostate cancer patients with oligometastatic disease.
Authors: Dalla Volta A, Antonelli A, Simeone C, Berruti A PMID: 30298712 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - October 10, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Ischemia time and beyond: the concept of global renal damage.
Authors: Mir MC, Autorino R, Porpiglia F PMID: 30256078 [PubMed - in process] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 27, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Improved prediction of nephron-sparing surgery versus radical nephrectomy by the optimized R.E.N.A.L. (optR.E.N.A.L.) score in patients undergoing surgery for renal masses.
CONCLUSIONS: optR.E.N.A.L. represents a promising improvement of the preexisting R.E.N.A.L. score with higher predictive ability for nephrectomy type than established MS and may serve as a benchmarking tool for nephrectomy assessment and comparison of surgical strategies. PMID: 30256079 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 27, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Long-term oncologic and functional outcomes after robot-assisted partial nephrectomy in elderly patients.
CONCLUSIONS: In a high-volume center, robot-assisted approach is feasible and safe in surgical fit elderly patients with good long-term oncologic outcomes. PMID: 30230293 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 20, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Adherence to hormonal deprivation therapy in prostate cancer in clinical practice: a retrospective, single-centre study.
CONCLUSIONS: Adherence to ADT was optimal, probably owing to its balanced side effect and benefit profile. Patient's death was the most frequent reason for discontinuation. PMID: 30230294 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 20, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Cigarette smoking is not associated with prostate cancer diagnosis and agressiveness: a cross sectional italian study.
CONCLUSIONS: In our cross-sectional study, smoking is not predictive of PCa or high-grade disease. Further studies should evaluate if smoking could influence PCa diagnosis and aggressiveness. PMID: 30230295 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 20, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Risk factors and prognostic implications for pathologic upstaging to T3a after partial nephrectomy.
Authors: Beksac AT, Paulucci DJ, Gul Z, Reddy BN, Kannappan M, Martini A, Sfakianos JP, Gin GE, Abaza R, Eun DD, Bhandari A, Hemal AK, Porter J, Badani KK Abstract BACKGROUND: Performing a partial nephrectomy (PN) on a cT1 tumor, which post- operatively is upgraded to pT3a can possibly lead to compromise of cancer specific mortality. We therefore aimed to identify risk factors for pathologic T3a upstaging of cT1 tumors and to analyze the association between upstaging, positive surgical margins (PSM) and overall survival (OS). METHODS: The present study included patients who underwent PN for a clinically localiz...
Source: Minerva Urologica e Nefrologica - September 20, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

New insight in penile cancer.
Authors: Marchioni M, Berardinelli F, De Nunzio C, Spiess P, Porpiglia F, Schips L, Cindolo L Abstract Penile cancer is a rare disease. Most of penile cancer are squamous cell carcinoma. Diagnosis is based on self-examination, clinical examination and confirmatory biopsy. Several imaging technique could be used for staging purpose. However, the best modality for staging in intermediate and high risk patients is by surgical evaluation and the use of inguinal lymph node dissection, that has also a therapeutic effect. Unfortunately, inguinal lymph node dissection is underused. Penile cancer treatment may have a major ...
Source: Minerva Urologica e Nefrologica - September 20, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Fluoroscopy-free techn ıque is relıable and safe in retrograde intrarenal surgery.
CONCLUSIONS: Fluoroscopyfree retrograde intrarenal surgery seems to be a technically feasible and safe for the treatment of renal and proximal ureteral stone disease in uncomplicated selected cases. PMID: 30230298 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 20, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Comparison of diagnostic efficacy by two urine PCA3 scores in prostate cancer patients undergoing repeat biopsies: a meta-analysis.
CONCLUSIONS: Our meta-analysis suggested that when the PCA3 score cutoff value was 20, the unnecessary puncture was reduced and obtained a higher diagnostic efficacy. PMID: 30203935 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 13, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The pathologist's role in the detection of rare variants of bladder cancer and analysis of the impact on incidence and type detection.
The objective of this study is to evaluate the contribution of a dedicated uro-pathologist on the identification of rare bladder cancer variants. METHODS: We retrospectively analyzed the clinical and histological records of all patients which underwent a radical cystectomy and lymph node dissection between January 2000 and September 2015. The sample was divided in two groups: Group A, consists of patients who underwent radical cystectomy n the absence of a dedicated uro-pathologist at our institution, whereas the Group B consists of patients who underwent surgery when a dedicated uro-pathology service was available. We...
Source: Minerva Urologica e Nefrologica - September 13, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Risk factors for the delay in the diagnosis of penile lesions: results from a single center in Italy.
CONCLUSIONS: Patients education regarding this pathology and its potential danger is inadequate and thus it is necessary to implement a campaign of information and prevention in order to reduce delayed diagnosis. PMID: 30203937 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 13, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Clinical and histopathological features of carcinosarcoma of the renal pelvis: a systematic review of a rare tumour.
CONCLUSIONS: Carcinosarcoma of the kidney is a rare tumor of which little is known, especially about pathogenesis and oncological outcomes in the different therapeutic approaches described. Current literature is almost exclusively a case report that does not provide adequate information especially about survival and progression free survival. The creation of a shared database could in a matter of years lead us to increase the information about the oncological outcomes of the various possible treatments. PMID: 30203938 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 13, 2018 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research