14. A Multi-PGS Approach to Predicting Substance Use Disorders Diagnoses in the EHR
Substance use disorders (SUDs) are a major public health concern worldwide and identifying genetic factors underlying SUDs can inform prevention and treatment strategies. A previous study showed that a polygenic score (PGS) based on addiction liability can predict SUDs in biobank populations, but it is unclear if substance-specific PGSs add predictive value beyond the addiction factor (AF). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Brandon Coombes, Tyler Oesterle, Mariela Jennings, Vanessa Pazdernik, Anthony Batzler, Jacob Frank, Victor Karpyak, Euijung Ryu, Rachel Kember, Sandra Sanchez-Roige, Joanna Biernacka, PsycheMERGE SUD-Working Group Source Type: research
18. Systematic Organization of Cortical Thickness Co-Alterations in Substance Use Disorders
Previous research has demonstrated systematic structural alterations in neuropsychiatric disorders, linked to the human connectome's intrinsic organization. However, it remains unclear if similar coordinated co-alteration effects extend to substance use disorders (SUDs). Here, we examined substance use co-alteration networks (SUDcov) to uncover macroscale principles of illness and substance-use effects across the cortex. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sofie Valk, Foivos Georgiadis, Meike Hettwer, Sophia Thomopoulos, Paul Thompson, Scott Mackey, Patrica Conrod, Hugh Garavan, Clara Moreau, Boris C. Bernhardt, Matthias Kirschner, ENIGMA Addiction Working Group Source Type: research
23. Capturing Dynamic Patterns of Task-Based Functional Connectivity During Drug Cue Reactivity in Fronto-Amygdala Circuit
Frontopolar-amygdala circuit has been identified as a predictor of relapse in addiction, which is consistent with the heightened emotional reactivity or increased salience attributed to drug-related cues. Yet, the temporal dynamics of this circuit in response to drug cues remain unexplored. We investigated whether this circuitry undergoes sensitization, which would be consistent with an increase in drug salience with repeated exposure among individuals with methamphetamine use disorders (MUD). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ghazaleh Soleimani, Rayus Kulplicki, Martin Paulus, Kelvin Lim, Hamed Ekhtiari Source Type: research
29. Cues Augment Working Memory Proficiency in Smokers: Preliminary Evidence That Attentional Bias Enhances Executive Function
Attentional bias to drug-related cues is a core feature of addiction. Whereas attention bias is often associated with decrements in cognitive function, few studies have investigated the potential for cues to enhance cognition. We investigated the effects of smoking cues on working memory (WM) and neural engagement among cigarette smokers using a novel cued N-back task. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Emilie-Clare O'Mara, Reem Tamimi, Vaibhav A. Diwadkar, Leslie H. Lundahl, Dalal Khatib, Hilary Marusak, Mark K. Greenwald, Eric A. Woodcock Source Type: research
35. Investigating Endocannabinoid Metabolism in Opioid Treated Chronic Pain Patients With and Without Opioid Use Disorder: A PET Study With Fatty Acid Amide Hydrolase Radioligand [C-11]CURB
Fatty acid amide hydrolase (FAAH), the anandamide-catabolizing enzyme, is a key determinant of endocannabinoid metabolism. Preclinical and clinical findings suggest reduced FAAH is associated with altered addiction risks and pain sensitivity. In our recent positron emission tomography (PET) studies with FAAH radiotracer [11C]CURB, reduced FAAH was implicated in cannabis and alcohol use disorder. However, the status of FAAH in opioid use disorder (OUD) remains unknown. The present study aims to determine whether FAAH levels are lower in chronic pain patients with OUD (OUD+) compared to opioid exposed patients (OUD-) and hea...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Claire Shyu, Kevin Butler, Rachel F. Tyndale, Andrew Smith, Vitor S. Tardelli, Stefan Kloiber, Bernard Le Foll, Isabelle Boileau Source Type: research
Role of the addiction clinical nurse specialist in acute hospital settings
CONCLUSION: Participants indicated several benefits to implementing an ACNS role in their hospital, such as ensuring that patients who misuse substances experienced continuity of care which began at admission, was followed-up during inpatient stays and was maintained in the community.PMID:38680049 | DOI:10.7748/ns.2024.e12305 (Source: Nursing Standard)
Source: Nursing Standard - April 29, 2024 Category: Nursing Authors: Sadie Lavelle-Cafferkey Catherine Comiskey Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: cmaj - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: Canadian Medical Association Journal - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: cmaj - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Role of the addiction clinical nurse specialist in acute hospital settings
CONCLUSION: Participants indicated several benefits to implementing an ACNS role in their hospital, such as ensuring that patients who misuse substances experienced continuity of care which began at admission, was followed-up during inpatient stays and was maintained in the community.PMID:38680049 | DOI:10.7748/ns.2024.e12305 (Source: Nursing Standard)
Source: Nursing Standard - April 29, 2024 Category: Nursing Authors: Sadie Lavelle-Cafferkey Catherine Comiskey Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: Canadian Medical Association Journal - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Role of the addiction clinical nurse specialist in acute hospital settings
CONCLUSION: Participants indicated several benefits to implementing an ACNS role in their hospital, such as ensuring that patients who misuse substances experienced continuity of care which began at admission, was followed-up during inpatient stays and was maintained in the community.PMID:38680049 | DOI:10.7748/ns.2024.e12305 (Source: Nursing Standard)
Source: Nursing Standard - April 29, 2024 Category: Nursing Authors: Sadie Lavelle-Cafferkey Catherine Comiskey Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: cmaj - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: Canadian Medical Association Journal - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Role of the addiction clinical nurse specialist in acute hospital settings
CONCLUSION: Participants indicated several benefits to implementing an ACNS role in their hospital, such as ensuring that patients who misuse substances experienced continuity of care which began at admission, was followed-up during inpatient stays and was maintained in the community.PMID:38680049 | DOI:10.7748/ns.2024.e12305 (Source: Nursing Standard)
Source: Nursing Standard - April 29, 2024 Category: Nursing Authors: Sadie Lavelle-Cafferkey Catherine Comiskey Source Type: research
