Isotretinoin is not associated with inflammatory bowel disease even when compared to topical antibiotics and topical retinoids
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 9, 2023 Category: Dermatology Authors: Khalaf Kridin, Ralf J. Ludwig Source Type: research
Isotretinoin is not associated with inflammatory bowel disease even when compared with topical antibiotics and topical retinoids
To the Editor: We read with great interest the commentary of Lin et al1 about our paper entitled: “Isotretinoin and the risk of inflammatory bowel disease and irritable bowel syndrome: a large-scale global study.”2 Throughout the last decades, the dermatologic community has struggled with considerable controversy regarding the risk of inflammatory bowel diseas e (IBD) among patients treated with isotretinoin. Previous observational studies yielded inconsistent observations.3 (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 9, 2023 Category: Dermatology Authors: Khalaf Kridin, Ralf J. Ludwig Tags: JAAD Online: Notes & comments Source Type: research
A new perspective on isotretinoin in pregnancy: Pregnancy outcomes, evaluation of complex phenotypes, and importance of teratological counselling
CONCLUSIONS: Our study demonstrated that study design, long-term follow-up, teratological counseling, and implementation of advanced molecular analysis in complex phenotypes with novel phenotypical features are beneficial for understanding the association of congenital anomalies with isotretinoin exposure. While evaluating congenital anomalies, we detected statistically significant differences between isotretinoin exposure before and during the pregnancy vs control, but we did not detect any statistically significant differences between isotretinoin exposure before the pregnancy and controls. Another finding of the study i...
Source: Reproductive Biology - October 27, 2023 Category: Reproduction Medicine Authors: Mustafa Tar ık Alay Aysel Kalayci Mehmet Seven Source Type: research
The role of oral nutraceuticals as adjunctive therapy to reduce side effects from isotretinoin: A systematic review
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - October 21, 2023 Category: Dermatology Authors: Ali Shields, Sophia Ly, Bruna Wafae, Yu-Feng Chang, Priya Manjaly, Marjorie Archila, Christina Heinrich, Lara Drake, Arash Mostaghimi, John Barbieri Source Type: research
A new perspective on isotretinoin in pregnancy: Pregnancy outcomes, evaluation of complex phenotypes, and importance of teratological counselling
Teratogens are responsible for 5% of all known causes of congenital anomalies. Isotretinoin, a retinoic acid –derived agent, leads to congenital anomalies in 21-52% of cases when exposure occurs during pregnancy according to studies conducted before 2006. However, rates of congenital anomalies were much lower in later studies. The purpose of this study was to investigate the rates of congenital anomalies in isotretinoin exposure during pregnancy, isotretinoin exposure before pregnancy, and a control group unexposed to any teratogenic agents. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - October 18, 2023 Category: OBGYN Authors: Mustafa Tar ık Alay, Aysel Kalaycı Yiğin, Mehmet Seven Tags: Full length article Source Type: research
Molecules, Vol. 28, Pages 7110: Solubility and Thermodynamic Analysis of Isotretinoin in Different (DMSO + Water) Mixtures
A. Alsarra
The solubility and solution thermodynamics of isotretinoin (ITN) (3) in numerous {dimethyl sulfoxide (DMSO) (1) + water (H2O) (2)} combinations were studied at 298.2–318.2 K under fixed atmospheric pressure of 101.1 kPa. A shake flask methodology was used to determine ITN solubility, and correlations were made using the “van’t Hoff, Apelblat, Buchowski-Ksiazczak λh, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van’t Hoff models”. In mixtures of {(DMSO (1) + H2O (2)}, the solubility of ITN in mole fractions was enhanc...
Source: Molecules - October 16, 2023 Category: Chemistry Authors: Faiyaz Shakeel Nazrul Haq Sultan Alshehri Miteb Alenazi Abdulrahman Alwhaibi Ibrahim A. Alsarra Tags: Article Source Type: research
Effect of isotretinoin treatment on inflammatory and hematological parameters in patients with acne vulgaris
CONCLUSION: Our study suggests that the MPV and NLR ratio as biomarkers can be used as indicators of atherosclerosis-related inflammation due to ISO treatment, but the MHR, NHR, LHR, PHR, MLR, LMR ratios cannot be used. Moreover, we believe that the ratios of TG/HDL, LDL/HDL, and total cholesterol/HDL offer a new contribution as indicators of cardiovascular risk and systemic inflammation related to ISO treatment.PMID:37837334 | DOI:10.1080/15569527.2023.2268166 (Source: Atherosclerosis)
Source: Atherosclerosis - October 14, 2023 Category: Cardiology Authors: Mustafa Esen Source Type: research
Effect of isotretinoin treatment on inflammatory and hematological parameters in patients with acne vulgaris
CONCLUSION: Our study suggests that the MPV and NLR ratio as biomarkers can be used as indicators of atherosclerosis-related inflammation due to ISO treatment, but the MHR, NHR, LHR, PHR, MLR, LMR ratios cannot be used. Moreover, we believe that the ratios of TG/HDL, LDL/HDL, and total cholesterol/HDL offer a new contribution as indicators of cardiovascular risk and systemic inflammation related to ISO treatment.PMID:37837334 | DOI:10.1080/15569527.2023.2268166 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 14, 2023 Category: Toxicology Authors: Mustafa Esen Source Type: research
Effect of isotretinoin treatment on inflammatory and hematological parameters in patients with acne vulgaris
CONCLUSION: Our study suggests that the MPV and NLR ratio as biomarkers can be used as indicators of atherosclerosis-related inflammation due to ISO treatment, but the MHR, NHR, LHR, PHR, MLR, LMR ratios cannot be used. Moreover, we believe that the ratios of TG/HDL, LDL/HDL, and total cholesterol/HDL offer a new contribution as indicators of cardiovascular risk and systemic inflammation related to ISO treatment.PMID:37837334 | DOI:10.1080/15569527.2023.2268166 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 14, 2023 Category: Toxicology Authors: Mustafa Esen Source Type: research
