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Assessment of the In Vivo Reprotoxicity of Isotretinoin in Sprague-Dawley Male Rat
CONCLUSION: These observations suggest that ISO was reprotoxic, and future therapies should be further reassessed.PMID:37587808 | DOI:10.2174/1570163820666230816155855 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 17, 2023 Category: Drugs & Pharmacology Authors: Ahmad Khalil Mai Daradkeh Amneh Alrabie Hasan Abo Siam Source Type: research

Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis
Conclusion: This study shows a limited impact of the 2018 RMMs on oral retinoids utilisation patterns among females of child-bearing age in four European countries. Pregnancies still occur during retinoid use, and oral retinoids are still prescribed to pregnant women. Contraception and pregnancy testing information was limited in most databases. Regulators, policymakers, prescribers, and researchers must rethink implementation strategies to avoid any pregnancy becoming temporarily related to retinoid use. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Source Type: research

Apo B-48 gene expression and low-density lipoprotein as a factor for increased insulin resistance and severity of acne
CONCLUSION: Acne patients had an abnormal in lipid profile. Acne individuals with severe form are more inclined to acquire resistance to insulin as well as higher glucose and insulin levels. Apo B-48 gene expression is elevated in acne individuals with severe form who have lipid abnormalities. This illustrating the importance of genetic variables in acne, insulin resistance, lipid profile modifications as well as Isotretinoin, a standard acne medication, can also cause lipid irregularities.PMID:37572798 | DOI:10.1016/j.gene.2023.147703 (Source: Gene)
Source: Gene - August 12, 2023 Category: Genetics & Stem Cells Authors: Ahmed Ibrahim AbdElneam Mohammed Saleh Al-Dhubaibi Saleh Salem Bahaj Ghada Farouk Mohammed Lina Mohamed Atef Source Type: research

Modified red light 5-aminolevulinic acid photodynamic therapy versus low dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study
Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) and isotretinoin (ISO) are effective treatments for moderate to severe acne vulgaris. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 7, 2023 Category: Dermatology Authors: Linglin Zhang, Yutong Yang, Bo Wang, Yan Zhao, Peiru Wang, Jia Liu, Jiayi Yang, Yun Wu, Ting Lv, Ziyu Wei, Xiaojing Liu, Ruiping Wang, Harrison Wong, Qiang Ju, Lei Shi, Xiuli Wang Source Type: research

Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study
Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) and isotretinoin (ISO) are effective treatments for moderate to severe acne vulgaris. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 7, 2023 Category: Dermatology Authors: Linglin Zhang, Yutong Yang, Bo Wang, Yan Zhao, Peiru Wang, Jia Liu, Jiayi Yang, Yun Wu, Ting Lv, Ziyu Wei, Xiaojing Liu, Ruiping Wang, Harrison Wong, Qiang Ju, Lei Shi, Xiuli Wang Tags: Original article Source Type: research

[[Translated article]]Acne Fulminans: A Narrative Review
In conclusion, acne fulminans mainly affects the face and trunk of male adolescents with a history of acne vulgaris. The main subtype was acne fulminans with systemic symptoms, and most patients were treated with systemic corticosteroids. The effect of acne fulminans on quality of life is underreported.PMID:37506824 | DOI:10.1016/j.ad.2023.05.029 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - July 28, 2023 Category: Dermatology Authors: R Guti érrez-Meré I Tajes P Dominguez D Soto-Garc ía S Mart ínez-Fernández A Batalla Source Type: research