Oral isotretinoin combined with topical clobetasol 0.05% and tacrolimus 0.1% for the treatment of frontal fibrosing alopecia: A randomized controlled trial.
Authors: Mahmoudi H, Rostami A, Tavakolpour S, Nili A, Teimourpour A, Salehi Farid A, Abedini R, Amini M, Daneshpazhooh M Abstract Background: Frontal fibrosing alopecia (FFA) is a scarring alopecia with no promising treatment.Objective: To evaluate the additive efficacy of oral isotretinoin to topical treatments.Methods: Between November 2017 and August 2018, FFA patients were randomly assigned to receive either isotretinoin (20mg/d) plus topical treatments (clobetasol 0.05% and tacrolimus 0.1%) or monotherapy with topical treatments. Treatments' efficacy was evaluated through Frontal Fibrosing Alopecia Severity I...
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effects of Different Doses of Systemic Isotretinoin on Eyes: A Histopathological and Immunohistochemical Study in Rats
Purpose: To evaluate ocular side effects associated with systemic isotretinoin histopathologically. Methods: In this multicenter study, a total of 15 male and 15 female rats were randomly divided into 3 equal groups according to the oral dose of isotretinoin they were administered: 0 mg/kg/d (group A), 7.5 mg/kg/d (group B), and 15 mg/kg/d (group C). Biopsy specimens were taken from the globe conjunctiva, cornea, and eyelid conjunctiva. Expression levels of human beta-defensin-1, human beta-defensin-2, toll-like receptor (TLR)-2, and TLR-4 were evaluated by immunohistochemical methods. Results: The number of goblet...
Source: Cornea - April 2, 2020 Category: Opthalmology Tags: Clinical Science Source Type: research

Clinical characteristics of pediatric patients with acne fulminans associated to chronic non-bacterial osteomyelitis.
CONCLUSION: CNO/CRMO associated to AF occurs predominantly in male adolescents and is characterized by frequent involvement of the axial skeleton and arthritis. Epidemiological and clinical features of these patients differ from general CNO/CRMO cohorts. Clinical management requires careful handling of isotretinoin doses. PMID: 32238518 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 1, 2020 Category: Rheumatology Authors: Meinzer U, See H, Bader-Meunier B, Juillard C, Duquesne A, Melki I, Faye A, Bourrat E, Groupe de recherche de la Société Française de Dermatologie Pédiatrique; Société Francophone pour la rhumatologie et les Maladies Inflammatoires en Pédiatrie (S Tags: J Rheumatol Source Type: research

Erythema nodosum induced by oral isotretinoin in a patient with condylomata acuminata
We present herein a 20-year-old woman with multiple vulvar condylomata acuminata who developed EN two weeks after onset of oral isotretinoin therapy. To the best of our knowledge, this is the first report of EN occurring during isotretinoin treatment in a patient without acne and strongly indicates that the pathogenesis of EN can be directly related to the biological actions of isotretinoin. Erythema nodosum should be regarded as a rare... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Extensive and recalcitrant common warts in an immunocompetent patient: rapid and complete remission after oral isotretinoin monotherapy.
Authors: Pasmatzi E, Badavanis G, Kapranos N, Apostolidou A, Monastirli A, Tsambaos D Abstract An immunocompetent patient with extensive and recalcitrant common warts that was orally treated with isotretinoin (1 mg/kg/day) is reported. His lesions revealed a complete remission after 6 weeks of treatment, which was well tolerated. The patient has presently completed a 23-month follow-up and shows no evidence of relapse of his skin lesions. In view of these remarkable therapeutic results, further randomized controlled clinical studies in large numbers of patients are now warranted, which will definitely determine whe...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - March 25, 2020 Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research

Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes.
Discussion: These changes are consistent with an acute increase in sebocyte lipogenesis and support the potential of biguanides to cause an initial flare-up in patients suffering from severe acne. PMID: 32158247 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 13, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline
ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 fema...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Pilot Study of a Novel Therapeutic Approach for Refractory Advanced Stage Folliculotropic Mycosis Fungoides.
We report here a high response rate using a novel therapeutic regimen combining interferon gamma, isotretinoin in low dose and topical carmustine, and in some cases concomitant skin-directed therapies, among 6 consecutive patients with refractory folliculotropic mycosis fungoides with stages IB through IIIB who had previously failed both topical and systemic therapies. The potential mechanisms of this multimodality approach are discussed. PMID: 32128597 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 4, 2020 Category: Dermatology Authors: Del Guzzo C, Jariwala N, Haun PA, MacArthur KM, Mowad CM, Richard EG, Rook AH Tags: Acta Derm Venereol Source Type: research

Optimizing Isotretinoin Treatment of Acne: Update on Current Recommendations for Monitoring, Dosing, Safety, Adverse Effects, Compliance, and Outcomes
AbstractAcne vulgaris is the most common skin disease treated by dermatologists. It can be severe and result in permanent scars. Isotretinoin is the most effective treatment for acne and has the potential for long-term clearance. Prescribing and monitoring protocols can vary widely among prescribers. Recent studies, reports, and consensus statements help shed light on optimizing the use of isotretinoin for acne. A recent literature review is summarized in this article to help the practitioner optimize isotretinoin use for acne. The article outlines the advantages and disadvantages of standard, high-dose, and low-dose isotr...
Source: American Journal of Clinical Dermatology - February 27, 2020 Category: Dermatology Source Type: research

Can monocyte/HDL show inflammatory activity of isotretinoin treatment in acne patients?
In this study, 116 nodulocystic acne patients who received ISO treatment for at least three months were evaluated retrospectively. ISO treatment was given to patients at a dose of 0.5-1 mg/kg. Pre-treatment and post-treatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, mean platelet volume (MPV), platelet, plateletcrit, platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), total cholesterol, LDL cholesterol, triglyceride, HDL cholesterol and MHR were evaluated.Results: MPV and MHR values were significantly increased after 3 month treatment (p 0...
Source: Cutaneous and Ocular Toxicology - February 26, 2020 Category: Toxicology Authors: Önder S, Ozturk M Tags: Cutan Ocul Toxicol Source Type: research

Cancers, Vol. 12, Pages 519: Monitoring Immune Responses in Neuroblastoma Patients during Therapy
ierkens Neuroblastoma (NBL) is the most common extracranial solid tumor in childhood. Despite intense treatment, children with this high-risk disease have a poor prognosis. Immunotherapy showed a significant improvement in event-free survival in high-risk NBL patients receiving chimeric anti-GD2 in combination with cytokines and isotretinoin after myeloablative consolidation therapy. However, response to immunotherapy varies widely, and often therapy is stopped due to severe toxicities. Objective markers that help to predict which patients will respond or develop toxicity to a certain treatment are lacking. Immunothera...
Source: Cancers - February 24, 2020 Category: Cancer & Oncology Authors: Celina L. Szanto Annelisa M. Cornel Saskia V. Vijver Stefan Nierkens Tags: Review Source Type: research

Isotretinoin therapy for idiopathic aseptic facial granuloma.
PMID: 32068885 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Lee G, Fischer G Tags: Australas J Dermatol Source Type: research

Simplifying Contraception Requirements for iPLEDGE: A Decision Analysis
For persons of childbearing potential prescribed isotretinoin, the iPLEDGE program requires use of two simultaneous methods of contraception or commitment to abstinence. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 14, 2020 Category: Dermatology Authors: John S. Barbieri, Andrea H. Roe, Arash Mostaghimi Source Type: research

Relationship between sociodemographic factors and geographic distribution of pharmacies dispensing isotretinoin in Washington, DC
This study analyzed the distribution of iPLEDGE pharmacies in the District of Columbia (DC) and its correlation with sociodemographic factors. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 13, 2020 Category: Dermatology Authors: Nidhi Shah, Michelle Truong, A. Yasmine Kirkorian Tags: Letter Source Type: research

Effect of isotretinoin (13-cis-retinoic acid) on levels of soluble VEGF receptors (sVEGFR1, sVEGFR2, sVEGFR3) in patients with acne vulgaris.
Conclusions: We think that the effect of isotretinoin on sVEGFR1, sVEGFR2 and sVEGFR3 may be secondary to its effects on the VEGF family. However, after clarifying the effect of isotretinoin on the VEGF family, we think that it can be used in some tumors and vascular diseases. PMID: 32043381 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 12, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Prevalence and associated risk factors of acne relapse among Saudi acne vulgaris patients using Isotretinoin
ConclusionAlmost half of the patients showed relapse of acne after using isotretinoin. A lack of understanding regarding relapse and side effects indicates a need to improve public and professional awareness of isotretinoin. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

New onset of axial spondyloarthropathy in patients treated with isotretinoin for acne vulgaris: incidence, follow-up, and MRI findings
ConclusionIsotretinoin-induced axial SpA is a prevalent side effect in acne vulgaris patients. Early detection and follow-up of isotretinoin-induced sacroiliitis can be facilitated by MRI. Cessation of isotretinoin resulted in complete resolution in all affected patients.Key Points•Detection of underdiagnosed isotretinoin side effects which are common but not always correctly diagnosed and managed.•Incidence, diagnosis, and management of these side effects in a real-world setting.• This is the first large prospective longitudinal cohort study to report on axial manifestations in patients treated with isotret...
Source: Clinical Rheumatology - February 7, 2020 Category: Rheumatology Source Type: research

Combination of ultra-low-dose isotretinoin and antihistamines in treating Morbihan disease - a new long-term approach with excellent results and a minimum of side effects.
This study presents four patients treated with a combination of ultra-low-dose isotretinoin and antihistamines for a mean duration of 14 months. While no side effects other than dryness of the lips were noted, a significant reduction of the erythema and edema could be observed in all patients. Specialists evaluated the treatment's success by photodocumentation and measured a 91.5% alleviation of erythema, and 85% reduction of edema, respectively. Based on these results, this new regimen in the therapeutic approach toward Morbihan disease is suggested due to its anti-inflammatory features and low risk of side effects. P...
Source: Journal of Dermatological Treatment - February 6, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of sebaceous gland hyperplasia: a review of the literature.
Conclusions: Our work shows that SGH can be treated effectively by customizing the treatment technique according to different parameters, while effectively maintaining clearance of SGH lesions with best cosmetic outcome.Subject classification code: RL - Dermatology. PMID: 32011918 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 6, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Challenges and Solutions in Oral Isotretinoin in Acne: Reflections on 35 Years of Experience.
This article provides a commentary on 4 key areas: the use of oral isotretinoin vs oral antibiotics, including the importance of early recognition of nonresponse to treatment, the psychological effects of acne and isotretinoin treatment, the side effects of isotretinoin therapy, and cosmetic treatment options that can help alleviate predictable side effects. The authors, who have all participated in various international expert groups, draw on relevant literature and their extensive professional experience with oral isotretinoin in the treatment of acne. The aim of this article is to provide an informative and practical ap...
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Mucocutaneous adverse effects of the genital and perianal skin from Isotretinoin therapy
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 4, 2020 Category: Dermatology Authors: Louise Cunningham, Stephanie Menzies, Edward Moore, Emma Shudell, Fergal J. Moloney, Nicola Ralph Source Type: research

Cancers, Vol. 12, Pages 309: Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1)
Castellani Gaze Garaventa Pearson Lode To explore the effects of immunotherapy in the International Society of Paediatric Oncology Europe Neuroblastoma Group SIOPEN high-risk neuroblastoma 1 trial (HR-NBL1 trial), two cohorts were studied: one prior to and one after the introduction of dinutuximab beta. All patients received standard induction and high-dose therapy (HDT) with autologous stem cell rescue (ASCR); the local control comprised surgery and radiotherapy to the primary tumour site, followed by isotretinoin. A landmark timepoint of 109 days, resulting from the median time between ASCR and initiatio...
Source: Cancers - January 28, 2020 Category: Cancer & Oncology Authors: Ladenstein P ötschger Valteau-Couanet Luksch Castel Ash Laureys Brock Michon Owens Trahair Chi Fung Chan Ruud Schroeder Beck-Popovic Schreier Loibner Ambros Holmes Castellani Gaze Garaventa Pearson Lode Tags: Article Source Type: research

Effects of isotretinoin on new bone formation after maxillary sutural expansion
AbstractPurposeThe aim of this study was to examine the effects of isotretinoin on new bone formation after maxillary sutural expansion in rats.Materials and methodsA total of 32  male Wistar rats were selected and randomly divided into four groups. The isotretinoin group was treated with 7.5 mg/kg isotretinoin, and the soybean group was treated with 2 ml/kg soybean oil for 57 days. The substances were applied via oral gavage. The expansion-only and the control groups were not treated with any substance. In the experiment groups, expansion springs were applied on day 41 of the experiment, and after day 5...
Source: Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie - January 21, 2020 Category: ENT & OMF Source Type: research

Therapy-recalcitrant folliculitis decalvans controlled successfully with adalimumab
We present the therapy-recalcitrant case of FD which is controlled successfully by subcutaneous injections of Adalimumab (Humira®) with no serious adverse events throughout the treatment. (Source: International Journal of Trichology)
Source: International Journal of Trichology - January 14, 2020 Category: Dermatology Authors: Meshal M Alhameedy Adel M Alsantali Source Type: research

Severe Rhabdomyolysis Associated With Low-Dose Isotretinoin Therapy.
oni P PMID: 31932002 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - January 10, 2020 Category: Dermatology Authors: Morgado-Carrasco D, Del Rosario A, Fustà-Novell X, Giavedoni P Tags: Actas Dermosifiliogr Source Type: research

NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma
SummaryPreclinical studies suggest that histone deacetylase (HDAC) inhibitors may restore tumor sensitivity to retinoids and have synergistic anti-tumor activity when combined. We performed a Phase I clinical trial to evaluate the safety and preliminary efficacy of combining the oral HDAC inhibitor vorinostat and isotretinoin in patients with advanced renal cell carcinoma (RCC). Vorinostat was administered at 300  mg orally twice daily in combination with escalating doses of isotretinoin for 3 consecutive days per week. A standard 3 + 3 dose escalation design was used. Dose limiting toxicities (DLT) were...
Source: Investigational New Drugs - January 3, 2020 Category: Drugs & Pharmacology Source Type: research

Contradictory iPledge Requirements Hinder Physician Practice and Patient Care —Reply
In Reply We thank Pousti and Mollanazar for their interest in our study and for furthering the discussion surrounding the burden and need for improvement of iPLEDGE ’s stringent requirements. Our work aimed to describe fetal exposure to isotretinoin in the iPLEDGE era. We found that although the number of pregnancy-related adverse events has declined since the implementation of iPLEDGE in 2006, rates have remained steady since 2010. Patients continue to have adverse outcomes despite the imposition of iPLEDGE on all parties involved, underscoring the need for further objective evaluation of this system. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 2, 2020 Category: Dermatology Source Type: research

Isotretinoin: experts convene to investigate new concerns over suicide risk
(Source: BMJ News)
Source: BMJ News - December 31, 2019 Category: General Medicine Source Type: research

Isotretinoin Induced Urethritis: A Case Report & Review of the Literature
We report a case of urethritis in a 17-year-old non-sexually active male that developed after starting isotretinoin treatment for his acne. Clinicians must be vigilant about this adverse effect and elicit a thorough medication history prior to administering antibiotics in patients taking isotretinoin treatment for acne. (Source: Urology Case Reports)
Source: Urology Case Reports - December 24, 2019 Category: Urology & Nephrology Source Type: research

Truncal Acne: A Neglected Entity
This article reviews available information as well as recent recommendations for treatment. J Drugs Dermatol. 2019;18(12):1205-1208. PMID: 31859617 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 21, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

YouTube as a Source of Dermatologic Information on Isotretinoin
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - December 13, 2019 Category: Dermatology Authors: Laura Xiang, Sairekha Ravichandran, Nina Tamashunas, Angie Wan, Rishabh S. Mazmudar, Jeffrey F. Scott Source Type: research

Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: Can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment?
In this study, it is aimed to examine the effect of the ISO treatment on the MHR and other inflammatory markers in patients with acne vulgaris.Material and methods: In this study, 89 out of 120 patients with severe/very severe acne vulgaris according to the Global Acne Grading Scale who received at least 3 months of ISO treatment were evaluated. The complete blood counts including mean levels of mean platelet volume, plateletcrit (PTC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), MHR and serum biochemistry panel were evaluated before and after ISO treatment.Results: The mean platelet value, NL...
Source: Cutaneous and Ocular Toxicology - December 6, 2019 Category: Toxicology Authors: Kutlu Ö Tags: Cutan Ocul Toxicol Source Type: research

Use of Topical and Systemic Retinoids in Solid Organ Transplant Recipients: Update and Review of the Current Literature
CONCLUSION Retinoids constitute a highly efficacious alternative for the management of the most common conditions that affect SOTRs. Acitretin has the most robust evidence for chemoprophylaxis in SOTRs. Knowledge about the specific indications and expected side effects of topical and systemic retinoids may help optimize their therapeutic potential. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - November 27, 2019 Category: Dermatology Tags: Review Article Source Type: research

Comparative Pharmacokinetic Profiles of a Novel Low-dose Micronized-isotretinoin 32 mg Formulation and Lidose-isotretinoin 40 mg in Fed and Fasted Conditions: Two Open-label, Randomized, Crossover Studies in Healthy Adult Participants.
Abstract Two open-label, crossover studies compared the bioavailability of micronized-isotretinoin 32 mg and Lidose-isotretinoin 40 mg in healthy adults. In the fed bioequivalence/food-effect study, participants (n = 71) received single doses of fed-state micronized-isotretinoin 32 mg, fed-state Lidose-isotretinoin 40 mg and fasted-state micronized-isotretinoin 32 mg. In the fasting study, participants (n = 8) received single doses of fasted-state micronized-isotretinoin 32 mg and fasted-state Lidose-isotretinoin 40 mg. Bioavailability was assessed by isotretinoin LnAUC0-t, LnAUC0-&infi...
Source: Acta Dermato-Venereologica - November 27, 2019 Category: Dermatology Authors: Madan S, Kumar S, Segal J Tags: Acta Derm Venereol Source Type: research

Isotretinoin-induced sacroiliitis in patients with hidradenitis suppurativa: a case-based review
In this study, we discussed two cases who presented with low back pain after isotretinoin was used for the treatment of acne vulgaris. The patients did not have low back pain before isotretinoin use and did not have enthesitis, dactylitis, uveitis, psoriasis, recent infection, trauma, and family history spondylitis. HLA-B27 was negative. Bone-marrow edema was detected at the sacroiliac joint on magnetic resonance imaging. Because of these findings, sacroiliitis related to the drug was considered in our patients and isotretinoin treatments were discontinued. Because the patients ’ low back pain continued when they adm...
Source: Rheumatology International - November 25, 2019 Category: Rheumatology Source Type: research

Determination of isotretinoin (13-cis-retinoic acid) using a sensor based on reduced graphene oxide modified with copper nanoparticles
Publication date: Available online 23 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Victoria Quintas Fernandes, Martin K. Leme Silva, Ivana CesarinoAbstractThe electrochemical behaviour of isotretinoin (13-cis-RA) on an electrode modified with a composite based on reduced graphene oxide (rGO) modified with copper nanoparticles (CuNPs) was investigated. The rGO-CuNPs composite was successfully synthesized by a simple chemical reduction step and then characterized by microscopic and electrochemical techniques. The rGO-CuNPs modified glassy carbon (GC) electrode was applied successfully in the direct e...
Source: Journal of Electroanalytical Chemistry - November 25, 2019 Category: Chemistry Source Type: research

Isotretinoin-induced pruriticerythematous lesions and acute chest pain in a 15-year-old girl
We report a case of a 15-year-old girl given isotretinoin for severe acne vulgaris who developed pruriticerythematous lesions and chest pain 5 min after taking the first dose 20 mg of isotretinoin. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - November 15, 2019 Category: Emergency Medicine Authors: Ömer Doğan Alataş, Emine Tuba Alataş Source Type: research

Isotretinoin-induced pruritic erythematous lesions and acute chest pain in a 15-year-old girl
We report a case of a 15-year-old girl given isotretin oin for severe acne vulgaris who developed pruritic erythematous lesions and chest pain 5 min after taking the first dose 20 mg of isotretinoin. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - November 15, 2019 Category: Emergency Medicine Authors: Ömer Doğan Alataş, Emine Tugba Alataş Source Type: research

Use of oral isotretinoin to treat acne in the public system: a hospital-based retrospective cohort.
CONCLUSION: Sequelae of acne at the onset of treatment reveal delayed indication of isotretinoin, which can have negative psychosocial impacts on quality of life. Isotretinoin should be indicated early to prevent this. Its use is supported by its lack of laboratory alterations and controllable adverse events. PMID: 31691769 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - November 8, 2019 Category: General Medicine Authors: Evaristo LSBF, Bagatin E Tags: Sao Paulo Med J Source Type: research

Acne Vulgaris: A Patient and Physician ’s Experience
AbstractIn this article, the first coauthor, a young woman with acne vulgaris, shares her experience with the condition; she not only describes the clinical presentation and the eventual successful treatment of her acne, but also the emotional consequences that this skin disorder caused. The second coauthor, the patient ’s dermatologist, reviews some of the features of acne vulgaris: morphologic manifestations, pathogenesis, and treatment options. He also summarizes the patient’s response to isotretinoin therapy. In addition, he reveals his subsequent enlightenment regarding the acne-related non-dermatologic ef...
Source: Dermatology and Therapy - November 7, 2019 Category: Dermatology Source Type: research

November 2019 Editorial Message
VOL. 12, NO. 11 • NOVEMBER 2019  Dear Colleagues:  Welcome to the November 2019 issue of The Journal of Clinical and Aesthetic Dermatology. We begin the issue with results from an open-label, Phase IV study by Del Rosso et al, which evaluated long-term relapse rates following Lidose-isotretinoin taken without food in patients with severe recalcitrant […] (Source: Journal of Clinical and Aesthetic Dermatology)
Source: Journal of Clinical and Aesthetic Dermatology - November 1, 2019 Category: Dermatology Authors: JCAD Online Editor Tags: Current Issue Editorial Message Source Type: research

Isotretinoin, Patient Safety, and Patient-Centered Care
This Viewpoint reviews the consequences of iPLEDGE and proposes reforms to optimize its contraception requirements and ease its administrative burden. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 30, 2019 Category: Dermatology Source Type: research

Isotretinoin-induced Acne Fulminans without Systemic Symptoms Treated Successfully with Oral Dapsone.
PMID: 31626323 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 18, 2019 Category: Dermatology Authors: Legal K, Misery L Tags: Acta Derm Venereol Source Type: research

Acne Vulgaris: Diagnosis and Treatment.
Abstract Acne vulgaris is the most prevalent chronic skin disease in the United States, affecting nearly 50 million people per year, mostly adolescents and young adults. Potential sequelae of acne, such as scarring, dyspigmentation, and low self-esteem, may result in significant morbidity. Typical acne lesions involve the pilosebaceous follicles and the interrelated processes of sebum production, Cutibacterium acnes (previously called Propionibacterium acnes) colonization, and inflammation. Acne may be classified as mild, moderate, or severe based on the number and type of skin lesions. Multiple treatment agents a...
Source: American Family Physician - October 15, 2019 Category: Primary Care Authors: Oge' LK, Broussard A, Marshall MD Tags: Am Fam Physician Source Type: research

Oral isotretinoin for treating mucocutaneous human papillomavirus infections: A systematic review and meta-analysis
Conclusion: Oral isotretinoin is superior to placebo for treating mucocutaneous human papillomavirus infections, particularly plane warts. The recurrence rate and risk of severe side effects are low. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - October 11, 2019 Category: Dermatology Authors: Ting-Hua Yang Tsai-Hsien Lee Yu-Chen Huang Source Type: research

A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma.
CONCLUSIONS: Adding hu14.18K322A to induction chemotherapy produced early PR or better in most patients, reduced tumor volumes, improved CSs at the end of induction, and yielded an encouraging 2-year EFS. These results, if validated in a larger study, may change the standard of care for children with high-risk neuroblastoma. PMID: 31601569 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 10, 2019 Category: Cancer & Oncology Authors: Furman WL, Federico SM, McCarville MB, Shulkin BL, Davidoff AM, Krasin MJ, Sahr N, Sykes A, Wu J, Brennan RC, Bishop MW, Helmig S, Stewart E, Navid F, Triplett B, Santana VM, Bahrami A, Anthony G, Yu AL, Hank J, Gillies SD, Sondel PM, Leung WH, Pappo AS Tags: Clin Cancer Res Source Type: research

Molecular characterization of a toxicological tipping point during human stem cell differentiation
Publication date: Available online 7 October 2019Source: Reproductive ToxicologyAuthor(s): Katerine S. Saili, Todor Antonijevic, Todd J. Zurlinden, Imran Shah, Chad Deisenroth, Thomas B. KnudsenAbstractEndoderm gives rise to the gut tube in the early embryo. We differentiated human induced pluripotent stem cells (hiPSCs) to embryonic endoderm to identify a tipping point at which the developing system did not recover from perturbations caused by exposure to all-trans retinoic acid (ATRA). Differentiating iPSC-derived endoderm exposed to five concentrations of ATRA between 0.001 and 10 µM at 6 h, 96 h, or...
Source: Reproductive Toxicology - October 9, 2019 Category: Toxicology Source Type: research

JAAD Game Changers: Compliance with pregnancy prevention measures during isotretinoin therapy
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 28, 2019 Category: Dermatology Authors: Kristin Lee Source Type: research

Isotretinoin is indirectly effective in sebocytes.
ulis CC, Törőcsik D Abstract In a recently published research letter Burney et al. demonstrated that isotretinoin (13-cis-retinoic acid, 13CRA) induced acnegenic changes in SEB-1 cultured human sebocytes1 . However, Melnik et al., suggested that the observed changes may largely be influenced by the Simian virus (SV)-40 immortalization of the used cell line, which may inhibit the p53 pathway and together with 13CRA lead to changes, such as the down-regulation of the forkhead box O (FoxO) pathway. In contrast, they found that the FoxO pathway was upregulated in samples from patients receiving 13CRA treatment f...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Kovács D, Hegyi K, Szegedi A, Deák D, Póliska S, Rühl R, Zouboulis CC, Törőcsik D Tags: Br J Dermatol Source Type: research

Isotretinoin in the Treatment of Hidradenitis Suppurativa: A Retrospective Study.
Conclusions: Our data suggest that for HS patients, having a history of pilonidal cyst is associated with a beneficial response to isotretinoin. PMID: 31535587 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - September 21, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research