The Microbiome and Acne: Perspectives for Treatment
AbstractThe skin microbiome consists of the microorganisms populating the human skin.Cutibacterium acnes (C. acnes, formerly namedPropionibacterium acnes) is recognized as a key factor in acne development, regulating inflammatory and immune pathways. Dysbiosis has been described as the imbalance in skin microbiome homeostasis and may play a role in acne pathogenesis. Microbial interference has been shown to be a contributor to healthy skin homeostasis and staphylococcal strains may exclude acne-associatedC. acnes phylotypes. In this review we present an update on the skin microbiome in acne and discuss how current acne...
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris
Conclusion:Supplementation of ω-3 fatty acids could alleviate the inflammation of acne vulgaris by increasing the abundance of butyric acid producing bacteria.PMID:38164791 | DOI:10.1080/09546634.2023.2299107 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 2, 2024 Category: Dermatology Authors: Yaxin Huang Fuming Liu Jindong Lai Shiyu Jiang Xiaoqi Tan Lingna Chen Yong Xu Xia Xiong Yongqiong Deng Source Type: research
Errors in Figures 3 and 4
This article has been corrected. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 1, 2024 Category: Dermatology Source Type: research
Pityriasis Rubra Pilaris: An Updated Review of Clinical Presentation, Etiopathogenesis, and Treatment Options
AbstractPityriasis rubra pilaris (PRP) is a rare papulosquamous reaction pattern with a significant impact on quality of life. Type I PRP is the most common PRP variant, presenting as erythematous papules emerging in a follicular distribution and later coalescing into plaques with characteristic islands of sparing; histologically, an alternating pattern of orthokeratosis and parakeratosis is considered the hallmark of PRP (checkerboard hyperkeratosis). Other PRP variants (types II –V) differ in their age of onset and clinical presentation. Type VI PRP is a rare PRP subtype associated with human immunodeficiency virus inf...
Source: American Journal of Clinical Dermatology - December 30, 2023 Category: Dermatology Source Type: research
The primary role of sebum in the pathophysiology of acne vulgaris and its therapeutic relevance in acne management
CONCLUSIONS: To date, only combined oral contraceptives and oral spironolactone (both limited to female patients), oral isotretinoin and topical clascoterone (cortexolone 17α-propionate) modulate sebum production in patients with AV. A better understanding of mechanisms underlying sebaceous gland changes driving AV development is needed to expand the AV treatment armamentarium.PMID:38146664 | DOI:10.1080/09546634.2023.2296855 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 26, 2023 Category: Dermatology Authors: James Q Del Rosso Leon Kircik Source Type: research
Efficacy of alitretinoin in the treatment of Darier disease: a case report
We report the case of a female patient with Darier disease that was unsuccessfully treated with acitretin and isotretinoin but showed significant improvement with alitretinoin. Previous reports on the efficacy of alitretinoin in Darier disease are reviewed.PMID:38126103 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Andreja Pagon Mateja Dolenc Volj č Source Type: research
