Distinct Microbial Communities in Dilated Cardiomyopathy Explanted Hearts Are Associated With Different Myocardial Rejection Outcomes
ConclusionsThis initial study investigating on infectious agents and inflammation in the IDCM explanted hearts showed that the association between M. pneumoniae and hepatitis B core was associated with a worse outcome after HT, represented by MR and PMR, suggesting that different IDCM microbial communities may be contributing to post-transplant myocardial rejection.
T cell polyfunctionality is a hallmark of protective immunity against pathogens and cancer, yet the molecular mechanism governing it remains mostly elusive. We found that canonical Wnt agonists inhibited human memory CD8+ T cell differentiation while simultaneously promoting the generation of highly polyfunctional cells. Downstream effects of Wnt activation persisted after removal of the drug, and T cells remained polyfunctional following subsequent cell division, indicating the effect is epigenetically regulated. Wnt activation induced a gene expression pattern that is enriched with stem cell–specific gene signature...
Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling between 2 unique age-dependent lymphocyte subpopulations, CD153+PD-1+CD4+ senescence-associated T (SAT) cells and CD30+T-bet+ age-associated B cells (ABCs), as a driver for TLT expansion. SAT cells, which produced ABC-inducing factors IL-21 and IFN-γ, and ABCs progressively accumulated within TLTs in aged kidneys after injury. Notably, in kidney injury models, CD153 or...
TUESDAY, Jan. 18, 2022 -- Real-world data show steady improvement in overall survival (OS) for patients with Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) who experienced relapse after allogeneic hematopoietic cell transplantation...
HIV-positive kidney- and liver-transplant patients can expect good long-term outcomes following the transplant, comparable with those of matched HIV-negative peers, according to a new study.Reuters Health Information
An observational, multicenter Chinese study showed that diabetes plus low HDL-C significantly links with a nearly doubled peritonitis rate in patients on peritoneal dialysis.First Look
Funding Opportunity RFA-AI-22-002 from the NIH Guide for Grants and Contracts. This purpose of this RFA is to solicit applications for the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), a multi-center, cooperative program dedicated to developing, optimizing, and evaluating approaches to induce and maintain immune tolerance to allogeneic transplants in nonhuman primate (NHP) models. The over-arching goal is to facilitate clinical translation of safe and effective tolerance-induction protocols for long-term graft survival.
Conclusion: Our data indicate that the expression of the glycolytic phenotype of metabolic markers, especially GLUT1 and MCT4, correlates with a more severe course of HCC occurring in NASH patients.Pathobiology
Patients treated with immune checkpoint inhibitors may realize a greater risk for developing hyponatremia and other electrolyte disorders. How common are these events?Nephrology Dialysis Transplantation
CONCLUSION: It is concluded that co-culture of MSCs with Molt-4 cells could be involved in the changing the methylation status of hTERT gene promoter, cell cycle and hTERT protein expression; it could potentially beneficial for further investigations regarding the cell transplantation and cell-based therapy.PMID:35040412 | DOI:10.2174/1566524022666220118103136
CONCLUSIONS: This initial study investigating on infectious agents and inflammation in the IDCM explanted hearts showed that the association between M. pneumoniae and hepatitis B core was associated with a worse outcome after HT, represented by MR and PMR, suggesting that different IDCM microbial communities may be contributing to post-transplant myocardial rejection.PMID:34912727 | PMC:PMC8668412 | DOI:10.3389/fcimb.2021.732276
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