Siponimod for multiple sclerosis
Cochrane Database Syst Rev. 2021 Nov 16;11:CD013647. doi: 10.1002/14651858.CD013647.pub2.ABSTRACTBACKGROUND: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system, with an unpredictable course. Current MS therapies such as disease-modifying therapies focus on treating exacerbations, preventing new exacerbations and avoiding the progression of disability. Siponimod (BAF312) is an oral treatment, a selective sphingosine-1-phosphate (S1P) receptor modulator, for the treatment of adults with relapsing forms of MS including active, secondary progressive MS with relapses.OBJECTIVES: To assess the benefits and adverse effects of siponimod as monotherapy or combination therapy versus placebo or any active comparator for people diagnosed with MS.SEARCH METHODS: On 18 June 2020, we searched the Cochrane Multiple Sclerosis and Rare Diseases of the CNS Trials Register, which contains studies from CENTRAL, MEDLINE and Embase, and the trials registry databases ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP). We also handsearched relevant journals and screened the reference lists of published reviews and retrieved articles and searched reports (2004 to June 2020) from the MS societies in Europe and America.SELECTION CRITERIA: We included randomised parallel controlled clinical trials (RCTs) that evaluated siponimod, as monotherapy or combination therapy, versus placebo or any active comparator in people with MS. There w...
ConclusionsImprovement was seen in most patients. One year after the start of treatment, more than half of the patients were untreated and around one-third in remission. Residual symptoms and deficits were common regardless of treatment.
ConclusionsIn this updated systematic review and meta-analysis, uterine exteriorization was associated with an increased risk of IONV but no significant change in perioperative hemoglobin decrease compared within situ repair.Study registrationPROSPERO (CRD42020190074); registered 5 July 2020.
ConclusionsGiven the perceived benefits of regional over general anesthesia, approximately half of the members of three regional anesthesia societies seem to have expanded their use of regional anesthesia techniques during the initial surge of the COVID-19 pandemic.
“For me, my own personal stories of opioid patients come to mind, including one who keyed my car when I stopped prescribing his opioid after an acute injury. I think of some local opioid overdose deaths in my community. I would love to hear what other doctors and clinicians have to say about these issues,Read more …Coal mining culture and the opioid crisis [PODCAST] originally appeared inKevinMD.com.
AbstractPurposeTraumatic thoracolumbar vertebral fractures are frequently treated with posterior fixation (PF) and vertebral augmentation. Sometimes, it is deemed too risky to offer vertebral augmentation under fluoroscopic guidance alone. Adjuvant CT/fluoroscopy-guided percutaneous vertebroplasty (PVP) could be offered in certain scenarios. The aim was to evaluate feasibility, safety and effectiveness of PVP in patients presenting with vertebral non-union (VNU) following PF performed without concomitant vertebral augmentation.Materials and MethodsAll patients treated in our institution with PVP between July 2015 and July ...
AbstractMigraineurs show impaired cognitive functions interictally, mainly involving information processing speed, basic attention, and executive functions. We aimed to assess executive impairment in migraine patients with different attack frequencies through a task-switching protocol designed to assess different sub-processes of executive functioning. We enrolled 42 migraine patients and divided them into three groups based on the attack frequency: 13 subjects had episodic migraine with a low frequency (LFEM, 4 –7 migraine days per month), 14 subjects had high-frequency episodic migraine (HFEM, 8–14 days)...
PARACETAMOL, also known as acetaminophen, is a commonly used medicine that can help treat pain and reduce a high temperature. Paracetamol is widely available as tablets and capsules.
My years teaching in universities – and my own children – have changed my attitude to the storm of disability our young people faceI ’ve been teaching at Australian universities for 25 years now. I began when I was 27 – I’m now 52. This means I’ve been next to university students since 1996, and if you’re curious about these things, you see patterns begin to emerge.Every parent, every aunt or uncle, every grandparent, and in fact anyone who has anything to do with young people today is anxious about one thing: anxiety. It seems it ’s on the rise. Itison the rise. Each semeste...
A Horsham medical device company signed a deal to get its lasers distributed in Israel.
I am on the virtual conference with society of pain practice management today and they specifically stated: First coast and Noridian only currently still have depomedrol approved for ESI. Otherwise, Depomedrol/methylpred is not an accepted steroid for use, by the new medicare guidelines, for ESI. so if they audit you and you used depo, they will claw back money.
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