A safe, effective diet pill - the elusive holy grail

Trade in illegal, ineffective drugs flourishes as pharmaceutical industry repeatedly fails to produce successful pillAttempts to invent a safe and effective diet pill have foundered time and again, allowing the internet trade in illegal and ineffective herbal supplements and dangerous drugs, such as DNP, to flourish.A successful diet pill could make billions for the pharmaceutical industry, but efforts to date have ended in disaster, with patients harmed, drugs banned and massive compensation paid out.Fen-phen, an appetite suppressant, was the most spectacular failure. It was withdrawn in the US in 1997 after causing widespread heart valve damage.More recently, two other appetite suppressants have been taken off the market in the UK – sibutramine (Reductil) and rimonabant (Acomplia). Both went through the extensive trials required to get a licence and appeared to work, but once they were being widely used, dangerous side-effects emerged.Rimonabant made some people feel suicidal. Sibutramine increased the chances of having a non-fatal heart attack or stroke.The only drug that has official NHS approval – orlistat, sold under the brand name Xenical – is unpopular. It works by preventing the absorption of fat in the gut and often causes diarrhoea. It does nothing to dampen the appetite. The National Institute for Health and Care Excellence recommends it for obese patients, but only if they have managed to lose 2.5kg (5.5lb) over four weeks through dieting. It mu...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: The Guardian Diets and dieting Drugs trade Healthcare industry World news Pharmaceuticals industry & wellbeing Health policy Society Politics UK news Life and style Public services policy Business Science Source Type: news

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This study aims to assess whether older adults with low muscle mass or strength, in the presence of obesity, have an increased risk of knee (TKR) and hip replacement (THR) over 13  years. 1082 community-dwelling older adults (51% women; mean age 62.9 ± 7.5 years) were studied at baseline and multiple time points over 13 years. The incidence of TKR and THR was determined by data linkage to National Joint Replacement Registry. Appendicular lean and fat mass were measure d using DXA. Lower-limb muscle strength (LMS) was assessed by dynamometer. Low muscle mass and strength were defined as t...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Publication date: Available online 2 June 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Sabine Moehner, Kerstin Becker, Jens A. Lange, Sophia von Stockum, Klaas Heinemann
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
ABSTRACT Objective To assess the outcome of an educational nutritional intervention in the quality of diet of women with breast cancer in adjuvant treatment. Methods Women with breast cancer and admitted for surgical treatment were divided in an intervention group (n=18) and a comparison group (n=78), and participated in a nonrandomized clinical trial. Participants were assessed before and after the treatment and/or intervention. A food frequency questionnaire was applied and the quality of diet was calculated using the Brazilian Healthy Eating Index Revised. The educational nutritional intervention lasted 12 months and wa...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
Publication date: Available online 2 June 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Zhaoxie Tang, Saijun Huang, Rui Ma, Hao Zheng, Yanna Zhu
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 2 June 2020Source: Journal of ColoproctologyAuthor(s): Nasrin Sarabi
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Conclusions: In the largest study to date of symptomatic individuals under 50 years of age undergoing colonoscopy in the USA, advanced CRN was most often detected in the distal colon and was associated with anemia, but not with abnormal bowel habits or abdominal pain. We also found that patients with CRN under 50 years of age were more likely to be male, smokers, and obese. These findings should prompt further investigation of these risk factors alone and in combination.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Background and aim Recent clinical trials have confirmed that Helicobacter pylori infection is positively associated with nonalcoholic fatty liver disease (NAFLD), although some research has shown a negative association. Therefore, to confirm whether H. pylori eradication treatment is feasible for NAFLD patients in our hospital, we aimed to establish the association between H. pylori infection and NAFLD. Methods We enrolled 91 patients with NAFLD diagnosed by abdominal B-mode ultrasonography between January and December 2018. H. pylori infection was confirmed by C13 urea breath test, and liver function, glycometabolis...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Publication date: Available online 2 June 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Timur Ekiz, Ahmet Cemal Pazarlı
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Francesco Squadrito, Michelangelo Rottura, Natasha Irrera, Letteria Minutoli, Alessandra Bitto, Maria Antonietta Barbieri, Giuseppe Cicala, Anna Mecchio, Giovanni Pallio, Sebastiano Marino, Giacomo Picciolo, Domenica Altavilla, Vincenzo Arcoraci
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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