A safe, effective diet pill - the elusive holy grail

Trade in illegal, ineffective drugs flourishes as pharmaceutical industry repeatedly fails to produce successful pillAttempts to invent a safe and effective diet pill have foundered time and again, allowing the internet trade in illegal and ineffective herbal supplements and dangerous drugs, such as DNP, to flourish.A successful diet pill could make billions for the pharmaceutical industry, but efforts to date have ended in disaster, with patients harmed, drugs banned and massive compensation paid out.Fen-phen, an appetite suppressant, was the most spectacular failure. It was withdrawn in the US in 1997 after causing widespread heart valve damage.More recently, two other appetite suppressants have been taken off the market in the UK – sibutramine (Reductil) and rimonabant (Acomplia). Both went through the extensive trials required to get a licence and appeared to work, but once they were being widely used, dangerous side-effects emerged.Rimonabant made some people feel suicidal. Sibutramine increased the chances of having a non-fatal heart attack or stroke.The only drug that has official NHS approval – orlistat, sold under the brand name Xenical – is unpopular. It works by preventing the absorption of fat in the gut and often causes diarrhoea. It does nothing to dampen the appetite. The National Institute for Health and Care Excellence recommends it for obese patients, but only if they have managed to lose 2.5kg (5.5lb) over four weeks through dieting. It mu...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: The Guardian Diets and dieting Drugs trade Healthcare industry World news Pharmaceuticals industry & wellbeing Health policy Society Politics UK news Life and style Public services policy Business Science Source Type: news

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Authors: Ye MB, Chen YL, Wang Q, An J, Ye F, Jing P Abstract OBJECTIVES: Stroke is a common condition after a transient ischemic attack (TIA) or minor ischemic stroke (IS). Adding clopidogrel to aspirin may yield more beneficial outcomes than aspirin mono-therapy; meanwhile, the risk of bleeding in the acute phase remains poorly understood. Therefore, there is increasing emphasis on the risks and benefits of clopidogrel with aspirin compared with aspirin mono-therapy in an effort to treat TIA/IS. DESIGN: We searched several electronic databases, including PubMed, Cochrane, and Embase, to identify eligible rando...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
CONCLUSION: Arterial hypertension and elevated diastolic blood pressure are associated with a risk for AS requiring surgery in subjects below 60 years of age. Strict blood pressure control in this group is strongly advocated to avoid other cardiovascular diseases correlated to hypertension. If hypertension and elevated diastolic blood pressure are risk factors for developing AS requiring surgery need further investigations. Notably, elevated fasting glucose levels were related to AS requiring surgery in older adults without concomitant CAD. PMID: 31109205 [PubMed - in process]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Publication date: Available online 22 May 2019Source: Toxicology ReportsAuthor(s): María F. Kroker-Lobos, Christian S. Alvarez, Alvaro Rivera-Andrade, Joshua W. Smith, Patricia Egner, Olga Torres, Mariana Lazo, Neal D. Freedman, Eliseo Guallar, Barry I. Graubard, Katherine A. McGlynn, Manuel Ramírez-Zea, John D. GroopmanAbstractAflatoxin B1 (AFB1) is a known human hepatocarcinogen and a recent study reported elevated AFB1 levels, measured by serum albumin biomarkers, among Guatemalan adults. While AFB1 can contaminate a variety of foodstuffs, including maize, Guatemala’s main dietary staple, the relatio...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Authors: Trivino A, Gumireddy A, Meng F, Prasad D, Chauhan H Abstract The major goal of this research was to successfully formulate solid dispersion (SD) of the poorly soluble anticancer drug flutamide (FLT) using various hydrophilic polymers. Furthermore, to get more insight into SD, solid-state studies (miscibility and molecular interaction) were correlated with solution study (precipitation inhibition, dissolution). Hydrophilic polymers like PVP K90, HPMC, Eudragit EPO, and PEG 8000 were used at different drug-to-polymer w/w ratios. Solid-state miscibility studies were carried out using modulated differential sc...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: Current literature show similar risks for bacterial pathogens. Studies are limited for viral and parasitic pathogens. The evaluated risk-factors for PI-IBS varied among the included studies and the existing evidence is insufficient to identify pathogen-specific risk factors. PMID: 31112663 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
The Care Quality Commission has observed improvements to culture at an accident and emergency department at the centre of a major bullying scandal.
Source: HSJ - Category: UK Health Source Type: news
Philips Healthcare has garnered U.S. Food and Drug Administration (FDA) 510(k)...Read more on AuntMinnie.comRelated Reading: Philips releases IntraSight interventional app platform Philips' Lumify lands Army airworthiness certification Philips, MIM to collaborate on radiation therapy Philips launches CT, MR simulation scanners at ASTRO Philips launches MRI prostate treatment planning
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 22 May 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Francesco Martino, Eliana Martino, Paolo Versacci, Tarcisio Niglio, Cristina Zanoni, Paolo Emilio PudduAbstractLifestyle habits including indoor and outdoor activities among community school children, adherence to the Mediterranean diet and awareness about total cholesterol blood levels represent determinant factors in cardiovascular disease (CVD) prevention. The aim of this study was to analyze the relationship between adherence to the Mediterranean diet, total cholesterol blood levels, body composition and ho...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Bernadetta Lis, Beata OlasAbstractSince ancient times, dandelion (Taraxacum officinale L.) has been consumed in various forms as a valuable source of nutrients, minerals and vitamins which can also have beneficial effects on various complex diseases. It is described as a nontoxic herb with exceptional biological activity. The aim of this review is to present the multidirectional activity of various dandelion products whose dietary intake may help to prevent, or reduce the risk of, the development of a range of diseases, including cancer, ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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