Manganese Induced neurodegenerative diseases and possible therapeutic approaches.

Manganese Induced neurodegenerative diseases and possible therapeutic approaches. Expert Rev Neurother. 2020 Aug 17;: Authors: Martins AC, Gubert P, Villas Boas GR, Meirelles Paes M, Santamaría A, Lee E, Tinkov AA, Bowman AB, Aschner M Abstract INTRODUCTION: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and prion disease represent important public health concerns. The etiology of neurodegenerative diseases is not completely understood, but genetic factors and environmental factors clearly contribute to their development. As environmental factors, heavy metals such as manganese (Mn) an essential trace element, are required for several physiological processes. In addition, exposures to high levels may culminate in adverse health effects. AREAS COVERED: In this critical review, the authors address the role of Mn in the etiology of neurodegenerative diseases and discuss emerging treatments of Mn overload, such as chelation therapy. In addition, the authors discuss natural and synthetic compounds under development as prospective therapeutics. Moreover, bioinformatic approaches to identify new potential targets and therapeutic substances to reverse the neurodegenerative diseases are discussed. EXPERT OPINION: Here, the authors highlight the importance of better understanding the molecular mechanisms of toxicity associated with neurodegenerative diseases, and the role of Mn i...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research

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