An Approach to the Evaluation of Berries for Cancer Prevention with Emphasis on Esophageal Cancer

Our laboratory has f cancer prevention using freeze-dried berries, mainly black raspberries, for more than two decades. Berries contain many known agents with chemopreventive potential including certain vitamins, minerals, simple and complex polyphenols, phytosterols, and various fiber constituents. Because berries are approximately 80–90 % water, the freeze-drying process concentrates these bioactive constituents approximately tenfold. This chapter describes methods we use to harvest the berries, grind them into a powder, and determine the nutrient, chemical, and microbial content of the powder before use in both preclinical and clinical studies. We have found that berry powder, when added at 5.0–10 % of the diet, protects against chemically induced cancer in the rodent esophagus and colon, and other laboratories have demonstrated protective effects in the rodent oral cavity, mammary gland, and skin. Bio-fractionation studies indicate that the anthocyanins in black raspberries are important for their chemopreventive effects. The berries function to reduce cell proliferation, inflammation, and angiogenesis and to stimulate apoptosis and differentiation, and they influence the expression levels of multiple genes and signaling pathways associated with these cellular functions. Black raspberry and strawberry powders are well tolerated by humans for at least 6–9 months when consumed orally at doses as high as 60 g/day. As an example of their effects in humans, w...
Source: Springer protocols feed by Pharmacology/Toxicology - Category: Drugs & Pharmacology Source Type: news

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Conclusions: Most cancers may be insensitive to social development. Internal factors, including aging, may be a key factor for the occurrence of cancer. PMID: 32462031 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Discussion: There are a number of assumptions underlying these estimates, but overall all of them seem to be conservative.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Results from this study recently published online in Addiction found primary care physicians providing smokers with a free, two week starter kit of nicotine replacement therapy (NRT) increased quit attempts While sitting in the dentist's office, Hollings Cancer Center researcher Matthew Carpenter, Ph.D., of the Medical University of South Carolina, had a bright idea. As he received his goody bag with dental hygiene products, he wondered why not conduct a study and have primary care providers do the same thing for their patients who use tobacco. The bags would contain educational material, free lozenges and tobacco cessati...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
Santosh K. Ghosh1*, Thomas S. McCormick1,2 and Aaron Weinberg1* 1Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States 2Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States Human beta-defensins (hBDs, −1, 2, 3) are a family of epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges. In addition to their antimicrobial activities, they possess other functions; e.g., cell activation, proliferation, regulation of cytokine/chemokine production, migration, diffe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Olsen I, Yilmaz Ö Abstract There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a significant risk factor for orodigestive carcinogenesis. Porphyromonas gingivalis is proposed as a keystone pathogen in chronic periodontitis causing both dysbiosis and discordant immune response. The present review focuses on the growing recognition of a relationship between P. gingivalis and orodigestive cancers. Porphyromonas gingivalis has been...
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
Authors: Kresty LA, Fromkes JJ, Frankel WL, Hammond CD, Seeram NP, Baird M, Stoner GD Abstract Black raspberries inhibit a broad range of cancers in preclinical models which has led to clinical evaluations targeting premalignant lesions of the colon, oral cavity and esophagus. A phase I pilot study was conducted in twenty Barrett's esophagus (BE) patients to investigate the effect of lyophilized black raspberries (LBR) on urinary metabolites and markers of lipid peroxidation, DNA damage and tissue markers of cellular proliferation, detoxification, and inflammation. Surveys, biopsies, blood and urine samples were co...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSIONS: Since tissue weights are not usually included in recommendations for research tissue procurement or for frozen tissues stored in biorepositories, we offer this data as a practical guide to researcher acceptable tissue weights for selected sites based on a 3-year researcher request and acceptance history. PMID: 30379574 [PubMed - as supplied by publisher]
Source: Biopreservation and Biobanking - Category: Biomedical Science Tags: Biopreserv Biobank Source Type: research
This report provides a comprehensive assessment of recent tobacco-associated cancer incidence for each cancer type by sex, age, race/ethnicity, metropolitan county classification, tumor characteristics, U.S. census region, and state. These data are important for initiation, monitoring, and evaluation of tobacco prevention and control measures. PERIOD COVERED: 2010-2014. DESCRIPTION OF SYSTEM: Cancer incidence data from CDC's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results program were used to calculate average annual age-adjusted incidence rate...
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
(Natural News) You may want to rethink about downing another bottle of beer. Scientists have confirmed that alcohol increases the risk of getting cancer. Research revealed that frequent alcohol drinkers are more prone to contract cancers of the oral cavity and pharynx, esophagus, larynx, breast, liver, colon or rectum, and stomach. Several studies were conducted aiming...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Clinical Significance of Human Papillomavirus Type 16 for Breast Cancer &Adenocarcinomas of Various Internal Organs and Alzheimer's Brain with Increased β-amyloid (1-42); Combined Use of Optimal Doses of Vitamin D3 and Taurine 3 times/day Has Significant Beneficial Effects of Anti-Cancer, Anti-Ischemic Heart, and Memory &Other Brain Problems By Significant Urinary Excretion of Viruses, Bacteria, and Toxic Metals &Substances. Acupunct Electrother Res. 2016;41(2):127-134 Authors: Omura Y Abstract Human Papillomavirus type 16 (HPV-16) has a significant role in various cancers and Alzheime...
Source: Acupuncture and Electro-Therapeutics Research - Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research
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