State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy

This article summarizes the best available evidence interventions for preventing and managing cerebral palsy in 2019.Recent FindingsEffective prevention strategies include antenatal corticosteroids, magnesium sulfate, caffeine, and neonatal hypothermia. Effective allied health interventions include acceptance and commitment therapy, action observations, bimanual training, casting, constraint-induced movement therapy, environmental enrichment, fitness training, goal-directed training, hippotherapy, home programs, literacy interventions, mobility training, oral sensorimotor, oral sensorimotor plus electrical stimulation, pressure care, stepping stones triple P, strength training, task-specific training, treadmill training, partial body weight support treadmill training, and weight-bearing. Effective medical and surgical interventions include anti-convulsants, bisphosphonates, botulinum toxin, botulinum toxin plus occupational therapy, botulinum toxin plus casting, diazepam, dentistry, hip surveillance, intrathecal baclofen, scoliosis correction, selective dorsal rhizotomy, and umbilical cord blood cell therapy.SummaryWe have provided guidance about what works and what does not to inform decision-making, and highlighted areas for more research.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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Cerebral palsy is the most common cause of childhood motor disability, affecting 2 to 3/1000 children worldwide. Clinical abnormalities in tone, posture, and movement are the result of brain dysgenesis or injury early in life, and impairment varies in type, distribution, and in severity. The underlying brain disorder may also lead to other associated neurologic and systemic impairments. Variability in functional impairments, which can change during development, necessitates an individualized treatment plan. Treatment options are primarily symptomatic and directed toward optimizing independence, function, and/or ease of car...
Source: Neurologic Clinics - Category: Neurology Authors: Source Type: research
Authors: Tousoulis D PMID: 32252971 [PubMed - in process]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Authors: de Seze J, Bigaut K Abstract During the 20 past years, the management of multiple sclerosis (MS) has largely changed especially concerning therapeutical approach. Before 1996, treatments were restricted to corticosteroids for relapses, several symptomatic treatments and unselective immunosuppressive drugs (azathioprine, cyclophosphamide, methotrexate) with a low evidence of any efficacy. In the present review, we analyze the principal real-life cohorts of MS during several periods (before therapeutical modern area, first-generation treatment area and most recent period). Despite many methodological problem...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Nowadays, tissue engineering vascularisation has become an important means of organ repair and treatment of major traumatic diseases. Vascular endothelial layer regeneration and endothelial functionalisation are prerequisites and important components of tissue engineering vascularisation. The present researches of endothelial functionalisation mainly focus on tissue engineering scaffold preparation and implant surface modification. Few studies have reported the interaction of endothelial functionalisation and scaled materials, especially the nanomaterials. Magnesium (Mg), as an essential cytotropic active element in the hu...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Publication date: Available online 8 April 2020Source: Physics Letters AAuthor(s): F.S. Wang, Y. Li, Y.X. Zhang, G.Y. Chen
Source: Physics Letters A - Category: Physics Source Type: research
CONCLUSIONS: Corticosteroids are widely used when treating patients with COVID-19, but we found no association between therapy and outcomes in patients without acute respiratory distress syndrome. An existing HBV infection may delay SARS-CoV-2 clearance, and this association should be further investigated. PMID: 32266987 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/D0TA01033B, PaperWeijun Zhou, Jizhang Chen, Minfeng Chen, Anran Wang, Aixiang Huang, Xinwu Xu, Junling Xu, Ching Ping Wong Aqueous zinc-ion batteries (AZIBs) are promising due to their intrinsic safety and low cost. However, the unsatisfactory cathode materials with low mass loading (
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSIONS: The purpose of the SSI program is to reduce the extent of poverty by providing monthly payments to eligible individuals with disabilities. The authors found that a large and growing number of adults with autism receive SSI benefits. This finding underscores the importance of future research related to the economic security of adults on the autism spectrum. PMID: 32264799 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Authors: Caplan LJ Abstract This Open Forum describes the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR), a component of the Administration for Community Living under the U.S. Department of Health and Human Services. NIDILRR funds applied research and development projects to improve the abilities of individuals with disabilities, including those with mental illness, to perform activities of their choice in the community and to expand society's capacity to provide full opportunities and accommodations for its citizens with disabilities. PMID: 32264797 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
This study aims to determine the sexual problems of the patients with spinal cord injury and to analyze the relationship between these problems and the hopelessness levels of the patients. This descriptive cross-sectional study, which employed a mixed method (qualitative and quantitative) was conducted on 53 inpatients at a physical therapy and rehabilitation hospital in Turkey. Questionnaire on Sociodemographic and Clinical Characteristics, Arizona Sexual Experiences Scale, Beck Hopelessness Scale and Semi-Structured Interview Form on Sexuality and Hopelessness were used for data collection. Statements of the participants...
Source: Sexuality and Disability - Category: Disability Source Type: research
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