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No magic pill to cure alcohol dependence yet
(Society for the Study of Addiction) A new study published by the scientific journal Addiction has found no reliable evidence for using nalmefene, naltrexone, acamprosate, baclofen or topiramate to control drinking in patients with alcohol dependence or alcohol use disorder. At best, some treatments showed low to medium efficacy in reducing drinking, but those findings were from studies with a high risk of bias. None demonstrated any benefit on health outcomes. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 21, 2017 Category: International Medicine & Public Health Source Type: news

Severity of baclofen self-poisoning linked to psychiatric co-morbidity in alcohol-dependent patients: better measurement of risk and benefit - Pelissier F, de Haro L, Rolland B, Franchitto N.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - July 16, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers
Primary care patients with high-risk alcohol consumption have significantly better rates of low-risk drinking or abstinence with baclofen vs placebo, the results of a French study indicate.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 22, 2017 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Alcoholism drug baclofen 'is a stammer cure'
The treatment was discovered by chance after the man found he stopped stammering when he was given baclofen, a relaxant that eases stiff muscles caused by multiple sclerosis. (Source: the Mail online | Health)
Source: the Mail online | Health - May 12, 2017 Category: Consumer Health News Source Type: news

Baclofen and alcohol-dependent patients: a real risk of severe self-poisoning - Boels D, Victorri-Vigneau C, Grall-Bronnec M, Tour é A, Garnier A, Turcant A, Le Roux G.
This study aimed to determine the change in number and profile of self-poisoning with ba... (Source: SafetyLit)
Source: SafetyLit - March 23, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Self-poisoning with baclofen in alcohol-dependent patients: national reports to French Poison Control Centers, 2008-2013 - Pelissier F, de Haro L, Cardona F, Picot C, Puskarczyk E, Sapori JM, Tournoud C, Franchitto N.
BACKGROUND: Alcohol use disorders are frequently associated with self-intoxication in attempted suicide. In France since 2008, the off-label use of baclofen for treatment of alcohol dependence has greatly increased, leading to temporary regulation of use o... (Source: SafetyLit)
Source: SafetyLit - February 14, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Kemstro (Baclofen) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 26, 2017 Category: Drugs & Pharmacology Source Type: news

Gablofen (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 15, 2016 Category: Drugs & Pharmacology Source Type: news

Lioresal Intrathecal (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 15, 2016 Category: Drugs & Pharmacology Source Type: news

More Evidence Baclofen for Alcohol Dependence Be Reconsidered More Evidence Baclofen for Alcohol Dependence Be Reconsidered
Another study of high-dose baclofen, widely used in France to treat alcohol dependence, does not appear to bolster abstinence rates in findings that suggest its use should be reconsidered.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 6, 2016 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Study suggests prescribing of baclofen for alcohol dependence'should be reconsidered '
The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomized controlled trial found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 30, 2016 Category: Science Source Type: news

Prescribing of baclofen for alcohol dependence 'should be reconsidered'
(European College of Neuropsychopharmacology) The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomised controlled trial from the University of Amsterdam found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 30, 2016 Category: Global & Universal Source Type: news

ECG Reveals Effects of Multi-Substance Suicide Attempt
The Case Medic 49 was called to a wooded area near a private residence for a missing person and concern for overdose. Police were already on scene and had walked approximately 0.5 miles into the wooded area behind the home where they found a 30-year-old female unresponsive with several pill bottles nearby. The family, who had reported the patient missing, stated that the patient had a history of suicidal thoughts. On EMS arrival, the patient was still unresponsive and hypoxic with an oxygen saturation of 76% on RA. The patient was also tachycardic to 130 and had an initial blood pressure of 140/90. The patient was not movi...
Source: JEMS Patient Care - September 29, 2016 Category: Emergency Medicine Authors: Jeffrey J. Bell, RN, BSN, CEN, NREMT-P Tags: Patient Care Source Type: news

Arbaclofen-ER Decreases MS-Related Spasticity Arbaclofen-ER Decreases MS-Related Spasticity
Arbaclofen extended-release tablets can decrease spasticity related to multiple sclerosis, with a better safety profile than baclofen, new research suggests.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 16, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Teligent, Inc. Announces Health Canada Approval Of Three Baclofen Injection Products
BUENA, N.J., Aug. 25, 2016 -- (Healthcare Sales & Marketing Network) -- Teligent, Inc. (TLGT), a New Jersey-based specialty generic pharmaceutical company, today announced that its Estonian subsidiary, Teligent OÜ, has received three Abbreviated New ... Biopharmaceuticals, Generics, Regulatory Teligent, Baclofen (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 25, 2016 Category: Pharmaceuticals Source Type: news

Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms - de Witte LD, Dekker D, Veraart J, Kromkamp M, Kaasjager K, Vinkers CH.
BACKGROUND: Baclofen is increasingly prescribed for alcohol dependency. Subsequently, the risk of self-intoxication with this medicinal product is increasing. CASE DESCRIPTION: A 23-year-old man with a history of alcohol dependence was admitted to our hosp... (Source: SafetyLit)
Source: SafetyLit - August 6, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Baclofen Injection (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 19, 2016 Category: Drugs & Pharmacology Source Type: news

Well-known U of L researcher loses federal funding for study
A well-known University of Louisville researcher has lost federal funding for a nearly $1 million biomedical study because of concerns involving oversight and whether the data was valid. According to the Kentucky Center for Investigative Reporting, Dr. Susan Harkema had been studying the effects of a muscle relaxer, called Baclofen, on patients who were undergoing treadmill therapy. Funding for that $914,000 study was pulled in March by the National Institute on Disability, Independent Living and… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 12, 2016 Category: Pharmaceuticals Authors: Baylee Pulliam Source Type: news

Pharmacotherapy Utilisation in Alcohol Dependence
The objectives of this project are: Use expert knowledge and systematic investigation to develop a case definition for alcohol dependence in CPRD; Compare treatment utilisation for patients with alcohol dependence; Explore factors that may influence the treatment pathway; Explore the national-level variation in the overall usage of medication for alcohol dependence; and Compare the attrition of drugs used in alcohol dependence as indexed by persistence of prescribing. Outline of Methods The data was sourced from the Clinical Practice Research Datalink (CPRD), a large database which contains anonymised primary c...
Source: Alcohol Research UK - June 8, 2016 Category: Addiction Authors: admin Tags: Alcohol Insights Source Type: news

Medtronic reorganizes its restorative therapies segment
Medtronic (NYSE:MDT) is shuffling the deck at its restorative therapies group as it looks to boost its ailing spine and neuromodulation businesses. Fridley, Minn.-based Medtronic said yesterday that restorative therapies sales were up just 1% to $1.88 billion, including a -1% decline for its spine division at $737 million and a -5% slide to $494 million in neuromodulation. Discussing the company’s fiscal 4th-quarter results with analysts yesterday, chairman & CEO Omar Ishrak said a “speed to scale” program in spine helped drive a steady cadence of new product launches, resulting in &ldq...
Source: Mass Device - June 1, 2016 Category: Medical Equipment Authors: Brad Perriello Tags: MassDevice Earnings Roundup Neuromodulation/Neurostimulation Spinal Wall Street Beat Medtronic Source Type: news

Baclofen (Baclofen Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 22, 2016 Category: Drugs & Pharmacology Source Type: news

FDA Warns Compounders of Contaminated APIs
The U.S. FDA has advised that certain lots of baclofen active pharmaceutical ingredient from China may be contaminated with particulates and should not be used to compound sterile injectable drugs. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - December 11, 2015 Category: Pharmaceuticals Source Type: news

FDA Warns of Contamination Risk for Some Baclofen API LotsFDA Warns of Contamination Risk for Some Baclofen API Lots
Certain lots of baclofen active pharmaceutical ingredient (API) may be at risk for contamination with particulates and should not be used to compound sterile injectable drugs, the FDA warns. News Alerts (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - December 10, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Baclofen Active Pharmaceutical Ingredient from Taizhou Xinyou Pharmaceutical and Chemical: FDA Statement - FDA Warns of Potential Contamination
The affected lots may potentially pose serious safety risks for U.S. patients who use or receive injectable drug products compounded with the affected baclofen, especially when administered directly into the spinal column. (Source: FDA MedWatch)
Source: FDA MedWatch - December 10, 2015 Category: American Health Source Type: news

Therapeutic plasma exchange in poisoned patients
1 out of 5 stars Therapeutic plasma exchange in poisoning: 8 years’ experience of a university hospital. Disel NR et al. Am J Emerg Med 2015 Oct;33:1391-1395. Abstract In therapeutic plasma exchange (TPE), blood is removed from the body, and plasma is separated from components such as RBCs, WBCs, and platelets. Those components are re-infused along with a replacement fluid such as fresh-frozen plasma or albumin. This procedure is usually used to removed pathological immunoglobulins in various conditions such as thrombotic thrombocytopenic purpura. There have been some case reports and small c...
Source: The Poison Review - November 8, 2015 Category: Toxicology Authors: Leon Tags: Medical apheresis plasma exchange poisoned patient toxicology Source Type: news

What Are Treatments for Hiccups?
Discussion Hiccups affect nearly everyone at sometime in their life but continue to be poorly understood and are usually considered a nuisance. The medical term for hiccups is singultus which comes from the Latin meaning “to be caught in the act of sobbing.” Hiccups are caused by a diaphragmatic spasm that causes a sudden inhalation that is interrupted by the spasmodic closure of the glottis that produces the characteristic hiccup sound. The ‘hic’ in hiccup occurs 4-60 times/minute and in adults has no physiological purpose, but in fetuses may help train inspiratory muscles for respiration after de...
Source: PediatricEducation.org - October 19, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

High-Dose Baclofen Supports Abstinence in AlcoholismHigh-Dose Baclofen Supports Abstinence in Alcoholism
High-dose baclofen supports abstinence among alcohol-dependent patients compared with placebo and is reasonably well tolerated. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - June 30, 2015 Category: Psychiatry Tags: Psychiatry News Source Type: news

baclofen, Gablofen, Lioresal
Title: baclofen, Gablofen, LioresalCategory: MedicationsCreated: 1/25/1999 12:00:00 AMLast Editorial Review: 6/8/2015 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 8, 2015 Category: Drugs & Pharmacology Source Type: news

Non-controlled and over-the-counter drugs of abuse
  2.5 out of 5 stars Abuse of Medications That Theoretically Are Without Abuse Potential. Reeves RR et al. South Med J 2015 Mar;108:151-157. Abstract This review of noncontrolled prescription and over-the-counter drugs that can be and have been abused for non-medical or recreational purposes is rather sketchy and anecdotal (as the authors admit,) but nevertheless contains some useful information. Classes of drugs discussed include: Cold & Cough products: pseudoephedrine, ephedrine, oxymetazoline, dextromethorphan Anticholinergics: diphenhydramine, benztropine, trihexyphenidyl (Artane) Antipsychotics: quetiap...
Source: The Poison Review - March 24, 2015 Category: Toxicology Authors: Leon Tags: Medical cough/cold preparations dextromethorphan medication abuse otc over-the-counter Source Type: news

Excellent review of lipid rescue therapy
3.5 out of 5 stars Intravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent Literature. Cao D et al. J Emerg Med 2014 Dec 19 [Epub ahead of print] Abstract This excellent comprehensive review of lipid rescue therapy (LRT) is vitiated only by the unavoidable fact that available clinical evidence  is so inconclusive. As the authors point out, published literature consists mostly of case reports and small case series. The vast majority of these reported cases have good outcomes and reflect positive effects from ILE, but the evidence is marred by multiple confounding variables (such ...
Source: The Poison Review - February 25, 2015 Category: Toxicology Authors: Leon Tags: Medical intralipid lipid emulsion lipid rescue therapy lipid sink Review Source Type: news

Gablofen (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 23, 2015 Category: Drugs & Pharmacology Source Type: news

Baclofen-Naltrexone-Sorbitol for Charcot-Marie-Tooth DiseaseBaclofen-Naltrexone-Sorbitol for Charcot-Marie-Tooth Disease
Combining three familiar drugs that treat other conditions may help patients with Charcot-Marie-Tooth type 1A disease (CMT1A), a new proof-of-concept study suggests. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2014 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Intrathecal baclofen therapy in children with acquired brain injuries after drowning: A case series - Walter M, Altermatt S, Furrer C, Meyer-Heim A.
OBJECTIVE: To investigate clinical efficacy as well as the incidence and extent of complications regarding intrathecal baclofen (ITB) therapy in children. METHODS: This is a retrospective medical chart review of three paediatric patients with acqui... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 5, 2014 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

University of Minnesota-developed drug for rigid muscles moves ahead in clinical trials
(University of Minnesota Academic Health Center) A new formulation for a University of Minnesota-developed drug targeted at rare disorders is under development, with the potential to help a small number of Americans each year. The new formulation of the drug baclofen is designed to prevent serious complications that can occur when drug delivery is interrupted. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 24, 2014 Category: Global & Universal Source Type: news

Emma Ross, 10, who suffered cardiac arrest wakes from 5 month coma
Emma Ross, 10, is the first child to be fitted with a £27,000 Baclofen pump at Yorkhill Children’s Hospital in Glasgow, having been diagnosed with cardiomyopathy. (Source: the Mail online | Health)
Source: the Mail online | Health - July 4, 2014 Category: Consumer Health News Source Type: news

Episode #4: Poisoning and the diagnosis of brain death
Conclusion: unclear how long to wait before pronouncing brain death as many factors such as pharmacogenetics can alter normal metabolism   Summary Drug overdose can mimic brain death Be especially cautious in overdose involving the scary B’s: baclofen, barbiturate, benzodiazepine The 3-5 half life rule for drug clearance cannot be applied in the cases of overdose Half lives are measured at therapeutic levels Multiple other factors can alter metabolism in overdoses, such as pharmacogenetics, and cross reactivity with other ingestants Consult a toxicologist if there is any question regarding possible overdose...
Source: The Poison Review - May 20, 2014 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

Toxicity from phenibut, a legal over-the-counter baclofen analogue
3 out of 5 stars Phenibut, the appearance of another potentially dangerous product in the Univted States. O’Connell CW et al. Am J Med 2014 Apr 5 [Epub ahead of print] Reference This short case report describes a 25-year-old man who was brought to the emergency department after being found with decreased mental status and responsiveness. On arrival at the hospital, his vital signs were stable and pulse oximetry 100% on room air. He was minimally responsive to painful stimuli. Neurological exam was non-focal and head CT unremarkable. A roommate reported that the patient had been taking 1.5 grams of “Phenibu...
Source: The Poison Review - April 22, 2014 Category: Toxicology Authors: Leon Tags: Medical baclofen GABA agonist legal high noofen phenibut sedative Source Type: news

Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males - Weerts A, Pattyn N, Van de Heyning P, Wuyts F.
This study aimed to investigate the clinical and cognitive side effects of baclofen (10 mg), meclizine (50 mg), dimenhydrinate (40 mg) plus cinnarizine (20 mg) and promethazine (25 mg) plus d-amphetamine (5 mg). The study had a double-blind, placebo contro... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - December 21, 2013 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Patient woke up just a docs about to remove her organs
My recent column in Emergency Medicine News, about the patient in a Syracuse, NY hospital who woke up in the operating room just before her organs were about to be harvested for donation, is now online.  The read it, click here. (Source: The Poison Review)
Source: The Poison Review - October 31, 2013 Category: Toxicology Authors: Leon Tags: Medical baclofen brain death organ donation syracuse ny Source Type: news

Class I Medical Device Recall: Codman and Shurtleff MedStream Programmable Infusion Pump and Refill Kits - Drug Over Infusion
The MedStream Programmable Infusion Pump is an implanted drug delivery system used in the US for the chronic delivery of Baclofen to treat muscle symptoms and used in Europe, Middle East, and Africa (EMEA) for the chronic delivery of Morphine or Baclofen. (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - October 23, 2013 Category: Medical Equipment Source Type: news

Official report about overdose patient who awoke in OR just before surgeons harvested her organs
Several days ago TPR posted  about a distressing case from Syracuse (NY), in which an overdose patient woke up in the operating room just as surgeons were about to harvest her organs. There were some details in the Syracuse Post-Standard story. An astute reader sent a comment pointing out that the report investigating this case — produced by the Centers for Medicare & Medicaid Services — noted that the patient was on baclofen (in addition to Xanax and diphenhydramine. Baclofen is notorious for producing prolonged coma and a clinical syndrome indistinguishable from brain death in overdose...
Source: The Poison Review - July 11, 2013 Category: Toxicology Authors: Leon Tags: Best of TPR Medical baclofen brain death organ donation Source Type: news

PR manager jumped to her death from bridge over the Thames after getting addicted to drug to help with alcoholism
Anna Sargent, 36, who worked in PR in London, had come across baclofen online when she was trying to find a way to get over her addiction to alcohol. (Source: the Mail online | Health)
Source: the Mail online | Health - July 9, 2013 Category: Consumer Health News Source Type: news

Hospital fined after overdose patient awakes just before surgeons harvest her organs
The Syracuse (NY) Post-Standard reports that St. Joseph’s Hospital Health Center has been fined $22,000 for a 2009 incident in which a patient declared brain dead and cleared for organ donation woke up in the operating room just before the harvesting procedure was to begin. According to the report, the 41-year-old patient was brought to the emergency department comatose. Although staff at the hospital thought she had suffered a cardiac catastrophe, she was actually suffering from effects of an intentional overdose of drugs including Xanax, diphenhydramine, and a muscle relaxant. It is not clear from the new...
Source: The Poison Review - July 8, 2013 Category: Toxicology Authors: Leon Tags: Medical drug overdose organ donation Source Type: news

Arbaclofen placarbil
XenoPort has discontinued its potential spasticity treatment (a slow release version of baclofen) after a phase 3 trail showed it was no more effective than placebo. Reuters Spacticity - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - May 19, 2013 Category: Neurology Source Type: news

IV Baclofen Good for Spasm-Related Pain (CME/CE)
NEW ORLEANS (MedPage Today) -- Intravenous baclofen can effectively combat migraine and muscle spasm pain, researchers found. (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - May 10, 2013 Category: Psychiatry Source Type: news