Study: Misuse of Certain Nonopioid Analgesics on the Rise
Research suggests that as the number of prescriptions written for opioids has dropped, there has been a corresponding rise in the use of nonopioid medications such as gabapentin and baclofen to treat certain types of pain. (Source: AAFP News)
Source: AAFP News - January 9, 2020 Category: Primary Care Source Type: news

Misuse of Nonopioid Medications Appears to Be on the Rise in U.S.
Increases seen for misuse/abuse, suicide attempts, and hospitalizations linked to gabapentin, baclofen (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - December 19, 2019 Category: Psychiatry Tags: Family Medicine, Internal Medicine, Emergency Medicine, Nursing, Pharmacy, Psychiatry, Anesthesiology & amp; Pain, Journal, Source Type: news

Misuse of Nonopioid Medications Appears to Be on the Rise in U.S.
THURSDAY, Dec. 19, 2019 -- Misuse/abuse, use in suicide attempts, and hospital admissions associated with gabapentin and baclofen have significantly increased among U.S. adults since 2013, according to a study published online Dec. 1 in Clinical... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 19, 2019 Category: Pharmaceuticals Source Type: news

Trends in gabapentin and baclofen exposures reported to U.S. poison centers - Reynolds K, Kaufman R, Korenoski A, Fennimore L, Shulman J, Lynch M.
Context: Prescriptions for nonopioid pharmacological therapies such as gabapentin and baclofen have been increasing. While gabapentin and baclofen are less likely than opioids to result in fatal overdose, they are each associated with dependence, mi... (Source: SafetyLit)
Source: SafetyLit - December 5, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Study highlights 'worrying' increase in misuse of non-opioid medications
(Taylor& Francis Group) A major new analysis of the non-opioid medications, gabapentin and baclofen, shows 'worrying' increases in related suicide attempts and hospital admissions in US adults since 2013 -- coinciding with a decrease in opioid prescriptions. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 2, 2019 Category: International Medicine & Public Health Source Type: news

ASN: Encephalopathy Up in CKD Patients on Higher-Dose Baclofen
WEDNESDAY, Nov. 13, 2019 -- The incidence of encephalopathy is increased with prescription of higher versus lower doses of baclofen among older patients with chronic kidney disease (CKD), according to a study published online Nov. 9 in the Journal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 13, 2019 Category: Pharmaceuticals Source Type: news

Common Muscle Relaxant, Baclofen, Could Pose Mental Dangers for Seniors
SATURDAY, Nov. 9, 2019 -- A commonly prescribed muscle relaxant known as baclofen can leave older kidney patients so disoriented that they land in the hospital, a new study warns. " It can present with acute stroke-like symptoms, even though it's... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 9, 2019 Category: General Medicine Source Type: news

Common Muscle Relaxant Baclofen Could Pose Mental Dangers for Seniors
SATURDAY, Nov. 9, 2019 -- A commonly prescribed muscle relaxant known as baclofen can leave older kidney patients so disoriented that they land in the hospital, a new study warns. " It can present with acute stroke-like symptoms, even though it's... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 9, 2019 Category: General Medicine Source Type: news

Common Muscle Relaxant Could Pose Mental Dangers for Seniors
SATURDAY, Nov. 9, 2019 -- A commonly prescribed muscle relaxant known as baclofen can leave older kidney patients so disoriented that they land in the hospital, a new study warns. " It can present with acute stroke-like symptoms, even though it's not... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 9, 2019 Category: General Medicine Source Type: news

Examining muscle relaxant dose, risk of encephalopathy in patients with CKD
(JAMA Network) Whether a higher or lower dose of the muscle relaxant baclofen was associated with 30-day risk of hospitalization with encephalopathy (defined as a main diagnosis of delirium, disorientation, transient alteration of awareness, transient ischemic attack or an unclear diagnosis of dementia) among newly prescribed patients with chronic kidney disease was the focus of this observational study with nearly 16,000 older adults. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 9, 2019 Category: International Medicine & Public Health Source Type: news

Common muscle relaxant causes severe confusion in patients with kidney disease
(University of Western Ontario) One in 25 patients with very low kidney function were admitted to hospital with severe confusion and other cognitive-related symptoms a few days after being prescribed a common muscle relaxant.A new study has shown that patients with kidney dysfunction who were prescribed a high dose of the drug baclofen, were more likely to be admitted to hospital for disorientation and confusion, than those who weren't prescribed the drug. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 9, 2019 Category: International Medicine & Public Health Source Type: news

Surgery Best Option in the Uncommon Case When PPIs Fail to Stem Heartburn Surgery Best Option in the Uncommon Case When PPIs Fail to Stem Heartburn
When heartburn is refractory to proton-pump inhibitor (PPI) treatment, antireflux surgery is a better option than reflux-reducing medication such as baclofen or treatment with neuromodulators, a new clinical trial shows.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - October 18, 2019 Category: Surgery Tags: Gastroenterology News Source Type: news

Ozobax (Baclofen Oral Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 25, 2019 Category: Drugs & Pharmacology Source Type: news

Baclofen (Baclofen Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 2, 2019 Category: Drugs & Pharmacology Source Type: news

New Partnership Forms to Develop Breakthrough Neuromodulation Device
WeHealth, an e-health department of Servier Group, said it is in a partnership with Pathmaker Neurosystems, a pioneering clinical-stage bioelectronic medicine company. The two companies revealed plans to develop and commercialize the first neuromodulation technology designed to treat muscle spasticity non-invasively. The new technology will be known as the MyoRegulator device. The new MyoRegulator PM-200 provides a non-invasive treatment option for patients suffering from muscle spasticity, a common condition found in many patients suffering from stroke, cerebral palsy, multiple sclerosis, spinal cord injury, and traumatic...
Source: MDDI - March 26, 2019 Category: Medical Devices Authors: Kristopher Sturgis Tags: Business Source Type: news

Children With CP May Have Worse Pain, Be Less Active When Parents Catastrophize Children With CP May Have Worse Pain, Be Less Active When Parents Catastrophize
If their parents catastrophize pain, children with cerebral palsy (CP) have worse pain and more impaired activities of daily living after intrathecal baclofen (ITB) surgery to control spasticity, according to results of a study presented last month at the International Association for the Study of Pain (IASP) World Congress on Pain in Boston.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - October 17, 2018 Category: Surgery Tags: Anesthesiology News Source Type: news

Gabapentin vs. Baclofen
Title: Gabapentin vs. BaclofenCategory: MedicationsCreated: 3/22/2018 12:00:00 AMLast Editorial Review: 3/22/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - March 22, 2018 Category: Anesthesiology Source Type: news

"Wonder drug" for alcohol abuse disorders found to be completely ineffective after careful review
(Natural News) Baclofen has been heralded by the pharmaceutical industry as a one-stop treatment for alcohol use disorders. The supposed “wonder drug” has even been called a cure for alcoholism. But no pharma cash cow should go without scrutiny — and it turns out that baclofen actually doesn’t stand up to the test. While a number... (Source: NaturalNews.com)
Source: NaturalNews.com - March 19, 2018 Category: Consumer Health News Source Type: news

Baclofen and Flexeril (Side Effects and Interactions)
Title: Baclofen and Flexeril (Side Effects and Interactions)Category: MedicationsCreated: 2/8/2018 12:00:00 AMLast Editorial Review: 2/8/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - February 8, 2018 Category: Anesthesiology Source Type: news

Baclofen vs, Flexeril (Side Effects and Interactions)
Title: Baclofen vs, Flexeril (Side Effects and Interactions)Category: MedicationsCreated: 2/8/2018 12:00:00 AMLast Editorial Review: 2/8/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - February 8, 2018 Category: Anesthesiology Source Type: news

Enjoying life to her full potential with cerebral palsy
For a month, Nikki Puzzo walked around with a hockey puck strapped to her torso. But this mother of two wasn’t just being silly or exhibiting her love of sports. Instead, she was demonstrating solidarity with her younger daughter, Stella. The little girl, who has spastic diplegia cerebral palsy (CP), had a device called a baclofen pump implanted into her abdomen. “I wanted her to feel more comfortable and know that she wasn’t alone,” explains Nikki. Targeting spasticity Like many kids with CP, Stella has spasticity, or severe tightness and stiffness, in her leg muscles. A medication called baclofen...
Source: Thrive, Children's Hospital Boston - January 23, 2018 Category: Pediatrics Authors: Jessica Cerretani Tags: Diseases & Conditions Our Patients’ Stories baclofen pump cerebral palsy Cerebral Palsy Center Dr. Brian Snyder Dr. Donna Nimec Dr. Elizabeth Barkoudah Kristin Buxton Source Type: news

Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals
We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the -aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for...
Source: ScienceNOW - January 18, 2018 Category: Science Authors: Kitson, P. J., Marie, G., Francoia, J.-P., Zalesskiy, S. S., Sigerson, R. C., Mathieson, J. S., Cronin, L. Tags: Chemistry reports Source Type: news

Medtronic touts therapy delivered via SynchroMed pump in patients with post-stroke spasticity
Medtronic (NYSE:MDT)  touted data today showing that intrathecal baclofen therapy delivered via the company’s SychroMed II infusion pump performed better than the conventional treatment for patients with severe post-stroke spasticity. The medtech titan’s SynchroMed II pump is the only device approved in the U.S. for ITB therapy. Get the full story at our sister site, Drug Delivery Business News. The post Medtronic touts therapy delivered via SynchroMed pump in patients with post-stroke spasticity appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - January 11, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Neurological Pharmaceuticals Wall Street Beat Medtronic Source Type: news

New Study Shows Superiority of Intrathecal Baclofen Therapy (ITB Therapy(SM)) Over Oral Medication for the Treatment of Severe Post-Stroke Spasticity
Therapy Delivered via the Medtronic SynchroMed(TM) II Infusion System DUBLIN - January 11, 2018 -- (Healthcare Sales & Marketing Network) -- Medtronic plc (NYSE:MDT) today announced the publication of results from the 'Spasticity In Stroke-Randomised St... Devices, Drug Delivery, Neurology Medtronic, Intrathecal Baclofen Therapy, baclofen, SynchroMed, Stroke (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 11, 2018 Category: Pharmaceuticals Source Type: news

Skelaxin vs. Baclofen
Title: Skelaxin vs. BaclofenCategory: MedicationsCreated: 1/5/2018 12:00:00 AMLast Editorial Review: 1/5/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - January 5, 2018 Category: Anesthesiology Source Type: news

EMedHome's Clinical Pearl: Spotting Baclofen Pump Complications Early
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - January 1, 2018 Category: Emergency Medicine Tags: EMedHome's Clinical Pearl Source Type: news

Response to the letter to the editor regarding "Baclofen and alcohol-dependent patients: a real risk of severe self-poisoning." - Boels D, Victorri-Vigneau C, Grall-Bronnec M, Tour é A, Brunet M, Hamel JF, Le Roux G.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - December 5, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Baclofen vs. Lorazepam
Title: Baclofen vs. LorazepamCategory: MedicationsCreated: 10/27/2017 12:00:00 AMLast Editorial Review: 10/27/2017 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - October 27, 2017 Category: Drugs & Pharmacology Source Type: news

Sun Pharma ’s Phase III trials of Baclofen GRS fail to meet primary endpoint
India-based Sun Pharma Advanced Research (SPARC) has reported top-line results from two Phase III clinical trials of Baclofen GRS to treat spasticity in patients suffering from multiple sclerosis. (Source: Drug Development Technology)
Source: Drug Development Technology - October 9, 2017 Category: Pharmaceuticals Source Type: news

ACMT Position Statement: Toxicology Issues in Determining Brain Death
4 out of 5 stars ACMT Position Statement: Determining Brain Death in Adults After Drug Overdose. Neavyn MJ et al. J Med Toxicol 2017;13:271-273. Full Text The American Academy of Neurology guidelines on determining brain death in adults states that the clinician can not make such a determination unless he or she can  “[e]xclude the presence of a CNS-depressant drug effect by history, drug screen, calculation of clearance using 5 times the drug’s half-life (assuming normal hepatic and renal function), or, if available, drug plasma levels below the therapeutic range.” Excluding drug effect in...
Source: The Poison Review - September 27, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical american college of medical toxicology baclofen brain death position statement Source Type: news

Pills prescribed for alcoholism might not work, study finds
Review of five drugs – including one linked to deaths – says there is no body of reliable evidence behind any of themThere is no magic pill to cure alcoholism, according to a scientific review of the evidence of five drugs being prescribed by doctors.None of the five drugs has a body of reliable evidence behind it, say the scientists, even though one of the drugs, nalmefene, has been approved for use in the NHS by Nice, the National Institute for Health and Care Excellence. Another, baclofen, has generated huge excitement, especially in France, but has been linked to deaths.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 21, 2017 Category: Science Authors: Sarah Boseley Health editor Tags: Alcoholism Health Society NHS Drugs Pharmaceuticals industry Business Science UK news Source Type: news

No magic pill to cure alcohol dependence yet
(Society for the Study of Addiction) A new study published by the scientific journal Addiction has found no reliable evidence for using nalmefene, naltrexone, acamprosate, baclofen or topiramate to control drinking in patients with alcohol dependence or alcohol use disorder. At best, some treatments showed low to medium efficacy in reducing drinking, but those findings were from studies with a high risk of bias. None demonstrated any benefit on health outcomes. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 21, 2017 Category: International Medicine & Public Health Source Type: news

Severity of baclofen self-poisoning linked to psychiatric co-morbidity in alcohol-dependent patients: better measurement of risk and benefit - Pelissier F, de Haro L, Rolland B, Franchitto N.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - July 16, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers
Primary care patients with high-risk alcohol consumption have significantly better rates of low-risk drinking or abstinence with baclofen vs placebo, the results of a French study indicate.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 22, 2017 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Alcoholism drug baclofen 'is a stammer cure'
The treatment was discovered by chance after the man found he stopped stammering when he was given baclofen, a relaxant that eases stiff muscles caused by multiple sclerosis. (Source: the Mail online | Health)
Source: the Mail online | Health - May 12, 2017 Category: Consumer Health News Source Type: news

Baclofen and alcohol-dependent patients: a real risk of severe self-poisoning - Boels D, Victorri-Vigneau C, Grall-Bronnec M, Tour é A, Garnier A, Turcant A, Le Roux G.
This study aimed to determine the change in number and profile of self-poisoning with ba... (Source: SafetyLit)
Source: SafetyLit - March 23, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Self-poisoning with baclofen in alcohol-dependent patients: national reports to French Poison Control Centers, 2008-2013 - Pelissier F, de Haro L, Cardona F, Picot C, Puskarczyk E, Sapori JM, Tournoud C, Franchitto N.
BACKGROUND: Alcohol use disorders are frequently associated with self-intoxication in attempted suicide. In France since 2008, the off-label use of baclofen for treatment of alcohol dependence has greatly increased, leading to temporary regulation of use o... (Source: SafetyLit)
Source: SafetyLit - February 14, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Kemstro (Baclofen) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 26, 2017 Category: Drugs & Pharmacology Source Type: news

Gablofen (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 15, 2016 Category: Drugs & Pharmacology Source Type: news

Lioresal Intrathecal (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 15, 2016 Category: Drugs & Pharmacology Source Type: news

More Evidence Baclofen for Alcohol Dependence Be Reconsidered More Evidence Baclofen for Alcohol Dependence Be Reconsidered
Another study of high-dose baclofen, widely used in France to treat alcohol dependence, does not appear to bolster abstinence rates in findings that suggest its use should be reconsidered.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 6, 2016 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Study suggests prescribing of baclofen for alcohol dependence'should be reconsidered '
The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomized controlled trial found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 30, 2016 Category: Science Source Type: news

Prescribing of baclofen for alcohol dependence 'should be reconsidered'
(European College of Neuropsychopharmacology) The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomised controlled trial from the University of Amsterdam found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 30, 2016 Category: Global & Universal Source Type: news

ECG Reveals Effects of Multi-Substance Suicide Attempt
The Case Medic 49 was called to a wooded area near a private residence for a missing person and concern for overdose. Police were already on scene and had walked approximately 0.5 miles into the wooded area behind the home where they found a 30-year-old female unresponsive with several pill bottles nearby. The family, who had reported the patient missing, stated that the patient had a history of suicidal thoughts. On EMS arrival, the patient was still unresponsive and hypoxic with an oxygen saturation of 76% on RA. The patient was also tachycardic to 130 and had an initial blood pressure of 140/90. The patient was not movi...
Source: JEMS Patient Care - September 29, 2016 Category: Emergency Medicine Authors: Jeffrey J. Bell, RN, BSN, CEN, NREMT-P Tags: Patient Care Source Type: news

Arbaclofen-ER Decreases MS-Related Spasticity Arbaclofen-ER Decreases MS-Related Spasticity
Arbaclofen extended-release tablets can decrease spasticity related to multiple sclerosis, with a better safety profile than baclofen, new research suggests.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 16, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Teligent, Inc. Announces Health Canada Approval Of Three Baclofen Injection Products
BUENA, N.J., Aug. 25, 2016 -- (Healthcare Sales & Marketing Network) -- Teligent, Inc. (TLGT), a New Jersey-based specialty generic pharmaceutical company, today announced that its Estonian subsidiary, Teligent OÜ, has received three Abbreviated New ... Biopharmaceuticals, Generics, Regulatory Teligent, Baclofen (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 25, 2016 Category: Pharmaceuticals Source Type: news

Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms - de Witte LD, Dekker D, Veraart J, Kromkamp M, Kaasjager K, Vinkers CH.
BACKGROUND: Baclofen is increasingly prescribed for alcohol dependency. Subsequently, the risk of self-intoxication with this medicinal product is increasing. CASE DESCRIPTION: A 23-year-old man with a history of alcohol dependence was admitted to our hosp... (Source: SafetyLit)
Source: SafetyLit - August 6, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Baclofen Injection (Baclofen Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 19, 2016 Category: Drugs & Pharmacology Source Type: news

Well-known U of L researcher loses federal funding for study
A well-known University of Louisville researcher has lost federal funding for a nearly $1 million biomedical study because of concerns involving oversight and whether the data was valid. According to the Kentucky Center for Investigative Reporting, Dr. Susan Harkema had been studying the effects of a muscle relaxer, called Baclofen, on patients who were undergoing treadmill therapy. Funding for that $914,000 study was pulled in March by the National Institute on Disability, Independent Living and… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 12, 2016 Category: Pharmaceuticals Authors: Baylee Pulliam Source Type: news