Prognostic Implications of the Complement Protein C1q in Gliomas

The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including melanoma, prostate, mesothelioma, and ovarian cancers, where it can exert a protective or a harmful effect on cancer progression. Despite local synthesis of C1q in the central nervous system, the involvement of C1q in glioma pathogenesis has been poorly investigated. We, therefore, performed a bioinformatics analysis, using Oncomine dataset and UALCAN database in order to assess whether the expression of the genes encoding for the three chains of C1q (C1qA, C1qB, and C1qC) could serve as a potential prognostic marker for gliomas. The obtained results were then validated using an independent glioma cohort from the Chinese Glioma Genome Atlas datasets. Our bioinformatics analysis, coupled with immunohistochemistry and fluorescence microscopy, appears to suggest a positive correlation between higher levels of C1q expression and unfavorable prognosis in a diverse g...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: January 2020Source: Trends in Food Science &Technology, Volume 95Author(s): Ali Atamaleki, Mohsen Sadani, Amir Raoofi, Ali Miri, Saeed Gharibian Bajestani, Yadolah Fakhri, Zoha Heidarinejad, Amin Mousavi KhaneghahAbstractBackgroundThere is an increasing trend in the consumption of egg on a worldwide scale, however, it can be a source of potentially toxic elements (PTEs) which could threaten the health of consumers.Scope and approachThe related studies on the concentration of PTEs in eggs by databases including PubMed, Scopus, Web of Science and Embase in a global scale were retrieved and following met...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
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Source: Food Research International - Category: Food Science Source Type: research
This study aimed to examine the effects of carrier, benefit, and trust in information channel about functional foods on purchase intention as well as the demographic differences of these effects. A survey with 1,144 respondents from Mainland China revealed that carriers were more important factors than benefits for perceived attractiveness and purchase intention. Benefits were more positively evaluated when attached to a more attractive carrier. Benefits of improving the body’s natural defense system were most favored by all groups; benefits about specific diseases were suitable to tailor for certain groups. Consumer...
Source: Food Quality and Preference - Category: Food Science Source Type: research
In this study, a statistical model, combining principal components analysis (PCA), stepwise-canonical discriminant analysis (stepwise-CDA), classification and regression tree (CART), partial least squares-discriminant analysis (PLS-DA) and an innovative multidimensional analysis (MDA), was build up to predict the geographical origin of edible porcini (Boletus sect. Boletus). To this purpose, the elemental signatures of 180 commercial and manually harvested samples from different Italian production areas, China and Poland, were chemometrically elaborated. PCA differentiated Italian products from Chinese and Polish mushrooms...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 13 November 2019Source: Current Opinion in VirologyAuthor(s): Marta M Gaglia, Karl Munger
Source: Current Opinion in Virology - Category: Virology Source Type: research
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Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
This article discusses various educational interventions implemented in a new patient/family education program at the University of South Alabama Children's &Women's Hospital in Mobile, Alabama, for patients and family members of those newly diagnosed with pediatric cancer and other chronic illnesses. Tablet computers were made available to access reputable, easy to understand health resources during the educational processes upon diagnosis and continued treatment at the hospital. MedlinePlus, Patient Education Institute's X-Plain videos and other National Library of Medicine resources were available at the bedside and...
Source: Journal of Hospital Librarianship - Category: Databases & Libraries Tags: J Hosp Librariansh Source Type: research
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Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
CONCLUSION: CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion. Furthermore, rs2794521 may be a predictor of the efficacy of antidepressants in female patients. PMID: 31711279 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
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