Chronic Lyme arthritis: A mystery solved?

In 1975, researchers from Yale investigated an epidemic of 51 patients with arthritis who lived near the woodsy town of Lyme, Connecticut. The most common symptom was recurrent attacks of knee swelling. A few had pain in other joints, such as the wrist or ankle. Many had fever, fatigue, and headache. Some remembered a round skin rash before the onset of knee swelling. We now know that Lyme disease is an infection acquired from tick bites, caused by a spiral bacterium named Borrelia burgdorferi. After a tick bite, Borrelia bacteria wriggle through the skin away from the bite site. This leads to a circular red rash, known as erythema migrans. In its more advanced stages, erythema migrans may take on a bullseye appearance. Many people are unaware of the rash, as it is usually painless, and ticks may bite in less visible locations, such as a buttock or shoulder blade. Lyme disease is diagnosed with blood tests that detect antibodies to B. burgdorferi. Two-step testing is traditionally performed. A rapid enzyme immunoassay is performed first. If this is positive, a more time-consuming Western blot test is sent for confirmation. The FDA recently approved two rapid tests for Lyme disease that are performed simultaneously, reducing the turnaround time. Lyme disease often leads to Lyme arthritis Although Lyme disease may affect many organs, such as the heart and nervous system, joint involvement tends to be the most common and persistent manifestation, resulting in joint swelling and ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Bones and joints Infectious diseases Source Type: blogs

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So in this "fellowship" that i resigned from recently, I asked long time ago whether tail was covered.I was told yes. When I signed paperwork after resigining I was told that I'd be covered for the premium for the tail. When I was like what?! That's not what I was told. I was told that "it would be covered if I finished the fellowship." That seems shady and illegal. Obviously paying thousands of dollars for tail would be reasonable on an attending salary, but now it seems they are pissed I... Tail coverage
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
ConclusionsOur study is the first study analyzing the impact of API on genital mucous membranes. In our study conditions, API had no impact on the mucous membranes, suggesting that it can be used safely.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 November 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Carina Bodden, Anthony J. Hannan, Amy C. ReicheltGlobally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesit...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Victor Fattori, Tiago H. Zaninelli, Fernanda S. Rasquel-Oliveira, Rubia Casagrande, Waldiceu A. VerriAbstractWe now appreciate that the mechanism of resolution depends on an active and time-dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called specialized pro-resolving lipid mediators (SPMs). These SPMs are biosynthesized from the omega-3 fatty acids arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), or docosahexaenoic acid (DHA). Despite effective for a fractio...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study aimed to investigate the mechanism of action of ginger extract and its compound, 6-shogaol, on pancreatic islets as well as on expressions of TRPV-1 and NMDAR2B in the spinal cord of streptozotocin (STZ)-induced mice model of PDN.Materials and methodsSixty-four 5–6 months old male-Balb/C mice were induced with 110 mg/kgBW STZ i.p., while eight mice were used as control group. Mice with blood glucose level ≥200 mg/d, that suffered hyperalgesia and allodynia were classified as PDN mice. Hot plate and von Frey filament tests were performed once a week until termination. At day 28 after considered as PDN,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionWithin the limitations of the study, GBR with or without autogenous block graft may be an effective approach in augmenting horizontally deficient mandibular or maxillary ridges, before the placement of dental implants. However, more complications may be seen with the use of an autogenous block graft related to the donor sites.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionThe authors recommended short implants whenever the height of available bone permits optimum implant placement. The authors concluded that both treatment options are considered viable clinically and radiographically. However, short implants have shown reduced postoperative discomfort, minimal invasiveness, and reduced cost.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionsThe authors concluded that oral health interventions focusing on indigenous populations have shown mixed results regarding improvements in oral health and other related outcomes.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionLimited available evidence suggests that patients with RAS may experience a reduction in the number of ulcers, DOU, NOE, and UP when using a SLS-free dentifrice as compared to using a dentifrice containing SLS.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
This study is an attempt to investigate the effects of intrathecal administration of Melissa officinalis on the pain induced by heat and formalin.In this experimental study, seventy male Wistar rats with an average weight of 270-320 g were randomly divided into 5 groups: control; sham, that received 25 μl of saline through the spinal catheter; and three experimental groups, that received 5, 10 or 20 mg/kg Melissa officinalis via the spinal catheter respectively. Five days after catheterization of the spinal cord from the lumbar region under anesthesia, the effects of Intrathecal administration of Melissa officinalis on ...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
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